Pharmacy Education最新文献_第9页

Effect of heating temperature on citric acid-locust bean gum synthesis 加热温度对柠檬酸-槐豆胶合成的影响

IF 0.5

Pharmacy Education Pub Date : 2024-05-01 DOI: 10.46542/pe.2024.243.216221

Wuryanto Hadinugroho, Stephanie Florencia Winarko, Echa Imanuela Sinta, S. Y. Esar, Jefri Prasetyo

{"title":"Effect of heating temperature on citric acid-locust bean gum synthesis","authors":"Wuryanto Hadinugroho, Stephanie Florencia Winarko, Echa Imanuela Sinta, S. Y. Esar, Jefri Prasetyo","doi":"10.46542/pe.2024.243.216221","DOIUrl":"https://doi.org/10.46542/pe.2024.243.216221","url":null,"abstract":"Background: Citric acid-locust bean gum (CA-LBG) is a derivative of locust bean gum. Its synthesis has been carried out previously using UV light as an energy source. Heat is an alternative energy source that is simple and affordable.\u0000Objective: To determine the effect of temperature on the synthesis of CA-LBG.\u0000Method: The synthesis of CA-LBG was achieved through the esterification process of citric acid (CA), locust bean gum (LBG), hydrochloric acid (HCl), and water bath. The temperatures used were 20oC, 40oC, 60oC, and 80oC for 30 minutes. CA-LBG was synthesised chemically and physically.\u0000Result: At 20oC, the viscosity of the mucilago was high, so mucilago was difficult to precipitate. At 80, the viscosity of the mucilago was very low, which affected the precipitation and denaturation process. The temperatures reported for further synthesis were 40°C and 60°C. FTIR spectra showed carbonyl ester as a specific group at 40°C (1738.6 cm-1) and 60°C (1735.1 cm-1). Evaluation of the effect of 40°C and 60°C heating on the swelling index was 3.09% and 3.15%; pH was 4.82 and 4.88; and yield was 39.76% and 37.18%, respectively.\u0000Conclusion: The higher temperature increased the UV wavelength, Mp, pH, and swelling index and decreased the yield.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141053757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Docking study of ferulic acid derivates on FGFR1, ADME prediction, and QSPR analysis 阿魏酸衍生物与 FGFR1 的对接研究、ADME 预测和 QSPR 分析

IF 0.5

Pharmacy Education Pub Date : 2024-05-01 DOI: 10.46542/pe.2024.243.178184

Darwin Riyan Ramadhan, J. Ekowati, Denayu Pebrianti, Farrah Yulian Listyandi, N. Diyah, M. Adrianto, Deepakkumar Mishra

{"title":"Docking study of ferulic acid derivates on FGFR1, ADME prediction, and QSPR analysis","authors":"Darwin Riyan Ramadhan, J. Ekowati, Denayu Pebrianti, Farrah Yulian Listyandi, N. Diyah, M. Adrianto, Deepakkumar Mishra","doi":"10.46542/pe.2024.243.178184","DOIUrl":"https://doi.org/10.46542/pe.2024.243.178184","url":null,"abstract":"Background: FGFR-1 is an angiogenic receptor that plays a huge role in the cancer growth pathway. Angiogenesis inhibitory drugs released have significant side effects. Therefore, research into discovering anti-angiogenic agents to achieve good health and well-being is still necessary.\u0000Objective: To design the novel anti-angiogenic candidates from ferulic acid (FA) by docking study on FGFR1, to predict the ADME profile, and to find out the structural relationship of their pharmacokinetic properties as QSPR analysis.\u0000Method: Autodock Tools performed a docking study. ADME prediction was conducted using SwissADME. The MLR approach determined the QSPR model.\u0000Result: The docking results showed that FA-8 and FA-18 had the lowest free energy binding, inhibition constant, and GI absorption. The QSPR analysis obtained the equation model: Log HIA = 0,018 Log P2 + 0,069 Log P + 0,020 CMR + 0,001 Etotal + 1,771 with n = 24, correlation coefficient (r)= 0.621, p-value= 0.046 and F-value= 2.975.\u0000Conclusion: Modifying FA on the phenolic moiety replaced by an ester increased the activity and ADME profile. The predicted bioavailability was supported by high Log P, molar refractivity (CMR), and electronic factor (Etotal). It is recommended that lipophilicity be increased to achieve better pharmacokinetic properties.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141041704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of combining ondansetron with dexamethasone in delayed chemotherapy-induced nausea and vomiting 昂丹司琼与地塞米松联用对延迟化疗引起的恶心和呕吐的疗效

IF 0.5

Pharmacy Education Pub Date : 2024-05-01 DOI: 10.46542/pe.2024.243.211215

Ratih Pratiwi, M. Prenggono, Aditya Maulana, Perdana Putra, D. Atmaja, M. Rahmadi, Suharjono, Antiemetics Chemotherapy, Dexamethasone Efficacy Ondansetron

{"title":"The efficacy of combining ondansetron with dexamethasone in delayed chemotherapy-induced nausea and vomiting","authors":"Ratih Pratiwi, M. Prenggono, Aditya Maulana, Perdana Putra, D. Atmaja, M. Rahmadi, Suharjono, Antiemetics Chemotherapy, Dexamethasone Efficacy Ondansetron","doi":"10.46542/pe.2024.243.211215","DOIUrl":"https://doi.org/10.46542/pe.2024.243.211215","url":null,"abstract":"Background: Chemotherapy is the primary recourse for patients with cancer that cannot be treated using local surgery or radiotherapy. Its practical application often leads to adverse effects, including nausea and vomiting. \u0000Objective: This study determined the efficacy of oral ondansetron and oral dexamethasone as an antiemetic regimen among patients covered by the National Health Insurance. \u0000Methods: This cross-sectional study, conducted at one of the largest hospitals in South Kalimantan, Indonesia, involved 114 chemotherapy patients who received a combination antiemetic regimen of ondansetron and dexamethasone. Data on the incidence of delayed nausea and vomiting after chemotherapy were collected using the Index Nausea Vomiting and Retching (INVR) questionnaire from March to May 2023. \u0000Results: A cohort of 114 individuals were enrolled in the present investigation, with 57.02% and 42.98% of the participants receiving non-anthracycline and anthracycline-based treatment protocols, respectively. The results showed that only 1.84% of patients did not experience chemotherapy-related adverse events, 13.16% experienced mild symptoms, 21.84% had moderate symptoms, 55.26% faced severe symptoms, and 7.89% suffered from intense symptoms of nausea and vomiting. \u0000Conclusion: The antiemetic regimen covered by Badan Penyelenggara Jaminan Sosial (BPJS) (Social Insurance Administration Organization), consisting of a combination of ondansetron and dexamethasone, is moderately effective in preventing chemotherapy-induced delayed nausea and vomiting.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141029986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of antipsychotic side effects on schizophrenia patients at Dr Radjiman Wediodiningrat Hospital, Indonesia 印度尼西亚 Radjiman Wediodiningrat 医生医院抗精神病药物对精神分裂症患者副作用的评估

IF 0.5

Pharmacy Education Pub Date : 2024-05-01 DOI: 10.46542/pe.2024.243.191196

Divaz Hedya Putri, Julaeha Julaeha, Agus Sugianto

{"title":"Evaluation of antipsychotic side effects on schizophrenia patients at Dr Radjiman Wediodiningrat Hospital, Indonesia","authors":"Divaz Hedya Putri, Julaeha Julaeha, Agus Sugianto","doi":"10.46542/pe.2024.243.191196","DOIUrl":"https://doi.org/10.46542/pe.2024.243.191196","url":null,"abstract":"Background: Schizophrenia is the most common mental illness with a poor prognosis. Antipsychotics are the major treatment for Schizophrenia. \u0000Objective: This study examines schizophrenia patients' side effects and antipsychotic medication. \u0000Method: A retrospective study with cross-sectional observational analysis was conducted in June 2023, with only the data from schizophrenia patients in Dr. Radjiman Wediodiningrat Hospital, Indonesia. Data were collected from the prescription records of schizophrenia inpatients from January to June 2023. The Chi-square test was used to analyse and measure the relationship between the incidence of adverse events with antipsychotics in schizophrenia patients. \u0000Result: Schizophrenia inpatients were majority male (74.7%) and the age 18-35 years was 41%. This study showed that the pattern of prescription of antipsychotics is atypical monotherapy (37.6%) and combinations (24.9%) were the most antipsychotics prescribed. Most of the schizophrenia outpatients have extrapyramidal syndrome side effects (31.9%), such as rigidity (12.2%), tremor (3.5%), dystonia (6.6%), and other side effects (11.8%). \u0000Conclusion: This study highlighted that atypical antipsychotics were the most common choice for treatment in the inpatient setting. Atypical have a lower risk of extrapyramidal side effects than typical. The negative effects of atypical antipsychotics, including metabolic syndrome, have not been identified. Thus, more research is required.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141040813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining evidence requirements for a Development Framework for Pharmacists (DFP) in community pharmacy practice 确定社区药房实践中药剂师发展框架 (DFP) 的证据要求

IF 0.5

Pharmacy Education Pub Date : 2024-04-22 DOI: 10.46542/pe.2024.241.248261

Joy Boon Ka Chong, Shun Wei Lim, Xue Liang Goh, Sarah Li Hui Gan, H. Wee

{"title":"Defining evidence requirements for a Development Framework for Pharmacists (DFP) in community pharmacy practice","authors":"Joy Boon Ka Chong, Shun Wei Lim, Xue Liang Goh, Sarah Li Hui Gan, H. Wee","doi":"10.46542/pe.2024.241.248261","DOIUrl":"https://doi.org/10.46542/pe.2024.241.248261","url":null,"abstract":"Background: The Development Framework for Pharmacists (DFP) was implemented in a pharmacy chain to guide pharmacist development. Both pharmacists and their supervisors faced challenges in defining evidence and performance levels for Domain 1 (Expert professional practice) standards. This study explored these challenges in a community pharmacy setting.\u0000Methods: Three online focus group discussions (FGDs) involving a DFP workgroup member and representatives from community pharmacies and polyclinics were conducted. The FGDs were facilitated by guiding questions and evidences gathered from pharmacists who had attempted the DFP. The FGDs were recorded, transcribed, and coded thematically.\u0000Results: Participants viewed the DFP as relevant to community practice but suggested aligning DFP evidence examples with community pharmacists’ responsibilities. Key themes from the FGDs included: (1) The need for clear definitions for descriptors, especially when identical evidence was used for different standards; (2) Professional education can be Domain 1 evidence when skills learned are demonstrated in the workplace; (3) Potential inclusion of education and training activities in Domain 1. (4) The need for a criteria model to assess pharmacists’ performance level in various roles and situations; (5) Clarification regarding the term \"group of patients\" (6) Considering back-end work as Domain 1 evidence.\u0000Conclusion: Addressing the above themes could enhance DFP integration for community pharmacists.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140673081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of student pharmacists’ academic performance with and without required attendance in a pharmacotherapy course 药剂师学生参加和不参加药物疗法课程的学习成绩比较

IF 0.5

Pharmacy Education Pub Date : 2024-04-22 DOI: 10.46542/pe.2024.241.270276

Dana Bowers, Alanda Barash, Kimberly McKiernan

{"title":"Comparison of student pharmacists’ academic performance with and without required attendance in a pharmacotherapy course","authors":"Dana Bowers, Alanda Barash, Kimberly McKiernan","doi":"10.46542/pe.2024.241.270276","DOIUrl":"https://doi.org/10.46542/pe.2024.241.270276","url":null,"abstract":"Background: Studies evaluating the association between absenteeism and academic performance have had mixed results; some demonstrate a positive correlation between course attendance and academic performance.\u0000Objective: To compare student pharmacists’ performance in a cohort with graded attendance and those without a graded attendance in a pharmacotherapy course and to evaluate student performance within the required attendance cohort on course learning objectives.\u0000Methods: All students enrolled during Fall 2021 and Fall 2022 were included in this study. Attendance data for the graded attendance cohort and the Assessment performance data for both cohorts were exported. With the student’s t-test, the average examination performance on college-level learning outcomes (CLLOs) between groups was compared.\u0000Results: The comparison between the graded and ungraded attendance cohorts demonstrated a significant difference in academic performance for all three levels of Bloom’s taxonomy, and one CLLO on Examination One and in all categories on Examination Two. Within the graded attendance cohort, comparing students who met unit attendance competency with those who did not resulted in a significant difference.\u0000Conclusion: The results of this study support graded attendance in a pharmacotherapy course. Student pharmacists demonstrated better academic performance when attendance was graded than a cohort without a graded attendance requirement. ","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140676284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the theory-practice gap in pharmacy education using an authentic learning approach: A cross-sectional study 使用真实学习方法弥合药学教育中的理论与实践差距：横向研究

IF 0.5

Pharmacy Education Pub Date : 2024-04-22 DOI: 10.46542/pe.2024.241.262269

Clare Depasquale, Gwen Gray

{"title":"Bridging the theory-practice gap in pharmacy education using an authentic learning approach: A cross-sectional study","authors":"Clare Depasquale, Gwen Gray","doi":"10.46542/pe.2024.241.262269","DOIUrl":"https://doi.org/10.46542/pe.2024.241.262269","url":null,"abstract":"Background: Authentic learning environments highlight real-world relevance to students, contributing to readiness for practice. This study evaluated the impact of an educational activity on student pharmacist learning and personal/professional development.\u0000Methods: An activity similar to that used by practising pharmacy professionals to record errors during dispensing was included in simulated community pharmacy workshops delivered to Year-2 students as part of a Professional Practice Module. Students were instructed to complete entries when academic staff identified errors during final accuracy checks. Student evaluation surveys were analysed at the end of terms one and two of the academic year. Descriptive statistics were used for closed questions, and thematic analysis for open-ended responses.\u0000Results: Of the 75 student pharmacists who completed both evaluation surveys, 64% (n=48) recorded fewer errors in term two. Respondents considered the exercise helpful in highlighting the need for more attention to detail and identifying negative trends in their dispensing process. A positive response to personal/professional development was noted, with student pharmacists commenting that the activity facilitated reflection.\u0000Conclusion: This activity has allowed students to experience real-world working situations, extending their learning experience, facilitating personal/professional development, and encouraging best practices.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140675438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring student perceptions: Factors influencing academic performance in a school of pharmacy in Nigeria 探索学生的看法：影响尼日利亚一所药学院学习成绩的因素

IF 0.5

Pharmacy Education Pub Date : 2024-04-12 DOI: 10.46542/pe.2024.241.238247

A. Jegede, Kayode Toyosi Olabanji, Tunmise Arolagbade

{"title":"Exploring student perceptions: Factors influencing academic performance in a school of pharmacy in Nigeria","authors":"A. Jegede, Kayode Toyosi Olabanji, Tunmise Arolagbade","doi":"10.46542/pe.2024.241.238247","DOIUrl":"https://doi.org/10.46542/pe.2024.241.238247","url":null,"abstract":"Background: The failure and success rate of students in pharmacy school has been shown to be dependent on some courses that predict academic performance. The study identified factors that could impact failure and academic performances of pharmacy students at Obafemi Awolowo University.\u0000Methods: The study was a cross-sectional study of 219 undergraduate pharmacy students from third, fourth and fifth years of a school of pharmacy in Nigeria. A pre-tested questionnaire gathered data on demographics, course perceptions and academic factors. Descriptive and inferential statistics such as percentages, weighted averages, and Chi squared tests were used to analyse the data obtained at p < 0.05.\u0000Results: Financial constraints, family challenges, and a lack of peer interaction were significantly associated with repeating a year. Specific courses perceived as difficult included “Pharmaceutical organic chemistry” (PHC 202), “Practical pharmaceutics I” (PHA 201) and “Medicinal chemistry II” (PHC 402). Courses perceived as difficult, particularly in the fourth year, were notably linked to academic stress.\u0000Conclusion: The study identified specific factors and courses that affect pharmacy students’ performance in the Nigerian context. Policy makers and faculty can take vital feedback to adjust the training content, methods and assessment system to possibly deliver a holistic education to pharmacy students. \u0000 ","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation of academic resilience, resilience, and empathy in pharmacy students: Implications for pharmacy education 对药学专业学生的学习适应力、复原力和同理心的调查：对药学教育的启示

IF 0.5

Pharmacy Education Pub Date : 2024-04-12 DOI: 10.46542/pe.2024.241.226237

Syafiqah Nadiah Halimi, Ardalan Mirzaei, Debra Rowett, Karen Luetsch

{"title":"An investigation of academic resilience, resilience, and empathy in pharmacy students: Implications for pharmacy education","authors":"Syafiqah Nadiah Halimi, Ardalan Mirzaei, Debra Rowett, Karen Luetsch","doi":"10.46542/pe.2024.241.226237","DOIUrl":"https://doi.org/10.46542/pe.2024.241.226237","url":null,"abstract":"Background: Resilience supports pharmacists and students in thriving in challenging healthcare and academic environments. Empathy is necessary to provide patient-centred care. Knowledge of how these attributes influence pharmacy students is limited, and correlations between academic resilience, empathy, and academic success continue to be explored.\u0000Methods: This study explores the relationships between levels of academic resilience, resilience, and empathy with the academic achievements of pharmacy students at a Malaysian university. Participants were pharmacy students enrolled from 2020/2021 to 2022/2023. Academic resilience was assessed using the Academic-Pharmacy-Resilience-Scale-16, resilience through the Brief-Resilience-Scale, and empathy with the Kiersma-Chen Empathy-Scale. Scores were related to students’ academic grades. Both descriptive and inferential statistical methods were utilised to analyse associations among variables.\u0000Results: Responses were received from 359 students. The levels of resilience of students were deemed to be moderate. Small, statistically significant variations were found in academic resilience scores across cohorts, resilience scores, and empathy scores in relation to gender. Academic resilience showed a correlation to academic grades.\u0000Conclusion: Academic resilience positively correlated with academic success and was positively influenced by work experience. Strengthening students’ resilience in pharmacy education may support their academic achievement, particularly during times of change like the COVID-19 pandemic.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory effects of eggshell membrane hydrolysates on carrageenan-induced rat 蛋壳膜水解物对卡拉胶诱导的大鼠的抗炎作用

IF 0.5

Pharmacy Education Pub Date : 2024-04-01 DOI: 10.46542/pe.2024.242.152157

S. Vikasari, E. Sukandar, Tri Suciati, I. Adnyana

{"title":"Anti-inflammatory effects of eggshell membrane hydrolysates on carrageenan-induced rat","authors":"S. Vikasari, E. Sukandar, Tri Suciati, I. Adnyana","doi":"10.46542/pe.2024.242.152157","DOIUrl":"https://doi.org/10.46542/pe.2024.242.152157","url":null,"abstract":"Background: Eggshells are one of the most common culinary wastes, yet using eggshell membrane detritus in medical treatments remains largely unexplored.\u0000Objective: This study aims to assess the anti-inflammatory potential of eggshell membrane hydrolysate.\u0000Method: Eggshell membrane hydrolysate was prepared using acid-base hydrolysis. The intraplantar carrageenan-induced inﬂammation model was used to test the anti-inflammatory effect. The experimental group consisted of a control, comparison (4.5 mg/kg BW diclofenac-Na, 4.5 mg/kg BW hyaluronic acid, and 45 mg/kg BW collagen), and eggshell membrane hydrolysates (9, 22.5, 45 and 90 mg/kg BW). Observations of inflammation, percentage of inflammation, and percentage of inhibition of inflammation were measured every 30 minutes for 180 minutes. Statistical analysis was performed using the t-test and also trendline analysis.\u0000Result: The findings revealed that collagen and hyaluronic acid demonstrated the ability to suppress inflammation compared to controls (p < 0.05). Compared to the control group, the group that received eggshell membrane hydrolysate at doses of 9, 22.5, 45, and 90 mg/kg BW also exhibited inhibition of inflammation (p < 0.05). Furthermore, increasing the dosage of eggshell membrane hydrolysate correlated with an increase in the percentage of inflammation inhibition in carrageenan-induced rats.\u0000Conclusion: Eggshell membrane hydrolysate has the potential to act as an anti-inflammatory agent.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0