Isolation and structural elucidation of two novel lignans from the flowers of Gardenia jasminoides with potent α-glucosidase inhibitory activity

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-04-14 DOI:10.1016/j.phytol.2025.102959

Qingsen Shao , Huiyu Li , Mingfeng Li , Wei Yi , Qiugui Zhou , Lijuan Zheng , Meng Wang , Hong-mei Hu , Chao Wen , Yun Tang , Wei Li

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Abstract

This research presents the isolation and structural elucidation of two novel lignans, designated as Jasminoside U (1) and Jasminoside W (2), from the flowers of Gardenia jasminoides. The structures of these compounds were determined using a comprehensive analytical approach that included NMR spectroscopy, HR-ESI-MS, and detailed analysis of ROE correlations and coupling constants. Additionally, the α-glucosidase inhibitory activities of compounds 1 and 2 were evaluated using a standard enzyme assay protocol. The assay results demonstrated that both Jasminoside U (1) and Jasminoside W (2) possess significant inhibitory effects on α-glucosidase, with IC₅₀ values determined to be 266 and 323 μmol/L, respectively, indicating their potential as therapeutic agents for the treatment of diabetes and related metabolic disorders.

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从具有强效α-葡萄糖苷酶抑制活性的栀子花中分离并阐明两种新型木脂素的结构

本研究从栀子花中分离并鉴定了两种新型木脂素，分别为Jasminoside U(1)和Jasminoside W(2)。这些化合物的结构是通过综合分析方法确定的，包括核磁共振波谱，HR-ESI-MS，以及详细分析ROE相关性和耦合常数。此外，采用标准酶测定方案评估化合物1和2的α-葡萄糖苷酶抑制活性。结果表明，栀子苷U(1)和W(2)对α-葡萄糖苷酶均有明显的抑制作用，IC50分别为266 μmol/L和323 μmol/L，具有治疗糖尿病及相关代谢紊乱的潜力。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.