Two new phenolic derivatives with neuroprotective activities from the fruits of Magnolia denudata

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-05-14 DOI:10.1016/j.phytol.2025.102980

Lin-Fen Ding , Xiang-Yue Zhang , Qiu-Hua Wang , Qiu-Ye Zhao , Shi-Huan Yin , Liu-Dong Song , Xing-De Wu

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Abstract

Two new phenolic derivatives, magnodatins A and B (1 and 2), were isolated from the fruits of Magnolia denudata Desr., along with two known compounds, denudalide (3) and lettowipyraquinol (4). The structures of 1 and 2 were determined through comprehensive analysis using NMR, HR-ESI-MS, and IR data. Notably, compound 1 featured a 3,7-dimethylocta-2,6-dienyl chain motif. Additionally, the neuroprotective effects of compounds 1 and 2 were evaluated in vitro against corticosterone-induced damage in PC12 cells. Compounds 1 and 2 showed weak neuroprotective activities at a concentration of 20 μmol/L with PC12 cell viability of 62.39 % for 1 and 61.79 % for 2, compared to 60.09 ± 0.04 % for the model group.

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白玉兰果实中两种具有神经保护活性的新酚类衍生物

从白玉兰（Magnolia denudata Desr）果实中分离到两个新的酚类衍生物，magnnodatins A和B（1和2）。，以及两种已知的化合物，白杨苷(3)和莱托维吡喹诺(4)。通过NMR、HR-ESI-MS和IR数据综合分析确定了1和2的结构。值得注意的是，化合物1具有3,7-二甲基-2,6-二烯基链基序。此外，化合物1和2在体外对皮质酮诱导的PC12细胞损伤的神经保护作用进行了评估。化合物1和2在浓度为20 μmol/L时表现出较弱的神经保护活性，1和2的PC12细胞存活率分别为62.39 %和61.79 %，而模型组为60.09 ± 0.04 %。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.