来自稀有针叶油杉内生植物Diaporthe sp. RYF-Br-5的一个新的10元内酯衍生物

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-05-16 DOI:10.1016/j.phytol.2025.102981

Li-Hong Yan , Hao-Wei Chen , Peng Hu , Jiyang Li , Juan Xiong , Ze-Xin Jin , Jin-Feng Hu

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引用次数: 0

摘要

从中国特有针叶树油杉（Keteleeria pubescens）鲜枝内生真菌Diaporthe sp. RYF-Br-5中分离得到一个新的10元内酯衍生物（diaporolide, 1）和3个已知的聚酮（2-4）。通过详细的光谱分析和理论ECD计算，确定了化合物1的结构和绝对立体化学性质。在抗菌实验中，化合物1对金黄色葡萄球菌表现出抑制作用，MIC值为64 µg/mL。

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Diaporolide, a new 10-membered lactone derivative from the endophytic Diaporthe sp. RYF-Br-5 associated with the rare conifer Keteleeria pubescens

A new 10-membered lactone derivative (diaporolide, 1) and three known polyketides (2–4) were obtained from the endophytic fungus Diaporthe sp. RYF-Br-5, which was derived from the fresh branches of Keteleeria pubescens, a rare endemic conifer native to China. Through a detailed spectroscopic analysis and theoretical ECD calculations, the structure and absolute stereochemistry of compound 1 were confirmed. In antimicrobial assays, compound 1 exhibited an inhibitory effect against Staphylococcus aureus with an MIC value of 64 µg/mL.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.