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Structurally diverse alkaloids from stems and leaves of Baphicacanthus cusia and their neuraminidase inhibitory activity 水蛭茎叶生物碱的结构多样性及其神经氨酸酶抑制活性
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-07-12 DOI: 10.1016/j.phytol.2025.103013
Xiaofan Fan , Yingzhe Li , Min Jae Kim , Zhihong Cheng
{"title":"Structurally diverse alkaloids from stems and leaves of Baphicacanthus cusia and their neuraminidase inhibitory activity","authors":"Xiaofan Fan ,&nbsp;Yingzhe Li ,&nbsp;Min Jae Kim ,&nbsp;Zhihong Cheng","doi":"10.1016/j.phytol.2025.103013","DOIUrl":"10.1016/j.phytol.2025.103013","url":null,"abstract":"<div><div>Three new alkaloids, namely, ethyl 2-[(1<em>H</em>-indol-3-ylcarbonyl)amino]benzoate (<strong>1</strong>), 3-[(<em>R</em>)-1-benzyl-1-ethoxycarbonyl]-2,4(1<em>H</em>,3<em>H</em>)-quinazolinedione (<strong>2</strong>), and (±)-11-ethoxycarbonyl-baphicacanthcusine D (<strong>3</strong>), along with 21 known alkaloids (<strong>4</strong>–<strong>25</strong>), were isolated from the stems and leaves of <em>Baphicacanthus cusia</em>. Among these alkaloids, compounds <strong>1</strong>–<strong>3</strong> were proposed as new artifacts, and compounds <strong>4</strong> and <strong>16</strong>–<strong>18</strong> were identified as new natural products. The phytochemical investigation demonstrated that the herb has a high degree of structural diversity in alkaloids, with at least four types of alkaloids (e.g., indole-, quinazolone-, organic amine-, and quinoline-types) being present. All the alkaloids were assessed for their neuraminidase inhibitory activity using a fluorescence-based assay. Twelve alkaloids demonstrated the potential activity, with IC<sub>50</sub> values ranging from 40.16 to 144.73 μM.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103013"},"PeriodicalIF":1.3,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New challenges for natural products in bioactive molecules discovery - PSE YSM 2023 - Special Issue - Editorial 天然产物在生物活性分子发现中的新挑战- PSE YSM 2023 -特刊-社论
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-07-10 DOI: 10.1016/j.phytol.2025.103009
{"title":"New challenges for natural products in bioactive molecules discovery - PSE YSM 2023 - Special Issue - Editorial","authors":"","doi":"10.1016/j.phytol.2025.103009","DOIUrl":"10.1016/j.phytol.2025.103009","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103009"},"PeriodicalIF":1.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-target directed ligands design of 1-O-Acetylbritannilactone derivatives: Dual anti-neuroinflammatory and acetylcholinesterase inhibitory activities 1- o -乙酰苯内酯衍生物的多靶点定向配体设计:双重抗神经炎和乙酰胆碱酯酶抑制活性
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-07-08 DOI: 10.1016/j.phytol.2025.103011
Yan-Peng Liang , Qian Gao , Hong Chen , Rui Ma , Xiao-Bo Zhao , Xiao-Jie Jin , Jian Zhang , Yan-Ping Shi , Wei Ha
{"title":"Multi-target directed ligands design of 1-O-Acetylbritannilactone derivatives: Dual anti-neuroinflammatory and acetylcholinesterase inhibitory activities","authors":"Yan-Peng Liang ,&nbsp;Qian Gao ,&nbsp;Hong Chen ,&nbsp;Rui Ma ,&nbsp;Xiao-Bo Zhao ,&nbsp;Xiao-Jie Jin ,&nbsp;Jian Zhang ,&nbsp;Yan-Ping Shi ,&nbsp;Wei Ha","doi":"10.1016/j.phytol.2025.103011","DOIUrl":"10.1016/j.phytol.2025.103011","url":null,"abstract":"<div><div>Alzheimer’s disease, a progressive neurodegenerative disorder of the central nervous system, presents a complex pathological mechanism that limits the efficacy of conventional single-target drugs. Utilizing the unique advantages of natural products in multi-target intervention, this study employed the active component 1-<em>O</em>-acetylbritannilactone (ABL) from <em>Inula britannica</em> L. as the parent structure. Guided by the multi-target directed ligands (MTDLs) strategy, four novel derivatives (ABL-1 to ABL-4) were successfully designed and synthesized by introducing acetylcholinesterase (AChE) inhibitory pharmacophores into the ABL scaffold. <em>In vitro</em> pharmacological evaluation demonstrated that ABL-2, ABL-3, and ABL-4 not only preserved the anti-neuroinflammatory activity of the parent compound but also endowed compound ABL with AChE inhibitory potency. Notably, ABL-4 displayed the most promising dual efficacy profile, achieving an AChE inhibition rate of 40.09 ± 0.73 % at 30 μM and an anti-neuroinflammatory activity (EC<sub>50</sub> = 8.43 ± 0.5 μM). Molecular docking simulations revealed that the dual-target synergistic mechanism of ABL derivatives arises from hydrogen bonding and π-π stacking interactions with key residues of both AChE and inducible nitric oxide synthase (iNOS). This work not only validates the feasibility of the MTDLs strategy in optimizing natural product scaffolds but also provides a structurally novel lead compound with significant potential for developing multi-target anti-AD therapeutics.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103011"},"PeriodicalIF":1.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and computational characterization of a novel cyanogenic glucoside from Centaurea microcarpa with antiviral potential against SARS-CoV-2: DFT, ADMET, and molecular docking analysis 具有抗病毒SARS-CoV-2潜力的半马尾草新型氰苷的分离和计算表征:DFT、ADMET和分子对接分析
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-07-08 DOI: 10.1016/j.phytol.2025.103010
Rachida Kerkour , Samia Baatouche , Abir Boublia , Nadjib Chafai , Ramadan Seghiri , Djamel Sarri
{"title":"Isolation and computational characterization of a novel cyanogenic glucoside from Centaurea microcarpa with antiviral potential against SARS-CoV-2: DFT, ADMET, and molecular docking analysis","authors":"Rachida Kerkour ,&nbsp;Samia Baatouche ,&nbsp;Abir Boublia ,&nbsp;Nadjib Chafai ,&nbsp;Ramadan Seghiri ,&nbsp;Djamel Sarri","doi":"10.1016/j.phytol.2025.103010","DOIUrl":"10.1016/j.phytol.2025.103010","url":null,"abstract":"<div><div>This study reports the isolation and structural elucidation of a novel cyanogenic glucoside, 6′-methacrylate prunasin (6-MPr), from <em>Centaurea microcarpa</em> Coss. &amp; Dur. The structure of 6-MPr was confirmed through spectroscopic techniques, including HRESI-MS NMR, and FTIR, revealing a molecular ion peak [M+Na]<sup>+</sup> at <em>m/z</em> 364.1. Its antiviral potential against SARS-CoV-2 was assessed using in silico approach that integrates DFT calculations, ADMET profiling, and molecular docking. Results indicate that 6-MPr has good stability, favorable pharmacokinetic properties for oral administration, and strong binding affinities to key viral enzymes (Mpro, PLpro, RdRp, Nsp3). These findings highlight 6-MPr as a promising candidate for antiviral drug development, warranting further experimental validation.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103010"},"PeriodicalIF":1.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flavonoids and butanolides from the bark of Machilus robusta and their bioactivities 黄酮类化合物和丁醇内酯及其生物活性研究
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-07-03 DOI: 10.1016/j.phytol.2025.103007
Rui-Qi Liu , Shan-Shan Ling , Xian-Da Hu , Bing Peng , Yan-Ru Li
{"title":"Flavonoids and butanolides from the bark of Machilus robusta and their bioactivities","authors":"Rui-Qi Liu ,&nbsp;Shan-Shan Ling ,&nbsp;Xian-Da Hu ,&nbsp;Bing Peng ,&nbsp;Yan-Ru Li","doi":"10.1016/j.phytol.2025.103007","DOIUrl":"10.1016/j.phytol.2025.103007","url":null,"abstract":"<div><div>One new flavanone glycoside, named (2<em>R</em>,3<em>R</em>)-dihydrokaempferol-5-<em>O</em>-α-L-arabinopyranoside (<strong>1</strong>), together with 11 known compounds, was isolated from the ethanol extract of <em>Machilus robusta</em> bark. Their structures were elucidated by a combination of spectroscopic and chemical analysis. Compounds <strong>4</strong> and <strong>5</strong> showed neuroprotective activity against serum deprivation induced PC12 cell damage by increasing the cell viability from 66.6 ± 9.2 % to 81.96 ± 8.13 % and 78.38 ± 11.65 %, respectively, at a concentration of 10 µM. And at the same concentration, compound <strong>4</strong> showed stronger hepatoprotective activity against WB-F344 cell damage induced by DL-galactosamine than that of the positive drug bicyclol. In addition, compound <strong>3</strong> showed certain antioxidant activity inhibiting Fe<sup>2 +</sup> -cystine-induced rat liver microsomal lipid peroxidation.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103007"},"PeriodicalIF":1.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural drug discovery – Editorial 天然药物发现-社论
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-06-27 DOI: 10.1016/j.phytol.2025.103006
Didem Şöhretoğlu
{"title":"Natural drug discovery – Editorial","authors":"Didem Şöhretoğlu","doi":"10.1016/j.phytol.2025.103006","DOIUrl":"10.1016/j.phytol.2025.103006","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103006"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Antifungal natural products from the culture medium of Trichoderma orarium 18F0041” [Phytochem. Lett. 67 (2025) 102945] 《木霉18F0041培养基的抗真菌天然产物》的勘误表[植物化学]。Lett. 67 (2025) 102945]
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-06-27 DOI: 10.1016/j.phytol.2025.103008
Hui-Tzu Ni , Jih-Jung Chen , Hsia-Wei Liu , Ming-Der Wu , Yu-Hui Wei , Min Tseng , Yuan-Hsiang Yu , Ming-Jen Cheng
{"title":"Corrigendum to “Antifungal natural products from the culture medium of Trichoderma orarium 18F0041” [Phytochem. Lett. 67 (2025) 102945]","authors":"Hui-Tzu Ni ,&nbsp;Jih-Jung Chen ,&nbsp;Hsia-Wei Liu ,&nbsp;Ming-Der Wu ,&nbsp;Yu-Hui Wei ,&nbsp;Min Tseng ,&nbsp;Yuan-Hsiang Yu ,&nbsp;Ming-Jen Cheng","doi":"10.1016/j.phytol.2025.103008","DOIUrl":"10.1016/j.phytol.2025.103008","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103008"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two new neo-clerodane furanoditerpenoids and other bioactive constituents from the stem bark of the Cameroonian Croton macrostachyus (Euphorbiaceae) 喀麦隆大戟科Croton macrostachyus茎皮中两个新氯烷呋喃二萜及其活性成分
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-06-16 DOI: 10.1016/j.phytol.2025.103004
Franck Landry Djila Possi , Jean Koffi Garba , Kevine Johane Jumeta Dongmo , Billy Toussie Tchegnitegni , Appolinaire Kene Dongmo , Yannick Stéphane Fotsing Fongang , Noella Molisa Efange , Jean Jules Kezetas Bankeu , Jean Rodolphe Chouna , Lawrence Ayong , Pépin Nkeng-Efouet-Alango , Norbert Sewald , Bruno Ndjakou Lenta
{"title":"Two new neo-clerodane furanoditerpenoids and other bioactive constituents from the stem bark of the Cameroonian Croton macrostachyus (Euphorbiaceae)","authors":"Franck Landry Djila Possi ,&nbsp;Jean Koffi Garba ,&nbsp;Kevine Johane Jumeta Dongmo ,&nbsp;Billy Toussie Tchegnitegni ,&nbsp;Appolinaire Kene Dongmo ,&nbsp;Yannick Stéphane Fotsing Fongang ,&nbsp;Noella Molisa Efange ,&nbsp;Jean Jules Kezetas Bankeu ,&nbsp;Jean Rodolphe Chouna ,&nbsp;Lawrence Ayong ,&nbsp;Pépin Nkeng-Efouet-Alango ,&nbsp;Norbert Sewald ,&nbsp;Bruno Ndjakou Lenta","doi":"10.1016/j.phytol.2025.103004","DOIUrl":"10.1016/j.phytol.2025.103004","url":null,"abstract":"<div><div>In our continued search for potent bioactive agents with antiplasmodial activity from Cameroonian <em>Croton</em> species to roll back malaria, we undertook the chemical investigation of the stem bark of <em>C. macrostachyus</em>, a medicinal plant widely used in folk medicine to treat several diseases including malarial. Two previously undescribed <em>neo</em>-clerodane furanoditerpenoids named crotomaclerodane (<strong>1</strong>) and macrostaclerodane (<strong>2</strong>) along with 11 known compounds (<strong>3–13</strong>) were isolated from the methanol extract of the stem bark of <em>C. macrostachyus</em>. The structures of these compounds were characterized by spectroscopic (1D and 2D NMR) analyses, HRESIMS, and single-crystal X-ray diffraction techniques. The crude extract, fractions and isolated compounds were assessed <em>in vitro</em> for their antiplasmodial activity towards the chloroquine-sensitive (3D7) and the multidrug-resistant (Dd2) strains of <em>Plasmodium falciparum</em>. In addition, the antibacterial activity was also performed against some Gram-positive and Gram-negative strains. The results showed that neither the crude extract, nor the fractions were active towards both strains. Nevertheless, compounds <strong>4</strong>, <strong>6</strong>, <strong>7</strong>, and <strong>13</strong> showed good to moderate <em>in vitro</em> antiplasmodial activity with IC<sub>50</sub> values ranging from 8.40 <img> 51.39 <em>µ</em>g/mL against the two tested strains of <em>Plasmodium falciparum</em>. Furthermore, compound <strong>9</strong> showed good to moderate antibacterial activity on <em>Klebsiella pneumonia</em> clinical isolate, <em>Pseudomonas aeruginosa</em> HM801, <em>Staphylococcus aureus</em> 700698, <em>S. aureus</em> 12600 with MIC values ranging from 7.8<img>250 <em>µ</em>g/mL.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103004"},"PeriodicalIF":1.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Batzelladine Q, a new guanidine alkaloid from the marine sponge Monanchora arbuscula Batzelladine Q:一种从海海绵中提取的新型胍类生物碱
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-06-13 DOI: 10.1016/j.phytol.2025.103005
Marcelo R. de Amorim , Anderson L. Noronha , Kamila L. Macedo , Karina F. Baracco , Caue A.W. Zuccarino , Tiago A. Paz , Antonio G. Ferreira , Tiago Venâncio , Eduardo Hajdu , Roberto G.S. Berlinck
{"title":"Batzelladine Q, a new guanidine alkaloid from the marine sponge Monanchora arbuscula","authors":"Marcelo R. de Amorim ,&nbsp;Anderson L. Noronha ,&nbsp;Kamila L. Macedo ,&nbsp;Karina F. Baracco ,&nbsp;Caue A.W. Zuccarino ,&nbsp;Tiago A. Paz ,&nbsp;Antonio G. Ferreira ,&nbsp;Tiago Venâncio ,&nbsp;Eduardo Hajdu ,&nbsp;Roberto G.S. Berlinck","doi":"10.1016/j.phytol.2025.103005","DOIUrl":"10.1016/j.phytol.2025.103005","url":null,"abstract":"<div><div>A chemical investigation of the organic-soluble extract obtained from the marine sponge <em>Monanchora arbuscula</em>, collected at the southeastern coastline of Brazil, led to the isolation of a new minor guanidine alkaloid, batzelladine Q (<strong>1</strong>), along with known alkaloids batzelladines L (<strong>2</strong>) and F (<strong>3</strong>), clathriadic acid (<strong>4</strong>), mirabilin B (<strong>5</strong>), ptilocaulin (<strong>6</strong>), netamine M (<strong>7</strong>) and the degraded carotenoid derivative 9-apoastaxanthinone (<strong>8</strong>). All compounds were identified by analysis of spectroscopic data. The absolute configurations of compounds <strong>4</strong> and <strong>8</strong> were for the first time established by the comparison of experimental ECD spectra with calculated CD data.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103005"},"PeriodicalIF":1.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two undescribed C18-diterpenoid alkaloids from Delphinium naviculare var. lasiocarpum W. T. Wang 两种未描述的飞燕草(Delphinium naviculare var. lasiocarpum) c18 -二萜生物碱
IF 1.3 4区 生物学
Phytochemistry Letters Pub Date : 2025-06-12 DOI: 10.1016/j.phytol.2025.103000
Wen-juan Xue , Nurfida Ablajan , Bo Zhao , Yu-qing Yang , Xue-ying Lu , Jiang-yu Zhao , Shamansur Sagdullaev , Haji Akber Aisa
{"title":"Two undescribed C18-diterpenoid alkaloids from Delphinium naviculare var. lasiocarpum W. T. Wang","authors":"Wen-juan Xue ,&nbsp;Nurfida Ablajan ,&nbsp;Bo Zhao ,&nbsp;Yu-qing Yang ,&nbsp;Xue-ying Lu ,&nbsp;Jiang-yu Zhao ,&nbsp;Shamansur Sagdullaev ,&nbsp;Haji Akber Aisa","doi":"10.1016/j.phytol.2025.103000","DOIUrl":"10.1016/j.phytol.2025.103000","url":null,"abstract":"<div><div>Two C<sub>18</sub>-diterpenoid alkaloids naviculamine A (<strong>1</strong>) and naviculamine B (<strong>2</strong>), together with one known C<sub>19</sub>-diterpenoid alkaloids septentriodine (<strong>3</strong>) were isolated from the aerial part of <em>Delphinium naviculare</em> var<em>. lasiocarpum</em>. Compound <strong>1</strong> was an unprecedented skeleton C<sub>18</sub>-diterpenoid alkaloid with chemical bond breakage between C-7 and C-17. Compound <strong>2</strong> was a relatively rare nitrone C<sub>18</sub>-diterpenoid alkaloid discovered from natural. Their chemical structures were established on the basis of spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR spectroscopic data and ECD. The inhibitory effects of these diterpenoid alkaloids on hERG and CaV3.1 channels were also evaluated.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103000"},"PeriodicalIF":1.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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