Four new sesquiterpenoids from Michelia yunnanensis Franch. ex Finet & Gagnep. and their nitric oxide inhibitory activity

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-04-01 DOI:10.1016/j.phytol.2025.102952

Lin-Fen Ding , Yi-Fan Shen , Qiu-Hua Wang , Qiu-Ye Zhao , Shi-Huan Yin , Liu-Dong Song , Xing-De Wu

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引用次数: 0

Abstract

Four new sesquiterpenoids, named michelianins A-D (1-4), were isolated from the branches and leaves of Michelia yunnanensis Franch. ex Finet & Gagnep., along with seven known compounds (5-11). The chemical structures of 1-4 were elucidated through comprehensive analysis using ¹H, ¹³C, and 2D NMR, HR-ESI-MS, and IR data. The absolute configuration of all the new compounds remained unidentified. Structurally, michelianin A was a rare michampane sesquiterpenoid possessing a bicyclo[6.2.0]decane motif, and michelianins C and D were farnesane sesquiterpenoids containing a ditetrahydrofuran moiety. Compounds 1-11 were tested for their nitric oxide (NO) inhibitory activity. Among them, compound 7 displayed moderate inhibitory effect toward LPS-induced NO release in RAW 264.7 cells with an inhibitory rate of 47.63 % at a concentration of 50 μM.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.