Ocular Immunology and Inflammation最新文献_第4页

Outcomes After Silicone Oil Removal in Patients with Acute Retinal Necrosis Who Underwent Vitrectomy.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-27 DOI: 10.1080/09273948.2025.2477193

Boya Lei, Xin Chen, Min Zhou, Ting Zhang, Ruiping Gu, Qinmeng Shu, Qing Chang, Gezhi Xu, Rui Jiang

{"title":"Outcomes After Silicone Oil Removal in Patients with Acute Retinal Necrosis Who Underwent Vitrectomy.","authors":"Boya Lei, Xin Chen, Min Zhou, Ting Zhang, Ruiping Gu, Qinmeng Shu, Qing Chang, Gezhi Xu, Rui Jiang","doi":"10.1080/09273948.2025.2477193","DOIUrl":"https://doi.org/10.1080/09273948.2025.2477193","url":null,"abstract":"Purpose: To investigate the outcomes after silicone oil removal (SOR) in patients with acute retinal necrosis (ARN).Methods: Retrospective case series. Patients diagnosed with ARN-associated retinal detachment (RD) who underwent vitrectomy and silicone oil tamponade and subsequent SOR between January 2013 and December 2021 who were followed up for ≥1 year after SOR were included. The medical records before and after SOR were reviewed.Results: Fifty-three eyes from 52 patients were included. SOR was conducted at 201.3 ± 104.1 days (range, 63‒547) after vitrectomy. The duration of follow-up after SOR was 1266.8 ± 797.2 days (range, 384-3865). The logMAR BCVA before SOR, at 1 year after SOR, and at the last follow-up were 1.249 ± 0.816, 1.086 ± 0.791, and 1.488 ± 0.961. The intraocular pressure (IOP) at the corresponding times were 13.2 ± 3.6, 10.9 ± 3.4, and 10.4 ± 3.5 mmHg. Seven patients (13.5%) experienced recurrent RD at 81.0 ± 46.7 days (range, 18‒154) after SOR. At 1 year after SOR, 4 eyes (7.5%) had hypotony and 26 (49.1%) had macular edema; the corresponding numbers were 7 (13.5%) and 27 (51.9%) at the last follow-up. The IOP at the time of SOR (r = -0.438, p = 0.001) was the risk factor for the occurrence of hypotony after SOR (area under the ROC curve: 0.873; cutoff value: 11.30 mmHg).Conclusion: The BCVA and IOP continued to change after SOR in ARN patients. Ocular complications mostly occurred within the first year after SOR. IOP at the time of SOR was a main predictor of the clinical outcomes after SOR.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Challenges in Fuchs' Uveitis Syndrome in China: A Multi-Center Comparative Study of Three Criteria. 中国福氏葡萄膜炎综合征的诊断难题：三种标准的多中心比较研究。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-25 DOI: 10.1080/09273948.2025.2475034

Jianguo Huang, Cheng Jin, Dan Lin, Xue-Fei Zhu, Yu Chen, Zhiqi Tao, Jiaqing Wu, Wei Chi, Yuqin Wang

{"title":"Diagnostic Challenges in Fuchs' Uveitis Syndrome in China: A Multi-Center Comparative Study of Three Criteria.","authors":"Jianguo Huang, Cheng Jin, Dan Lin, Xue-Fei Zhu, Yu Chen, Zhiqi Tao, Jiaqing Wu, Wei Chi, Yuqin Wang","doi":"10.1080/09273948.2025.2475034","DOIUrl":"https://doi.org/10.1080/09273948.2025.2475034","url":null,"abstract":"Objective: To evaluate and compare the diagnostic accuradcy of three Fuchs' Uveitis Syndrome (FUS) diagnostic criteria-La Hey Diagnostic Criteria (LHDC), the Standardization of Uveitis Nomenclature (SUN) Criteria, and Yang's Revised Diagnostic Criteria (RDC)-in the absence of a universally accepted gold standard.Methods: A multicenter, case-control study was conducted with 673 patients (331 FUS and 342 non-FUS) from three tertiary eye centers in China. Sensitivity, specificity, and area under the curve (AUC) values were calculated and compared across the three criteria.Results: RDC demonstrated the highest sensitivity (86.1%), followed by LHDC (61.9%) and SUN (54.4%). The SUN criteria had the highest specificity (98.5%), with no statistically significant differences in specificity between the criteria. RDC showed superior diagnostic performance with an AUC of 0.909. Key diagnostic features contributing to the higher sensitivity of RDC included the absence of posterior synechiae, stellate keratic precipitates, and diffuse iris depigmentation.Conclusion: The RDC provides enhanced sensitivity for diagnosing FUS within Chinese populations, suggesting that tailoring diagnostic criteria to demographic characteristics may improve diagnostic precision and clinical application.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiology of Anterior Uveitis in a Finnish Single-Center Register Study - Differences in Clinical Characteristics, Treatment Outcomes, and Ocular Complications.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-24 DOI: 10.1080/09273948.2025.2482687

Aada Leino, Mira Siiskonen, Pasi Ohtonen, Nina Hautala

{"title":"Etiology of Anterior Uveitis in a Finnish Single-Center Register Study - Differences in Clinical Characteristics, Treatment Outcomes, and Ocular Complications.","authors":"Aada Leino, Mira Siiskonen, Pasi Ohtonen, Nina Hautala","doi":"10.1080/09273948.2025.2482687","DOIUrl":"https://doi.org/10.1080/09273948.2025.2482687","url":null,"abstract":"Purpose: To evaluate clinical characteristics, treatment outcomes, and complications in anterior uveitis (AU) with idiopathic, systemic disease-associated, infectious, postoperative, and posttraumatic etiology.Methods: Long-term analysis of a single-center register study from adults with AU in 2009. Etiology, age at onset, sex distribution, course of uveitis, visual outcomes, treatments, and ocular complications were studied during 1998-2018.Results: A total of 413 patients with AU were included. A total of 195 patients (47%) had idiopathic, 150 (36%) systemic disease-associated, 25 (6%) infectious, 26 (6%) postoperative, and 17 (4%) traumatic AU. Average onset age varied from 38 ± 13 (95% CI, 36.2-40.5) in systemic disease-associated to 59 ± 19 (95% CI, 51.5-66.5) in postoperative AU (p < 0.001). Sex distribution varied between 62% females in postoperative and 29% females in traumatic uveitis. Traumatic AU was predominantly acute (59%), and infectious AU recurrent (44%) or chronic (40%). Idiopathic (58%), systemic disease-associated (65%), and postoperative AU (62%) were commonly chronic (p = 0.036). After the active follow-up, traumatic patients gained +2 ETDRS letters, while vision remained stable in idiopathic (-0.5 letters) and systemic disease-associated (+0.8 letters) AU. Patients with infectious and postoperative AU lost -2 and -10 letters, respectively. Highest frequency of complications occurred in traumatic (50%) and the lowest in postoperative AU (35%). Three patients with idiopathic and two with postoperative AU were blind after the follow-up.Conclusion: The study underscores significant differences in the onset age, course of uveitis, vision, intraocular pressure, flare, and treatment modalities among the etiological subgroups of AU. However, no substantial differences were observed concerning complications or visual outcomes.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic Orbital Cellulitis and Optic Neuropathy from High-Pressure Diesel Fuel Injury: A Case Report and Literature Review.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-23 DOI: 10.1080/09273948.2025.2483428

Seyed Mohsen Rafizadeh, Mohammad Taher Rajabi, Amirhossein Aghajani, Elham Rahmanikhah, Ghazal Ghochani, Seyedeh Zahra Seyedi, Ali A Haydar

{"title":"Toxic Orbital Cellulitis and Optic Neuropathy from High-Pressure Diesel Fuel Injury: A Case Report and Literature Review.","authors":"Seyed Mohsen Rafizadeh, Mohammad Taher Rajabi, Amirhossein Aghajani, Elham Rahmanikhah, Ghazal Ghochani, Seyedeh Zahra Seyedi, Ali A Haydar","doi":"10.1080/09273948.2025.2483428","DOIUrl":"https://doi.org/10.1080/09273948.2025.2483428","url":null,"abstract":"Purpose: High-pressure injuries to the orbit are rare, yet they can cause severe damage due to mechanical destruction and the toxicity of the injected substance. Diesel fuel toxicity can lead to rapid necrosis and inflammation, complicating the prognosis even with prompt medical intervention.Methods: A 39-year-old male presented with a right orbital injury from a diesel fuel explosion. Initial symptoms included mild periorbital swelling and a laceration on the upper eyelid. Despite early management with antibiotics and surgical repair, the patient's condition rapidly deteriorated, developing severe periorbital swelling, pain, and decreased vision. Multiple surgical debridements were performed to remove necrotic tissue and residual diesel fuel. Aggressive treatment with broad-spectrum antibiotics and corticosteroids was administered.Results: Despite the aggressive treatment, the patient's vision deteriorated to no light perception, indicative of optic neuropathy. Over the following days, the patient showed significant improvement and was eventually discharged with ongoing antibiotic therapy. At a 6-month follow-up, the patient had good cosmetic outcomes despite mild limitations in eye movement.Conclusion: High-pressure orbital injuries, especially those involving toxic substances like diesel fuel, require early and aggressive management. A multidisciplinary approach, including prompt surgical intervention, broad-spectrum antibiotics, and corticosteroids, is essential to improve outcomes and preserve vital structures. Long-term follow-up is crucial to address functional and cosmetic sequelae. Further research is needed to develop evidence-based protocols, especially for toxic orbital cellulitis.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic Multicentric Castleman's Disease Presenting with Chorioretinal Undulation: A Case Report. 表现为脉络膜视网膜起伏的特发性多中心卡斯特曼病：病例报告

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-18 DOI: 10.1080/09273948.2025.2453883

Suowang Zhou, Liang Wang, Xin Li, Xiaona Zuo, Aifeng Wu, Xiaoyan Peng

{"title":"Idiopathic Multicentric Castleman's Disease Presenting with Chorioretinal Undulation: A Case Report.","authors":"Suowang Zhou, Liang Wang, Xin Li, Xiaona Zuo, Aifeng Wu, Xiaoyan Peng","doi":"10.1080/09273948.2025.2453883","DOIUrl":"https://doi.org/10.1080/09273948.2025.2453883","url":null,"abstract":"Purpose: To describe a case of idiopathic multicentric Castleman's disease (iMCD) with initial ocular involvement, presenting with chorioretinal undulation.Methods: Observational case report of iMCD patient with ocular manifestation on fundus photography, auto-fluorescein and swept-source optical coherence tomography (SS-OCT), initially and after treatment.Results: A 75-year-old patient with painless vision loss for 2 years right eye (RE) and 3-month left eye (LE). Fundus examination revealed several yellow-white lesions along with the inferior arcade, with extensive pigment disturbance of the right eye and exudative retinal detachment of the left eye. SS-OCT showed choroid and retinal pigment epithelium (RPE) undulations, choroid thickening and hyperreflective dots at the choroidal level. Interleukin-6 (IL-6) in the anterior chamber was very high (1595 pg/ml RE and 749.3 pg/ml LE). After cervical lymph node biopsy, the patient was finally diagnosed with iMCD. Siltuximab, an interleukin-6 inhibitor, was administered. After two cycles of therapy, the patient's ocular manifestations improved significantly, the choroid and RPE undulation and the ERD resolved without local treatment.Conclusion: Chorioretinal undulation and elevated IL-6 in intraocular fluid could be ocular manifestations of MCD.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Treatment Outcomes with a Single 0.19 Mg Fluocinolone Acetonide Implant in Non-Infectious Uveitis - A Real-World Study.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-13 DOI: 10.1080/09273948.2025.2478207

Warda Darwisch, Maria Della Volpe Waizel, Robert Patrick Finger, Kai Januschowski, Berthold Seitz, Fabian Norbert Fries, Annekatrin Rickmann

{"title":"Long-Term Treatment Outcomes with a Single 0.19 Mg Fluocinolone Acetonide Implant in Non-Infectious Uveitis - A Real-World Study.","authors":"Warda Darwisch, Maria Della Volpe Waizel, Robert Patrick Finger, Kai Januschowski, Berthold Seitz, Fabian Norbert Fries, Annekatrin Rickmann","doi":"10.1080/09273948.2025.2478207","DOIUrl":"10.1080/09273948.2025.2478207","url":null,"abstract":"Purpose: To evaluate time to first additional treatment following intravitreal 0.19 mg fluocinolone acetonide (FAc) in non-infectious uveitis with posterior segment involvement (NIU-PS) in a real-world setting.Methods: Prospective observational study on 37 eyes (30 patients) with chronic or recurrent NIU-PS, treated with FAc after achieving control - indicated by absence of vitreous haze or clearly visible posterior pole. Over a median follow-up of 48.0 ± 0.0 months, we assessed time to and number of additional treatments, inflammatory activity, central subfield macular thickness (CSMT), visual acuity (VA) and intraocular pressure (IOP).Results: Restricted mean time to first adjuvant treatment was 31.9 ± 2.97 months, with 52.8% requiring no additional treatment ≥ 48 months. VA remained stable (baseline 0.56 ± 0.44 logMAR, p = 0.86). A negative correlation was found between the number of prior steroid implants (DEX-I) and time to additional treatment (r = -0.44, p = 0.001). For up to 24 months, FAc reduced anterior chamber flare (0.44 ± 0.81 to 0.00 ± 0.00, p < 0.001), vitreous haze (0.28 ± 0.51 to 0.00 ± 0.00, p = 0.01), and CSMT (407.1 ± 135.9 µm at baseline to 324.2 ± 75.7 µm at M24, p = 0.001). Within 48 months, ocular hypertension (≥25 mmHg) occurred in 22.2% of eyes (8/36), with 19.4% (7/36) requiring new-onset IOP-lowering drops.Conclusion: FAc demonstrated efficacy in managing low-grade NIU-PS, reducing the need for additional treatments and controlling intraocular inflammation for an average of 32 months.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular Manifestations in Selected Dermatological Disorders: A Narrative Review.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-11 DOI: 10.1080/09273948.2025.2477194

Agnieszka Leszyńska, Dominika Kozłowska, Julia Bałoniak, Julia Linke, Emilia Bachoń, Michalina Doligalska, Aleksandra Stremel, Wiktoria Wesołowska

{"title":"Ocular Manifestations in Selected Dermatological Disorders: A Narrative Review.","authors":"Agnieszka Leszyńska, Dominika Kozłowska, Julia Bałoniak, Julia Linke, Emilia Bachoń, Michalina Doligalska, Aleksandra Stremel, Wiktoria Wesołowska","doi":"10.1080/09273948.2025.2477194","DOIUrl":"https://doi.org/10.1080/09273948.2025.2477194","url":null,"abstract":"Skin disorders are often associated with ocular symptoms. In this review, we aim to identify the most common ocular manifestations observed in selected dermatological diseases, specifically psoriasis, atopic dermatitis, rosacea, and pemphigus. We highlight key ophthalmological conditions linked to these diseases to raise awareness among ophthalmologists who may encounter patients with these dermatological conditions in their clinical practice. Analyzing the original studies, the most common ocular manifestations include various types of inflammation, such as conjunctivitis and blepharitis. Additionally, more severe conditions, such as keratitis, uveitis, and meibomian gland dysfunction, are frequently observed. Ocular symptoms in pemphigus vulgaris and rosacea can precede dermatological signs. Dry eye disease is commonly seen across various dermatological conditions. Treatments like calcineurin inhibitors (used for atopic dermatitis and psoriasis) have shown efficacy for both dermatological and ocular symptoms. In atopic dermatitis, the use of dupilumab has been linked to increased rates of conjunctivitis, necessitating collaboration between dermatologists and ophthalmologists to distinguish drug side effects from disease manifestations. Psoriasis treatments, including phototherapy and biologics like secukinumab and ustekinumab, require careful monitoring for potential ocular effects, as their safety profiles are still being evaluated. For ocular rosacea, cyclosporine has demonstrated superior efficacy over doxycycline in managing symptoms such as burning and corneal involvement. This review underscores the importance of recognizing the interplay between dermatological and ocular health. Early diagnosis, interdisciplinary collaboration, and tailored treatments are essential for managing these complex conditions effectively.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Syphilitic Optic Neuropathy: A Prospective Cross-Sectional Study.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-06 DOI: 10.1080/09273948.2025.2456654

Kui-Fang Du, Hai-Yan Li, Xiao-Dan Wang, Xiao-Na Li, Wen-Jun Kong, Lian-Yong Xie, Ming Zhang, Zhen-Zhen Yan, Wen-Jia Weng, Hong-Wei Dong, Yan-Qing Gao

{"title":"Assessment of Syphilitic Optic Neuropathy: A Prospective Cross-Sectional Study.","authors":"Kui-Fang Du, Hai-Yan Li, Xiao-Dan Wang, Xiao-Na Li, Wen-Jun Kong, Lian-Yong Xie, Ming Zhang, Zhen-Zhen Yan, Wen-Jia Weng, Hong-Wei Dong, Yan-Qing Gao","doi":"10.1080/09273948.2025.2456654","DOIUrl":"https://doi.org/10.1080/09273948.2025.2456654","url":null,"abstract":"Purpose: To evaluate the clinical features of syphilis optic neuropathy (SON) and explore its underlying pathogenesis by measuring the peripapillary retinal nerve fiber layer (pRNFL).Methods: This was a prospective cross-sectional study. Syphilitics, regardless of ocular complaints, in the ophthalmology department in 2020 were screened for SON, which was defined as isolated optic neuropathy without overt signs of syphilitic uveitis. We analyzed the demographic and clinical information, including ultra-wide-field fundus photographs, fundus fluorescein angiography (FFA), and pRNFL thickness measured by spectral-domain-OCT (SD-OCT).Results: Of 577 cases with syphilis, 25 patients (4.3% ± 0.8%) presented with optic disc edema and 7 patients (1.2% ± 0.5%) with optic atrophy. Of the eyes with optic disc edema, (35 eyes, 40% biocular), 40% had no ocular symptoms, and 45.7% had visual acuity (VA) better than 20/25, whereas 100% showed optic disc leakage in FFA. Of the eyes with optic atrophy (14 eyes, 100% biocular), 100% were male and presented severe vision impairment (VA worse than 20/70), but no optic disc leakage in FFA. A higher rapid plasma reagin (RPR) level was more frequently observed in patients with SON (p = 0.009). Additionally, the pRNFL thickness in non-ocular syphilis was not related to the RPR level or the syphilis duration (all p > 0.05).Conclusion: The SONs could manifest as asymptomatic optic disc edema or blinding optic atrophy, which were independent episodic reactions from ocular or cerebral syphilis, respectively. Our data highlighted the need for ophthalmic screening and prompt neurosyphilis treatment.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Bilateral Irreversible Loss of Vision in a Young Child Due to Mumps Retinitis.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-06 DOI: 10.1080/09273948.2025.2476062

Vivek B Wani, Deepashri Mutalik, Padmamalini Mahendradas, Mounesh Patil

{"title":"A Case of Bilateral Irreversible Loss of Vision in a Young Child Due to Mumps Retinitis.","authors":"Vivek B Wani, Deepashri Mutalik, Padmamalini Mahendradas, Mounesh Patil","doi":"10.1080/09273948.2025.2476062","DOIUrl":"10.1080/09273948.2025.2476062","url":null,"abstract":"Purpose: To describe a case of severe visual loss due to bilateral retinitis after mumps fever in a young child.Methods: Observational case report.Case report: A five-year-old boy presented with bilateral blindness 2 days after suffering from fever and parotid swelling. His examination showed vision of only perception of light, grade 2 anterior chamber activity, outer retinal necrosis involving whole retina with frosted branch angiitis like picture, inferior retinal detachment and few retinal hemorrhages in both eyes. His optical coherence tomography of retina showed diffuse thickening of the retina, subfoveal fluid and subretinal hypereflective material (SHRM) at the posterior pole with diffuse disruption of EZ and external limiting membrane (ELM). The serological test was positive for IgG and IgM antibodies against mumps virus. He did not respond to intravenous methylprednisolone, oral valganciclovir, hyperbaric oxygen and plasmapheresis. He developed foveal thinning, loss of external limiting membrane, ellipsoid zone and retinal pigment epithelial signals on optical coherence tomography with final vision of perception of light only.Conclusions: Mumps retinitis is rare and can result in severe visual loss. The unique findings in our case were exudative retinal detachment, subretinal fluid and hyperreflective material at the posterior pole.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Risk of Retinal Vasculitis May Be Associated with Aflibercept 8 mg: A Pharmacovigilance Analysis of the FAERS Database.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-03-06 DOI: 10.1080/09273948.2025.2476061

M Hossein Nowroozzadeh, Maryam Hajipourkhorasani

{"title":"Increased Risk of Retinal Vasculitis May Be Associated with Aflibercept 8 mg: A Pharmacovigilance Analysis of the FAERS Database.","authors":"M Hossein Nowroozzadeh, Maryam Hajipourkhorasani","doi":"10.1080/09273948.2025.2476061","DOIUrl":"https://doi.org/10.1080/09273948.2025.2476061","url":null,"abstract":"Purpose: To evaluate the risk of retinal vasculitis and related adverse events (AEs) among five commercially available anti-vascular endothelial growth factor (anti-VEGF) agents using data from the FDA Adverse Event Reporting System (FAERS).Methods: A retrospective pharmacovigilance study was conducted using FAERS data from Q1 2004 to Q4 2024. Adverse drug reactions (ADRs) were categorized using the Medical Dictionary for Regulatory Activities (MedDRA), with \"Retinal Vasculitis\" as the primary outcome and \"Uveitis\" and \"Vitritis\" as secondary outcomes. Disproportionality analysis was performed using ranibizumab as the reference drug. Logistic regression identified associations between demographic factors and ADRs. The analysis included only reports linking a single drug to the ADR and was limited to patients aged ≥18 years.Results: Out of 49,114 initial reports 45,768 met the inclusion criteria. Retinal vasculitis was reported in 314 cases (0.7%), vitritis in 689 cases (1.5%), and uveitis in 1,344 cases (2.9%). Older age (OR 1.012; p = 0.045) and female sex (OR 1.747; p < 0.001) were significantly associated with retinal vasculitis. All agents showed higher odds of uveitis and retinal vasculitis compared to ranibizumab, with brolucizumab having the highest reporting odds ratio (ROR) for retinal vasculitis (331.61). Aflibercept 8 mg showed a significantly higher ROR (62.8) for retinal vasculitis compared to the 2 mg dose (3.82).Conclusions: This study identified a safety signal indicating a possible increased risk of retinal vasculitis with aflibercept 8 mg compared to the conventional 2 mg dose. This finding requires confirmation through future postmarketing studies.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-3"},"PeriodicalIF":2.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0