深海源真菌scoparia FS716的两个新的细胞孢素衍生物

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-03-07 DOI:10.1016/j.phytol.2025.02.014

TingYue Wen , YuChan Chen , JiaXi Li , HongXin Liu , WeiMin Zhang , XiaoXia Gao

{"title":"深海源真菌scoparia FS716的两个新的细胞孢素衍生物","authors":"TingYue Wen , YuChan Chen , JiaXi Li , HongXin Liu , WeiMin Zhang , XiaoXia Gao","doi":"10.1016/j.phytol.2025.02.014","DOIUrl":null,"url":null,"abstract":"<div><div>Two new cytosporin derivatives, cytosporin Y4 (1) and cytosporin Y5 (2), together with seven known compounds (3–9) were isolated from Eutypella scoparia FS716, a fungus from the deep-sea sediment in South China Sea. The chemical structures of compounds 1 and 2 were established by 1D, 2D NMR, HRESIMIS, IR and UV spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. As a result, compounds 3–6, 8 and 9 showed significant anti-inflammatory activities.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"66 ","pages":"Pages 131-135"},"PeriodicalIF":1.4000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two new cytosporin derivatives from the deep-sea-derived fungus Eutypella scoparia FS716\",\"authors\":\"TingYue Wen , YuChan Chen , JiaXi Li , HongXin Liu , WeiMin Zhang , XiaoXia Gao\",\"doi\":\"10.1016/j.phytol.2025.02.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Two new cytosporin derivatives, cytosporin Y4 (1) and cytosporin Y5 (2), together with seven known compounds (3–9) were isolated from Eutypella scoparia FS716, a fungus from the deep-sea sediment in South China Sea. The chemical structures of compounds 1 and 2 were established by 1D, 2D NMR, HRESIMIS, IR and UV spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. As a result, compounds 3–6, 8 and 9 showed significant anti-inflammatory activities.</div></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"66 \",\"pages\":\"Pages 131-135\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874390025010262\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390025010262","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

从南海深海沉积物中分离得到两个新的胞孢素衍生物，胞孢素Y4(1)和胞孢素Y5(2)，以及7个已知化合物（3-9）。化合物1和2的化学结构通过1D、2D NMR、HRESIMIS、IR和UV光谱分析得到。所有分离的化合物都进行了细胞毒性和抗炎活性的评价。结果表明，化合物3 ~ 6、8、9具有明显的抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Two new cytosporin derivatives from the deep-sea-derived fungus Eutypella scoparia FS716

Two new cytosporin derivatives, cytosporin Y₄ (1) and cytosporin Y₅ (2), together with seven known compounds (3–9) were isolated from Eutypella scoparia FS716, a fungus from the deep-sea sediment in South China Sea. The chemical structures of compounds 1 and 2 were established by 1D, 2D NMR, HRESIMIS, IR and UV spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. As a result, compounds 3–6, 8 and 9 showed significant anti-inflammatory activities.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.