Two new diterpenes isolated from the roots of Grangea maderaspatana

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-05-12 DOI:10.1016/j.phytol.2025.102973

Jittraporn Tipmala , Natcha Injan , Somkiat Nokbin , Ratchanaporn Chokchaisiri , Surat Laphookhieo , Kittirat Saharat , Narawadee Rujanapun , Rawiwan Charoensup , Thunwadee Limtharakul , Sarot Cheenpracha

引用次数: 0

Abstract

Two new diterpenes, maderaspatins A (1) and B (2), and four known analogues (3–6) were isolated from an acetone extract of the roots of Grangea maderaspatana (L.) Poir. Their chemical structures were elucidated by the 1D and 2D NMR spectra, complemented by HR-ESI-MS data. The absolute configurations were determined through comparative analysis of experimental CD and calculated ECD spectra. The in vitro cytotoxic activity of purified compounds against the SW480 cell line were evaluated.

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两种新二萜化合物的分离

从草根丙酮提取物中分离得到2个新的二萜，马德拉帕丁苷A(1)和B(2)，以及4个已知的类似物（3-6）。Poir。它们的化学结构通过1D和2D核磁共振谱和HR-ESI-MS数据得到了证实。通过对比分析实验CD和计算ECD谱，确定了绝对构型。对纯化后的化合物对SW480细胞株的体外细胞毒活性进行了评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.