卡波姆和乙基纤维素在制备盐酸环丙沙星黏附微球中的优化

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2023-10-10 DOI:10.46542/pe.2023.234.2731

Lusia Oktora Ruma Kumala Sari, Lintang Qonita Fardliana, Dwi Nurahmanto, Eka Deddy Irawan

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引用次数: 0

摘要

背景:盐酸环丙沙星(CH)是一种用于治疗尿路感染的抗生素。CH半衰期短，生物利用度低。微球联合黏液系统可延长药物在胃内的停留时间，从而提高CH的生物利用度。目的:采用因子设计法，研究卡波姆作为黏液聚合物和乙基纤维素作为基质聚合物的最佳用量。方法:采用因子设计22确定卡波姆和乙基纤维素的用量，以制备最佳的黏附微球。在本研究中观察到三种反应:粒径、包裹效率和粘接强度。结果:包封率为69.0%，粒径为404.52 nm，粘接强度为64.3 g，载药量和得率分别为19.13%和99.8%。结论:含300 mg卡波姆和1000 mg乙基纤维素的最佳配方响应值最高。

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Carbomer and ethyl cellulose optimisation in the preparation of mucoadhesive microspheres ciprofloxacin hydrochloride

Background: Ciprofloxacin hydrochloride (CH) is an antibiotic used to treat urinary tract infections. CH has a short half-life and low bioavailability. Microspheres combined with a mucoadhesive system can increase the residence time of the drug in the stomach to increase the bioavailability of CH. Objective: This research was conducted to obtain the best amount of carbomer as a polymer mucoadhesive and ethyl cellulose as a matrix polymer based on factorial design. Method: The factorial design 22 was used to determine the amount of carbomer and ethyl cellulose to produce optimum mucoadhesive microspheres. Three responses were observed in this study: particle size, entrapment efficiency, and mucoadhesive strength. Result: The resulting entrapment efficiency was 69.0%, particle size was 404.52 nm, and mucoadhesive strength was 64.3 grams, with drug loading and yield values of 19.13% and 99.8%, respectively. Conclusion: The optimum formula with the highest response value is the formula containing 300 mg carbomer and 1000 mg ethyl cellulose.

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.