一种新的苯醌类和二氢黄酮类化合物及其生物活性

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-07-14 DOI:10.1016/j.phytol.2025.103012

Jian-Fen Xiao, Ming-Rui Yang, Pin-Xiang Fu, Rui Yang, Hong-Ping He, Hua-Yi Jiang

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引用次数: 0

摘要

从多花菜的乙酸乙酯部分分离得到了一个新的苯醌和一个新的二氢黄酮，鱼多胺素A(1)和B(2)，以及4个已知化合物（3-6）。1和2的结构主要通过核磁共振和质谱相结合的方法确定。化合物5和6为首次从该植物中分离得到。化合物1、4和6对lps诱导的RAW 264.7细胞一氧化氮（NO）的产生有抑制作用。化合物2和4的抗氧化活性较弱。

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A new benzoquinone and a new dihydroflavone from Fissistigma polyanthum and their bioactivity

A new benzoquinone and a new dihydroflavone, fispolyanins A (1) and B (2), along with four known compounds (3–6), were isolated from the ethyl acetate fraction of Fissistigma polyanthum. The structures of 1 and 2 were established primarily by a combination of NMR and MS methods. Compounds 5 and 6 were obtained from F. polyanthum for the first time. Compounds 1, 4, and 6 exhibited inhibitory activities against the production of nitric oxide (NO) in LPS-induced RAW 264.7 cells. Compounds 2 and 4 showed weak anti-oxidant activities.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.