Phytochemistry Letters最新文献_第4页

Isolation of a new natural bromopyrrole alkaloid agenakasine, a biosynthetically related metabolite laughine, and norzooanemonin from a marine sponge Agelas nakamurai 一种新的天然溴吡咯生物碱agenakasine、一种生物合成相关代谢物laughine和从中村海苔中分离出的去虫anemonin

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-13 DOI: 10.1016/j.phytol.2025.102975

Chung-Wei Fu , Atallah F. Ahmed , Lin Chiang , Shu-Fen Chiou , Hui-Chun Wang , Jyh-Horng Sheu

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The effects of upstream processing on the chemical profile and immunomodulating activity of Echinacea purpurea tinctures 上游加工对紫锥菊酊剂化学成分及免疫调节活性的影响

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-12 DOI: 10.1016/j.phytol.2025.102971

Kate Tolan , Mohammed Ali Selo , Ismael Obaidi , Peter O’Connell , Michael Carty , Shipra Nagar , Anne Marie Healy , Helen Sheridan

{"title":"The effects of upstream processing on the chemical profile and immunomodulating activity of Echinacea purpurea tinctures","authors":"Kate Tolan , Mohammed Ali Selo , Ismael Obaidi , Peter O’Connell , Michael Carty , Shipra Nagar , Anne Marie Healy , Helen Sheridan","doi":"10.1016/j.phytol.2025.102971","DOIUrl":"10.1016/j.phytol.2025.102971","url":null,"abstract":"<div><div>Echinacea purpurea (L.) Moench is a medicinal plant that is widely known for its immunomodulating properties. There is a lack of understanding regarding how E. purpurea tinctures should be prepared to ensure the most favourable biological activity. To address this gap, a total of 24 tinctures of E. purpurea were prepared with fresh or dried plant material, that was chopped (>2000 µm) or shredded (500–2000 µm), and that was 2 or 3-years-old at the time of harvest. Tinctures contained herba or radix or a combination of both. The chemical profile of the tinctures was determined using HPLC coupled with a principal component analysis of 1H NMR data. This analysis revealed that tinctures prepared with dried plant material (n = 8) had significantly higher concentrations of caffeic acid derivatives than tinctures prepared with fresh plant material, with the exception of 4 tinctures. The immunomodulating ability of tincture extracts, at a concentration of 100 µg/mg, was evaluated in vitro using non stimulated and lipopolysaccharide (LPS)-stimulated immortalised bone marrow derived macrophages (iBMDM) and THP-1 cell lines. Tincture extracts containing dried plant material reduced IL-6 production in LPS-stimulated iBMDM and THP-1 cells and increased production of TNF-α in THP-1 cells to a greater extent than tincture extracts prepared with fresh plant material. Despite the absence of caffeic acid derivatives, a number of tincture extracts prepared with fresh and shredded plant material had significant anti-inflammatory activity. The inclusion of herba in the tincture was seen to significantly inhibited IL-6 in both iBMDM and THP-1 cells. This study highlights the importance of selecting appropriate upstream processing methods to ensure the production of quality E. purpurea tinctures.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102971"},"PeriodicalIF":1.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum to "Peganutonin A, a novel melatonin analogue from the seeds of Peganum harmala" [Phytochem. Lett. 56 (2023) 78–80] “Peganutonin A，一种新的褪黑素类似物，来自Peganum harmala种子”的勘误表[植物化学]。Lett. 56 (2023) 78-80]

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-12 DOI: 10.1016/j.phytol.2025.102978

Jian-Bo Liu , Wan-Ying Li , Xue Zhao , Feng-Ying Yang , Lei Fang

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Two new diterpenes isolated from the roots of Grangea maderaspatana 两种新二萜化合物的分离

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-12 DOI: 10.1016/j.phytol.2025.102973

Jittraporn Tipmala , Natcha Injan , Somkiat Nokbin , Ratchanaporn Chokchaisiri , Surat Laphookhieo , Kittirat Saharat , Narawadee Rujanapun , Rawiwan Charoensup , Thunwadee Limtharakul , Sarot Cheenpracha

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Capillary electrophoresis as a green and rapid technique for the quantification of caffeic acid phenethyl ester (CAPE): Correlation between CAPE contents and anti-inflammatory activities of propolis extracts 毛细管电泳作为一种绿色快速定量咖啡酸苯乙酯（CAPE）的技术：CAPE含量与蜂胶提取物抗炎活性的相关性

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-10 DOI: 10.1016/j.phytol.2025.102970

Zeynep Kalaycıoğlu , Çisil Alim , Sevgi Kolaylı , F. Bedia Erim

{"title":"Capillary electrophoresis as a green and rapid technique for the quantification of caffeic acid phenethyl ester (CAPE): Correlation between CAPE contents and anti-inflammatory activities of propolis extracts","authors":"Zeynep Kalaycıoğlu , Çisil Alim , Sevgi Kolaylı , F. Bedia Erim","doi":"10.1016/j.phytol.2025.102970","DOIUrl":"10.1016/j.phytol.2025.102970","url":null,"abstract":"<div><div>Caffeic acid phenethyl ester (CAPE) is propolis's most notable bioactive compound. Since CAPE has many pharmacological properties, the bioactivities of propolis can mostly be attributed to its CAPE content. As the administration of propolis extracts to the body for therapeutic purposes increases, reliable determination of the CAPE content of the extracts becomes important. This study developed a green micellar electrokinetic chromatography (MEKC) method to determine the CAPE amount in propolis extracts rapidly. The method was applied for the determination of CAPE amounts in commercial propolis spray samples and two propolis samples collected from beekeepers in Anatolia. Moreover, the anti-inflammatory activities of propolis samples were measured based on the in-vitro inhibitory activity of the tumor necrosis factor-α (TNF-α) enzyme. The correlation between the amount of CAPE and the anti-inflammatory activities of the samples was investigated and found to be 0.90. This high correlation indicates that CAPE has an important role in the anti-inflammatory effect of propolis.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102970"},"PeriodicalIF":1.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Bidesmosidic triterpenoid saponins and other bioactive constituents from the stem bark of Pittosporum viridiflorum 绿花Pittosporum viridiflorum茎皮中的Bidesmosidic三萜皂苷及其他生物活性成分

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-09 DOI: 10.1016/j.phytol.2025.102972

Mathilda Loinseboh Amahndong , Kevine Johanne Jumeta Dongmo , Christine Claire Waleguele , Billy Toussie Tchegnitegni , Georges Bellier Tabouekeng , Jean Rodolphe Chouna , Céline Nguefeu Nkenfou , Jean Jules Kezetas Bankeu , Bruno Ndjakou Lenta , Norbert Sewald

{"title":"Bidesmosidic triterpenoid saponins and other bioactive constituents from the stem bark of Pittosporum viridiflorum","authors":"Mathilda Loinseboh Amahndong , Kevine Johanne Jumeta Dongmo , Christine Claire Waleguele , Billy Toussie Tchegnitegni , Georges Bellier Tabouekeng , Jean Rodolphe Chouna , Céline Nguefeu Nkenfou , Jean Jules Kezetas Bankeu , Bruno Ndjakou Lenta , Norbert Sewald","doi":"10.1016/j.phytol.2025.102972","DOIUrl":"10.1016/j.phytol.2025.102972","url":null,"abstract":"<div><div>Three previously unreported triterpenoid saponins namely pittosposides A–C (1–3), were isolated from the stem bark of Pittosporum viridiflorum, alongside nine known compounds 4−11. The structures were elucidated based on spectroscopic data as well as chemical conversions. The extract, fractions, and some isolated compounds were assessed for their antibacterial activity against sixteen multi-resistant bacterial strains. The extract and fractions exhibited good antibacterial activity on at least one of the tested strains. The EtOAc fraction was the most active against almost all the strains (MIC values, 15.6<img>500 μg/mL). 2,6‑Dimethoxybenzoquinone (7) was active against almost all the selected bacterial strains with the best activity against E. coli ATCC35218 (MIC = 1.9 μg/mL). In addition, the extract, fractions, and compounds 1−4, 7, and 11 were assessed for their cytotoxic activity on the normal Vero cell line. Compounds 1, 2 and 4 were further assessed for their cytotoxic activity on the KB-3–1 cervical carcinoma cell line against which compound 4 displayed moderate cytotoxicity (IC50 = 23.9 μM). The chemophenetic significance of the isolates was discussed.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102972"},"PeriodicalIF":1.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synthesis and cytotoxicity evaluation of tyrosine-3 or tyrosine-6 fluorinated analogues of RA-VII, an antitumor bicyclic hexapeptide from Rubia cordifolia 芦笋抗肿瘤双环六肽RA-VII的酪氨酸-3或酪氨酸-6氟化类似物的合成及细胞毒性评价

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-06 DOI: 10.1016/j.phytol.2025.102967

Yukio Hitotsuyanagi, Ken Morita, Tatsuro Anzai, Tomoyo Hasuda, Niro Inaba, Koichi Takeya

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Sesquiterpenes from the Saudi Arabian Red Sea sponge Lamellodysidea herbacea 沙特阿拉伯红海海绵的倍半萜素

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-01 DOI: 10.1016/j.phytol.2025.102969

Mohamed A. Tammam , Leto-Aikaterini Tziveleka , Carlos M. Duarte , Efstathia Ioannou , Vassilios Roussis

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Characterization of a new lyso-ornithine lipid from the shipworm symbiont Teredinibacter turnerae 船虫共生体Teredinibacter turnerae中一种新的溶鸟氨酸脂质的特性

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-28 DOI: 10.1016/j.phytol.2025.102960

Ernest Guiller S. Pineda, Jacquelyn E. Peran, Jeremiah D. Batucan, Zildjian G. Acyatan, Shalice R. Susana-Guevarra, Lilibeth A. Salvador-Reyes

{"title":"Characterization of a new lyso-ornithine lipid from the shipworm symbiont Teredinibacter turnerae","authors":"Ernest Guiller S. Pineda, Jacquelyn E. Peran, Jeremiah D. Batucan, Zildjian G. Acyatan, Shalice R. Susana-Guevarra, Lilibeth A. Salvador-Reyes","doi":"10.1016/j.phytol.2025.102960","DOIUrl":"10.1016/j.phytol.2025.102960","url":null,"abstract":"<div><div>Teredinibacter turnerae dedicates a significant portion of its genome to secondary metabolite biosynthesis. In this study, we purified the new lyso-ornithine lipid N-3-hydroxyoleoyl ornithine (1) from T. turnerae strains 4401H.S.1B.02-A and 4409 W.S.0 A.02-C. This compound is characterized by a monohydroxylated C18:1 fatty acid attached to an ornithine head group through an amide bond. N-3-hydroxyoleoyl ornithine demonstrated weak antimicrobial activity against planktonic Staphylococcus epidermidis (% inhibition = 53.5 ± 11.8 % at 256 µg/mL (620 µM)) and weak cytotoxicity against HK-2 normal human kidney cells (IC50 = 11 µM) and HCT116 human colorectal carcinoma (% cell viability = 47.6 ± 8.0 % at 100 µM). The antimicrobial and cytotoxic activities of 1 are, in part, facilitated by its membrane-disrupting activity. N-3-hydroxyoleoyl ornithine (1) caused an indirect and irreversible amplification of Ca2+ uptake in dorsal root ganglion (DRG) neurons that are insensitive to either menthol or capsaicin at 10 µg/mL (24 µM). Time course studies further revealed that the production of 1 in T. turnerae 4409 W.S.0 A.02-C is negatively regulated by phosphate control, possibly via a Pho-dependent regulation of olsB expression.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102960"},"PeriodicalIF":1.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The synthesis of arylmethylene bisindoles catalyzed by nickel perchlorate as potential antifungal agent against Clarireedia homoeocarpa 高氯酸镍催化合成芳基亚甲基双吲哚的研究

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-24 DOI: 10.1016/j.phytol.2025.102966

Ye Zhou , Ruyuan Wang , Rui Feng , Bi Wang , Shu Xu , Mei Tian , Wenhao Liang , Jin Chen , Yu Chen , Xu Feng , Li Lin , Jinyue Luo , Jianlan Wang , Fei Liu

{"title":"The synthesis of arylmethylene bisindoles catalyzed by nickel perchlorate as potential antifungal agent against Clarireedia homoeocarpa","authors":"Ye Zhou , Ruyuan Wang , Rui Feng , Bi Wang , Shu Xu , Mei Tian , Wenhao Liang , Jin Chen , Yu Chen , Xu Feng , Li Lin , Jinyue Luo , Jianlan Wang , Fei Liu","doi":"10.1016/j.phytol.2025.102966","DOIUrl":"10.1016/j.phytol.2025.102966","url":null,"abstract":"<div><div>Arylmethylene bisindole alkaloids are predominantly found in cruciferous plants and as metabolites in marine organisms, exhibiting a diverse range of biological activities. In recent years, these alkaloids have been increasingly explored and utilized for controlling plant pathogenic fungi. However, the synthesis and underlying mechanisms, particularly their effectiveness against plant pathogens such as Clarireedia homoeocarpa, still require further investigation. In this study, a series of arylmethylene bisindoles were synthesized with high yield using aromatic aldehydes and indoles catalyzed by NiClO4·6H2O. These compounds showed spectral antibacterial activity against six major phytopathogenic fungi and A13 exhibiting the highest antifungal activity against C. homoeocarpa with an EC50 value of 0.74 mg/L. Furthermore, in vivo antifungal assays were performed to assess the efficacy of the active compounds against C. homoeocarpa. To elucidate the antifungal mechanism of arylmethylene bisindoles, a comprehensive analysis of physiological and biochemical indices, along with transcriptome profiling, was carried out to elucidate. The results demonstrated that A13 treatment can efficiently disrupt the cell membranes of C. homoeocarpa. Additionally, we identified and screened the candidate genes implicated in cell membrane alterations under A13 treatments. KEGG pathway analysis revealed that a considerable number of down-regulated DEGs were significantly enriched in metabolic pathways, biosynthesis of secondary metabolic, and ribosome biogenesis in eukaryotes. This research provides valuable insights for the effective management of lawn coin spot disease.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102966"},"PeriodicalIF":1.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0