Three new sesquiterpenes with cytotoxic activity from Croton tiglium

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-04-07 DOI:10.1016/j.phytol.2025.102957

Wen-Ying Zhou , Xiao-Xiao Zheng , Yang-Mei Ou , Yang-Lin Ou , Hong-Yu Jang , Yu-Xin Peng , Yi-Yi Wang , Bi-Qing Zhao , Li Li

引用次数: 0

Abstract

Sesquiterpenes are a class of natural products known for their diverse structures and biological activities. In this study, three new sesquiterpenes, crotiglimins A (1), B (2) and C (3) were isolated from the leaves of Croton tiglium collected in Yibin County of Sichuan Province, People’s Republic of China. The structures of all isolated compounds were determined on the basis of extensive spectroscopic analyses, as well as by comparison with literature reports. Compounds 1–3 were examined for their cytotoxic activities against the HepG2 cells, and IC₅₀ values of 1, 2, and 3 are 20.67, 10.13, and 9.65 μM, respectively. Therefore, compounds 1–3 have the value of further research and may be serve as potential anti-liver cancer agent in the future.

查看原文本刊更多论文

三种具有细胞毒活性的倍半萜化合物

倍半萜是一类天然产物，以其多样的结构和生物活性而闻名。本研究从中国四川省宜宾县的Croton tiglium叶片中分离到了3个新的倍半萜，crotiglium A(1)、B(2)和C(3)。所有分离化合物的结构都是通过广泛的光谱分析以及与文献报道的比较来确定的。测定化合物1 ~ 3对HepG2细胞的细胞毒活性，1、2、3的IC50值分别为20.67、10.13、9.65 μM。因此，化合物1 ~ 3具有进一步研究的价值，未来可能作为潜在的抗肝癌药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.