牛膝两种新的酚类苷及其对子宫平滑肌的松弛作用

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-25 DOI:10.1016/j.phytol.2025.02.010

Mei-Ji Sun , Rui Zhao , Min Wen , Chun-Wang Meng , Hai-Guo Su , Fu-Xin Mi , Cheng Peng , Juan Liu , Liang Xiong

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引用次数: 0

摘要

从牛蹄草的乙酸乙酯萃取物中分离出2种新的酚类苷，3-甲氧基苯乙酮-4- o -β- d -apiofuranosyl-(1→2)-β- d -glucopyranoside(1)和3-甲氧基苯乙酮-4- o -β- d -hydroxybenzoyl -（5′- o -对羟基苯甲酰）-apiofuranosyl-(1→2)-β- d -glucopyranoside(2)，以及1种已知的类似物(3)。广泛的光谱分析和化学方法确定了它们的结构和绝对构型。采用大鼠子宫平滑肌收缩模型研究分离化合物对催产素诱导的子宫收缩的松弛作用。结果表明，化合物1和2对催产素诱导的子宫平滑肌收缩均有抑制作用。

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Two new phenolic glycosides from Cyathula officinalis and their relaxant effects on uterine smooth muscle

Two novel phenolic glycosides, 3-methoxyacetophenone-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (1) and 3-methoxyacetophenone-4-O-β-D-(5′′-O-p-hydroxybenzoyl)-apiofuranosyl-(1→2)-β-D-glucopyranoside (2), along with one known analogue (3), were isolated from the ethyl acetate extract of Cyathula officinalis. Extensive spectroscopic analyses and chemical methods determined their structures and absolute configurations. The relaxant effects of the isolated compounds on uterine contractions induced by oxytocin were investigated using a rat uterine smooth muscle contraction model. The results indicated that both compounds 1 and 2 had inhibitory effects on oxytocin-induced uterine smooth muscle contraction.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.