Phytochemistry Letters最新文献_第5页

A pair of polyketide lactone enantiomers from the South China Sea sponge Hippospongia lachne 南海海绵体的一对聚酮内酯对映体

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2026-01-08 DOI: 10.1016/j.phytol.2025.104108

Qiongyan Fang , Yafang Ding , Xue Wu , Xinyi Yu , Xuting Lan , Jie Wang

引用次数: 0

Two new naphthopyrones and a new prenylisoflavone from Berchemia lineata 两个新的萘吡咯酮和一个新的苯乙烯异黄酮

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2026-01-05 DOI: 10.1016/j.phytol.2026.104111

Ling Li , Lin Feng , Lihua Peng , Weilin Qiao , Wei Li , De-an Guo

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Bioinformatics-based discovery of a new norsesquiterpenoid from agarwood targeting CHRM2 and regulating the PI3K-Akt pathway in liver cancer 以生物信息学为基础，从沉香中发现一种新的诺倍半萜类化合物，靶向CHRM2并调节肝癌中PI3K-Akt通路

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2025-12-18 DOI: 10.1016/j.phytol.2025.104101

Zi-Xiao Jiang, Jian Feng, Wen-Cheng Hou, Mei-Ran Wang, Shu-Nan Zhang, Hao-Jie Liang, Yang-Yang Liu

引用次数: 0

Exploring the therapeutic potentials of Bischofia javanica: Evidence of analgesic, antidiarrheal, and hypoglycemic activities 探索爪哇花的治疗潜力：镇痛、止泻和降糖活性的证据

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2026-01-02 DOI: 10.1016/j.phytol.2025.104099

Payar Hossain , Md. Hossain Rasel , Md. Jahirul Islam Mamun , Md. Abdul Alim , S.M. Naim Uddin

引用次数: 0

Harnessing phytoconstituents to treat COVID-19 triggered acute respiratory distress syndrome: Insights from network pharmacology, and molecular modeling 利用植物成分治疗COVID-19引发的急性呼吸窘迫综合征：来自网络药理学和分子模型的见解

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2026-01-14 DOI: 10.1016/j.phytol.2025.104105

Pragati Gupta , Kamal Dev , Chirag N. Patel , Gurjot Kaur

{"title":"Harnessing phytoconstituents to treat COVID-19 triggered acute respiratory distress syndrome: Insights from network pharmacology, and molecular modeling","authors":"Pragati Gupta , Kamal Dev , Chirag N. Patel , Gurjot Kaur","doi":"10.1016/j.phytol.2025.104105","DOIUrl":"10.1016/j.phytol.2025.104105","url":null,"abstract":"<div><div>Developing effective therapies for COVID-19-triggered acute respiratory distress syndrome (ARDS) remains a major challenge. Inflammatory signaling molecules have emerged as promising druggable targets. This study employed an integrated network pharmacology and molecular modeling strategy to investigate the anti-inflammatory phytoconstituents (PCs) against COVID-19-triggered ARDS. Putative targets of PCs and disease genes were retrieved from multiple databases, followed by PPI and enrichment analyses, along with network visualization. Network pharmacology identified key phytoconstituents: 1-dehydro-6-gingerol, apigenin-7-glucoside, and quercetin, and crucial targets including EGFR, JAK2, RELA, HSP90AA1, and PIK3CA from the F-B-PCs-T-P network. Enriched inflammatory pathways included Toll-like receptor, PI3K-Akt, NOD-like receptor, and HIF-1 signaling. Molecular docking and dynamics simulations further confirmed stable, high-affinity interactions between these targets and selected PCs. Specifically, apigenin-7-glucoside showed strong binding with JAK2 and RELA, while quercetin favoured JAK2 and EGFR. Overall, the findings underscore the therapeutic potential of these PCs and validate integrated in silico approaches (in) drug discovery.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104105"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five new cassane diterpenoids from Pterolobium macropterum 大翼菜中五个新的木薯二萜类化合物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2025-12-06 DOI: 10.1016/j.phytol.2025.104093

Bin Wang , Gang Ke , Yue-Ping Lan , En Yuan , Pu-Zhao Zhang

引用次数: 0

Announcements of the Phytochemical Society of Europe 欧洲植物化学学会公告

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2026-01-30 DOI: 10.1016/S1874-3900(26)00019-4

引用次数: 0

Cytotoxic secondary metabolites from submerged cultures of Chaetomium sp. isolated from decaying wood 腐木毛藻浸没培养的细胞毒性次生代谢物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2025-12-13 DOI: 10.1016/j.phytol.2025.104095

Bel Youssouf G. Mountessou , Gesquiere Laure M. Tiani , Joseph Tchamgoue , Rukesh Maharjan , Aron Trucksess , Rainer Kalscheuer , Muhammad I. Choudhary , Simeon F. Kouam

{"title":"Cytotoxic secondary metabolites from submerged cultures of Chaetomium sp. isolated from decaying wood","authors":"Bel Youssouf G. Mountessou , Gesquiere Laure M. Tiani , Joseph Tchamgoue , Rukesh Maharjan , Aron Trucksess , Rainer Kalscheuer , Muhammad I. Choudhary , Simeon F. Kouam","doi":"10.1016/j.phytol.2025.104095","DOIUrl":"10.1016/j.phytol.2025.104095","url":null,"abstract":"<div><div>This study aimed to investigate the chemical constituents of a Chaetomium strain (CECA 170) isolated from decaying wood and to assess their antimicrobial and cytotoxic activities. One previously unreported macrolide (1), one ketone-derived isoxazolidine (2), and one naturally occurring chromone (3), along with four known metabolites (4 −7), were isolated from the submerged culture of Chaetomium sp. The structures of the new compounds were established by extensive spectroscopic and spectrometric analyses (NMR, MS). The known compounds were identified by comparing their experimental data with previously published literature. Compound 1 exhibited cytotoxic activities against human breast cancer cells (MCF-7) and HeLa cervical cancer cells, with IC50 values of 7.84 µM and 18.7 µM, respectively. In contrast, compound 2 displayed stronger cytotoxicity against HeLa cells (IC50 = 14.3 µM) than MCF-7 cells (IC50 = 18.5 µM). However, none of the tested compounds showed antimicrobial activity on the evaluated microorganisms. These results underscore the potential of fungi from underexplored niches, like decaying wood, for the discovery of new chemotherapeutic leads.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104095"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sesquiterpenoids with antibacterial and cytotoxic activities from the soft coral Litophyton arboreum 软珊瑚中具有抗菌和细胞毒活性的倍半萜类化合物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2025-11-26 DOI: 10.1016/j.phytol.2025.104087

Ahmed H. Eissa, Helnan A. Aboseada, Seif-Eldin N. Ayyad

{"title":"Sesquiterpenoids with antibacterial and cytotoxic activities from the soft coral Litophyton arboreum","authors":"Ahmed H. Eissa, Helnan A. Aboseada, Seif-Eldin N. Ayyad","doi":"10.1016/j.phytol.2025.104087","DOIUrl":"10.1016/j.phytol.2025.104087","url":null,"abstract":"<div><div>A chemical investigation of the CH2Cl2/MeOH extract of the Red Sea soft coral Litophyton arboreum led to the isolation of a new eudesmane-type sesquiterpenoid, 11-acetoxy-5β,8β-epidioxy-6-eudesmene (1), together with three known analogues (2–4). The structures of the isolated metabolites were elucidated using comprehensive spectroscopic techniques, including NMR and HRESIMS, supported by detailed comparison with reported data of related analogues. The antiproliferative properties of metabolites 1–4 were evaluated against Hep G2 and NCI-H1299 human cancer cell lines. Among them, compounds 1 and 4 exhibited weak cytotoxic activity against NCI-H1299, with IC50 values of 39.8 ± 0.93 and 43.1 ± 0.61 μM, respectively, compared to doxorubicin as a reference. The antibacterial screening revealed that the isolated sesquiterpenoids displayed weak to moderate activity, with inhibition observed at relatively high concentrations (50–150 µg/mL). Compounds 1, 3, and 4 showed selective inhibition of Bacillus cereus and Staphylococcus aureus, whereas Gram-negative bacteria were less affected. Although MIC values could not be determined owing to limited sample availability, the results suggest a weak but measurable antibacterial potential consistent with other eudesmane-type sesquiterpenoids. The combined cytotoxic and antibacterial data indicate that these metabolites may serve as useful scaffolds for future structure–activity and mechanistic studies.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104087"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New γ-lactams from Paraphoma sp. AC-G1 isolated from Artemisia argyi 从艾蒿中分离得到的Paraphoma sp. AC-G1新γ-内酰胺

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2025-11-21 DOI: 10.1016/j.phytol.2025.104084

Xu-Ping Zhang, Xue-Kai Zhao, Wei-Guang Wang, Qian-Qian Yin, Lu Gao

引用次数: 0