Ocular Immunology and Inflammation最新文献_第4页

Incident Ocular Inflammation After COVID-19 Infection in a US Veteran Population. 美国退伍军人感染 COVID-19 后出现眼部炎症。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-01-09 DOI: 10.1080/09273948.2023.2296035

Sydney Roston, Caroline L Minkus, Karen R Armbrust

{"title":"Incident Ocular Inflammation After COVID-19 Infection in a US Veteran Population.","authors":"Sydney Roston, Caroline L Minkus, Karen R Armbrust","doi":"10.1080/09273948.2023.2296035","DOIUrl":"10.1080/09273948.2023.2296035","url":null,"abstract":"Purpose: To investigate whether COVID-19 infection is a risk factor for incident ocular inflammatory disease.Design: Retrospective case-crossover study.Methods: The US Veterans Health Administration Corporate Data Warehouse was used to identify patients with positive COVID-19 testing and incident ocular inflammatory disease between March 2020 and May 2022. The timing of incident ocular inflammation and COVID-19 testing was assessed for each participant to determine whether positive COVID-19 testing occurred 0-60 days prior to incident ocular inflammation diagnosis (risk period) or 15-75 days after incident ocular inflammation diagnosis (control period). The main outcome measure was the odds of positive COVID-19 testing in the risk period versus control period.Results: Of the 1006 patients with incident ocular inflammation and a positive COVID-19 test in the study period, the age mean ± standard deviation was 62.6 ± 9.8 years and 840 (83%) were male. The odds of COVID-19 exposure was higher in the risk than control period (odds ratio [OR], 1.56; 95% confidence interval [CI], 1.04-2.36; P = 0.03). Ocular inflammation was more likely to be bilateral in the risk period (OR, 3.97; 95% CI, 1.01-23.01; P = 0.03). Other ocular features and demographic characteristics were similar in the risk and control periods. Most cases of ocular inflammation were quiescent at the most recent eye examination.Conclusions: Incident ocular inflammation is associated with COVID-19 infection, but the increased risk is small, and the ocular inflammation is typically acute.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1937-1944"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Key Pathological Indicators for Disease Progression in Vogt Koyanagi Harada Disease and Sympathetic Ophthalmia Through Advanced Choroidal Volume Analysis. 通过高级脉络膜体积分析揭示 Vogt Koyanagi Harada 病和交感神经性眼炎疾病进展的关键病理指标。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-05-06 DOI: 10.1080/09273948.2024.2337836

Akira Tanikawa, Kazuichi Maruyama, Shiyi Liu, Zaixing Mao, Zhenguo Wang, Nobuhiko Shiraki, Noriyasu Hashida, Ryo Kawasaki, Kinpui Chan, Kohji Nishida

{"title":"Unveiling Key Pathological Indicators for Disease Progression in Vogt Koyanagi Harada Disease and Sympathetic Ophthalmia Through Advanced Choroidal Volume Analysis.","authors":"Akira Tanikawa, Kazuichi Maruyama, Shiyi Liu, Zaixing Mao, Zhenguo Wang, Nobuhiko Shiraki, Noriyasu Hashida, Ryo Kawasaki, Kinpui Chan, Kohji Nishida","doi":"10.1080/09273948.2024.2337836","DOIUrl":"10.1080/09273948.2024.2337836","url":null,"abstract":"Purpose: To evaluate the association between quantitative parameters derived from volume analysis of optical coherence tomography (OCT) data and disease worsening in Vogt-Koyanagi-Harada disease (VKHD) and sympathetic ophthalmia (SO).Methods: This retrospective study, conducted at Osaka University Hospital, employed swept-source OCT scans from patients diagnosed with VKHD or SO between October 2012 and January 2021. The choroidal vessel structure was segmented and visualized in three dimensions, generating quantitative vessel volume maps. Region-specific choroidal vessel volume (CVV), choroidal volume (CV), and vessel index (VI) were scrutinized for their potential correlation with disease severity.Results: Thirty-five eyes of 18 VKHD and 2 SO patient (8 females, 10 males) were evaluated. OCT-derived CVV maps revealed regional CV alterations in VKHD and SO patients. Two parameters, i.e. CV at 3- and 6-month follow-ups (p = 0.044, p = 0.040, respectively, with area under the ROC curve of 0.70) and CVV at 6 months (p = 0.046, area under the ROC curve of 0.71), were significantly higher in recurrent VKHD and SO compared to effectively treated cases.Conclusions: The volume analysis of OCT images facilitates a three-dimensional visualization of choroidal alterations, which may serve as a reflection of disease severity in VKHD and SO patients. Furthermore, noninvasive initial CVV or CV measurements may serve as potential biomarkers for predicting disease recurrence in VKHD and SO.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"2170-2178"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Clinical Outcomes of the 0.18 Mg Fluocinolone Acetonide Intravitreal Implant Following Local Corticosteroid Burst in Noninfectious Uveitis. 非感染性葡萄膜炎患者局部注射皮质类固醇后，使用 0.18 毫克氟西诺龙-醋酸萘内酯玻璃体内植入剂的长期临床疗效。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-01-09 DOI: 10.1080/09273948.2023.2296031

Timothy M Janetos, Anjum Koreishi, Debra A Goldstein

{"title":"Long-Term Clinical Outcomes of the 0.18 Mg Fluocinolone Acetonide Intravitreal Implant Following Local Corticosteroid Burst in Noninfectious Uveitis.","authors":"Timothy M Janetos, Anjum Koreishi, Debra A Goldstein","doi":"10.1080/09273948.2023.2296031","DOIUrl":"10.1080/09273948.2023.2296031","url":null,"abstract":"Purpose: The 0.18 mg fluocinolone acetonide implant (FAi) is marketed for up to 36 months for treatment of noninfectious uveitis. An additional short-term corticosteroid burst prior to the 0.18 mg FAi, followed by attempt at long-term inflammation control with the 0.18 mg FAi may be beneficial given the low dose of the implant. We retrospectively reviewed all patients undergoing this treatment approach at our institution to determine its efficacy.Methods: Patients who received a corticosteroid burst followed by the 0.18 mg FAi with at least 6-month follow-up post 0.18 mg FAi were included. The primary outcome, treatment escalation (defined as worsening inflammation requiring escalation of therapy), was modeled using Kaplan-Meier analysis. Secondary outcomes included cystoid macular edema (CME), central macular thickness, retinal vasculitis, visual acuity, anterior chamber and vitreous cell, use of systemic therapy, use of corticosteroid drops, IOP, number of IOP lowering medications, need for glaucoma surgery, need for cataract surgery, and additional local corticosteroids.Results: 32 eyes were included (mean follow-up: 19.8 months). Prior to corticosteroid burst, 37.5% were on systemic therapy, 53% had CME, and 25% had retinal vasculitis. At FAi visit, CME had decreased to 18.8%. Mean time to treatment escalation after FAi was 20.3 months (95% CI 14.8-25.7 months). No patient discontinued systemic therapy and on average 15.0% of eyes required additional local corticosteroids at each follow-up interval.Conclusions: This treatment approach demonstrates that the 0.18 mg FAi is a useful adjuvant for the treatment of noninfectious uveitis but may not be adequate as solo therapy.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1923-1928"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uveitis and Dry Eye Disease in Children: A Cross-Sectional Comparative Study. 儿童葡萄膜炎和干眼症：横断面比较研究

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-02-20 DOI: 10.1080/09273948.2024.2317416

William Rojas-Carabali, Germán Mejía-Salgado, Valeria Villabona-Martínez, Doménico Barraquer-López, Carlos Cifuentes-González, Guillermo Marroquín, Pilar Del Rosario Guarnizo Zuccardi, Alejandra de-la-Torre

{"title":"Uveitis and Dry Eye Disease in Children: A Cross-Sectional Comparative Study.","authors":"William Rojas-Carabali, Germán Mejía-Salgado, Valeria Villabona-Martínez, Doménico Barraquer-López, Carlos Cifuentes-González, Guillermo Marroquín, Pilar Del Rosario Guarnizo Zuccardi, Alejandra de-la-Torre","doi":"10.1080/09273948.2024.2317416","DOIUrl":"10.1080/09273948.2024.2317416","url":null,"abstract":"Purpose: This study aims to evaluate the ocular surface characteristics in children diagnosed with uveitis and explore the association between uveitis and dry eye disease (DED).Methods: We included 84 children, 42 with uveitis and 42 healthy children. We performed the OSDI questionnaire and several ocular surface tests, including osmolarity, NITBUT, Schirmer test, and vital staining. We used Fisher's exact test and Mann-Whitney to compare variables and a binomial logistic regression to determine the factors associated with DED.Results: The difference in the prevalence of DED between uveitis (54.8%) and healthy (31%) groups was statistically significant (p < 0.05). Most patients with uveitis had mixed DED, and none of the healthy subjects had a severe form of the disease. There were no statistically significant differences in most of the tear film tests. However, all parameters tended to worsen in the uveitis group, and lipid layer thickness was thinner (p < 0.036). The uveitis group exhibited significantly more symptoms (p < 0.05). In the multivariate logistic regression, uveitis was associated with an odds ratio (OR) of 3.0 (95% CI: 1.07-8.42, p < 0.05) for DED.Conclusions: Our findings demonstrate a significantly higher prevalence of DED in children with uveitis compared to their healthy counterparts. Furthermore, our analysis indicates that the risk of DED in pediatric patients with uveitis is threefold higher than in healthy children. Therefore, it is crucial for clinicians to vigilantly monitor the development of DED in pediatric patients with uveitis and consider the implementation of preventive treatments.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"2045-2051"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Accuracy and Completeness of an Artificial Intelligence Large Language Model About Uveitis: An Evaluation of ChatGPT. 调查关于葡萄膜炎的人工智能大型语言模型的准确性和完整性：对 ChatGPT 的评估。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-02-23 DOI: 10.1080/09273948.2024.2317417

Rayna F Marshall, Krishna Mallem, Hannah Xu, Jennifer Thorne, Bryn Burkholder, Benjamin Chaon, Paulina Liberman, Meghan Berkenstock

{"title":"Investigating the Accuracy and Completeness of an Artificial Intelligence Large Language Model About Uveitis: An Evaluation of ChatGPT.","authors":"Rayna F Marshall, Krishna Mallem, Hannah Xu, Jennifer Thorne, Bryn Burkholder, Benjamin Chaon, Paulina Liberman, Meghan Berkenstock","doi":"10.1080/09273948.2024.2317417","DOIUrl":"10.1080/09273948.2024.2317417","url":null,"abstract":"Purpose: To assess the accuracy and completeness of ChatGPT-generated answers regarding uveitis description, prevention, treatment, and prognosis.Methods: Thirty-two uveitis-related questions were generated by a uveitis specialist and inputted into ChatGPT 3.5. Answers were compiled into a survey and were reviewed by five uveitis specialists using standardized Likert scales of accuracy and completeness.Results: In total, the median accuracy score for all the uveitis questions (n = 32) was 4.00 (between \"more correct than incorrect\" and \"nearly all correct\"), and the median completeness score was 2.00 (\"adequate, addresses all aspects of the question and provides the minimum amount of information required to be considered complete\"). The interrater variability assessment had a total kappa value of 0.0278 for accuracy and 0.0847 for completeness.Conclusion: ChatGPT can provide relatively high accuracy responses for various questions related to uveitis; however, the answers it provides are incomplete, with some inaccuracies. Its utility in providing medical information requires further validation and development prior to serving as a source of uveitis information for patients.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"2052-2055"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Spectrum of Ophthalmic Manifestations in Myelin Oligodendrocyte Glycoprotein-Associated Disease (MOGAD): A Comprehensive Case Report. 髓鞘寡突胶质细胞糖蛋白相关疾病（MOGAD）眼科表现的临床谱系：综合病例报告。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-03-04 DOI: 10.1080/09273948.2024.2325053

Sanjeev Kumar Dhoot, Vikas Lakhanpal, Sameer Peer, Sugandha Prakash

{"title":"Clinical Spectrum of Ophthalmic Manifestations in Myelin Oligodendrocyte Glycoprotein-Associated Disease (MOGAD): A Comprehensive Case Report.","authors":"Sanjeev Kumar Dhoot, Vikas Lakhanpal, Sameer Peer, Sugandha Prakash","doi":"10.1080/09273948.2024.2325053","DOIUrl":"10.1080/09273948.2024.2325053","url":null,"abstract":"Purpose: To describe diverse ocular manifestations in a patient with Myelin oligodendrocyte glycoprotein-associated disease (MOGAD).Methods: A 15-year-old Indian male had severe loss of vision in one eye, followed by a recurrent attack of optic neuritis in the fellow eye a few weeks later. He had a history of vision loss, speech disturbances, altered sensorium and was a confirmed case of Myelin oligodendrocyte glycoprotein-associated disease (MOGAD). Apart from optic neuritis, other rare ophthalmic associations, namely, macular neuroretinopathy, retinal haemorrhages, severe optic nerve head edema, peri neuritis, and orbital enhancement on magnetic resonance imaging (MRI) were noted.Results: He responded dramatically to treatment with intravenous pulse steroids and relapses were controlled with long-term immunomodulation therapy.Conclusion: This case report reiterates the need for early treatment with pulse steroids in MOGAD and depicts the heterogeneous involvement of various ocular structures in the disease.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"2254-2260"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Low-Dose Pyrimethamine Use for the Prevention of Ocular Toxoplasmosis Recurrences: A Cohort Study. 长期使用小剂量嘧霉胺预防眼弓形虫病复发：队列研究。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-03-05 DOI: 10.1080/09273948.2024.2321270

Yuslay Fernández Zamora, Paula M Marinho, João Rafael Oliveira Dias, Thiago Cabral, Julio Casoy, Cristina Muccioli, Heloisa Nascimento, Rubens Belfort

{"title":"Long-Term Low-Dose Pyrimethamine Use for the Prevention of Ocular Toxoplasmosis Recurrences: A Cohort Study.","authors":"Yuslay Fernández Zamora, Paula M Marinho, João Rafael Oliveira Dias, Thiago Cabral, Julio Casoy, Cristina Muccioli, Heloisa Nascimento, Rubens Belfort","doi":"10.1080/09273948.2024.2321270","DOIUrl":"10.1080/09273948.2024.2321270","url":null,"abstract":"Purpose: To describe the effect of long-term, low-dose pyrimethamine for the prevention of ocular toxoplasmosis (OT) recurrences.Methods: Sixty-three consecutive patients with inactive ocular toxoplasmosis and positive toxoplasma IgG serology were included. Pyrimethamine (25 mg) + folinic acid (15 mg) were administered every other day (three times weekly) for 12 months. Eighteen patients received the treatment for an additional six months as part of an extension study.Results: Thirty-eight patients (60.3%, n = 63) were female; 38 (60.3%) had a previous history of recurrence and 37 (58.7%) had active OT within the preceding 12 months. Three (4.8%) patients had unilateral recurrences at 8, 12 and 18 months after starting intermittent pyrimethamine treatment. Five patients (7.9%) were discontinued due to hematological, renal and hepatic changes. Treatment was considered successful in 42 patients (84%).Conclusion: Long-term, low-dose pyrimethamine can be considered as a treatment option for the prevention of ocular toxoplasmosis recurrence in selected patients, with only a few, mild and reversible systemic adverse events.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"2068-2073"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratic Precipitates: An Overlooked Sign of Microsporidial Stromal Keratitis? 角膜沉淀物：被忽视的小孢子菌基质角膜炎征兆？

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-03-21 DOI: 10.1080/09273948.2024.2329805

Ipsita Muni, Smruti Rekha Priyadarshini, Srikant Kumar Sahu, Sujata Das

引用次数: 0

Bilateral Retinal Venous Occlusion in Atypical Hemolytic-Uremic Syndrome Due to Complement Factor H Mutation. 补体因子 H 基因突变导致非典型溶血性尿毒症综合征双侧视网膜静脉闭塞

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-03-27 DOI: 10.1080/09273948.2024.2333401

Saban Gonul, Serhat Eker

{"title":"Bilateral Retinal Venous Occlusion in Atypical Hemolytic-Uremic Syndrome Due to Complement Factor H Mutation.","authors":"Saban Gonul, Serhat Eker","doi":"10.1080/09273948.2024.2333401","DOIUrl":"10.1080/09273948.2024.2333401","url":null,"abstract":"Purpose: Atypical hemolytic uremic syndrome (aHUS) is a rare progressive thrombotic microangiopathy caused by overactivation in the alternative complement pathway. A wide spectrum of environmental triggers, such as viruses, vaccination, drugs, pregnancy, neoplasms, transplant, and autoimmune diseases can cause aHUS in genetically susceptible individuals. In this report, the diagnosis and treatment process of aHUS and bilateral retinal venous occlusion (RVO) will be presented.Methods: Single-case, retrospective management of ophthalmological and systemic manifestations.Results: A 28-year-old G2P2 female with acute blurred vision and history of acute renal failure. She was diagnosed with preeclampsia in her gestation history. After the laboratory work-up, the diagnosis of aHUS was confirmed. She was treated with eculizumab following 14 days of plasmapheresis. However, her visual acuity was 20/20 on the right and 20/60 on the left at the time of admission. Retinal examination revealed flame-shaped hemorrhages, exudation, and macular edema. The patient was diagnosed with branch RVO in the right eye. Subsequently, central RVO was occurred in the left eye. Intravitreal dexamethasone implant was administered for both eyes since there was no reasonable regression in retinal findings with bevacizumab treatment. She went into remission and her BCVA reached 20/25 during the 12-month follow-up period under the eculizumab therapy.Conclusion: Diagnosis of aHUS is challenging especially during pregnancy and the postpartum period. Although ocular involvement is quite rare, we described bilateral RVO in aHUS case with homozygous nonsense mutation (c.2134 G > T p.G712). Dexamethasone implant should be considered for the treatment of RVO in aHUS cases.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"2285-2289"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Outcomes in Uveitic Glaucoma: Long-Term Evaluation of Trabeculectomy, Non-Penetrating Deep Sclerectomy, Ex-PRESS Shunt and Ahmed Glaucoma Valve. A 3-Year Follow-Up Study. 葡萄膜炎性青光眼的手术效果：小梁切除术、非穿透性深巩膜切除术、Ex-PRESS 分流术和 Ahmed 青光眼瓣膜的长期评估。三年随访研究。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-02-21 DOI: 10.1080/09273948.2024.2315194

David Aragón-Roca, David Oliver-Gutierrez, Sandra Banderas García, Jaume Rigo, Antonio Dou, Marta Castany

{"title":"Surgical Outcomes in Uveitic Glaucoma: Long-Term Evaluation of Trabeculectomy, Non-Penetrating Deep Sclerectomy, Ex-PRESS Shunt and Ahmed Glaucoma Valve. A 3-Year Follow-Up Study.","authors":"David Aragón-Roca, David Oliver-Gutierrez, Sandra Banderas García, Jaume Rigo, Antonio Dou, Marta Castany","doi":"10.1080/09273948.2024.2315194","DOIUrl":"10.1080/09273948.2024.2315194","url":null,"abstract":"Purpose: Uveitis can lead to secondary glaucoma, a condition with challenging management that can carry irreversible visual loss. Filtering surgery has demonstrated a higher failure rate, increased incidence of postoperative complications and reinterventions in uveitic patients. There is no consensus on the optimal surgical approach for uveitic glaucoma (UG) due to limited data comparing various intraocular pressure (IOP)-lowering surgeries. This retrospective cohort aims to assess the clinical outcomes of trabeculectomy (TBT), non-penetrating deep sclerectomy (NPDS), Ex-PRESS shunt and Ahmed glaucoma valve, providing additional insights into the long-term IOP control and safety of filtering surgeries in UG.Methods: The filtering surgery was performed on 32 eyes of 27 UG patients. Complete success was defined as IOP ≤ 18 mmHg or a 30% reduction. Qualified success allowed topical hypotensive treatment.Results: Complete success was 40.63% (13/32) at 12 months and 36.67% (11/30) at 36 months. Qualified success was 84.38% (27/32) at 12 months and 63.33% (19/30) at 36 months. In the survival analysis, both NPDS and Ex-PRESS demonstrated decreased failure rates compared to TBT (NPDS vs TBT: HR = 0.20, p = 0.049; Ex-PRESS vs TBT: HR = 0.28, p = 0.13). One or more reinterventions were required in 34.38% (11/32) of the eyes. NPDS had the lowest incidence of hypotony. Secondary cataract was a common complication in all groups.Conclusion: Various filtering surgeries are safe and effective procedures for lowering IOP and reducing the requirement of topical antihypertensives in UG at 36 months. However, one-third of the patients will require another IOP-lowering procedure.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"2008-2017"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0