Parasite最新文献_第3页

Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions. 隐孢子虫的分子致病机理和治疗干预措施的进展。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1051/parasite/2025001

Yilong Lu, Xiaoning Zhang, Zhiyu Guan, Rui Ji, Fujun Peng, Chunzhen Zhao, Wei Gao, Feng Gao

引用次数: 0

Leucocytozoon infections in tits (Aves, Paridae): blood and tissue stages investigated using an integrative approach. 在山雀（鸟，顶）白细胞感染：血液和组织阶段调查使用综合方法。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-21 DOI: 10.1051/parasite/2025007

Germán Alfredo Gutiérrez-Liberato, Mélanie Duc, Vytautas Eigirdas, Carolina Romeiro Fernandes Chagas

{"title":"Leucocytozoon infections in tits (Aves, Paridae): blood and tissue stages investigated using an integrative approach.","authors":"Germán Alfredo Gutiérrez-Liberato, Mélanie Duc, Vytautas Eigirdas, Carolina Romeiro Fernandes Chagas","doi":"10.1051/parasite/2025007","DOIUrl":"10.1051/parasite/2025007","url":null,"abstract":"Leucocytozoon species are cosmopolitan and prevalent avian parasites, with some infections being lethal, mainly due to the exo-erythrocytic development of the parasite in bird tissues. The patterns of exo-erythrocytic development in Leucocytozoon spp. infections in wild birds remain poorly studied. This study investigated the development of Leucocytozoon spp. tissue stages in tits (Paridae). Great tits (Parus major), Blue tits (Cyanistes caeruleus), and Coal tits (Periparus ater) were screened for infections using an integrative approach that consisted of microscopic analysis of thin blood smears, histological techniques, chromogenic in situ hybridization (CISH), PCR-based methods, and phylogenetic analysis. In total, 41 individuals were analyzed (eight naturally infected that were selected and euthanized, and 33 found dead in the wild and opportunistically sampled). Among the naturally infected birds, all individuals that were microscopically positive for Leucocytozoon species were also PCR-positive for these parasites. Co-infections with Plasmodium spp. and Haemoproteus spp. were commonly found, mainly among the opportunistically sampled birds. Two morphotypes were identified, Leucocytozoon majoris (Laveran, 1902) and Leucocytozoon fringillinarum Woodcock, 1910. Tissue stages were present in three birds sampled exclusively during the non-breeding season, two of them with meronts developing in the kidneys and liver, and one individual with a megalomeront in the heart. All the exo-erythrocytic stages were confirmed to be Leucocytozoon spp. by CISH using a Leucocytozoon genus-specific probe. Phylogenetic analysis placed parasite lineages with different morphotypes in separate clades. The developmental patterns of exo-erythrocytic stages of Leucocytozoon spp. in naturally infected passerines are poorly understood, requiring further research.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"13"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the pathogenic and immunological effects of ds-GFP as a control in in vivo RNA interference studies of Schistosoma japonicum. 在日本血吸虫体内RNA干扰研究中评价ds-GFP作为对照的致病性和免疫学作用。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-26 DOI: 10.1051/parasite/2025003

Lei Xiu, Xiaoling Wang, Shaoyun Cheng, Wanling Liu, Lu Wang, Jiaqi Li, Jinrui Zhang, Yaping Xuan, Wei Hu

{"title":"Evaluating the pathogenic and immunological effects of ds-GFP as a control in in vivo RNA interference studies of Schistosoma japonicum.","authors":"Lei Xiu, Xiaoling Wang, Shaoyun Cheng, Wanling Liu, Lu Wang, Jiaqi Li, Jinrui Zhang, Yaping Xuan, Wei Hu","doi":"10.1051/parasite/2025003","DOIUrl":"10.1051/parasite/2025003","url":null,"abstract":"Schistosomiasis affects over 250 million people in 78 countries. Despite praziquantel as the primary treatment, concerns about resistance in schistosomes underscore the need for alternative therapies. The success of RNA interference (RNAi) in schistosomes shows promise for identifying potential drug targets to facilitate drug discovery. Meanwhile, double-stranded RNA (dsRNA) is commonly used in functional gene analysis via RNAi, with double-stranded green fluorescent protein (ds-GFP) widely employed as a control in schistosome-related studies. However, the potential for off-target effects of dsRNAs in various biological systems raises concerns about the reliability of conventional controls in schistosome RNAi experiments. Therefore, this study aims to evaluate the safety and suitability of ds-GFP as an RNAi negative control in Schistosoma japonicum. Our data indicate that ds-GFP is innocuous and exerts no discernible impact on the host's physiology and immune responses. Comprehensive evaluations conducted in mice showed no significant alterations in body and organ weights. While a splenic immune response was observed, histopathological examinations of multiple organs confirmed the absence of significant lesions following ds-GFP treatment. Additionally, S. japonicum morphology, reproductive capacity, and host responses to parasite eggs showed no significant variations. Taken together, these findings bolster the endorsement of ds-GFP as an appropriate negative control in S. japonicum RNAi experiments, offering reliable outcomes crucial for advancing research on schistosomiasis and related parasitic diseases.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"16"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing larval mass-rearing techniques for Aedes mosquitoes: enhancing production and quality for genetic control strategies. 优化伊蚊幼虫大规模饲养技术：提高产量和质量用于遗传控制策略。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.1051/parasite/2025024

Wadaka Mamai, Cécile Brengues, Hamidou Maiga, Thomas Wallner, Anthony Herbin, Mathieu Whiteside, Simran Singh Kotla, Odet Bueno-Masso, Nanwintoum Sévérin Bimbilé Somda, Zhiyong Xi, Hanano Yamada, Chantel Janet de Beer, Jérémy Bouyer

{"title":"Optimizing larval mass-rearing techniques for Aedes mosquitoes: enhancing production and quality for genetic control strategies.","authors":"Wadaka Mamai, Cécile Brengues, Hamidou Maiga, Thomas Wallner, Anthony Herbin, Mathieu Whiteside, Simran Singh Kotla, Odet Bueno-Masso, Nanwintoum Sévérin Bimbilé Somda, Zhiyong Xi, Hanano Yamada, Chantel Janet de Beer, Jérémy Bouyer","doi":"10.1051/parasite/2025024","DOIUrl":"10.1051/parasite/2025024","url":null,"abstract":"The quantity and quality of laboratory-reared insects are pivotal for the success of any sterile male-release program. Optimizing larval mass-rearing methods to enhance both production and quality in Aedes mosquitoes is essential to meet the growing demand from FAO/IAEA Member States for the sterile insect technique (SIT) as a component of area-wide integrated pest management to control or suppress disease vectors. This study was designed to identify the most effective feeding regime and schedule that maximize pupae production with a single tilt/sorting event and to evaluate an alternative larval-rearing unit. The results demonstrated that ingredient particle size, mosquito strain and feeding regime significantly influenced insect production and quality, underscoring the critical need to account for these factors in mass-rearing operations. A daily feeding regime of 0.17, 0.33, 0.67, 0.67 and 0.5 mg per larva was identified as optimal for both species (Ae. aegypti and Ae. albopictus) achieving up to 80 ± 2.5% male pupae recovery rate when sorted 48 h after the onset of pupation. Production outcomes were not compromised with the exclusion of feeding on Days 2 and 3. Furthermore, under the conditions of this study, the Wolbaki rack (Model WBK-P0003-V2) was shown to be sufficient for mass-rearing Aedes mosquitoes. Finally, a 4-day feeding regime was implemented in a field program on Reunion island, yielding similar pupae recovery rates and contamination as the reference regime, a significant step toward improving cost-efficiency and scaling-up the program. These findings provide valuable information for refining standard operating procedures (SOPs) for mass-rearing, thereby enhancing the efficiency and scalability of SIT programs.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"29"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Trachemys scripta elegans in polystome (Platyhelminthes, Monogenea, Polystomatidae) spillover and spillback following the trade of freshwater turtles in southern Europe and North America. 在南欧和北美淡水龟贸易后多口虫（单目，多口虫科）外溢和外溢中的作用

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-05-21 DOI: 10.1051/parasite/2025022

Olivier Verneau, Dennis Quinn, Kevin G Smith, John H Malone, Louis du Preez

{"title":"Role of Trachemys scripta elegans in polystome (Platyhelminthes, Monogenea, Polystomatidae) spillover and spillback following the trade of freshwater turtles in southern Europe and North America.","authors":"Olivier Verneau, Dennis Quinn, Kevin G Smith, John H Malone, Louis du Preez","doi":"10.1051/parasite/2025022","DOIUrl":"10.1051/parasite/2025022","url":null,"abstract":"The red-eared slider, Trachemys scripta elegans (Wied, 1938), has been introduced worldwide, partly because of the exotic pet trade in the 1980s and 1990s. When T. s. elegans is released or escapes into natural environments, it often establishes new feral populations due to its tolerance for a variety of aquatic ecosystems. Therefore, it is now considered one of the most invasive species in the world because it can compete with native turtle species. In the present study, our objectives were to identify the potential for polystome spillover and spillback resulting from the introduction of the red-eared slider into new environments in North America. Fieldwork investigations were thus conducted mainly in aquatic habitats in Florida and North Carolina, United States, but also in Connecticut, Indiana, Kansas, Maine, Nebraska and New York. Using DNA barcoding based on cytochrome c oxidase I (COI) sequences, we surveyed the species diversity of polystome within American freshwater turtles. These included T. s. elegans but also Apalone ferox, Apalone spinifera, Chelydra serpentina, Chrysemys picta, Kinosternon baurii, Pseudemys spp., Sternotherus minor and Sternotherus odoratus. Genetic evidence confirmed that invasive populations of T. s. elegans in southern Europe have transmitted their own polystomes to native host species following spillover effects, and revealed here that T. s. elegans in non-indigenous habitats in the United States acts as a new reservoir of infection for native polystomes following spillback effects, thus increasing indigenous parasite transmission in the wild. Together, these findings raise further concern about the spread of non-native turtles and their impact on parasite transmission.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"30"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological changes in Toxoplasma infection: a 7-year longitudinal study in pregnant women in Lyon, France, 2017-2023. 弓形虫感染的流行病学变化：2017-2023年法国里昂孕妇的7年纵向研究

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-05-21 DOI: 10.1051/parasite/2025023

Alvaro Roy, Laurent Gaucher, Damien Dupont, Jean Menotti, Anthony Atallah, Benoit de la Fournière, Mona Massoud, Bruno Lina, Pauline Tirard-Collet, Martine Wallon

{"title":"Epidemiological changes in Toxoplasma infection: a 7-year longitudinal study in pregnant women in Lyon, France, 2017-2023.","authors":"Alvaro Roy, Laurent Gaucher, Damien Dupont, Jean Menotti, Anthony Atallah, Benoit de la Fournière, Mona Massoud, Bruno Lina, Pauline Tirard-Collet, Martine Wallon","doi":"10.1051/parasite/2025023","DOIUrl":"10.1051/parasite/2025023","url":null,"abstract":"The epidemiology of Toxoplasma infection is known to vary geographically, but is also likely to vary over time, under the influence of many contributing factors. Monitoring is particularly useful in the context of preventing congenital toxoplasmosis. We took advantage of the French prenatal prevention programme to retrospectively assess changes between 2017 and 2023 in seroprevalence and incidence rates of Toxoplasma infection in pregnant women and the incidence of congenital infections. We conducted a longitudinal retrospective study including all pregnancies with known Toxoplasma status followed up at Lyon's public maternity hospitals between 2017 and 2023 (71,922 pregnancies). We used a multivariable logistic regression model to identify factors (age-group, WHO region of origin, population density of the area of residence and parity) associated with seropositivity. The seroprevalence of toxoplasmosis decreased consistently from 26.4% in 2017 to 22.1% in 2023 (p = 0.003), while maternal infection incidence remained stable at 1.3/1,000 pregnancies at risk. Notably, the seroprevalence showed a linear increase with age from 18.9% in women aged 25-29 years to 38.0% in women aged ≥40 years (p < 0.001). The seroprevalence was lower in pregnant women living in rural areas [adjusted seroprevalence ratio (aPR) = 0.87, 95% CI: 0.82-0.92] and higher in multiparous women (aPR = 1.08, 95% CI: 1.04-1.12). This study confirms the ongoing decline in toxoplasmosis seroprevalence while seroconversions remained stable, indicating a need for more tests in seronegative women in the future. These findings highlight the need for ongoing monitoring and refinement of congenital toxoplasmosis prevention strategies in high-income countries.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"31"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization and subtype analysis of Blastocystis sp. in captive wildlife in Henan, China. 河南圈养野生动物囊虫的分子特征及亚型分析。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1051/parasite/2025006

Zhaohui Cui, Xiyao Huang, Sulan Zhang, Kaifang Li, Aili Zhang, Qichen Li, Yutong Zhang, Junqiang Li, Meng Qi

{"title":"Molecular characterization and subtype analysis of Blastocystis sp. in captive wildlife in Henan, China.","authors":"Zhaohui Cui, Xiyao Huang, Sulan Zhang, Kaifang Li, Aili Zhang, Qichen Li, Yutong Zhang, Junqiang Li, Meng Qi","doi":"10.1051/parasite/2025006","DOIUrl":"10.1051/parasite/2025006","url":null,"abstract":"Blastocystis sp. is a zoonotic intestinal protozoan that is ubiquitous globally, residing in the gastrointestinal tracts of both humans and various animals. In the present study, a PCR-sequencing tool based on the SSU rRNA gene was employed to investigate the prevalence and subtypes of Blastocystis spp. in 204 fresh fecal samples collected from 20 captive wildlife species from a bird park in Henan Province, Central China. Overall, Blastocystis was present in 13.73% (28 out of 204) of the samples and 25% (5 out of 20) of the species. A total of four zoonotic subtypes of Blastocystis sp. were found: ST1, ST3, ST5, and ST27, with the latter being the most prevalent, accounting for 35.71% (10 out of 28) of the 5 species positive for Blastocystis sp. To the best of our knowledge, this is the first report of Blastocystis ST27 in birds in China, namely bar-headed goose (Anser indicus) and peafowl (Pavo muticus). The data suggest that captive wildlife, particularly those in bird parks, may frequently be infected with this zoonotic pathogen. Consequently, these animals may serve as potential reservoirs for zoonotic infections in humans.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"11"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leishmaniases: Strategies in treatment development. 利什曼病：治疗发展策略。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-03-05 DOI: 10.1051/parasite/2025009

Alissa Majoor, Grégory Michel, Pierre Marty, Laurent Boyer, Christelle Pomares

{"title":"Leishmaniases: Strategies in treatment development.","authors":"Alissa Majoor, Grégory Michel, Pierre Marty, Laurent Boyer, Christelle Pomares","doi":"10.1051/parasite/2025009","DOIUrl":"10.1051/parasite/2025009","url":null,"abstract":"Leishmaniases are vector-borne parasitic diseases that pose a threat to over 1 billion people worldwide. The parasites target cells of the reticulohistiocytic system, such as macrophages, where they replicate. The disease manifests in various forms, ranging from localized cutaneous leishmaniasis to life-threatening visceral forms, which are fatal in 95% of cases without treatment. Current treatments rely on the invasive administration of toxic and expensive drugs that are increasingly encountering resistance. Therefore, finding alternative treatments for this disease is imperative. This literature review focuses on recent advancements in alternative treatments and aims to present the various strategies designed to address current limitations, including cost, toxicity, off-target effects, administration routes, and the emergence of drug resistance. Starting with an overview of the existing approved treatments and their specific limitations, we categorize treatment development strategies into five key sections: (i) combination therapies using existing approved treatments to enhance efficacy and reduce resistance; (ii) nanoparticle formulations, which enable targeted delivery to infected organs and improved therapeutic efficiency; (iii) drug repositioning, a strategy that has already contributed to the approval of over half of current therapeutic compounds; (iv) immunomodulation, used in conjunction with standard chemotherapies to enhance treatment efficacy and lower relapse rates; and (v) ethnobotanicals, which have demonstrated promising in vitro results by combining low toxicity, immunomodulatory properties, and potent anti-parasitic effects. In summary, this review outlines current strategies in treatment development, emphasizing their advantages over conventional therapies while acknowledging their limitations.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"18"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Trichinella spiralis excretory-secretory antigens on expression of indoleamine 2, 3-dioxygenase on dendritic cells in vitro. 旋毛虫排泄分泌抗原对体外树突状细胞吲哚胺2,3 -双加氧酶表达的影响。

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-04-16 DOI: 10.1051/parasite/2025018

Wenhao Yu, Xuhong Yuan, Peng Zhai, Xiaoyun Li, Caixia Han

{"title":"Effects of Trichinella spiralis excretory-secretory antigens on expression of indoleamine 2, 3-dioxygenase on dendritic cells in vitro.","authors":"Wenhao Yu, Xuhong Yuan, Peng Zhai, Xiaoyun Li, Caixia Han","doi":"10.1051/parasite/2025018","DOIUrl":"https://doi.org/10.1051/parasite/2025018","url":null,"abstract":"Indoleamine 2, 3-dioxygenase (IDO) is a potent immunoenzyme found in dendritic cells (DCs). Research has demonstrated that Trichinella spiralis induces IDO expression in the host immune response through its excretory-secretory (ES) antigens. However, the role of IDO in the immune response to T. spiralis remains unclear. To examine the effects of T. spiralis ES antigens on IDO expression in DCs in vitro, assessments were conducted using qRT-PCR, Western blotting (WB), flow cytometry, and siRNA transfer. The findings indicated that ES antigen stimulation upregulated IDO expression in DCs in vitro. Furthermore, ES antigen significantly enhanced the expression of the proinflammatory cytokines TNF-α and IFN-γ, along with the anti-inflammatory cytokine IL-10, downstream of IDO in DCs. Flow cytometry analysis confirmed that surface molecules CD40, MHC-II, CD80, and CD86 on DCs were upregulated following stimulation with ES antigen and lipopolysaccharide (LPS). Compared to the ES antigen alone, siRNA620 effectively inhibited IDO levels, demonstrating a statistically significant reduction. Continuous stimulation of DCs by ES antigens may lead to immune tolerance through the activation of IDO-mediated inflammation-associated factors. These results suggest that IDO expression in DCs plays a crucial role in T. spiralis infection.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"26"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between imaging features and rEm18 antibodies in alveolar echinococcosis: results from a multicenter study in France. 肺泡包虫病的影像学特征与rEm18抗体的相关性：来自法国一项多中心研究的结果

IF 2.3 2区医学

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-07 DOI: 10.1051/parasite/2024076

Gabriel Simon, Frédéric Grenouillet, Carine Richou, Eric Delabrousse, Oleg Blagoskonov, Anne Minello, Gerard Thiefin, Emilia Frentiu, Martine Wallon, Solange Bresson-Hadni, Paul Calame

{"title":"Correlation between imaging features and rEm18 antibodies in alveolar echinococcosis: results from a multicenter study in France.","authors":"Gabriel Simon, Frédéric Grenouillet, Carine Richou, Eric Delabrousse, Oleg Blagoskonov, Anne Minello, Gerard Thiefin, Emilia Frentiu, Martine Wallon, Solange Bresson-Hadni, Paul Calame","doi":"10.1051/parasite/2024076","DOIUrl":"10.1051/parasite/2024076","url":null,"abstract":"Background: To correlate imaging features of alveolar echinococcosis (AE) with the antibodies to recombinant Em18 (rEm18AB) at diagnosis and evaluate initial imaging features associated with serologic response, this retrospective study used data from the prospective multicenter EchinoVISTA study (NCT02876146). Imaging and serology were performed at diagnosis and during follow-up. Univariate and multivariate analyses were used to evaluate imaging features associated with the rEm18AB index. Follow-up analyses evaluated the imaging features associated with serologic response (defined as a 50% reduction in the baseline value within 2 years) in non-operated patients treated with albendazole alone.Results: From June 2012 to July 2016, 45 patients were included, with 8/45 (18%) having an rEm18AB index < 1. Maximum lesion size (76 mm [IQR = 57-93] vs. 36 mm [IQR = 26-51], p = 0.006), microcyst percentage (70% [IQR = 3-8] vs. 20% [IQR = 0.5-3.5], p = 0.004), and maximum standardized uptake value (SUV) on fluorodeoxyglucose positron emission tomography (5.1 [IQR = 4.4-6.2] vs. 2.6 [IQR = 2.4-3.9], p = 0.001) were associated with an rEm18AB index > 1. In patients treated with albendazole, serologic responders at 2 years had smaller lesions (5.3 [IQR = 3.8-72] vs. 3.5 [IQR = 2.7-3.7], p = 0.010) with less pedicle involvement, and lower initial rEm18AB index (2.98 ± 1.63 vs. 7.81 ± 3.95, p = 0.011).Conclusion: Maximum lesion size, percentage of microcysts within the lesion, and maximum lesion SUV are significant imaging features of AE correlated with the rEm18AB index. Serologic response at 2 years occurs primarily in patients with small lesions and a low rEm18AB index.","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"8"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0