Daphnicalycinones A and B, Daphniphyllum alkaloids from the roots of Daphniphyllum calycinum with anti-inflammatory activity

IF 1.3 4区 生物学 Q4 CHEMISTRY, MEDICINAL
Jiaqi Guo , Wenlong Li , Runchao Ma , Lizhu Han , Jiani Ying , Xiongyu Meng , Huaqiang Li , Qi Shi , Luping Qin
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引用次数: 0

Abstract

Two undescribed Daphniphyllum alkaloids, daphnicalycinones A and B (1 and 2), together with three known analogues, daphnezomine D (3), calycindaphine H (4) and calycindaphine A (5) were isolated from the roots of Daphniphyllum calycinum. Their planar structures and stereo-structures were determined by extensively spectral analyses, including HRESIMS, NMR, DP4 + computational method and single-crystal X-ray crystallography. The anti-inflammatory activities of compounds 15 were tested on LPS-induced RAW 264.7 cells, and the results showed that 2 and 5 exhibited potent inhibitory effects with the IC50 values of 1.53 ± 0.35 μM and 10.13 ± 0.72 μM, respectively.
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来源期刊
Phytochemistry Letters
Phytochemistry Letters 生物-生化与分子生物学
CiteScore
3.00
自引率
11.80%
发文量
190
审稿时长
34 days
期刊介绍: Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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