Two new alkamides and a new polyacetylene glucoside from Achillea alpina L.

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-05-14 DOI:10.1016/j.phytol.2025.102968

Ang Li , Xiu-Wei Li , Huan Guo, Qiang Guo, Xia Wu, Xiao-Qing Chen

引用次数: 0

Abstract

In this study, nine compounds were isolated and identified from the Achillea alpina L. Among them, compounds 1 and 2 were new alkamides, named achilleamide E and achilleamide F, compound 3 was a polyacetylene glycoside, named achillneoside A, and compounds 4-9 were known as polyacetylene alkamides. In addition, compounds 1-3, 8 and 9 exhibited good neuroprotective activities against 6-OHDA-induced cell death on human neuroblastoma SH-SY5Y cells at 20 μM.

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从山茱萸中分离出两个新的烷酰胺和一个新的聚乙炔糖苷。

本研究从阿喀琉木中分离鉴定了9个化合物，其中化合物1和2为新生物酰胺，命名为阿喀琉木酰胺E和阿喀琉木酰胺F，化合物3为聚乙炔糖苷，命名为阿喀琉木糖苷a，化合物4-9为聚乙炔酰胺。此外，化合物1 ~ 3、8和9在20 μM下对6- ohda诱导的人神经母细胞瘤SH-SY5Y细胞死亡具有良好的神经保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.