Two undescribed phytoecdysteroids from Dianthus superbus L.

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-07-29 DOI:10.1016/j.phytol.2025.103015

Yi-Han Liu , Qing Zhang , Da-Zhi Zhang , Xu-Yang Fu , Wu-Yang Liu , Jun-Mian Tian

引用次数: 0

Abstract

A phytochemical investigation of Dianthus superbus L. led to the isolation of two previously undescribed phytoecdysteroids (1–2) and six known analogues (3–8). The structures of new compounds were elucidated through comprehensive spectroscopic data analysis, including NMR and HR-ESI-MS data, and by ECD data comparison. All isolated compounds were evaluated for anti-neuroinflammatory effects in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells and antibacterial activities. Compounds 3, 4, and 8 showed potent anti-neuroinflammatory activities. However, none of the compounds exhibited significant antibacterial activities (MIC > 100 μM).

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石竹中两种未描述的植物表皮甾体。

一项对石竹的植物化学研究分离出了两种以前未被描述的植物甾体（1-2）和六种已知的类似物（3-8）。通过NMR、HR-ESI-MS等综合波谱数据分析和ECD数据比对，对新化合物的结构进行了鉴定。所有分离的化合物在脂多糖（LPS）刺激的BV-2小胶质细胞中进行抗神经炎作用和抗菌活性评估。化合物3、4、8表现出较强的抗神经炎活性。然而，没有一种化合物显示出显著的抗菌活性(MIC >； 100μM)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.