Phytochemistry Letters最新文献_第6页

Two unprecedented 2-(2-phenylethyl)chromone dimers from the Cambodian agarwood of Aquilaria crassna 柬埔寨沉香中两种前所未有的2-（2-苯乙基）色素二聚体

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI: 10.1016/j.phytol.2025.104094

Yan Huang , Hao Wang , Wen-Li Mei , Hui-Qin Chen , Fei Wu , Yan-Mei Wei , Wen-Ming Cheng , Hao-Fu Dai

引用次数: 0

Phenolic glycosides from Ligusticum wallichii with cytotoxic activity 具有细胞毒活性的川芎酚类苷

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-02-01 Epub Date: 2025-11-27 DOI: 10.1016/j.phytol.2025.104082

Ninh Khac Thanh Tung , Nguyen Thi Tu Oanh , Nguyen Thi Minh Hang , Nguyen Thi Thu Ha , Tran My Linh , Vu Huong Giang , Yohan Seo , SeonJu Park , Nguyen Tien Dat , Nguyen Xuan Nhiem , Hyung Min Kim , Ninh Khac Ban

{"title":"Phenolic glycosides from Ligusticum wallichii with cytotoxic activity","authors":"Ninh Khac Thanh Tung , Nguyen Thi Tu Oanh , Nguyen Thi Minh Hang , Nguyen Thi Thu Ha , Tran My Linh , Vu Huong Giang , Yohan Seo , SeonJu Park , Nguyen Tien Dat , Nguyen Xuan Nhiem , Hyung Min Kim , Ninh Khac Ban","doi":"10.1016/j.phytol.2025.104082","DOIUrl":"10.1016/j.phytol.2025.104082","url":null,"abstract":"<div><div>Ligusticum wallichii Franch. (Apiaceae) is a traditional medicinal plant extensively used in Asia for treating circulatory and neurological disorders. Two new phenolic glycosides, ligusticosides A and B (1 and 2), along with five known compounds, 2-methoxy-4-(3-methoxy-1-propenyl)-phenol (3), ferulic acid (4), coniferin (5), 2-methoxy-2-(4′-hydroxyphenyl)ethanol (6), and falcarindiol (7) were isolated from the roots of L. wallichii. The chemical structures of the isolated compounds were elucidated by comprehensive spectroscopic and chemical analyses, including NMR and HR-ESI-MS. All compounds were evaluated for cytotoxic activity by the MTS assay on PC9 (lung), A2058 (melanoma), and HepG2 (liver) cancer cell lines. Compounds 1, 2, 5, and 7 exhibited significant cytotoxic activity with IC₅₀ values ranging from 3.2 to 9.8 µM against the tested cell lines. Compounds 1, 2, 5, and 7 also significantly increased caspase-3 activity (2.52–3.20-fold) and PARP-1 cleavage (2.41–2.88-fold), indicating apoptosis as a major mechanism of action.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"71 ","pages":"Article 104082"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of prenylflavonoids from hops against sodium nitroprusside-induced cell viability reduction in SH-SY5Y cells: Role of side chain length 啤酒花戊烯基类黄酮对硝普钠诱导的SH-SY5Y细胞活力降低的影响：侧链长度的作用

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-10-17 DOI: 10.1016/j.phytol.2025.104058

Theresa Bayerl , Veronika R. Huber , Herbert Riepl , Corinna Urmann

{"title":"Effects of prenylflavonoids from hops against sodium nitroprusside-induced cell viability reduction in SH-SY5Y cells: Role of side chain length","authors":"Theresa Bayerl , Veronika R. Huber , Herbert Riepl , Corinna Urmann","doi":"10.1016/j.phytol.2025.104058","DOIUrl":"10.1016/j.phytol.2025.104058","url":null,"abstract":"<div><div>The flavonoid class encompasses over 700 distinct structural variants, all of which have been demonstrated to confer a multitude of beneficial effects on human health. Given the correlation between oxidative stress and over 100 diseases, including neurodegenerative, cardiovascular, and inflammatory diseases, it is a valuable target for the development of therapeutic agents. This study examined the effects of prenylated chalcones and flavanones derived from hops (Humulus lupulus L.), including xanthohumol, xanthohumol A, and C, as well as isoxanthohumol, 6- and 8-prenylnaringenin, and 8-geranylnaringenin, on cell viability and on revising the effect of sodium nitroprusside (SNP) on cell viability in the neuroblastoma cell line SH-SY5Y. The lowest IC50 (10.14–20.42 µM) was observed in treatment with chalcones. With regard to the protective effect against SNP, a structure-activity relationship of prenylated and geranylated flavanones indicated that the extension of the prenyl side chain is beneficial for the protective effect of prenylated flavanones against SNP treatment. In accordance with the aforementioned methodology, 8-farnesylnaringenin, comprising a chain of three isoprene units, was synthesized and the effect on cell viability and protection against SNP-induced reduction of cell viability was subsequently evaluated. The strongest impact on cell viability (IC50) was observed for 8-farnesylnaringenin, which also demonstrated the most robust protective effect (25 %).</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 104058"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spondias tuberosa Arruda (Anacardiaceae) ethanolic leaf extract as a source of natural products inhibiting quorum sensing and pyocyanin production in planktonic Pseudomonas aeruginosa 作为抑制浮游铜绿假单胞菌群体感应和花青素产生的天然产物来源的海棘叶乙醇提取物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-11-20 DOI: 10.1016/j.phytol.2025.104078

A.S. Tareau , P.E. Bodet , J.R. Guedes da Silva Almeida , M. Barreau , O. Lesouhaitier , A. Tahrioui , R. Gonçalves de Oliveira Junior , R. Grougnet , P. Sitarek , L. Quintans-Junior , K. Baranger , S. Chevalier , L. Picot

{"title":"Spondias tuberosa Arruda (Anacardiaceae) ethanolic leaf extract as a source of natural products inhibiting quorum sensing and pyocyanin production in planktonic Pseudomonas aeruginosa","authors":"A.S. Tareau , P.E. Bodet , J.R. Guedes da Silva Almeida , M. Barreau , O. Lesouhaitier , A. Tahrioui , R. Gonçalves de Oliveira Junior , R. Grougnet , P. Sitarek , L. Quintans-Junior , K. Baranger , S. Chevalier , L. Picot","doi":"10.1016/j.phytol.2025.104078","DOIUrl":"10.1016/j.phytol.2025.104078","url":null,"abstract":"<div><div>Pseudomonas aeruginosa is a multidrug-resistant pathogen whose virulence is tightly regulated by quorum sensing (QS). Targeting QS offers a promising anti-virulence strategy by disarming pathogens without promoting resistance. Here, we screened Brazilian medicinal plant extracts for QS inhibition and identified the ethanolic leaf extract of Spondias tuberosa Arruda (STF) as a potent suppressor of pyocyanin production in planktonic P. aeruginosa cultures, without affecting bacterial growth. STF disrupted QS signaling, as demonstrated by the decreased production of QS mediators detected using a biosensor strain. Phytochemical profiling revealed candidate compounds potentially responsible for this activity. These findings highlight S. tuberosa as a promising natural source of QS inhibitors capable of attenuating P. aeruginosa virulence, particularly during the early stages of infection, and open perspectives for future research into its potential interest in anti-virulence therapeutic approaches.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 104078"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One new rearranged pyranone derivative with antibacterial activity from Xylaria curta YSJ-5 木霉YSJ-5中具有抗菌活性的新的重排吡喃酮衍生物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-11-10 DOI: 10.1016/j.phytol.2025.104075

Shan-Shan Wei , Dao-Jun Rong , Jia-Ying Lai , Chen Chen , Si-Ran Li , Zhong-Hua Yu , Hai-Bo Tan

引用次数: 0

Botryosphaeria dothidea fermentation enhances agarotetrol accumulation in the nonresinous heartwood of Aquilaria sinensis 葡萄球孢菌发酵促进沉香非树脂心材中木香素的积累

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-11-11 DOI: 10.1016/j.phytol.2025.104076

Xiao-Yan Duan , Hui Yan , Jun Yang , Ji-Feng Luo , Hataichanok Pandith , Terd Disayathanoowat , Angkhana Inta , Yue-Hu Wang

引用次数: 0

Chemical constituents of culture broth of the marine-derived fungus Towyspora aestuari and their antioxidant activity 海源真菌黄霉培养液的化学成分及其抗氧化活性研究

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-11-22 DOI: 10.1016/j.phytol.2025.104080

Mungyeong Gwon , Dae-Won Ki , Dae-Cheol Choi , Ji-Yul Kim , Won-Gi Seo , Yongkuk Lee , In-Kyoung Lee , Bong-Sik Yun

{"title":"Chemical constituents of culture broth of the marine-derived fungus Towyspora aestuari and their antioxidant activity","authors":"Mungyeong Gwon , Dae-Won Ki , Dae-Cheol Choi , Ji-Yul Kim , Won-Gi Seo , Yongkuk Lee , In-Kyoung Lee , Bong-Sik Yun","doi":"10.1016/j.phytol.2025.104080","DOIUrl":"10.1016/j.phytol.2025.104080","url":null,"abstract":"<div><div>Seven compounds including a new pyrone, towyspyrone A (1), and six known naphthalenes, 8-methoxy-1-naphthol (2), 5-methoxy-1-naphthol (3), 3,4,5-trihydroxy-1-tetralone (4), 3,4-dihydro-3,4,6,8-tetrahydroxy-1(2 H)-naphthalenone (5), scytalone (6), and 4,6,8-trihydroxy-3,4-dihydronaphthalene-1(2 H)-one (7), were isolated from culture broth of the marine-derived fungus Towyspora aestuari. Their structures were determined by extensive NMR and mass analyses. Free radical scavenging activity of the isolated compounds was assessed using 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Compounds 2 and 3 showed potent free radical scavenging activity with IC50 values of 12.6 µM and 10.8 µM, respectively, against the ABTS radical and of 224.0 µM and 191.1 µM against the DPPH radical.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 104080"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling naturally occurring hydroperoxide sesquiterpenoids from Indonesian Dysoxylum amooroides Miq 揭示天然存在的氢过氧化物倍半萜类化合物来自印度尼西亚的桃草

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-11-11 DOI: 10.1016/j.phytol.2025.104073

Latifah Gunawan , Al Arofatus Naini , Desi Harneti , Kindi Farabi , Sofa Fajriah , Elpri Eka Permadi , Sri Rahayu , Siriporn Jungsuttiwong , Unang Supratman

{"title":"Unveiling naturally occurring hydroperoxide sesquiterpenoids from Indonesian Dysoxylum amooroides Miq","authors":"Latifah Gunawan , Al Arofatus Naini , Desi Harneti , Kindi Farabi , Sofa Fajriah , Elpri Eka Permadi , Sri Rahayu , Siriporn Jungsuttiwong , Unang Supratman","doi":"10.1016/j.phytol.2025.104073","DOIUrl":"10.1016/j.phytol.2025.104073","url":null,"abstract":"<div><div>Hydroperoxides (–OOH) represent rare but biologically intriguing motifs in plant secondary metabolites, particularly within sesquiterpenoids. Phytochemical investigation of Dysoxylum amooroides yielded an undescribed sesquiterpenoid, amooroxyline A (1), together with 4β,10α-dihydroxyaromadendrane (2). The structure and absolute configuration of 1 were established by ECD analysis. Cytotoxicity assays revealed 1 inactive on MCF-7, while 2 showed moderate selective inhibition (IC₅₀ = 20.1 μM), with neither affecting normal CV-1 cells. In addition, molecular docking centered on the hydroperoxide scaffold (1 and related 10β,11-dihydroxy-1β-hydroperoxide-4αH,5αH,7αH-guaiane analogue) supported these results, showing weaker binding affinities to ESR1, ESR2, and aromatase compared to native ligands. Further in silico exploration suggested potential interactions with BACE1 and Plasmodium falciparum Falcipain-2, highlighting guaiane hydroperoxides as promising chemotypes for future studies in degenerative and infectious disease contexts.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 104073"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145516684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive butanolides and steroids from the Red Sea soft coral Sarcophyton ehrenbergi 红海软珊瑚中的生物活性丁烷内酯和甾体

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI: 10.1016/j.phytol.2025.104059

Sabry A.H. Zidan , Mostafa A. Asmaey , Mohamed R. Kamel , Eman Fawzy El Azab , Saleha Y.M. Alakilli , Mohamed N. Ibrahim , Mohamed A. Tantawy , Khaled M. Elokely , Katsuyoshi Matsunami , Waleed A. Abdel-Naime

{"title":"Bioactive butanolides and steroids from the Red Sea soft coral Sarcophyton ehrenbergi","authors":"Sabry A.H. Zidan , Mostafa A. Asmaey , Mohamed R. Kamel , Eman Fawzy El Azab , Saleha Y.M. Alakilli , Mohamed N. Ibrahim , Mohamed A. Tantawy , Khaled M. Elokely , Katsuyoshi Matsunami , Waleed A. Abdel-Naime","doi":"10.1016/j.phytol.2025.104059","DOIUrl":"10.1016/j.phytol.2025.104059","url":null,"abstract":"<div><div>In this study, a cytotoxicity-guided isolation approach was employed to isolate bioactive compounds from the crude extract of the Red Sea soft coral Sarcophyton ehrenbergi (S. ehrenbergi). The isolated compounds were tested against A549 and HepG2 cancer cell lines using the MTT colorimetric assay. This process led to the discovery of a new butanolide derivative (1), along with three known related metabolites (2, 3, and 4), as well as two steroids (5 and 6) from the most active ethyl acetate (EtOAc) fraction. The structures of these compounds were determined through comprehensive NMR spectroscopic analyses, HRESI-MS, and comparison with previously reported data. In bioassays, compound 5 demonstrated potent cytotoxicity against HepG2 cells, whereas compound 6 exhibited noticeable activity against A549 cells, comparable to that of etoposide. Molecular docking studies revealed a strong binding affinity of compounds 5 and 6 to the active site of potential targeted enzymes, highlighting their mechanisms of action. However, the isolated compounds did not display any anti-leishmanial activity against Leishmania major. This research provides valuable insights into the bioactive compounds of S. ehrenbergi and their potential as anticancer agents. Further studies are recommended to validate these findings in vivo.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 104059"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new furofuran lignan and other biologically active chemical constituents from the leaves of Jacaranda mimosifolia 从蓝花楹叶中提取新的呋喃木脂素和其他具有生物活性的化学成分

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-10-06 DOI: 10.1016/j.phytol.2025.104046

Carlos Maxime Ngéonkou , Mariscal Brice Tchatat Tali , Kevine Johanne Jumeta Dongmo , Georges Bellier Tabouekeng , Yannick Stéphane Fotsing Fongang , Jean Jules Kezetas Bankeu , Fabrice Boyom Fekam , Leon Azefack Tapondjou , Bruno Ndjakou Lenta , Norbert Sewald , Silvère Augustin Ngouela

{"title":"A new furofuran lignan and other biologically active chemical constituents from the leaves of Jacaranda mimosifolia","authors":"Carlos Maxime Ngéonkou , Mariscal Brice Tchatat Tali , Kevine Johanne Jumeta Dongmo , Georges Bellier Tabouekeng , Yannick Stéphane Fotsing Fongang , Jean Jules Kezetas Bankeu , Fabrice Boyom Fekam , Leon Azefack Tapondjou , Bruno Ndjakou Lenta , Norbert Sewald , Silvère Augustin Ngouela","doi":"10.1016/j.phytol.2025.104046","DOIUrl":"10.1016/j.phytol.2025.104046","url":null,"abstract":"<div><div>The chemical investigation of the ethanolic extract of the leaves of Jacaranda mimosifolia, which showed good to moderate activities against PfDd2 and Pf3D7 strains of Plasmodium falciparum during preliminary screening led to the isolation of a new furofuran lignan, jacaranin (1), together with eighteen known compounds (2 – 19). Their structures were determined based on their spectroscopic and spectrometric data. The fractions and some isolated compounds were assessed in vitro for their antiplasmodial activity against the same strains of P. falciparum. The ethyl acetate fraction displayed a promising activity against PfDd2, whereas the remaining fractions and ethanolic extract exhibited moderate activities. The ethanol crude extract, n-butanol fraction, compounds 6 and 10 exhibited good cytotoxic activity against normal Vero cell lines with high CC50 values. Some isolated compounds exhibited good to moderate activity against the tested strains. Compounds 1, 6, and 14 were predicted to have good pharmacokinetics and drug likeness ability using in silico studies. These results could justify the antiplasmodial activity of the plant and its use in folk medicine to treat malaria.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 104046"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0