一种新的天然溴吡咯生物碱agenakasine、一种生物合成相关代谢物laughine和从中村海苔中分离出的去虫anemonin

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-05-13 DOI:10.1016/j.phytol.2025.102975

Chung-Wei Fu , Atallah F. Ahmed , Lin Chiang , Shu-Fen Chiou , Hui-Chun Wang , Jyh-Horng Sheu

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引用次数: 0

摘要

对台湾海绵Agelas nakamurai次生代谢产物的化学研究，分离出一种未描述的天然溴吡咯生物碱酯，agenakasine(1)，以及已知的生物碱，laughine(2)和norzooanemonin(3)。这些化合物的结构通过详细的波谱分析，包括二维核磁共振波谱和文献数据比较来确定。化合物3结晶为TFA盐，其结构通过单晶x射线衍射分析得到证实。该属植物中首次分离到Laughine和norzooanemonin。本研究提出了agenakasine和laughine的生物合成途径。Agenakasine对肺炎克雷伯菌表现出有效的抑制活性。

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Isolation of a new natural bromopyrrole alkaloid agenakasine, a biosynthetically related metabolite laughine, and norzooanemonin from a marine sponge Agelas nakamurai

Chemical investigation of the secondary metabolites of a Formosan sponge, Agelas nakamurai, has led to the isolation of one undescribed natural bromopyrrole alkaloidal ester, agenakasine (1), along with known alkaloids, laughine (2) and norzooanemonin (3). The structures of these compounds were determined by detailed spectroscopic analysis, including 2D NMR spectroscopy, and literature data comparison. Compound 3 was crystallized as a TFA salt, with the structure confirmed by single-crystal X-ray diffraction analysis. Laughine and norzooanemonin were isolated for the first time from Agelas genus. The biosynthesis pathway of agenakasine and laughine was proposed in this study. Agenakasine demonstrated effective inhibitory activity against Klebsiella pneumoniae.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.