Parasite最新文献_第2页

Integrated evidence reveals a new subspecies of the genus Seuratascaris (Nematoda: Ascaridomorpha), with characterization of the complete mitochondrial genome. 综合证据揭示了丝状线虫属的一个新的亚种（线虫纲：丝状线虫科），具有完整线粒体基因组的特征。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-24 DOI: 10.1051/parasite/2025008

Xiao-Hong Gu, Jia-Tong Mu, Hui-Xia Chen, Liang Li

{"title":"Integrated evidence reveals a new subspecies of the genus Seuratascaris (Nematoda: Ascaridomorpha), with characterization of the complete mitochondrial genome.","authors":"Xiao-Hong Gu, Jia-Tong Mu, Hui-Xia Chen, Liang Li","doi":"10.1051/parasite/2025008","DOIUrl":"10.1051/parasite/2025008","url":null,"abstract":"Species of Seuratascaris Sprent, 1985 are a rarely reported group of ascaridoid nematodes, parasitising various frogs and toads. In the present study, a new subspecies of Seuratascaris, S. physalis bazhaiensis n. subsp. was described using integrated taxonomic methods, based on specimens collected from Odorrana graminea (Anura: Ranidae) in Guangxi Zhuang Autonomous Region, China. Results of the Assemble Species by Automatic Partitioning (ASAP) and Bayesian inference based on the mitochondrial cox1, cox2 and rrnS data all supported S. physalis bazhaiensis representing a distinct taxon from the nominate subspecies S. physalis physalis. Supplementary morphometric and genetic data of S. phy. physalis are presented based on newly collected material from Odorrana tiannanensis (Anura: Ranidae) and Rhacophorus sp. (Anura: Rhacophoridae) in Yunnan Province, China. A key to species of Seuratascaris is provided. The complete mitochondrial genome of S. physalis bazhaiensis was sequenced and annotated, and represents the first mitogenomic data for the genus Seuratascaris. This mitogenome has only 13,628 bp (including 12 protein-coding genes, 22 tRNA genes, 2 ribosomal RNAs, and only 1 non-coding region), and is the smallest of the reported ascaridoid mitogenomes so far.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"14"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a new fish trypanosome from the large yellow croaker (Larimichthys crocea) and description of its impact on host pathology, blood biochemical parameters and immune responses. 大黄鱼一种新锥虫的鉴定及其对宿主病理、血液生化指标和免疫反应的影响。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-01-22 DOI: 10.1051/parasite/2024078

Xiaoao Yang, Pengzhi Qi, Zhen Tao, Qingwei Zhang, Yanjie Wang, Denghui Zhu, Xiaojun Yan, Peipei Fu, Baoying Guo

{"title":"Identification of a new fish trypanosome from the large yellow croaker (Larimichthys crocea) and description of its impact on host pathology, blood biochemical parameters and immune responses.","authors":"Xiaoao Yang, Pengzhi Qi, Zhen Tao, Qingwei Zhang, Yanjie Wang, Denghui Zhu, Xiaojun Yan, Peipei Fu, Baoying Guo","doi":"10.1051/parasite/2024078","DOIUrl":"10.1051/parasite/2024078","url":null,"abstract":"The aim of this study was to clarify the taxonomic identification of a hemoflagellate and assess the effect of trypanosome infection on Larimichthys crocea. Giemsa staining showed the presence of three morphotypes of trypomastigotes. The trypanosomes had the following morphological characteristics: a slender body with a long flagellum at the front; body size 12.30-30.90 × 1.13-2.33 μm; elongated oval nucleus situated in the median region; kinetoplast small, oval, located at the posterior end. The parasite had significant morphological differences from Trypanosoma epinepheli Su, Feng, Jiang, Guo, Liu & Xu, 2014 and Trypanosoma carassii (Mitrofanov) Doflein, 1901. The 18S rDNA sequences of the trypanosome from L. crocea had the highest homology (98.4%) with T. carassii. Phylogenetic analysis indicated that the parasite clustered with freshwater fish trypanosomes. Based on the differences in morphological characteristics and molecular data, it is considered a new species, Trypanosoma larimichthysi n. sp. Trypanosome infection had no effect on the growth of L. crocea, but significantly increased the concentration of blood urea nitrogen (BUN), and induced pathological changes in the gills, liver, spleen and kidney. The pro-inflammatory immune genes, including TNF-α, IFN-γ, IL-1β, CXCL8 and iNOS, were significantly upregulated in the L. crocea infected with trypanosomes. These results suggest that the trypanosome has negative impacts on host health.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"1"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monogeneans on exotic Indian freshwater fish. 7. Results of a national study on ornamental fishes from 2019-2022. 外来的印度淡水鱼上的单系植物。7. 2019-2022年全国观赏鱼研究结果。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-05-12 DOI: 10.1051/parasite/2025021

Amit Tripathi, Chawan Matey, Kurt Buchmann, Christoph Hahn

{"title":"Monogeneans on exotic Indian freshwater fish. 7. Results of a national study on ornamental fishes from 2019-2022.","authors":"Amit Tripathi, Chawan Matey, Kurt Buchmann, Christoph Hahn","doi":"10.1051/parasite/2025021","DOIUrl":"10.1051/parasite/2025021","url":null,"abstract":"This study reports the results of a nationwide parasitological survey that was conducted from 2019 to 2022 to investigate the potential introduction of monogenean parasites into India via the ornamental fish trade. A total of 619 individual exotic ornamental fish representing 27 teleost species from nine families were collected from the country's major aquaria markets and examined for monogeneans. To identify monogeneans at the species level, we employed a morphometric analysis of sclerotised structures (haptoral and reproductive hard parts), as well as a molecular analysis of nuclear 28S rRNA and ITS2 regions. Indian conditions for importing exotic ornamental fish species require a pre-quarantine certificate, quarantine treatment, and post-quarantine follow-up. Despite these restrictions, 26 monogenean species from 12 known genera were detected and identified in 17 of the 27 fishes examined. Dactylogyrus was represented by a maximum of nine species, followed by Gyrodactylus with five. Cyprinidae was the most parasitised fish family (13 species), followed by Cichlidae (three species) and Helostomatidae, Poeciliidae, and Serrasalmidae (two species each). The majority of co-transported parasite species originated from Asia (65.38%, n = 17), followed by South America (23.07%, n = 6), North and Central America (7.69%, n = 2), and Africa (3.5%, n = 1). Three fish species were identified as the first host records for monogenean parasites: Chindongo socolofi for Cichlidogyrus tilapiae Paperna, 1960, Metynnis hypsauchen for Mymarothecium sp., and Betta splendens for Heteronchocleidus sp. In general, exotic populations had fewer parasite species than in their native distribution ranges.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"28"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stylopization by Xenos spp. (Xenidae, Strepsiptera) in invasive alien hornet, Vespa velutina, in South Korea. 韩国外来入侵大黄蜂的柱头分化（种蚊科，链翅目）。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1051/parasite/2025004

Il-Kwon Kim, Chang-Jun Kim, Jeong-Hwan Choi, Hyun Jun Kang, Moon Bo Choi

{"title":"Stylopization by Xenos spp. (Xenidae, Strepsiptera) in invasive alien hornet, Vespa velutina, in South Korea.","authors":"Il-Kwon Kim, Chang-Jun Kim, Jeong-Hwan Choi, Hyun Jun Kang, Moon Bo Choi","doi":"10.1051/parasite/2025004","DOIUrl":"10.1051/parasite/2025004","url":null,"abstract":"The invasive hornet Vespa velutina Lepeletier, which first invaded South Korea in 2003, has spread throughout the country, significantly affecting apiaries, ecosystems, and human health. Xenos spp. (Xenidae, Strepsiptera) are primarily parasitic to social wasps, with V. analis being the only known host in Korea. Until recently, no parasites or parasitoids on V. velutina had been discovered. In 2020, strepsipteran parasites were discovered on 11 hornet workers in Andong City, South Korea. These parasites, comprising four larvae and seven pupae, were all male, except for one individual of an undetermined sex. Molecular analysis and morphological examination identified the parasites as Xenos moutoni (du Buysson, 1903) and X. oxyodontes Nakase & Kato, 2013. This marks the first recorded instance of strepsipteran parasites on V. velutina in regions invaded by this hornet. Although the exact infection rate of these parasites could not be determined, it appears that native strepsipteran parasites have adapted to a non-native Vespa species. Stylopization, the condition caused by these parasites, is known to negatively affect hornet colonies: infected workers do not contribute to nest activities, hindering nest development, and infected reproductive individuals (males and new queens) do not mate, which impedes the establishment of new colonies. However, due to the hornet's high reproductive rate and compensatory mechanisms, the overall control effect of the parasites is likely to be minor.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"10"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic diversity of Trichomonads from Milu deer (Elaphurus davidianus) in China. 中国麋鹿毛滴虫的遗传多样性。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-04-09 DOI: 10.1051/parasite/2025015

Yilei Zhang, Zhouchun Li, Xinglong Song, Guodong Xiao, Lingru He, Jiade Bai, Zhenyu Zhong, Lijie Tian, Yan Chang, Zhuang Li, Qingyun Guo, Congshan Yang, Qingxun Zhang

{"title":"Genetic diversity of Trichomonads from Milu deer (Elaphurus davidianus) in China.","authors":"Yilei Zhang, Zhouchun Li, Xinglong Song, Guodong Xiao, Lingru He, Jiade Bai, Zhenyu Zhong, Lijie Tian, Yan Chang, Zhuang Li, Qingyun Guo, Congshan Yang, Qingxun Zhang","doi":"10.1051/parasite/2025015","DOIUrl":"https://doi.org/10.1051/parasite/2025015","url":null,"abstract":"The Milu deer, or Père David's deer (Elaphurus davidianus), a rare endemic species in China, represents a case of successful reintroduction of a species previously considered extinct in the wild. Trichomonads, protozoan symbionts capable of infecting vertebrates, are transmitted via the fecal-oral route; they are a subgroup of Parabasalia and include some pathogenic species that pose zoonotic risks. Until now, data on the diversity and prevalence of trichomonads in Chinese Milu deer have not been reported. To better understand the colonization status of trichomonads, fecal samples from 112 Milu deer across five nature reserves in China were collected. The ITS-1/5.8S/ITS-2 sequences were amplified using PCR to investigate the colonization rate of trichomonads and to assess evolutionary relationships and genetic characteristics through phylogenetic analysis. An occurrence of 38.39% was recorded in Milu deer, with sample collection sites (OR = 55.159, 95% CI = 3.166-961.113, p = 0.006), high relative humidity and average annual rainfall (OR = 11.675, 95% CI = 1.747-77.781, p = 0.011) identified as significant risk factors for trichomonads colonization. Undescribed trichomonads from four genera were identified, including Simplicimonas spp., Hypotrichomonas spp., Hexamastix spp., and Tetratrichomonas spp. To our knowledge, this is the first study to report on trichomonads in Milu deer in China. This study aims to enhance understanding of trichomonad colonization and associated risk factors, providing scientific guidance for the ex-situ conservation of Milu deer.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"23"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions. 隐孢子虫的分子致病机理和治疗干预措施的进展。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1051/parasite/2025001

Yilong Lu, Xiaoning Zhang, Zhiyu Guan, Rui Ji, Fujun Peng, Chunzhen Zhao, Wei Gao, Feng Gao

引用次数: 0

Leucocytozoon infections in tits (Aves, Paridae): blood and tissue stages investigated using an integrative approach. 在山雀（鸟，顶）白细胞感染：血液和组织阶段调查使用综合方法。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-21 DOI: 10.1051/parasite/2025007

Germán Alfredo Gutiérrez-Liberato, Mélanie Duc, Vytautas Eigirdas, Carolina Romeiro Fernandes Chagas

{"title":"Leucocytozoon infections in tits (Aves, Paridae): blood and tissue stages investigated using an integrative approach.","authors":"Germán Alfredo Gutiérrez-Liberato, Mélanie Duc, Vytautas Eigirdas, Carolina Romeiro Fernandes Chagas","doi":"10.1051/parasite/2025007","DOIUrl":"10.1051/parasite/2025007","url":null,"abstract":"Leucocytozoon species are cosmopolitan and prevalent avian parasites, with some infections being lethal, mainly due to the exo-erythrocytic development of the parasite in bird tissues. The patterns of exo-erythrocytic development in Leucocytozoon spp. infections in wild birds remain poorly studied. This study investigated the development of Leucocytozoon spp. tissue stages in tits (Paridae). Great tits (Parus major), Blue tits (Cyanistes caeruleus), and Coal tits (Periparus ater) were screened for infections using an integrative approach that consisted of microscopic analysis of thin blood smears, histological techniques, chromogenic in situ hybridization (CISH), PCR-based methods, and phylogenetic analysis. In total, 41 individuals were analyzed (eight naturally infected that were selected and euthanized, and 33 found dead in the wild and opportunistically sampled). Among the naturally infected birds, all individuals that were microscopically positive for Leucocytozoon species were also PCR-positive for these parasites. Co-infections with Plasmodium spp. and Haemoproteus spp. were commonly found, mainly among the opportunistically sampled birds. Two morphotypes were identified, Leucocytozoon majoris (Laveran, 1902) and Leucocytozoon fringillinarum Woodcock, 1910. Tissue stages were present in three birds sampled exclusively during the non-breeding season, two of them with meronts developing in the kidneys and liver, and one individual with a megalomeront in the heart. All the exo-erythrocytic stages were confirmed to be Leucocytozoon spp. by CISH using a Leucocytozoon genus-specific probe. Phylogenetic analysis placed parasite lineages with different morphotypes in separate clades. The developmental patterns of exo-erythrocytic stages of Leucocytozoon spp. in naturally infected passerines are poorly understood, requiring further research.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"13"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the pathogenic and immunological effects of ds-GFP as a control in in vivo RNA interference studies of Schistosoma japonicum. 在日本血吸虫体内RNA干扰研究中评价ds-GFP作为对照的致病性和免疫学作用。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-26 DOI: 10.1051/parasite/2025003

Lei Xiu, Xiaoling Wang, Shaoyun Cheng, Wanling Liu, Lu Wang, Jiaqi Li, Jinrui Zhang, Yaping Xuan, Wei Hu

{"title":"Evaluating the pathogenic and immunological effects of ds-GFP as a control in in vivo RNA interference studies of Schistosoma japonicum.","authors":"Lei Xiu, Xiaoling Wang, Shaoyun Cheng, Wanling Liu, Lu Wang, Jiaqi Li, Jinrui Zhang, Yaping Xuan, Wei Hu","doi":"10.1051/parasite/2025003","DOIUrl":"10.1051/parasite/2025003","url":null,"abstract":"Schistosomiasis affects over 250 million people in 78 countries. Despite praziquantel as the primary treatment, concerns about resistance in schistosomes underscore the need for alternative therapies. The success of RNA interference (RNAi) in schistosomes shows promise for identifying potential drug targets to facilitate drug discovery. Meanwhile, double-stranded RNA (dsRNA) is commonly used in functional gene analysis via RNAi, with double-stranded green fluorescent protein (ds-GFP) widely employed as a control in schistosome-related studies. However, the potential for off-target effects of dsRNAs in various biological systems raises concerns about the reliability of conventional controls in schistosome RNAi experiments. Therefore, this study aims to evaluate the safety and suitability of ds-GFP as an RNAi negative control in Schistosoma japonicum. Our data indicate that ds-GFP is innocuous and exerts no discernible impact on the host's physiology and immune responses. Comprehensive evaluations conducted in mice showed no significant alterations in body and organ weights. While a splenic immune response was observed, histopathological examinations of multiple organs confirmed the absence of significant lesions following ds-GFP treatment. Additionally, S. japonicum morphology, reproductive capacity, and host responses to parasite eggs showed no significant variations. Taken together, these findings bolster the endorsement of ds-GFP as an appropriate negative control in S. japonicum RNAi experiments, offering reliable outcomes crucial for advancing research on schistosomiasis and related parasitic diseases.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"16"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization and subtype analysis of Blastocystis sp. in captive wildlife in Henan, China. 河南圈养野生动物囊虫的分子特征及亚型分析。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1051/parasite/2025006

Zhaohui Cui, Xiyao Huang, Sulan Zhang, Kaifang Li, Aili Zhang, Qichen Li, Yutong Zhang, Junqiang Li, Meng Qi

{"title":"Molecular characterization and subtype analysis of Blastocystis sp. in captive wildlife in Henan, China.","authors":"Zhaohui Cui, Xiyao Huang, Sulan Zhang, Kaifang Li, Aili Zhang, Qichen Li, Yutong Zhang, Junqiang Li, Meng Qi","doi":"10.1051/parasite/2025006","DOIUrl":"10.1051/parasite/2025006","url":null,"abstract":"Blastocystis sp. is a zoonotic intestinal protozoan that is ubiquitous globally, residing in the gastrointestinal tracts of both humans and various animals. In the present study, a PCR-sequencing tool based on the SSU rRNA gene was employed to investigate the prevalence and subtypes of Blastocystis spp. in 204 fresh fecal samples collected from 20 captive wildlife species from a bird park in Henan Province, Central China. Overall, Blastocystis was present in 13.73% (28 out of 204) of the samples and 25% (5 out of 20) of the species. A total of four zoonotic subtypes of Blastocystis sp. were found: ST1, ST3, ST5, and ST27, with the latter being the most prevalent, accounting for 35.71% (10 out of 28) of the 5 species positive for Blastocystis sp. To the best of our knowledge, this is the first report of Blastocystis ST27 in birds in China, namely bar-headed goose (Anser indicus) and peafowl (Pavo muticus). The data suggest that captive wildlife, particularly those in bird parks, may frequently be infected with this zoonotic pathogen. Consequently, these animals may serve as potential reservoirs for zoonotic infections in humans.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"11"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leishmaniases: Strategies in treatment development. 利什曼病：治疗发展策略。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-03-05 DOI: 10.1051/parasite/2025009

Alissa Majoor, Grégory Michel, Pierre Marty, Laurent Boyer, Christelle Pomares

{"title":"Leishmaniases: Strategies in treatment development.","authors":"Alissa Majoor, Grégory Michel, Pierre Marty, Laurent Boyer, Christelle Pomares","doi":"10.1051/parasite/2025009","DOIUrl":"10.1051/parasite/2025009","url":null,"abstract":"Leishmaniases are vector-borne parasitic diseases that pose a threat to over 1 billion people worldwide. The parasites target cells of the reticulohistiocytic system, such as macrophages, where they replicate. The disease manifests in various forms, ranging from localized cutaneous leishmaniasis to life-threatening visceral forms, which are fatal in 95% of cases without treatment. Current treatments rely on the invasive administration of toxic and expensive drugs that are increasingly encountering resistance. Therefore, finding alternative treatments for this disease is imperative. This literature review focuses on recent advancements in alternative treatments and aims to present the various strategies designed to address current limitations, including cost, toxicity, off-target effects, administration routes, and the emergence of drug resistance. Starting with an overview of the existing approved treatments and their specific limitations, we categorize treatment development strategies into five key sections: (i) combination therapies using existing approved treatments to enhance efficacy and reduce resistance; (ii) nanoparticle formulations, which enable targeted delivery to infected organs and improved therapeutic efficiency; (iii) drug repositioning, a strategy that has already contributed to the approval of over half of current therapeutic compounds; (iv) immunomodulation, used in conjunction with standard chemotherapies to enhance treatment efficacy and lower relapse rates; and (v) ethnobotanicals, which have demonstrated promising in vitro results by combining low toxicity, immunomodulatory properties, and potent anti-parasitic effects. In summary, this review outlines current strategies in treatment development, emphasizing their advantages over conventional therapies while acknowledging their limitations.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"18"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0