Phytochemistry Letters最新文献_第7页

Corrigendum to "Peganutonin A, a novel melatonin analogue from the seeds of Peganum harmala" [Phytochem. Lett. 56 (2023) 78–80] “Peganutonin A，一种新的褪黑素类似物，来自Peganum harmala种子”的勘误表[植物化学]。Lett. 56 (2023) 78-80]

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-12 DOI: 10.1016/j.phytol.2025.102978

Jian-Bo Liu , Wan-Ying Li , Xue Zhao , Feng-Ying Yang , Lei Fang

引用次数: 0

Two new diterpenes isolated from the roots of Grangea maderaspatana 两种新二萜化合物的分离

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-12 DOI: 10.1016/j.phytol.2025.102973

Jittraporn Tipmala , Natcha Injan , Somkiat Nokbin , Ratchanaporn Chokchaisiri , Surat Laphookhieo , Kittirat Saharat , Narawadee Rujanapun , Rawiwan Charoensup , Thunwadee Limtharakul , Sarot Cheenpracha

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Capillary electrophoresis as a green and rapid technique for the quantification of caffeic acid phenethyl ester (CAPE): Correlation between CAPE contents and anti-inflammatory activities of propolis extracts 毛细管电泳作为一种绿色快速定量咖啡酸苯乙酯（CAPE）的技术：CAPE含量与蜂胶提取物抗炎活性的相关性

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-10 DOI: 10.1016/j.phytol.2025.102970

Zeynep Kalaycıoğlu , Çisil Alim , Sevgi Kolaylı , F. Bedia Erim

{"title":"Capillary electrophoresis as a green and rapid technique for the quantification of caffeic acid phenethyl ester (CAPE): Correlation between CAPE contents and anti-inflammatory activities of propolis extracts","authors":"Zeynep Kalaycıoğlu , Çisil Alim , Sevgi Kolaylı , F. Bedia Erim","doi":"10.1016/j.phytol.2025.102970","DOIUrl":"10.1016/j.phytol.2025.102970","url":null,"abstract":"<div><div>Caffeic acid phenethyl ester (CAPE) is propolis's most notable bioactive compound. Since CAPE has many pharmacological properties, the bioactivities of propolis can mostly be attributed to its CAPE content. As the administration of propolis extracts to the body for therapeutic purposes increases, reliable determination of the CAPE content of the extracts becomes important. This study developed a green micellar electrokinetic chromatography (MEKC) method to determine the CAPE amount in propolis extracts rapidly. The method was applied for the determination of CAPE amounts in commercial propolis spray samples and two propolis samples collected from beekeepers in Anatolia. Moreover, the anti-inflammatory activities of propolis samples were measured based on the in-vitro inhibitory activity of the tumor necrosis factor-α (TNF-α) enzyme. The correlation between the amount of CAPE and the anti-inflammatory activities of the samples was investigated and found to be 0.90. This high correlation indicates that CAPE has an important role in the anti-inflammatory effect of propolis.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102970"},"PeriodicalIF":1.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidesmosidic triterpenoid saponins and other bioactive constituents from the stem bark of Pittosporum viridiflorum 绿花Pittosporum viridiflorum茎皮中的Bidesmosidic三萜皂苷及其他生物活性成分

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-09 DOI: 10.1016/j.phytol.2025.102972

Mathilda Loinseboh Amahndong , Kevine Johanne Jumeta Dongmo , Christine Claire Waleguele , Billy Toussie Tchegnitegni , Georges Bellier Tabouekeng , Jean Rodolphe Chouna , Céline Nguefeu Nkenfou , Jean Jules Kezetas Bankeu , Bruno Ndjakou Lenta , Norbert Sewald

{"title":"Bidesmosidic triterpenoid saponins and other bioactive constituents from the stem bark of Pittosporum viridiflorum","authors":"Mathilda Loinseboh Amahndong , Kevine Johanne Jumeta Dongmo , Christine Claire Waleguele , Billy Toussie Tchegnitegni , Georges Bellier Tabouekeng , Jean Rodolphe Chouna , Céline Nguefeu Nkenfou , Jean Jules Kezetas Bankeu , Bruno Ndjakou Lenta , Norbert Sewald","doi":"10.1016/j.phytol.2025.102972","DOIUrl":"10.1016/j.phytol.2025.102972","url":null,"abstract":"<div><div>Three previously unreported triterpenoid saponins namely pittosposides A–C (1–3), were isolated from the stem bark of Pittosporum viridiflorum, alongside nine known compounds 4−11. The structures were elucidated based on spectroscopic data as well as chemical conversions. The extract, fractions, and some isolated compounds were assessed for their antibacterial activity against sixteen multi-resistant bacterial strains. The extract and fractions exhibited good antibacterial activity on at least one of the tested strains. The EtOAc fraction was the most active against almost all the strains (MIC values, 15.6<img>500 μg/mL). 2,6‑Dimethoxybenzoquinone (7) was active against almost all the selected bacterial strains with the best activity against E. coli ATCC35218 (MIC = 1.9 μg/mL). In addition, the extract, fractions, and compounds 1−4, 7, and 11 were assessed for their cytotoxic activity on the normal Vero cell line. Compounds 1, 2 and 4 were further assessed for their cytotoxic activity on the KB-3–1 cervical carcinoma cell line against which compound 4 displayed moderate cytotoxicity (IC50 = 23.9 μM). The chemophenetic significance of the isolates was discussed.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102972"},"PeriodicalIF":1.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and cytotoxicity evaluation of tyrosine-3 or tyrosine-6 fluorinated analogues of RA-VII, an antitumor bicyclic hexapeptide from Rubia cordifolia 芦笋抗肿瘤双环六肽RA-VII的酪氨酸-3或酪氨酸-6氟化类似物的合成及细胞毒性评价

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-06 DOI: 10.1016/j.phytol.2025.102967

Yukio Hitotsuyanagi, Ken Morita, Tatsuro Anzai, Tomoyo Hasuda, Niro Inaba, Koichi Takeya

引用次数: 0

Sesquiterpenes from the Saudi Arabian Red Sea sponge Lamellodysidea herbacea 沙特阿拉伯红海海绵的倍半萜素

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-01 DOI: 10.1016/j.phytol.2025.102969

Mohamed A. Tammam , Leto-Aikaterini Tziveleka , Carlos M. Duarte , Efstathia Ioannou , Vassilios Roussis

引用次数: 0

Characterization of a new lyso-ornithine lipid from the shipworm symbiont Teredinibacter turnerae 船虫共生体Teredinibacter turnerae中一种新的溶鸟氨酸脂质的特性

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-28 DOI: 10.1016/j.phytol.2025.102960

Ernest Guiller S. Pineda, Jacquelyn E. Peran, Jeremiah D. Batucan, Zildjian G. Acyatan, Shalice R. Susana-Guevarra, Lilibeth A. Salvador-Reyes

{"title":"Characterization of a new lyso-ornithine lipid from the shipworm symbiont Teredinibacter turnerae","authors":"Ernest Guiller S. Pineda, Jacquelyn E. Peran, Jeremiah D. Batucan, Zildjian G. Acyatan, Shalice R. Susana-Guevarra, Lilibeth A. Salvador-Reyes","doi":"10.1016/j.phytol.2025.102960","DOIUrl":"10.1016/j.phytol.2025.102960","url":null,"abstract":"<div><div>Teredinibacter turnerae dedicates a significant portion of its genome to secondary metabolite biosynthesis. In this study, we purified the new lyso-ornithine lipid N-3-hydroxyoleoyl ornithine (1) from T. turnerae strains 4401H.S.1B.02-A and 4409 W.S.0 A.02-C. This compound is characterized by a monohydroxylated C18:1 fatty acid attached to an ornithine head group through an amide bond. N-3-hydroxyoleoyl ornithine demonstrated weak antimicrobial activity against planktonic Staphylococcus epidermidis (% inhibition = 53.5 ± 11.8 % at 256 µg/mL (620 µM)) and weak cytotoxicity against HK-2 normal human kidney cells (IC50 = 11 µM) and HCT116 human colorectal carcinoma (% cell viability = 47.6 ± 8.0 % at 100 µM). The antimicrobial and cytotoxic activities of 1 are, in part, facilitated by its membrane-disrupting activity. N-3-hydroxyoleoyl ornithine (1) caused an indirect and irreversible amplification of Ca2+ uptake in dorsal root ganglion (DRG) neurons that are insensitive to either menthol or capsaicin at 10 µg/mL (24 µM). Time course studies further revealed that the production of 1 in T. turnerae 4409 W.S.0 A.02-C is negatively regulated by phosphate control, possibly via a Pho-dependent regulation of olsB expression.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102960"},"PeriodicalIF":1.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The synthesis of arylmethylene bisindoles catalyzed by nickel perchlorate as potential antifungal agent against Clarireedia homoeocarpa 高氯酸镍催化合成芳基亚甲基双吲哚的研究

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-24 DOI: 10.1016/j.phytol.2025.102966

Ye Zhou , Ruyuan Wang , Rui Feng , Bi Wang , Shu Xu , Mei Tian , Wenhao Liang , Jin Chen , Yu Chen , Xu Feng , Li Lin , Jinyue Luo , Jianlan Wang , Fei Liu

{"title":"The synthesis of arylmethylene bisindoles catalyzed by nickel perchlorate as potential antifungal agent against Clarireedia homoeocarpa","authors":"Ye Zhou , Ruyuan Wang , Rui Feng , Bi Wang , Shu Xu , Mei Tian , Wenhao Liang , Jin Chen , Yu Chen , Xu Feng , Li Lin , Jinyue Luo , Jianlan Wang , Fei Liu","doi":"10.1016/j.phytol.2025.102966","DOIUrl":"10.1016/j.phytol.2025.102966","url":null,"abstract":"<div><div>Arylmethylene bisindole alkaloids are predominantly found in cruciferous plants and as metabolites in marine organisms, exhibiting a diverse range of biological activities. In recent years, these alkaloids have been increasingly explored and utilized for controlling plant pathogenic fungi. However, the synthesis and underlying mechanisms, particularly their effectiveness against plant pathogens such as Clarireedia homoeocarpa, still require further investigation. In this study, a series of arylmethylene bisindoles were synthesized with high yield using aromatic aldehydes and indoles catalyzed by NiClO4·6H2O. These compounds showed spectral antibacterial activity against six major phytopathogenic fungi and A13 exhibiting the highest antifungal activity against C. homoeocarpa with an EC50 value of 0.74 mg/L. Furthermore, in vivo antifungal assays were performed to assess the efficacy of the active compounds against C. homoeocarpa. To elucidate the antifungal mechanism of arylmethylene bisindoles, a comprehensive analysis of physiological and biochemical indices, along with transcriptome profiling, was carried out to elucidate. The results demonstrated that A13 treatment can efficiently disrupt the cell membranes of C. homoeocarpa. Additionally, we identified and screened the candidate genes implicated in cell membrane alterations under A13 treatments. KEGG pathway analysis revealed that a considerable number of down-regulated DEGs were significantly enriched in metabolic pathways, biosynthesis of secondary metabolic, and ribosome biogenesis in eukaryotes. This research provides valuable insights for the effective management of lawn coin spot disease.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102966"},"PeriodicalIF":1.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new neolignans isolated from the endemic species Astracantha aitosensis 从特有种紫菀中分离的两个新木质素属

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-22 DOI: 10.1016/j.phytol.2025.102961

Yancho Zarev , Preslav Enchev , Rositsa Mihaylova , Georgi Momekov , Luc Pieters , Hans Michler , Iliana Ionkova

{"title":"Two new neolignans isolated from the endemic species Astracantha aitosensis","authors":"Yancho Zarev , Preslav Enchev , Rositsa Mihaylova , Georgi Momekov , Luc Pieters , Hans Michler , Iliana Ionkova","doi":"10.1016/j.phytol.2025.102961","DOIUrl":"10.1016/j.phytol.2025.102961","url":null,"abstract":"<div><div>Four compounds, a lignan 1, including two new neolignans 2 and 3, and one pterocarpan 4, were isolated from the arial parts of endemic Bulgarian species Astracantha aitosensis (syn. Astragalus aitosensis) (Ivan.) Fabaceae by means of conventional separation methods. The structure of those compounds was elucidated by means of spectroscopic methods, including 1D and 2D NMR, as well as HRESI-MS. Among the isolated compounds is a new neolignan (2) named astracandioxin and a new dihydrobenzofuran (3) named astracanamide, while for the maackiain-3-O-β-D-glucoside (4) this is the first report of isolation from the genus and for syringaresinol-4-O-β-D-glucoside (1) first report of isolation from A. aitosensis, respectively. The antiproliferative activity of the isolated compounds was assessed in a panel of human tumor cell lines of different origin.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102961"},"PeriodicalIF":1.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbonyl compounds and glycosides from the fruits of Alpinia oxyphylla as potential renoprotective agents 杉木果实中的羰基化合物和苷类化合物作为潜在的肾保护剂

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-17 DOI: 10.1016/j.phytol.2025.102965

Xiao-Ning Liu , Yue-Tong Zhu , Bo-Tao Lu , Yong-Xian Cheng , Yan-Zhi Wang

引用次数: 0