Ocular Immunology and Inflammation最新文献_第4页

Acute Angioid Streak Retinopathy is a Two-Phase Inflammatory Process Starting with Outer Retinal Inflammation, Followed by Secondary MEWDS. 急性血管样条纹视网膜病变是一个两阶段的炎症过程，从视网膜外炎症开始，继发MEWDS。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-19 DOI: 10.1080/09273948.2025.2505693

Sara Touhami, Sabrina Rigo, Emilien Faudi, Francesc March de Ribot, Bahram Bodaghi, Alain Gaudric

{"title":"Acute Angioid Streak Retinopathy is a Two-Phase Inflammatory Process Starting with Outer Retinal Inflammation, Followed by Secondary MEWDS.","authors":"Sara Touhami, Sabrina Rigo, Emilien Faudi, Francesc March de Ribot, Bahram Bodaghi, Alain Gaudric","doi":"10.1080/09273948.2025.2505693","DOIUrl":"https://doi.org/10.1080/09273948.2025.2505693","url":null,"abstract":"Purpose: To present a case of recurrent acute angioid streak retinopathy (AASR) and discuss its potential pathophysiological mechanisms based on multimodal imaging findings.Observations: A 19-year-old woman with pseudoxanthoma elasticum (PXE) experienced three distinct episodes of posterior segment inflammation associated with angioid streaks (AS), previously identified as AASR. Each episode started with acute subretinal inflammation due to a disruption of the retinal pigment epithelium (RPE)/Bruch's membrane (BM) complex at an AS site, which appeared as a peri-AS whitening on fundus photography. About one week later, as the peri-AS lesions resolved, multifocal white dots characteristic of multiple evanescent white dot syndrome (MEWDS) appeared around the optic disc and at the posterior pole. Multimodal imaging, including blue autofluorescence, fluorescein angiography, indocyanine green angiography, optical coherence tomography (OCT), and OCT-angiography, confirmed these findings. While the peri-AS lesions resembled multifocal choroiditis, they differed in their extension along the AS and faster resolution. Each AASR episode resulted in a detectable AS enlargement on fundus autofluorescence. These findings suggested that AASR could involve a two-phase inflammatory process: an initial disruption of the RPE/BM complex at an AS site triggering localized choroiditis/outer retinitis, followed by secondary MEWDS and subsequent AS enlargement.Conclusion: This case illustrates a recurring inflammatory pattern in PXE-associated AS, characterized by localized inflammation at AS sites with RPE/BM disruption, and secondary MEWDS. These findings highlight the pathophysiological mechanisms of AASR and its unique imaging features.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Anterior Segment Hyphema and Ocular Hypotony Following Treatment with Lutetium (177Lu) Vipivotide Tetraxetan (Pluvicto). 黄体（177Lu） Vipivotide Tetraxetan （Pluvicto）治疗双侧前段前房积血和低眼压。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-19 DOI: 10.1080/09273948.2025.2504582

Roger K Henry, Miriam Habiel, Aretha Zhu, Glen Gejerman, Albert S Khouri, Jonathan C Tsui

引用次数: 0

Bilateral Alternate Orbital and Ocular Manifestations in a VEXAS Syndrome Patient. 一名VEXAS综合征患者的双侧眼眶和眼部交替表现。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-19 DOI: 10.1080/09273948.2025.2507713

A Chierigo, M Akyol, B Sharma, J Michaels, F Afshar, V Joganathan, D Lorenzano

{"title":"Bilateral Alternate Orbital and Ocular Manifestations in a VEXAS Syndrome Patient.","authors":"A Chierigo, M Akyol, B Sharma, J Michaels, F Afshar, V Joganathan, D Lorenzano","doi":"10.1080/09273948.2025.2507713","DOIUrl":"https://doi.org/10.1080/09273948.2025.2507713","url":null,"abstract":"Purpose: VEXAS syndrome, caused by somatic UBA1 gene mutations, is a recently described autoinflammatory disorder characterized by systemic inflammation and hematologic abnormalities. Ocular involvement occurs in 28-40% of cases. This report describes a unique case of VEXAS syndrome with recurrent bilateral orbital and ocular inflammation, including the first documented concurrent ocular and orbital disease in the same patient, as well as of vitritis.Methods: A 79-year-old male presented with recurrent bilateral orbital and ocular inflammation, featuring periorbital oedema, dacryoadenitis, fibrinous anterior uveitis, vitritis, and macular oedema. He also developed fatigue, malaise, weight loss, dry cough, shortness of breath, joint and muscle pain, and chest pain and was followed for over one year.Results: Diagnostic work-up included multimodal ophthalmic imaging, CT orbits and serologic testing. The diagnosis was confirmed by genetic testing for UBA1 mutation and bone marrow biopsy. Treatment with oral corticosteroids led to complete resolution of symptoms, both ophthalmologically and systemically, and tocilizumab was later added as a second line immunosuppression steroid-sparing agent.Conclusions: This case emphasises the importance of considering VEXAS syndrome in the diagnosis of patients with recurrent orbital and ocular inflammation. It also reiterates the effectiveness of corticosteroids and tocilizumab association in managing this complex condition, contributing to the growing understanding of VEXAS syndrome and its ophthalmological features.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Intravitreal Onchocerciasis Associated with Panuveitis: A Case Report. 双侧玻璃体内盘尾丝虫病合并全葡萄膜炎1例。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-19 DOI: 10.1080/09273948.2025.2508409

Huseyin Baran Ozdemir, Benay Karabulut, Funda Dogruman Al, Ihsan Gokhan Gürelik

引用次数: 0

Paracentral Acute Middle Maculopathy in IRVAN Syndrome: A Case Report Highlighting Vascular Mechanisms. IRVAN综合征的中央旁急性中黄斑病变：一个强调血管机制的病例报告。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-16 DOI: 10.1080/09273948.2025.2507711

Ana Paula Couto, Giovanna Provenzano, Bruno F Fernandes, Raul N G Vianna

{"title":"Paracentral Acute Middle Maculopathy in IRVAN Syndrome: A Case Report Highlighting Vascular Mechanisms.","authors":"Ana Paula Couto, Giovanna Provenzano, Bruno F Fernandes, Raul N G Vianna","doi":"10.1080/09273948.2025.2507711","DOIUrl":"https://doi.org/10.1080/09273948.2025.2507711","url":null,"abstract":"Purpose: To describe a rare case of paracentral acute middle maculopathy (PAMM) in a patient with idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome, highlighting potential vascular mechanisms underlying this association.Methods: Observational Case report.Results: An 18-year-old male previously diagnosed with bilateral IRVAN syndrome presented with a sudden paracentral scotoma in the left eye. Multimodal imaging showed multiple macroaneurysms, retinal hemorrhages, focal arteriolar vasculitis, and lipid exudation in both eyes. Swept-source optical coherence tomography (SS-OCT) of the left eye revealed a hyperreflective band in the inner nuclear layer in the paracentral temporal superior macular area, consistent with PAMM, without clear evidence of arterial compression. A conservative approach was chosen, and after three years of follow-up, retinal features and visual acuity remained stable.Conclusion: PAMM may manifest in IRVAN independent of detectable localized aneurysm compression of the deep capillary plexus. The findings underscore the importance of multimodal imaging and long-term monitoring to assess ischemic complications. Further investigations are warranted to clarify the pathophysiological relationship between these conditions.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-3"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of Clinical Ophthalmic Presentations in Children with Presumed Trematode-Induced Ocular Inflammation in Beni Suef, Egypt. 在埃及贝尼苏韦夫，推测为虫源性眼部炎症的儿童的临床眼科表现模式。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-16 DOI: 10.1080/09273948.2025.2503336

Hossam El Din Mohamad Ahmed Khalil, Khaled Abdelaziz, Asmaa Mohamad Samir, Alaa Khalid Shalaby

{"title":"Patterns of Clinical Ophthalmic Presentations in Children with Presumed Trematode-Induced Ocular Inflammation in Beni Suef, Egypt.","authors":"Hossam El Din Mohamad Ahmed Khalil, Khaled Abdelaziz, Asmaa Mohamad Samir, Alaa Khalid Shalaby","doi":"10.1080/09273948.2025.2503336","DOIUrl":"https://doi.org/10.1080/09273948.2025.2503336","url":null,"abstract":"Purpose: To identify all possible ophthalmic presentations in children with Presumed trematode-induced uveitis, and determine their incidence in Beni Suef. Additionally, it explores potential correlations between ocular signs and demographic variables.Methods: The study is a retrospective, case series which was conducted in three phases. The first phase involved subject recruitment and demographic data collection. The second phase included a thorough general examination and laboratory workup. In the third phase, ophthalmological examination was conducted.Results: A total of 83 patients (99 eyes) were included. 80 of them were males. The mean age was 11.1 ± 2.7 years. Unilateral ocular involvement was seen in 66 patients. Anterior chamber granuloma was the most frequent presentation (71.7%), followed by ciliary body granuloma (15.2%) and vitritis (13.1%). Corneal granuloma occurred in 10.1%, macular edema in 9.1%, episcleral involvement in 6.1%, and iris involvement in 5.1%. Complications included cataracts (9 cases) and phthisis bulbi (1 case). One case showed hemorrhagic AC granuloma. Anterior chamber granuloma was more common in older children (mean age 11.5 years, p = 0.010), while vitritis was more common in younger ones (mean age 9.1 years, p = 0.029). No significant correlation was found between ocular signs and residence.Conclusion: In Beni Suef, children with presumed trematode-induced uveitis have diverse ocular manifestations, primarily anterior chamber and ciliary body granulomas with vitritis. Complications such as cataract and phthisis bulbi may occur. Atypical cases, including hemorrhage within a granuloma, may develop. The study suggests age-related variations in ocular signs but no significant correlation with residence.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical Coherence Tomography Biomarkers in Acute Vogt-Koyanagi-Harada Disease: Clinical Significance of Hyperreflective Outer Nuclear Layer and Bacillary Layer Detachment. 急性Vogt-Koyanagi-Harada病的光学相干断层扫描生物标志物：高反射外核层和细菌层脱离的临床意义。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-15 DOI: 10.1080/09273948.2025.2504583

Kubra Ozdemir Yalcinsoy, Merve Inanc Tekin, Pinar Cakar Ozdal

{"title":"Optical Coherence Tomography Biomarkers in Acute Vogt-Koyanagi-Harada Disease: Clinical Significance of Hyperreflective Outer Nuclear Layer and Bacillary Layer Detachment.","authors":"Kubra Ozdemir Yalcinsoy, Merve Inanc Tekin, Pinar Cakar Ozdal","doi":"10.1080/09273948.2025.2504583","DOIUrl":"https://doi.org/10.1080/09273948.2025.2504583","url":null,"abstract":"Purpose: To assess the clinical importance of hyperreflective outer nuclear layer (HONL) and bacillary layer detachment (BALAD) on optical coherence tomography in acute Vogt-Koyanagi-Harada (VKH) disease.Methods: A retrospective analysis of 24 patients with acute VKH, involving at least 12 months of follow-up.Results: Among the 42 eyes with serous retinal detachment (SRD) at presentation, BALAD was identified in 21 eyes (50%) and HONL in 23 eyes (55%). Eyes with BALAD and HONL had poorer median best corrected visual acuity (BCVA) at baseline (p = 0.023, p = 0.002), but the final BCVA showed no difference between groups (p = 0.965, p = 0.287). The height of SRD at presentation was greater in eyes with BALAD and HONL than those without (p = 0.026, p < 0.001).HONL was strongly associated with SRD height (p < 0.001). The rates of loss of ellipsoid zone (EZ) and retinal pigment epithelium (RPE) integrity were higher in eyes with BALAD at 1 month (p < 0.05), although no significant difference was noted at 1 year (p = 0.520). In the HONL group, EZ and RPE integrity loss rates were higher at 1 month and 1 year (p < 0.05). Subfoveal choroidal thickness values did not vary based on the presence of HONL or BALAD at 1 month, 1 year, and during the last visit after treatment (p > 0.05). Ocular complication and recurrence rates were comparable across all groups (p > 0.05). HONL and BALAD were not considered significant risk factors for recurrence (p > 0.05).Conclusion: In patients with acute VKH, HONL and BALAD were associated with more severe clinical features at presentation. However, HONL and BALAD did not affect long-term visual prognosis, recurrence, and development of ocular complications.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Topical Fumagillin 0.007% in the Management of Microsporidial Stromal Keratitis: Interventional Pilot Study with Literature Review. 0.007%外用富马青霉素治疗微孢子菌间质角膜炎的初步研究及文献综述。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-13 DOI: 10.1080/09273948.2025.2501028

Amrita Mohanty, Savitri Sharma, Lakshminarayanan Gowtham, Bhupesh Bagga

{"title":"Role of Topical Fumagillin 0.007% in the Management of Microsporidial Stromal Keratitis: Interventional Pilot Study with Literature Review.","authors":"Amrita Mohanty, Savitri Sharma, Lakshminarayanan Gowtham, Bhupesh Bagga","doi":"10.1080/09273948.2025.2501028","DOIUrl":"https://doi.org/10.1080/09273948.2025.2501028","url":null,"abstract":"Purpose: The standard management of Microsporidial Stromal Keratitis (MSK) traditionally involves therapeutic penetrating keratoplasty, often accompanied by complications. This pilot study investigated medical management, evaluating outcomes using topical fumagillin alone or in combination with topical voriconazole and oral albendazole.Methods: Mild to moderate MSK cases (January 2019-2024) with informed consent were included. The diagnosis was confirmed by microsporidial spores on smear (potassium hydroxide with calcofluor white, Gram, or modified Ziehl-Neelsen stain). Patients received 0.007% topical fumagillin (Sigma-Aldrich, F6771) alone or with topical voriconazole and oral albendazole.Results: Five patients (six eyes, 17.2%) of 29 MSK cases were enrolled, all males, with a mean age of 52.4 ± 12.3 years (37-74). Symptoms lasted 5.2 ± 3.8 months (1-12) before presentation. The mean IOP was 27.6 ± 7.6 mmHg; two were on anti-glaucoma medications. Corneal infiltrates measured 3.4 ± 0.8 mm (horizontal) and 3.4 ± 1.4 mm (vertical). Three patients received additional topical voriconazole 1% (Vozole) and oral albendazole 400 mg daily for 1 month. Clinical resolution occurred in all cases after 9.4 ± 5.2 months of treatment, with no recurrence over a 12.6 ± 3.4-month follow-up.Conclusion: The findings of this study support the potential of medical management for MSK, suggesting that topical fumagillin 0.007% may offer a viable treatment option for mild to moderate cases.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated Varicella-Zoster Virus-Associated Acute Retinal Necrosis in a Post-Bone Marrow Transplant Patient. 骨髓移植后患者弥散性水痘-带状疱疹病毒相关急性视网膜坏死

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-10 DOI: 10.1080/09273948.2025.2503327

Sai Bhakti Mishra, Ankush Kawali, Padmamalini Mahendradas, Rohit Shetty

{"title":"Disseminated Varicella-Zoster Virus-Associated Acute Retinal Necrosis in a Post-Bone Marrow Transplant Patient.","authors":"Sai Bhakti Mishra, Ankush Kawali, Padmamalini Mahendradas, Rohit Shetty","doi":"10.1080/09273948.2025.2503327","DOIUrl":"https://doi.org/10.1080/09273948.2025.2503327","url":null,"abstract":"Purpose: This case report highlights the risk of viral infections, particularly acute retinal necrosis (ARN), in patients undergoing immunosuppressive therapy for graft-versus-host disease (GVHD) following bone marrow transplantation.Methods: A 45-year-old male with aplastic anaemia who underwent a bone marrow transplantation developed GVHD and was treated with ruxolitinib and tacrolimus. The patient presented with ocular symptoms and was diagnosed with pseudodendritic keratitis in the right eye and ARN in the left eye. The diagnosis was confirmed through PCR analysis of the anterior chamber tap.Results: The patient's right eye symptoms were resolved with topical acyclovir and supportive care, achieving a best-corrected visual acuity of 6/6. Following systemic and intravitreal antiviral therapy, ARN resolved in left eye with thinning and retinal detachment. The patient was not cleared for surgery due to his compromised systemic condition.Conclusion: Our case highlights the disseminated and asymmetric nature of herpes zoster infection in the context of severe immunosuppression. This emphasizes the need to balance effective GVHD treatment and reinforces the importance of ongoing vigilance and timely management of these high-risk individuals.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-3"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tubercular Retinitis and Retinal Vasculitis: Manifestations of a Shared Disease Spectrum. 结核性视网膜炎和视网膜血管炎：共同疾病谱的表现。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-10 DOI: 10.1080/09273948.2025.2501737

Soumyava Basu, Ronnie Abhishek Talluri, Anup Kelgaonkar

{"title":"Tubercular Retinitis and Retinal Vasculitis: Manifestations of a Shared Disease Spectrum.","authors":"Soumyava Basu, Ronnie Abhishek Talluri, Anup Kelgaonkar","doi":"10.1080/09273948.2025.2501737","DOIUrl":"https://doi.org/10.1080/09273948.2025.2501737","url":null,"abstract":"Isolated retinal involvement in ocular tuberculosis (TB) is not well understood and remains largely underreported. TB retinal lesions can be classified into two broad categories: retinal vasculitis and isolated retinal granuloma. TB retinal vasculitis is the more recognized phenotype and may present with perivascular infiltrates alone or alongside other ocular signs such as subvascular lesions, focal vascular tortuosity, and occlusive vasculitis. These additional signs are crucial for diagnosing TB retinal vasculitis in TB-endemic regions. However, isolated retinal granulomas due to TB are rarely documented and poorly characterized. In this review, we have described the various clinical phenotypes of retinal TB, including a multimodal overview of an isolated intraretinal granuloma. We propose that TB retinitis and retinal vasculitis are part of a disease continuum of retinal TB. To support our hypothesis regarding retinal TB, we draw inferences from historical data derived from histopathological examinations of the eye as well as clinical and experimental studies on cerebral TB vasculitis. We have also reviewed other sites of TB vasculitis, such as the skin and major vessels, including the aorta. Understanding TB vasculitis in the brain and other organs could potentially elucidate not only the pathogenesis of retinal TB but also the diagnosis and management of this condition.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-13"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0