Pharmacy Education最新文献_第7页

Activities of ethanol-extract of red ginger (Zingiber officinale var. Rubrum) on Completed Freund's Adjuvant-induced arthritis in mice 红姜(Zingiber officinale var. Rubrum)乙醇提取物对完全性弗氏佐剂诱导小鼠关节炎的活性研究

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.242246

Fifteen Aprila Fajrin, Putri Robiatul Khasanah, Yokta Esa Mikailla, Diana Holidah, Ika Puspita Dewi

{"title":"Activities of ethanol-extract of red ginger (Zingiber officinale var. Rubrum) on Completed Freund's Adjuvant-induced arthritis in mice","authors":"Fifteen Aprila Fajrin, Putri Robiatul Khasanah, Yokta Esa Mikailla, Diana Holidah, Ika Puspita Dewi","doi":"10.46542/pe.2023.234.242246","DOIUrl":"https://doi.org/10.46542/pe.2023.234.242246","url":null,"abstract":"Background: Red ginger has been known to have anti-inflammatory and analgesic potency. Objective: This study aimed to analyse the ethanolic extract of red ginger (EERG) in mice's arthritis model induced by Completed Freund’s Adjuvant (CFA). Method: Red ginger was extracted using ethanol 96%. Arthritis mice (n = 25) were injected with CFA i.p., and sham mice (n = 5) were injected with normal saline. On day seven, mice were divided into six groups: sham, CFA, gabapentin 100 mg/kg BW, and EERG (dose 200; 400; 600 mg/kg BW). Treatments were administered orally once a day for seven days. Latency time and plantar thickness were measured on days zero, one, three, five, seven, eight, ten, twelve, and fourteen. On day 15, the mice were sacrificed, and the blood and spinal cords were collected. The haematology profiles were determined. Result: The EERG significantly prolonged the latency time towards thermal stimulus and decreased plantar thickness in arthritis mice, the same as gabapentin which served as the control. The EERG also reduced the number of leukocytes, lymphocytes, and neutrophils, and improved the morphology of the spinal cord's dorsal horn of arthritis mice. Conclusion: The EERG of 400 mg/kg BW significantly affects arthritis-induced hyperalgesia.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"249 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136353366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An assessment of platelet response to ticagrelor in post-percutaneous coronary intervention patients using light transmission platelet aggregometry (LTA) 应用光透射血小板聚集法(LTA)评价经皮冠状动脉介入术后患者对替格瑞洛的血小板反应

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.180184

Bambang Subakti Zulkarnain, Karima Samlan, Junaidi Khotib, Muhammad Yogiarto, Muhammad Aminuddin, Umi Fatmawati

引用次数: 0

Knowledge, attitudes, and practices for using and disposing of antibiotics: A cross-sectional study at an Indonesian community 使用和处置抗生素的知识、态度和做法:印度尼西亚一个社区的横断面研究

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.110115

Elida Zairina, Athaya B Azzahrya, Gesnita Nugraheni, Arie Sulistyarini

引用次数: 0

Polypharmacy as the risk factor of potentially inappropriate medication and medication regimen complexity index in hospitalised elderly patients 多药作为住院老年患者潜在不适当用药的危险因素及用药方案复杂性指数

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.325330

Din Amalia Widyaningrum, Mahardian Rahmadi, Khusnul Fitri Hamidah, Leopold N. Aminde, Cahyo Wibisono Nugroho, Bambang Subakti Zulkarnain

{"title":"Polypharmacy as the risk factor of potentially inappropriate medication and medication regimen complexity index in hospitalised elderly patients","authors":"Din Amalia Widyaningrum, Mahardian Rahmadi, Khusnul Fitri Hamidah, Leopold N. Aminde, Cahyo Wibisono Nugroho, Bambang Subakti Zulkarnain","doi":"10.46542/pe.2023.234.325330","DOIUrl":"https://doi.org/10.46542/pe.2023.234.325330","url":null,"abstract":"Background: The majority of elderly patients often receive complex therapy or polypharmacy due to physiological changes, which can develop into an adverse drug event. Objective: To analyse the risk factors of potentially Inappropriate Medications (PIMs) and medication regimen complexity in elderly patients. Method: This is an observational study with cohort retrospective methods, carried out at the In-patient Unit of Airlangga University Hospital, Surabaya. The inclusion criteria were patients aged ≥ 60 years old who were admitted between January to December 2019 for at least three days and received at least one drug. PIMs were monitored with Beers Criteria 2019 and therapy complexity was measured with Medication Regimen Complexity Index (MRCI) during admission, hospitalisation, and discharge. Result: Among 357 patients, 60.8% received at least one PIM on admission. Furthermore, the MRCI score decreased from 22.7 at the time of admission to 11.5 on discharge. Patients who received polypharmacy were two to three times more at risk of having PIMs (p < 0.001). The number of medications correlated with the MRCI scores (Correlation Coefficient= 0.815–0.877, p < 0.001). Conclusion: Polypharmacy is one of the risk factors of PIMs and medication regimen complexity, elderly patients who receive polypharmacy must be closely monitored to prevent adverse drug reactions.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbomer and ethyl cellulose optimisation in the preparation of mucoadhesive microspheres ciprofloxacin hydrochloride 卡波姆和乙基纤维素在制备盐酸环丙沙星黏附微球中的优化

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.2731

Lusia Oktora Ruma Kumala Sari, Lintang Qonita Fardliana, Dwi Nurahmanto, Eka Deddy Irawan

引用次数: 0

Role of work engagement in behavioural intention to use electronic medical records: A cross-sectional study 工作投入在使用电子病历行为意向中的作用:一项横断面研究

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.9298

Eka Wilda Faida, Titin Wahyuni, Diah Wijayanti Sutha, None Muhadi, Alinea Dwi Elisanti

{"title":"Role of work engagement in behavioural intention to use electronic medical records: A cross-sectional study","authors":"Eka Wilda Faida, Titin Wahyuni, Diah Wijayanti Sutha, None Muhadi, Alinea Dwi Elisanti","doi":"10.46542/pe.2023.234.9298","DOIUrl":"https://doi.org/10.46542/pe.2023.234.9298","url":null,"abstract":"Background: In this era of a rapidly advancing technological landscape, the Electronic Medical Record (EMR) has increased the awareness of health services on the importance of the roles of workers in utilising information technology. Objective: To analyse the factors influencing behavioural intention in the EMR system by adding the work engagement factor as an exogenous variable based on the Unified Theory of Acceptance and Use of Technology (UTAUT) theoretical framework. Method: This cross-sectional study enrolled a sample of 195 participants from a population of 390 medical students. Data analysis used structural models with multivariate structural equation modelling. Results: Facilitating conditions (t-statistic=3.154; p=0.0001), performance expectancy (t-statistic=2.983, p=0.003), and work engagement (t-statistic=4.998, p=0.0001) had an effect on the behavioural intention, while effort expectancy (t-statistic=0.779, p=0.436) and social influence (t-statistic=0.266, p=0.790) did not affect the behavioural intention. Conclusion: Performance expectancy, facilitating conditions, and work engagement could affect behavioural intention by R²=74%. Work engagement had the strongest effect among other exogenous variables.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with disrespect and abuse of women during labour and birth in health facilities in low-and middle-income countries: A systematic review and meta-analysis 低收入和中等收入国家卫生机构中妇女在分娩和分娩期间受到不尊重和虐待的相关因素:系统回顾和荟萃分析

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.5359

Angelina da Costa Fernandes, Stefanus Supriyanto, Chatarina Umbul Wahjuni, Hari Basuki Notobroto, Kayli Wild

{"title":"Factors associated with disrespect and abuse of women during labour and birth in health facilities in low-and middle-income countries: A systematic review and meta-analysis","authors":"Angelina da Costa Fernandes, Stefanus Supriyanto, Chatarina Umbul Wahjuni, Hari Basuki Notobroto, Kayli Wild","doi":"10.46542/pe.2023.234.5359","DOIUrl":"https://doi.org/10.46542/pe.2023.234.5359","url":null,"abstract":"Background: Disrespect and abuse by health providers during birth is a traumatic experience that jeaporadises women’s mental and physical health, lowers satisfaction with care and results in lower willingness to use health services. Objective: We aimed to assess the factors associated with disrespect and abuse of women during birth in low- and middle-income countries, in order to understand which women are more at risk of abuse, and to inform strategies for health service improvement. Method: The systematic review and meta-analysis followed PRISMA guidelines. Three databases were searched for articles published between 2018-2022. Of the 57 articles retrieved, nine met the inclusion criteria. Result: Women were more likely to experience disrespect and abuse if they had no formal education (aOR 5.92), gave birth in a public facility (aOR 4.34), had birth complications (aOR= 3.72), an instrumental vaginal birth (aOR 2.35) or lived in a rural area (aOR 2.03). Conclusion: Women who are already disadvantaged in terms of lack of education, rural residence and expieriencing birth complications are also the ones more likely to be mistreated by health providers during birth. The widespread discrimination and compounding intersections of inequality faced by women within birthing services deserves urgent attention. Future research and action should seek to understand the models of maternity care that underpin respectful client-practioner engagment, and the health system requirements to support these models.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The activity of bioactive compounds from bidara upas (Merremia mammosa (Lour) Hall. f.) as an inhibitor of SARS-CoV2 entry stage: In silico study 毛毛Merremia mammosa (Lour) Hall中生物活性化合物的活性。f.)作为SARS-CoV2进入阶段的抑制剂:计算机研究

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.340343

Neny Purwitasari, Mangestuti Agil, Siswandono Siswodihardjo, Saipul Maulana, Muhammad Sulaiman Zubair

{"title":"The activity of bioactive compounds from bidara upas (Merremia mammosa (Lour) Hall. f.) as an inhibitor of SARS-CoV2 entry stage: In silico study","authors":"Neny Purwitasari, Mangestuti Agil, Siswandono Siswodihardjo, Saipul Maulana, Muhammad Sulaiman Zubair","doi":"10.46542/pe.2023.234.340343","DOIUrl":"https://doi.org/10.46542/pe.2023.234.340343","url":null,"abstract":"Background: Covid 19 is a global pandemic caused by SARS-CoV2, a novel coronavirus. This virus enters target organ epithelial cells by utilising two host proteins; Transmembrane Serine Protease 2 (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2). The inhibition of TMPRSS2 has shown to be a promising means to prevent viral infection. Molecular docking, and Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis will determine the activity of Merremia mammosa (Lour) Hall.f. secondary metabolites against the TMPRSS2 of SARS-CoV2. Objective: This study aimed to investigate the in silico activity of Merremia mammosa (Lour) Hall.f. active compounds against TMPRSS2 of SARS-CoV2. Method: Molecular docking was performed on 206 compounds obtained through metabolite profiling from a previous study on the SARS-CoV TMPRSS-2 protein (PDB id.7MEQ) using the Maestro Schrodinger software. Result: The results indicated there were 6 compounds (three of which were flavonoids: cynarine, phellodensin F, and gemixanthone A) with docking scores lower than standard drugs (nafamostat as a native ligand). ADMET analysis revealed that among 6 compounds, cynarine has the highest drug-likeness and the greatest inhibitory potential against TMPRSS2. Conclusion: Cynarine was found to be active and promising to be developed as an inhibitor of the SARS-CoV2 entry step.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and perception of pharmacovigilance among pharmacy students and pharmacy professional students 药学专业学生和药学专业学生对药物警戒的认识和认知

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.4347

Fivy Kurniawati, Arief Rahman Hakim, Pradipta Dwinisa Novitasari, Pratiwi Dian Kumalasari, Lulu Wana Hamidah

{"title":"Knowledge and perception of pharmacovigilance among pharmacy students and pharmacy professional students","authors":"Fivy Kurniawati, Arief Rahman Hakim, Pradipta Dwinisa Novitasari, Pratiwi Dian Kumalasari, Lulu Wana Hamidah","doi":"10.46542/pe.2023.234.4347","DOIUrl":"https://doi.org/10.46542/pe.2023.234.4347","url":null,"abstract":"Background: Adverse Drug Reaction (ADR) contributes to high morbidity and mortality rate worldwide. This can be minimised through pharmacovigilance. It is important to evaluate the level of knowledge and perception of pharmacovigilance among pharmacy students. Objective: To describe the level of knowledge and perceptions of final-year pharmacy students and students of pharmacy professional programs in Yogyakarta regarding pharmacovigilance. Method: A cross-sectional study involved 437 pharmacy students from five different universities in Yogyakarta, who were selected using a convenience sampling technique. Data were analysed to describe the characteristics of the respondents and their level of knowledge and perceptions about pharmacovigilance. Result: The majority of final year students in pharmacy and pharmacy professional programs had acquired a high level of knowledge about pharmacovigilance with a percentage of 54.0%. They also shared a positive perception of the implementation of pharmacovigilance with a percentage of 55.6%. Conclusion: Final-year pharmacy students and students of the pharmacy professional program have good knowledge and perceptions towards pharmacovigilance.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medication complexity and COVID-19 pandemic impact on the cost burden in non-COVID elderly patients at the emergency department 用药复杂性和COVID-19大流行对急诊非covid老年患者费用负担的影响

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.264268

Khusnul Fitri Hamidah, Mahardian Rahmadi, Erfan Abdissalam, Indah Septiani, Febriansyah Nur Utomo, Wieka Rafelina Batubara

{"title":"Medication complexity and COVID-19 pandemic impact on the cost burden in non-COVID elderly patients at the emergency department","authors":"Khusnul Fitri Hamidah, Mahardian Rahmadi, Erfan Abdissalam, Indah Septiani, Febriansyah Nur Utomo, Wieka Rafelina Batubara","doi":"10.46542/pe.2023.234.264268","DOIUrl":"https://doi.org/10.46542/pe.2023.234.264268","url":null,"abstract":"Background: The global increase in the elderly population and the incidence of emergency conditions due to physiological changes pose cost challenges for emergency services. COVID-19 potentially affects the financial burden of medication in elderly patients. Objective: To analyse the impact of medication complexity on the cost burden in elderly patients admitted to the Emergency Department (ED) before and during the COVID-19 pandemic. Method: A retrospective observational study was conducted among elderly patients (aged > 60 years) who visited ED but were not hospitalised between January to April 2020. The medication complexity was measured using the Medication Regimen Complexity Index (MRCI) while the cost was collected from the hospital information system. Result: A total of 321 ED visits were included in this study. The results showed that the mean of the total medication was 3.89 ± 1.70, while the mean score of the MRCI was 15.20 ± 6.54. The mean medication cost required was IDR 56,342 for each ED visit. Conclusion: This study provided an overview and input to control medication costs for elderly patients in the emergency setting. Interested parties can design policies that are beneficial in economics and therapeutic outcomes.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0