杉木果实中的羰基化合物和苷类化合物作为潜在的肾保护剂

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-04-17 DOI:10.1016/j.phytol.2025.102965

Xiao-Ning Liu , Yue-Tong Zhu , Bo-Tao Lu , Yong-Xian Cheng , Yan-Zhi Wang

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引用次数: 0

摘要

木叶高寒果实的植物化学研究。分离和鉴定了17种结构不同的化合物，包括一种未描述的羰基化合物(1)和两种新的糖苷（6和10）以及14种已知化合物。通过光谱学和计算方法结合酸水解方法确定了它们的结构。9个化合物（1、2、6、8、10、11、14、15和17）对TGF-β1诱导的肾近端小管细胞的肾纤维化有抑制作用，其中化合物2、6和10存在剂量效应关系。化合物10的抗纤维化机制与抑制Smad2/3的磷酸化有关。

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Carbonyl compounds and glycosides from the fruits of Alpinia oxyphylla as potential renoprotective agents

The phytochemical investigation of the fruits of Alpinia oxyphylla Miq. led to the isolation and identification of seventeen structurally diverse compounds, including one undescribed carbonyl compound (1) and two new glycosides (6 and 10) together with fourteen known compounds. Their structures were assigned by spectroscopic and computational methods combined with acid hydrolysis. Nine compounds (1, 2, 6, 8, 10, 11, 14, 15 and 17) displayed inhibitory activities to renal fibrosis in TGF-β1 induced kidney proximal tubular cells, and a dose-effect relationship was observed in compounds 2, 6 and 10. The antifibrotic mechanism of compound 10 was related to the inhibition of phosphorylation of Smad2/3.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.