从与海绵Lendenfeldia共生的白灰链霉菌JM128中发现新的1-单甘油酯

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-08-05 DOI:10.1016/j.phytol.2025.103026

Yun-Ting Zeng , Chia-Ching Liaw , Yu-Chi Lin , Su-Ying Chien , You-Ying Chen , Li-Guo Zheng , Chih-Yin Huang , Hsi-Wen Sun , Ping-Jyun Sung

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引用次数: 0

摘要

从与海绵属Lendenfeldia属共生的革兰氏阳性菌Streptomyces albogriseolus JM128中分离到一种新的1-单甘油酯(S*)-2′，3′-dihydroxypropyl (Z)- 14-methylpentadecanoic acid(1)和一种已知的脂肪酸14-methylpentadecanoic acid(2)。用单晶x射线衍射（SC-XRD）分析确定了化合物2的结构。而化合物1的结构则通过二维NMR实验结合文献资料进行确认。代谢产物1和2在浓度为10 μM时均表现出抑制一氧化氮（NO）释放的活性。

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Discovery of a new 1-monoglyceride from Streptomyces albogriseolus JM128 symbiotic with Lendenfeldia sponge

A new 1-monoglyceride, (S*)-2′,3′-dihydroxypropyl (Z)-14-methylpentadec-9-enoate (1), and a known fatty acid, 14-methylpentadecanoic acid (2), were isolated from the Gram-positive bacterium Streptomyces albogriseolus JM128, which is symbiotic with the sponge identified as Lendenfeldia species. The structure of compound 2 was determined using single-crystal X-ray diffraction (SC-XRD) analysis. In contrast, the structure of compound 1 was confirmed through 2D NMR experiments combined with literature data. Both metabolites 1 and 2 exhibited inhibitory activity on nitric oxide (NO) release at a concentration of 10 μM.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.