标题纤毛杜鹃属天然新产物。Lyi

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-07-29 DOI:10.1016/j.phytol.2025.103020

Chun-Lin Guo , Si-Xuan Liu , Lu Zhang , Ling Li , Yong-Fu Lu , Si-Yang Dai , Chang Li , Yue-Hu Pei

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引用次数: 0

摘要

从纤毛杜鹃（Rhododendron ciliicalyx subsp）枝条和叶片中分离到两个新化合物，一个新的环烯醚萜(1)和一个新的亚甲基桥二聚体(2)。Lyi。化合物1的结构基于广泛的光谱数据分析，并与先前报道的核磁共振数据进行比较，通过ECD计算进一步证实了化合物1的绝对构型。在lps活化的RAW 264.7巨噬细胞中评估化合物对NO释放的抑制作用。

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New natural products from Rhododendron ciliicalyx subsp. Lyi

Two new compounds, one new iridoid (1), and one new methylene-bridged dimer (2) have been isolated from the twigs and leaves of Rhododendron ciliicalyx subsp. Lyi. Their structures were elucidated based on extensive spectroscopic data analysis and by comparison with previously reported NMR data, the absolute configuration of compound 1 was further confirmed by the ECD calculations. The NO release inhibitory effects of compounds were evaluated in LPS-activated RAW 264.7 macrophages.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.