Pharmacy Education最新文献_第10页

Adherence of HIV/AIDS patients to clinical outcome in Semarang City 三宝垄市艾滋病毒/艾滋病患者坚持临床治疗的情况

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.1722

Farroh Bintang Sabiti, Thendi Abdul Arief, Nada Aini Sofa, Rendi Adi Saputra, Iga Citra Aryani, Nindita Sari Nastiti, Arvin Faizatun

{"title":"Adherence of HIV/AIDS patients to clinical outcome in Semarang City","authors":"Farroh Bintang Sabiti, Thendi Abdul Arief, Nada Aini Sofa, Rendi Adi Saputra, Iga Citra Aryani, Nindita Sari Nastiti, Arvin Faizatun","doi":"10.46542/pe.2024.242.1722","DOIUrl":"https://doi.org/10.46542/pe.2024.242.1722","url":null,"abstract":"Background: The success of HIV therapy can be measured by clinical, immunological, and virological monitoring. Meanwhile, low adherence to antiretroviral therapy (ART) contributes significantly to the disease progression and emergence of drug-resistant HIV.\u0000Objective: This study aimed to determine the correlation between the adherence of HIV/AIDS patients to clinical outcomes in Semarang.\u0000Method: This was an observational and cross-sectional approach. The instrument used the Simple Medication Adherence Questionnaire (SMAQ), which was validated and distributed to 50 respondents. The data were analyzed using chi-square (p < 0.05), and the results showed a statistically significant relationship.\u0000Result: Respondents were male (96%), aged 26-45 years (76%), high school graduates (24%), working (88%), single (86%), without comorbidity (86%), length of treatment more than 12 months (80%), and general treatment (50%). A total of 31 respondents (62%) adhered to treatment with the combination regimen of Tenofovir/Lamivudine/Efavirenz (20%). There was a significant relationship (p = 0.006) between the length of treatment and patient adherence. The adherence results were not significantly related (p > 0.05) to virological outcomes.\u0000Conclusion: There is no significant relationship between the adherence of HIV/AIDS patients and clinical outcomes.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140763048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the satisfaction of hybrid learning among undergraduate health science students 评估健康科学本科生对混合学习的满意度

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.109114

Ganesh Sritheran Paneerselvam, Li Yan Lim, S. Beshir, M. Farrukh, H. Zulkifly, Long Chiau Ming, Chrismawan Ardianto, Andi Hermansyah, Wen-Han Chooi

{"title":"Evaluating the satisfaction of hybrid learning among undergraduate health science students","authors":"Ganesh Sritheran Paneerselvam, Li Yan Lim, S. Beshir, M. Farrukh, H. Zulkifly, Long Chiau Ming, Chrismawan Ardianto, Andi Hermansyah, Wen-Han Chooi","doi":"10.46542/pe.2024.242.109114","DOIUrl":"https://doi.org/10.46542/pe.2024.242.109114","url":null,"abstract":"Background: Hybrid learning combines traditional face-to-face instruction with online or digital learning components and has gained significant popularity in recent years.\u0000Objective: This study aimed to assess the satisfaction of hybrid learning among undergraduate health science students and identify the factors associated with the satisfaction level, providing further insights into improvements in hybrid learning adoption to make effective use of the learning approach.\u0000Methods: An online survey was distributed to the undergraduate health science students at Taylor’s University in Malaysia. Students’ satisfaction and the associated factors were assessed using a 5-point Likert scale using Pearson Chi-square and logistic regression analysis test where p-value < 0.05 is considered statistically significant.\u0000Results: More than half of the students (66.7%) in this study expressed positive satisfaction towards hybrid learning. Internet connection was determined as one of the students' satisfaction-related factors (p=xx). Multivariate binary logistics regression demonstrated that course structure, perceived ease of use, student-instructor interaction and students’ attitude toward hybrid learning had a statistically significant impact on students’ satisfaction with the hybrid learning approach.\u0000Conclusion: Students' satisfaction is valuable input for institutions and instructors to enhance the quality of hybrid learning in the future to optimise students' learning experience.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140777216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute toxicity test of tablets containing α-mangosteen, piperine, curcumin, methyl cinnamate and vitamin C in female wistar rats 含 α-山竹果、胡椒碱、姜黄素、肉桂酸甲酯和维生素 C 的药片对雌性腰果大鼠的急性毒性试验

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.158162

N. K. Sari, Sriwidodo, N. I. Fauzi, Ajeng Diantini, Diki Prayugo W

{"title":"Acute toxicity test of tablets containing α-mangosteen, piperine, curcumin, methyl cinnamate and vitamin C in female wistar rats","authors":"N. K. Sari, Sriwidodo, N. I. Fauzi, Ajeng Diantini, Diki Prayugo W","doi":"10.46542/pe.2024.242.158162","DOIUrl":"https://doi.org/10.46542/pe.2024.242.158162","url":null,"abstract":"Background: Traditional medicine has long been used and contributed to health services. Supplement tablets containing isolated -mangosteen, piperine, curcumin, methyl cinnamate, and vitamin C are potential antivirals.\u0000Objective: This study determined the LD50 of these supplement tablets as well as their influence on the liver, stomach, kidneys, spleen, and lungs after the acute oral administration of 5000 mg/kg to female Wistar rats, according to the OECD 425 Up and Down Procedure.\u0000Method: The test animals were observed for signs of toxicity for 14 days, the first 48 hours, with observation especially in the first 4 hours every 30 minutes.\u0000Results: They showed no signs of toxicity and non-irritating death and had an LD50 toxicity value >5000 mg/kg body weight. Therefore, the tablets were deemed practically non-toxic. Histopathology revealed no changes in the liver, spleen, and lungs, however desquamation and ulceration of the stomach and glomerular degeneration and atrophy in the kidney were light and reversible.\u0000Conclusion: The tablets containing isolated α-mangosteen, piperine, curcumin, methyl cinnamate and vitamin C were practically non-toxic.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140762005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of drug-related problems in ischemic stroke in-patients in one Indonesian district hospital 印度尼西亚一家地区医院缺血性中风住院病人的药物相关问题分析

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.134139

R. Andrajati, L. A. Kusumawardani, Isti Nurul Afifah, H. W. Risni

{"title":"Analysis of drug-related problems in ischemic stroke in-patients in one Indonesian district hospital","authors":"R. Andrajati, L. A. Kusumawardani, Isti Nurul Afifah, H. W. Risni","doi":"10.46542/pe.2024.242.134139","DOIUrl":"https://doi.org/10.46542/pe.2024.242.134139","url":null,"abstract":"Background: Ischemic stroke is one of the leading causes of death in Indonesia. Appropriate management, including the identification of drug-related problems (DRPs), is needed to prevent disability and death. \u0000Objective: This study aimed to analyse DRPs as defined by the Pharmaceutical Care Network Europe (PCNE). \u0000Method: This was a cross-sectional research using the medical records of in-patients with ischemic stroke aged >18 years. \u0000Result: Out of the 115 patients examined, 51.3% were male, and the mean age was 57.85 + 10.539 years. Exactly 204 cases of DRPs and 175 causes appeared in 101 patients. A total of 58 patients experienced one-to-two problems, and 43 patients experienced more than two problems. The problems domain consists of therapeutic effectiveness (P1, 133(65.2%)), adverse effects (P2, 67(32, 84%)), and medical expenses (P3, 4(1, 96%)). The DRPs mostly involved antihypertension and antiplatelet. The most common cause was a new indication for treatment (C1.9, 51(29.14%)) and drug interactions (C8.1, 48(27.43%)). Multivariate analysis of patient characteristics showed that patients taking more than eight medications were more likely to experience more than two DRPs than those on one-to-four medications (OR 5.593; 95%, CI 1.015-30.812). \u0000Conclusion: Most patients experienced one-to-two DRPs with the highest being a potentially suboptimal treatment. Clinical pharmacists are expected to monitor therapy, especially in polypharmacy patients.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of DAGUSIBU education on the level of community knowledge in obtaining, using, storing, and disposing of drugs in West Java, Indonesia DAGUSIBU 教育对印度尼西亚西爪哇获取、使用、储存和处置毒品的社区知识水平的影响

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.9398

Lusy Noviani, Putriana Rachmawati, Catleya Febrinella

{"title":"The effects of DAGUSIBU education on the level of community knowledge in obtaining, using, storing, and disposing of drugs in West Java, Indonesia","authors":"Lusy Noviani, Putriana Rachmawati, Catleya Febrinella","doi":"10.46542/pe.2024.242.9398","DOIUrl":"https://doi.org/10.46542/pe.2024.242.9398","url":null,"abstract":"Background: In 2022, health products were the best-selling category in the marketplace. Over-the-counter medicines are the only types of drugs that can be sold online. However, in reality, many prescription drugs are being traded online. A lack of public awareness about purchasing drugs online can have negative consequences, such as buying counterfeit and hazardous medicines and drugs without distribution permits. A community health initiative for public education, DAGUSIBU, is being powered by pharmacists and must be encouraged. \u0000Objective: To educate the public about the DAGUSIBU and measure the changes in public knowledge after the education process. \u0000Methods: A quasi-experimental one-group pre-test and post-test method was used to design the study. Univariate and bivariate Wilcoxon tests were used to analyse the data. \u0000Results: The level of public knowledge before education was 49.41% in the poor category, 36.72% in the good category, and 13.87% in the adequate category. Following education, the respondents’ level of knowledge was classified as good (48.46%), adequate (41.12%) and poor (10.42%). The p-value of the level of knowledge before and after education was < 0.05, according to the Wilcoxon test. \u0000Conclusion: DAGUSIBU education in digital platforms to obtain drugs had a significant impact on public knowledge","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development rat models of nephrotoxic: A pre-clinical test model to discover nephroprotective agents 开发肾毒性大鼠模型：发现肾保护剂的临床前试验模型

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.6370

N. M. Sandhiutami, Y. Desmiaty, Fahleni, Y. Noviani

{"title":"Development rat models of nephrotoxic: A pre-clinical test model to discover nephroprotective agents","authors":"N. M. Sandhiutami, Y. Desmiaty, Fahleni, Y. Noviani","doi":"10.46542/pe.2024.242.6370","DOIUrl":"https://doi.org/10.46542/pe.2024.242.6370","url":null,"abstract":"Background: The use of drugs, including aminoglycoside drugs and anticancer drugs, is one of the things that can cause toxicity to the kidneys. Therefore, the development of agents that function as nephroprotectors continues to be researched.\u0000Objective: This study aims to obtain a nephrotoxic experimental animal model for testing nephroprotective agents.\u0000Method: The treatment was normal group, groups given a single dose of Cisplatin 7 mg/kgBW i.p (Cis), Doxorubicin single dose 25 mg/kgBW i.p (Dox-25), Doxorubicin repeated dose 4 mg/kgBW i.p twice/week for two weeks (Dox-4 repeated dose), and Gentamicin single dose 112 mg/kgBW i.p (Gen). The nephrotoxic effect was assessed by the parameters of kidney weight ratio, Ureum, Creatinine and Albumin levels in rat serum.\u0000Result: The nephrotoxic effect was indicated by an increase in the renal weight ratio of the Cisplatin; Dox-25, Dox-4 repeated, and Gen groups than normal, respectively. There was an increase in serum BUN levels, an increase in serum creatinine, and a decrease in serum albumin levels compared to the normal group.\u0000Conclusion: Cisplatin, Doxorubicin and Gentamicin have nephrotoxic effects. The administration of a single dose of cisplatin at 7 mg/kg BW gave the strongest nephrotoxic effect, making it appropriate as a model of acute nephrotoxicity in rats.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of cognitive decline on the medication adherence in patients with type II diabetes mellitus 认知能力下降对 II 型糖尿病患者坚持服药的影响

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.163171

Indana Ayu Soraya, Rani Sauriasari, Pukovisa Prawirohardjo, H. W. Risni

{"title":"The effect of cognitive decline on the medication adherence in patients with type II diabetes mellitus","authors":"Indana Ayu Soraya, Rani Sauriasari, Pukovisa Prawirohardjo, H. W. Risni","doi":"10.46542/pe.2024.242.163171","DOIUrl":"https://doi.org/10.46542/pe.2024.242.163171","url":null,"abstract":"Background: Type II Diabetes Mellitus (T2DM) is a risk factor for decreased cognitive function that is rarely recognised by patients, apart from age and other factors.\u0000Objective: This study aims to assess the effect of decreased cognitive function on medication adherence in T2DM patients.\u0000Method: This study used a cross-sectional design conducted at the Pasar Minggu Community Health Center, Jakarta, Indonesia. Cognitive function was assessed using the validated Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina) questionnaire.\u0000Results: One hundred twenty-seven T2DM patients (75.6% female) with a mean age of 58.69 years were recruited. The proportion of T2DM patients with decreased cognitive function was quite high, namely 61%. The proportion of non-adherent patients in the group with decreased cognitive function (70.6%) was greater than in the normal group (29.4%). Decreased cognitive function significantly affected non-adherence in taking medication with aOR 3.744 (95% CI 1.485–9.442), p = 0.005, after controlling for age, education level, HbA1c value, and comorbid dyslipidemia.\u0000Conclusion: Patients with decreased cognitive function are 3.7 times more likely to be non-compliant with medication, regardless of age, education level, HbA1c value, and dyslipidemia. Special management is needed for T2DM patients with decreased cognitive function, such as caregiver assistance, education by pharmacists, and simpler drug regimes.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140793885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and evaluation of piperine-loaded ultra-small unilamellar carrier 哌啶超小型单拉美米尔载体的制备与评估

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.5257

Anugrah Putra Pharmaheri, Salman Umar, H. Lucida

{"title":"Formulation and evaluation of piperine-loaded ultra-small unilamellar carrier","authors":"Anugrah Putra Pharmaheri, Salman Umar, H. Lucida","doi":"10.46542/pe.2024.242.5257","DOIUrl":"https://doi.org/10.46542/pe.2024.242.5257","url":null,"abstract":"Background: Piperine is an alkaloid that has a stimulatory effect on the proliferation and dentricity of melanocytes. Therefore, it is a potential drug for vitiligo.\u0000Objectives: To formulate an Emulgel containing piperine-loaded Ultra-Small Unilamellar Carrier (USUC) with virgin coconut oil, soy lecithin and tween 80, and to evaluate the physicochemical properties.\u0000Method: Piperine-loaded USUC was formulated using a spontaneous water phase titration method at a stirring speed of 1500 rpm for 15 minutes with a base composition of 2.3% oil phase, 1% surfactant and 2.3% co-surfactant. Emulgel preparations were made by mixing USUC piperine into a 5% carbopol base.\u0000Result: Piperine-loaded USUC was obtained in the form of spherical globules with a Z-average size of 15.0 nm, a zeta potential of -39.5 mV and a polydispersion index of 0.312. The emulgel preparation has a pH of (6.5 ± 0.1), and a viscosity (of 44.800 ± 0.367) cP and is physically stable. Permeation of piperine from USUC emulgel follows zero-order kinetics (y = 0.130x-2.027; R2 = 0.9998) with a flux value of (3.408 ± 1.110) µg/cm2/hour, which is significantly different from permeation of non-USUC piperine gel (0.000 ± 0) µg/cm2/hour)(p <0.05).\u0000Conclusion: Piperine-loaded USUC in emulgel formulation produced nanosized spherical globules, indicating a significantly different amount of permeated piperine compared to conventional piperine gel.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and effectiveness of solid soap preparations from citronella grass (Cymbopogon nardus L.) essential oil extract against Listeria monocytogenes 香茅草（Cymbopogon nardus L.）精油提取物固体肥皂制剂的配制及其对李斯特菌的作用

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.3238

Lukky Jayadi, Sandry Kesuma, Muhammad Hasan Wattiheluw, Elok Widayanti, Nurma Sabila, Hanandayu Widwiastuti, Riska Yudhistia Asworo, Retno Ikayanti

{"title":"Formulation and effectiveness of solid soap preparations from citronella grass (Cymbopogon nardus L.) essential oil extract against Listeria monocytogenes","authors":"Lukky Jayadi, Sandry Kesuma, Muhammad Hasan Wattiheluw, Elok Widayanti, Nurma Sabila, Hanandayu Widwiastuti, Riska Yudhistia Asworo, Retno Ikayanti","doi":"10.46542/pe.2024.242.3238","DOIUrl":"https://doi.org/10.46542/pe.2024.242.3238","url":null,"abstract":"Background: The components of essential oils, such as citronellol, citronellal, and geraniol have been reported to possess the ability to inhibit bacteria. Furthermore, Listeria monocytogenes is a bacteria that often affects humans and its infections can cause meningitis and bacteremia. In pregnant women, Listeria monocytogenes can cause flu-like syndrome with complications of miscarriage, infant death, and meningitis in infants. \u0000Objective: This study evaluated the suitability of solid soap preparations from Citronella grass essential oil, based on its physical properties, such as organoleptic tests, as well as assessments of chemical tests and the effectiveness of the sample produced against bacteria. \u0000Method: The soap-making process was initiated by mixing the fat fraction (stearic acid and coconut oil) with an alkali, namely 30% NaOH. The soap stock was then added to the other ingredients and stirred until it became homogeneous for testing. \u0000Results: The test showed a pH value, water content, total fat, ethanol insoluble material, free fatty acids, chloride content, and unsaponificable fat of 10.8, 14.26, 74.84, 2.4, 0.26, 0.48, and 85.8, respectively. Furthermore, the sample showed a high level of inhibition against Listeria monocytogenes. \u0000Conclusion: Evaluation of citronella essential oil extract soap met the requirements, except for its unsaponifiable fat.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140771316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of a diet rich in carbohydrates, fats, and fructose on insulin resistance development 富含碳水化合物、脂肪和果糖的饮食对胰岛素抵抗发展的影响

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.121126

Agus Sulaeman, E. Susilawati, Marita Kaniawati, Irfan Mustofa, Yulvian Sani

{"title":"Impact of a diet rich in carbohydrates, fats, and fructose on insulin resistance development","authors":"Agus Sulaeman, E. Susilawati, Marita Kaniawati, Irfan Mustofa, Yulvian Sani","doi":"10.46542/pe.2024.242.121126","DOIUrl":"https://doi.org/10.46542/pe.2024.242.121126","url":null,"abstract":"Background: Insulin resistance can be caused by carbohydrates, fats, and fructose. Insulin resistance is defined as a decrease in insulin's ability to stimulate the use of glucose for distribution to other parts of the body or a decrease in organ/cell response (fat tissue, liver, and muscle) to insulin.\u0000Aim: The goal of this study is to see how different diets high in fat, carbohydrates, and fructose affect the incidence of insulin resistance.\u0000Methods: The study was conducted for 60 days and used 24 male white rats (Rattus norvegicus) Wistar strain aged two months with 180-200 grams body weight. They were divided into four groups, namely the normal group, the high-carbohydrate-fat (CF) diet group, the Carbohydrate-Fat-Fructose (CFF) and the Carbohydrate-fat-Fructose-Drink (CFFD) diet group. Blood glucose levels, the oral glucose tolerance test (ITT), and histological features of pancreatic beta cells were all measured.\u0000Results: The CFF group had the highest blood glucose level of 111.25 mg/dl and the highest insulin resistance with an ITT value of 2.81, while the CF group had pancreatic beta cell (β) necrosis.\u0000Conclusion: According to the findings of this study, the CFF group had insulin resistance, while the CF group had pancreatic beta cell necrosis.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140793864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0