烟孢新担子菌培养的4个新的α-吡咯酮衍生物

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-08-05 DOI:10.1016/j.phytol.2025.103025

Haiqi Li , Jing Hu , Xiaoqing Li , Yao Qin , Mingda Yao , Jiaojiao Wang , Yungeng Gao , Yan-Long Yang

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引用次数: 0

摘要

从担子菌真菌Neofomitella fumosipora的液体培养提取物中分离并鉴定了4个先前未被描述的α-吡咯酮衍生物，命名为fumopyrones A-D（1-4）。用广谱光谱法测定了它们的化学结构。Fumopyrone C(3)通过显著上调关键炎症细胞因子的mRNA水平，包括IL-6、TNF-α、IL-1β和生成NO的NOS2，显示出强大的促炎活性。

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Fumopyrones A-D, four new α-pyrone derivatives from cultures of the basidiomycete Neofomitella fumosipora

Four previously undescribed α-pyrone derivatives, named fumopyrones A-D (1-4), were isolated and characterized from the liquid culture extract of the basidiomycete fungus Neofomitella fumosipora. Their chemical structures were determined by extensive spectroscopic methods. Fumopyrone C (3) exhibited potent pro-inflammatory activity by significantly upregulating mRNA levels of key inflammatory cytokines, including IL-6, TNF-α, IL-1β, and NOS2 that generates NO.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.