{"title":"Two new megastigmane glycosides from the leaves of Cnidoscolus aconitifolius cultivated in Thailand","authors":"Jedsada Maliwong , Ingchanik Dithabumroong , Nitirat Chimnoi , Somsak Ruchirawat , Tripetch Kanchanapoom","doi":"10.1016/j.phytol.2025.103022","DOIUrl":null,"url":null,"abstract":"<div><div>Two new megastigmane glycosides, chayaionosides A (<strong>1</strong>) and B (<strong>2</strong>), together with breyniaionoside E (<strong>3</strong>), euodionoside F (<strong>4</strong>), (6<em>S</em>,9<em>S</em>)-roseoside (<strong>5</strong>), benzyl <em>O</em>-<em>β</em>-D-apiofuranosyl-(1→6)-<em>β</em>-D-glucopyranoside (<strong>6</strong>), benzyl <em>O</em>-<em>α</em>-L-rhamnopyranosyl-(1→6)-<em>β</em>-D-glucopyranoside (<strong>7</strong>), canthoside A (<strong>8</strong>), syringin (<strong>9</strong>), coniferin (<strong>10</strong>), scopolin (<strong>11</strong>), (+)-lariciresinol-4-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>12</strong>), dehydrodiconiferyl 4-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>13</strong>), kaempferol 3-<em>O</em>-<em>α</em>-L-rhamnopyranosyl-(1→2)-<em>β</em>-D-galactopyranoside (<strong>14</strong>), kaempferol 3-<em>O</em>-neohesperidoside (<strong>15</strong>), kaempferol 3-<em>O</em>-<em>α</em>-L-rhamnopyranosyl-(1→6)-<em>β</em>-D-galactopyranoside (<strong>16</strong>), kaempferol 3-<em>O</em>-rutinoside (<strong>17</strong>), drabanemoroside (<strong>18</strong>), kaempferol 3-<em>O</em>-(2″,6″-di-<em>O</em>-<em>α</em>-L-rhamnopyranosyl)-<em>β</em>-D-galactopyranoside (<strong>19</strong>), and kaempferol 3-<em>O</em>-(2″,6″-di-<em>O</em>-<em>α</em>-L-rhamnopyranosyl)-<em>β</em>-D-glucoside (<strong>20</strong>) were isolated from the leaves of <em>Cnidoscolus aconitifolius</em> cultivated in Thailand. The structural elucidations were based on physical data and spectroscopic evidence, including 1D and 2D NMR analyses.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"69 ","pages":"Article 103022"},"PeriodicalIF":1.4000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390025011127","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Two new megastigmane glycosides, chayaionosides A (1) and B (2), together with breyniaionoside E (3), euodionoside F (4), (6S,9S)-roseoside (5), benzyl O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (6), benzyl O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (7), canthoside A (8), syringin (9), coniferin (10), scopolin (11), (+)-lariciresinol-4-O-β-D-glucopyranoside (12), dehydrodiconiferyl 4-O-β-D-glucopyranoside (13), kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (14), kaempferol 3-O-neohesperidoside (15), kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside (16), kaempferol 3-O-rutinoside (17), drabanemoroside (18), kaempferol 3-O-(2″,6″-di-O-α-L-rhamnopyranosyl)-β-D-galactopyranoside (19), and kaempferol 3-O-(2″,6″-di-O-α-L-rhamnopyranosyl)-β-D-glucoside (20) were isolated from the leaves of Cnidoscolus aconitifolius cultivated in Thailand. The structural elucidations were based on physical data and spectroscopic evidence, including 1D and 2D NMR analyses.
期刊介绍:
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.