Isolation of macrocarpene-type sesquiterpenes from stigma maydis (Zea mays)

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-05-14 DOI:10.1016/j.phytol.2025.102977

Dan Wang , Ming Zhao , Xiaoxue Li , Shujun Zhang , Liqiu Sun , Jinlan Wang , Zhichun Shi , Jun Li , Yingnan Zhao

引用次数: 0

Abstract

Two new sesquiterpenes, zeaol C (1) and zeaone A (2), along with four known related analogues, were isolated from the styles and stigmas of Zea mays. The structures and absolute configurations of compounds 1 and 2 were elucidated through extensive spectroscopic techniques, including 1D- and 2D-NMR, HR-ESI-MS, and ECD. Compounds 1 and 2 exhibited weak cytotoxic activities against the SK-OV-3 cancer cell line, while compounds 1−6 enhanced glucose consumption in HepG2 cells.

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从玉米柱头中分离巨木型倍半萜

从玉米花柱和柱头中分离到了两个新的倍半萜类化合物zeaone C(1)和zeaone A(2)，以及四个已知的相关类似物。化合物1和2的结构和绝对构型通过广泛的光谱技术，包括1D和2D-NMR， HR-ESI-MS和ECD进行了阐明。化合物1和2对SK-OV-3癌细胞表现出较弱的细胞毒活性，而化合物1 ~ 6对HepG2细胞的葡萄糖消耗有促进作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.