New thiohydantoin derivatives from the roots of Lepidium meyenii

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-04-16 DOI:10.1016/j.phytol.2025.102964

Wen-Xin Liu , Jun Li , Cheng-Juan Liao , Fu-Wen Yang , Hui-Chun Geng , Min Zhou

引用次数: 0

Abstract

Three new thiohydantoin derivatives, namely, (4R,6R)-6-hydroxyl macathiohydantoin C (1), (4 R,6S)-6-hydroxyl macathiohydantoin C (2), and (4S,6S)-6-hydroxyl macathiohydantoin A (3), were isolated from the roots of Lepidium meyenii. The structures of these compounds were elucidated by extensive spectroscopic analyses. The absolute configuration of compound 1 was elucidated by electronic circular dichroism and extensive nuclear magnetic resonance chemical shift calculations, followed by DP4 + probability.

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从枸杞根中提取新的硫代乙托因衍生物

从毛蕊草（Lepidium memeenii）的根中分离得到3个新的硫代海因衍生物，分别为(4R,6R)-6-羟基海因C(1)、（4 R,6S）-6-羟基海因C(2)和(4S,6S)-6-羟基海因A(3)。这些化合物的结构通过广泛的光谱分析得以阐明。化合物1的绝对构型是通过电子圆二色性和广泛的核磁共振化学位移计算来阐明的，其次是DP4 + 概率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.