Phytochemistry Letters最新文献_第5页

Chalcone dimers from Astronium graveolens (Anacardiaceae) and their biological activities 天人菊中的查耳酮二聚体及其生物活性

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-08-02 DOI: 10.1016/j.phytol.2024.07.013

Eliezer P. da Silva , Jorge M. David , Juceni P. David , Clayton Q. Alves , Bruno O. Moreira

{"title":"Chalcone dimers from Astronium graveolens (Anacardiaceae) and their biological activities","authors":"Eliezer P. da Silva , Jorge M. David , Juceni P. David , Clayton Q. Alves , Bruno O. Moreira","doi":"10.1016/j.phytol.2024.07.013","DOIUrl":"10.1016/j.phytol.2024.07.013","url":null,"abstract":"<div>This work describes the chemical composition of the stems of Astronium graveolens Jacq. (Anacardiaceae). The CH2Cl2 and EtOAc soluble fractions of this extract were subjected to chromatographic procedures that allowed obtaining the unreported dimers (7\"R*, 8\"S*) 2′, 4,4′, 5-tetrahydroxychalcone-(2 → 7\", 8 → 8\")-2′\", 4\", 4′\"- trihydroxy-7\", 8’’-dihydrochalcone and (7 S*,8 R*,7\"S*,8\"S*)-2′,4,4′,5,7-pentahydroxy-7,8-dihydrochalcone-(2→7\",8→8\")-2′\",4\",4’’’-7 \", 8 \"- dihydrochalcone, the previously isolated chalcone dimer named matosine (7 S*,8 S*,7'' S*,8\"R*)-2′,4,4′, 5,7-pentahydroxy-7,8-dihydrochalcone-(2→7\", 8→8\")-2′\", 4\", 4′\"-trihydroxy-7\", 8\"- dihydrochalcone). Besides these specific chalcone dimers, sitosterol, sitosterol-3-O-β-D-glucoside, methyl gallate, gallic acid, and quercitrin were also isolated. These compounds were identified by mono and bidimensional NMR data analysis and HRMS. Methanolysis of triacylglycerides yielded a mixture of fatty acid methyl esters, which were identified by GC-MS. The profile indicated this fraction is composed of saturated (54.13 %) and unsaturated (46.21 %) fatty acids, and palmitic acid and oleic acid are the major components. The brine shrimp test of the extract showed that the soluble fraction CH2Cl2 of the stems exhibited high toxicity; meanwhile, the EtOAc soluble fraction presented moderate toxicity. The Elmann test indicated that the EtOAc was considered an expressive AChE inhibitor, and the chalcone dimers 1, 2, and 3 present excellent anticholinesterase activities inhibiting 83.88 %, 70.72 %, and 62.60 % AChE at concentrations of 500 µM, respectively.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 38-42"},"PeriodicalIF":1.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141884137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Announcements of the Phytochemical Society of Europe 欧洲植物化学学会公告

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-08-01 DOI: 10.1016/S1874-3900(24)00113-7

引用次数: 0

28-Norlupanes and dammaranes from the heartwood of Dipterocarpus costatus Gaertn. f. (Dipterocarpaceae) and their cytotoxic and antiplasmodial activities 28-Norlupanes and dammaranes from the heartwood of Dipterocarpus costatus Gaertn.

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-07-30 DOI: 10.1016/j.phytol.2024.07.010

Malai Satiraphan , Quoc Dang Thai , Perayot Pamonsinlapatham , Claire Cuyamendous , Elise Prost , Chavalit Sittisombut , Philippe Grellier , Christiane Garbay , Sylvie Michel , Xavier Cachet

{"title":"28-Norlupanes and dammaranes from the heartwood of Dipterocarpus costatus Gaertn. f. (Dipterocarpaceae) and their cytotoxic and antiplasmodial activities","authors":"Malai Satiraphan , Quoc Dang Thai , Perayot Pamonsinlapatham , Claire Cuyamendous , Elise Prost , Chavalit Sittisombut , Philippe Grellier , Christiane Garbay , Sylvie Michel , Xavier Cachet","doi":"10.1016/j.phytol.2024.07.010","DOIUrl":"10.1016/j.phytol.2024.07.010","url":null,"abstract":"<div>Triterpenoids of natural origin are of increasing interest due to their broad spectrum of biological activities. Previous studies on dipterocarpaceous plants have reported that they were valuable source of new active natural compounds. As part of an ongoing search for naturally occurring bioactive triterpenoids from Dipterocarpaceae, phytochemical investigation of Dipterocarpus costatus Gaertn. f. heartwood collected in Thailand was conducted. Seventeen triterpenoids (1-17) belonging to both 28-norlupane and dammarane series were isolated from the corresponding bioactive n-hexane extract. Among them, norlupane 1 was identified as previously undescribed and norlupane 2 was described for the first time from a natural source. Compound structures were elucidated by 1D/2D-NMR spectroscopy and mass (HRMS) spectrometry. All isolated molecules were tested for their cytotoxicity on two human colorectal carcinoma cell lines (i.e. HT-29 and HCT116), as well as for their antiplasmodial activity against chloroquine-resistant strain FcB1 of Plasmodium falciparum. Norlupanes 2 and 4 were shown to exhibit a good cytotoxic activity against HCT 116 (IC50=4.2 µM) and potent antiplasmodial activity (IC50=3.74 µM), respectively.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 31-36"},"PeriodicalIF":1.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187439002400106X/pdfft?md5=3b77c8bc8930efbcb242b00012b212cc&pid=1-s2.0-S187439002400106X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141884138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Two new pregnane alkaloids from Sarcococca orientalis 东方马兜铃中的两种新的孕烷生物碱

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-07-26 DOI: 10.1016/j.phytol.2024.07.009

Xiao-hui Sun , Wen-jian Gu , Tong-tong Min , Ya-mei Zhang , Pu-zhao Zhang

引用次数: 0

A new split-ring protoilludane-type sesquiterpenoid and prenylated aromatic compounds from Coriolopsis trogii 来自拟南芥的一种新的裂环原紫罗兰烷类倍半萜和前酰基芳香化合物

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-07-26 DOI: 10.1016/j.phytol.2024.07.008

Xin-Meng Zhai, Lu-Lu Wang, Ning Li, Fu-Cai Ren

引用次数: 0

7S,8R-Dihydroxydeepoxysarcophytoxide: A natural dihydrofuranocembranoid from the octocoral Sarcophyton stellatum 7S,8R-二羟基去氧石杉碱甲：一种来自八目鳗马钱子的天然二氢呋喃类生物碱

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-07-26 DOI: 10.1016/j.phytol.2024.07.012

Jyh-Horng Sheu , Li-Guo Zheng , You-Ying Chen , Su-Ying Chien , Ping-Jyun Sung

引用次数: 0

In vitro α-amylase and α-glucosidase inhibitory effects and antioxidant potential of new dihydrochalcones from Baphia massaiensis Taub Baphia massaiensis Taub 中新的二氢查耳酮的体外α-淀粉酶和α-葡萄糖苷酶抑制作用及抗氧化潜力

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-07-26 DOI: 10.1016/j.phytol.2024.07.007

Nayang A. Kgakatsi , Runner R.T. Majinda , Ishmael B. Masesane , Mutshinyalo S. Nwamadi , Taye B. Demissie , Keagile Bati

{"title":"In vitro α-amylase and α-glucosidase inhibitory effects and antioxidant potential of new dihydrochalcones from Baphia massaiensis Taub","authors":"Nayang A. Kgakatsi , Runner R.T. Majinda , Ishmael B. Masesane , Mutshinyalo S. Nwamadi , Taye B. Demissie , Keagile Bati","doi":"10.1016/j.phytol.2024.07.007","DOIUrl":"10.1016/j.phytol.2024.07.007","url":null,"abstract":"<div>Two previously undescribed dihydrochalcones, 4,2′-dihydroxy- [2″, 2″-dimethylpyrano (3″, 4″: 4′, 5′]) dihydrochalcone (1) and 4, 2′, 4′, 2″-tetrahydroxy-5′-(3″-methylbut-3″-enyl) dihydrochalcone (2), along with six known compounds (3-8) were isolated from chloroform-methanol (1:1) extract of Baphia Massaiensis twigs. Their chemical structures were determined using NMR analysis, mass spectrometry, electronic circular dichroism (ECD), density functional theory (DFT) calculations, and a thorough comparison with reported data from the literature. All the isolated compounds (1−8) were assessed for their antioxidant activities, α-amylase and α-glucosidase inhibition effects. Dihydrochalcone 1 showed significant antioxidant activity with IC50 value of 118.8 ± 2.95 µM, and a more potent antioxidant activity was exhibited by compounds 3 and 6 with IC50 values of 84.3 ± 0.07 µM and 62.1 ± 1.59 µM, respectively, compared to the positive control, gallic acid with IC50 value of 92.9 µM. Dihydrochalcone 2 showed moderate inhibition against α-amylase and α-glucosidase with IC50 values of 44.0 ± 4.83 µM and 51.7 ± 9.72 µM compared to the standard acarbose with IC50 values of 22.9 ± 0.92 µM and 31.5 ± 0.63 µM, respectively. Molecular docking studies of the new dihydrochalcones 1 and 2, revealed the active binding sites which support the observed α-amylase and α-glucosidase inhibitory effects.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 22-30"},"PeriodicalIF":1.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic steroidal glycosides from Paris rugosa rhizomes 巴黎根茎中的细胞毒性甾体苷

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-07-25 DOI: 10.1016/j.phytol.2024.07.011

Jian-Ke Jia , Jun Yang , Xing-Zhi Yang , Ji-Feng Luo , Xiao-Yan Duan , Ying-Li Yang , Jin-Fu Wan , Yue-Hu Wang

{"title":"Cytotoxic steroidal glycosides from Paris rugosa rhizomes","authors":"Jian-Ke Jia , Jun Yang , Xing-Zhi Yang , Ji-Feng Luo , Xiao-Yan Duan , Ying-Li Yang , Jin-Fu Wan , Yue-Hu Wang","doi":"10.1016/j.phytol.2024.07.011","DOIUrl":"10.1016/j.phytol.2024.07.011","url":null,"abstract":"<div>Two previously undescribed steroidal saponins, rugosarosides A (1) and B (2), as well as 16 known compounds (3–18), were isolated from the rhizomes of Paris rugosa H. Li & S. Kurita (Melanthiaceae). Their chemical structures were elucidated based on extensive analyses of NMR and MS data and acidic hydrolyses. These isolates were evaluated for their cytotoxicity to five human cancer cell lines (HL-60, SW480, MDA-MB-231, A549, and A549/Taxol) and the normal human bronchial epithelial cell line BEAS-2B using the MTS test. Spirostanol saponins 6–12 and furostanol saponin 16 showed cytotoxic activity, with IC50 values ranging from 0.13 to 3.88 μM. The furostanol saponins 14, 15, and 17 selectively inhibited HL-60, A549, and A549/Taxol cells (IC50: 3.45–9.51 μM), with no cytotoxicity to SW480 and MDA-MB-231 cells (IC50 > 40 μM).</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 1-7"},"PeriodicalIF":1.3,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical composition and biological activities of genus Ochrosia: A mini review 赭石属的化学成分和生物活性：微型综述

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-07-20 DOI: 10.1016/j.phytol.2024.07.005

Essam Abdel-Sattar, Riham A. El-Shiekh

{"title":"Chemical composition and biological activities of genus Ochrosia: A mini review","authors":"Essam Abdel-Sattar, Riham A. El-Shiekh","doi":"10.1016/j.phytol.2024.07.005","DOIUrl":"10.1016/j.phytol.2024.07.005","url":null,"abstract":"<div>Natural products have historically served as a rich source of potential remedies for cancer, a disease that is projected to become the leading cause of mortality. Ochrosia metabolites are potent cytotoxic drugs due to their ability to interact with nucleic acids. The scope of this review screens key features of the biological activities and phytochemical compositions of the genus Ochrosia. A comprehensive coverage of the literature has been conducted, revealing that alkaloids are the predominant metabolites, characterized by their noteworthy biological activities. Ochrosia plants also contain flavonoids, triterpenes, coumarins, resinol derivatives, and phenolic acids. Several pharmacological effects were reported, including cytotoxic, anti-inflammatory, antiviral, antiplasmodial, and antimicrobial activities. Investigation of the biological activities of ellipticines found potent anti-cancer properties, and several ellipticine derivatives have been the subject of clinical trials. Of particular interest, they have exhibited significant cytotoxic activity against various cell lines, including human breast carcinoma, leukemia cells, neuroblastoma cells, and glioblastoma cells. The ellipticine family of compounds exerts their biological activity via several modes of action, such as intercalation with DNA, topoisomerase II inhibition, interaction with the p53 transcription factor, kinase inhibition, bio-oxidation, and adduct formation. Overall, these studies highlight their diverse therapeutic potential in various types of cancer, indicating their promising role as antineoplastic agents.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"62 ","pages":"Pages 92-111"},"PeriodicalIF":1.3,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavonoids from Passiflora cincinnata (Passifloraceae): HPLC-DAD-MSn characterization, validation of an HPLC-DAD method for quantification and CPC isolation 西番莲（西番莲科）中的黄酮类化合物：HPLC-DAD-MSn 表征、HPLC-DAD 定量方法验证和 CPC 分离

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-07-18 DOI: 10.1016/j.phytol.2024.06.006

Jackson Roberto Guedes da Silva Almeida , Lívia Macedo Dutra , Victória Laysna dos Anjos Santos , Larissa Araújo Rolim , Norberto Peporine Lopes , Thomas Gaslonde , Raimundo Gonçalves de Oliveira-Júnior , Raphael Grougnet

{"title":"Flavonoids from Passiflora cincinnata (Passifloraceae): HPLC-DAD-MSn characterization, validation of an HPLC-DAD method for quantification and CPC isolation","authors":"Jackson Roberto Guedes da Silva Almeida , Lívia Macedo Dutra , Victória Laysna dos Anjos Santos , Larissa Araújo Rolim , Norberto Peporine Lopes , Thomas Gaslonde , Raimundo Gonçalves de Oliveira-Júnior , Raphael Grougnet","doi":"10.1016/j.phytol.2024.06.006","DOIUrl":"10.1016/j.phytol.2024.06.006","url":null,"abstract":"<div>Passiflora cincinnata Mast. is a native tree from the Brazilian Caatinga biome, popularly known as “maracujá do mato” and “maracujá da Caatinga”. This species has been used in folk medicine as a sedative and antihypertensive. This study presents the chemical characterization of P. cincinnata using a HPLC-DAD-MSn approach. Due to their nutraceutical and pharmaceutical interest, we also describe the validation of a simple and efficient HPLC-DAD method for the quantification of flavonoids. The ethanolic extract was submitted to centrifugal partition chromatography (CPC) for the isolation of flavonoids. HPLC-DAD-MSn analysis allowed the annotation of nine chemical constituents with chemotaxonomic importance, including orientin, isoorientin, vitexin and isovitexin, which are considered as analytical markers of Passifloraceae species. Thereafter, we developed and validated an HPLC-DAD method for the quantification of the flavonoids orientin, vitexin and isovitexin in order to contribute to the quality control assessment of P. cincinnata samples. The analytical method has proven to be linear, accurate, robust, reproducible and sensitive to all investigated flavonoids. Two flavonoids (isoorientin and isovitexin) were isolated in a single and fast CPC run followed by preparative HPLC, and their structures were confirmed by NMR analysis. This is the first report of a validated method for flavonoid quantification in this species, as well as the isolation of flavonoids using CPC; it may also be useful for nutraceutical and pharmaceutical industries in the development of new Passiflora products.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"62 ","pages":"Pages 84-91"},"PeriodicalIF":1.3,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0