Ocular Immunology and Inflammation最新文献

{"title":"The Quality of Life Impact of Acute Uveitis: A Prospective Study.","authors":"Juliana Rocha de Mendonça da Silva, Ana Luiza Biancardi, Henrique Maciel Vieira de Moraes, Haroldo Vieira de Moraes","doi":"10.1080/09273948.2025.2518253","DOIUrl":"10.1080/09273948.2025.2518253","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact on quality of life of acute uveitis diagnosis and management.</p><p><strong>Design: </strong>50 patients with acute uveitis were followed prospectively for three months in a tertiary hospital in Rio de Janeiro, Brazil. Vision-related (VR-) and health-related (HR-) quality of life (QoL) were respectively assessed by NEI-VFQ-25 and SF-36 questionnaires at the initial consultation and after three months. Associations between the questionnaire's subscale item scores with clinical/demographical data were assessed.</p><p><strong>Results: </strong>After generalized linear models, in the initial QoL evaluation lower visual acuity (VA) and unemployment/retirement were associated with lower scores in both questionnaires, while bilateral uveitis was associated with NEI-VFQ-25 questionnaire only and older age with SF-36 only. At the three-month QoL evaluation lower VA and older age were associated with lower scores and VA improvement with higher scores in both questionnaires and unemployment/retirement was associated with lower SF-36 score only. When evaluating the variation between the initial QoL scores and those after three months, older age was associated with lower VR- and HR-QoL improvement, while short interval between referral and the first appointment, higher final VA and VA improvement were associated with VR-QoL upgrade. Bilateral uveitis was associated with lower HR-QoL improvement.</p><p><strong>Conclusion: </strong>Older age and worse VA have a significant negative impact on VR-QoL and HR-QoL, while VA improvement has positive impact. Anatomic classification and etiology of uveitis did not seem to impact on variation of QoL during diagnosis and treatment of acute uveitis, as well as education level and self-reported color.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1643-1651"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide Trends in the Incidence and Use of Immunosuppressive Therapy for Non-Infectious Non-Anterior Uveitis in South Korea (2010-2021).","authors":"Sunjin Hwang, Jiyeong Kim, Min Ho Kang, Eun Hee Hong, Yong Un Shin","doi":"10.1080/09273948.2025.2524587","DOIUrl":"10.1080/09273948.2025.2524587","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the incidence of non-infectious non-anterior uveitis (NINAU) based on steroid prescriptions recorded in the Korean National Health Insurance Service (KNHIS) database, covering nearly the entire Korean population.</p><p><strong>Methods: </strong>Data were collected from patients diagnosed with uveitis who visited clinics between 2010 and 2021. Patients categorized as having NINAU prescribed steroids within one month were defined as \"true NINAU.\" We compared the demographics and underlying comorbidities between patients treated with steroids alone and those receiving immunomodulatory therapy (IMT). Additionally, we analysed trends in IMT use.</p><p><strong>Results: </strong>Among 38 271 patients with NINAU, the average incidence (per 100, 000 persons) was 6.2 (95% confidence interval, 6.1-6.3) increasing from 2010 to 2017 before gradually declining. Incidence rates increased with age. Most patients with NINAU were managed with systemic corticosteroids alone (approximately 89%); however, steroid-sparing IMT use increased from 2010 to 2021. By 2021, nearly one-third of patients treated with IMT required combination regimens, reflecting increased therapeutic complexity in refractory cases.</p><p><strong>Conclusion: </strong>We estimated the nationwide incidence of NINAU from the KNHIS database by incorporating steroid prescriptions as an additional criterion. These findings could help inform the national impact of NINAU in South Korea and may have implications for other countries.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1688-1696"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topographic, Biomechanical, in Vivo Confocal Microscopic and Ocular Surface Tests Evaluation of Corneal Changes and Dry Eye Disease in Patients with Scleroderma.","authors":"Yelda Yıldız Tascı, Nilufer Yesilirmak, Mehmet Icoz, Sukran Erten, Ozge Sarac","doi":"10.1080/09273948.2025.2528515","DOIUrl":"10.1080/09273948.2025.2528515","url":null,"abstract":"<p><strong>Purpose: </strong>To assess corneal tomographic and biomechanical changes and the presence of dry eye and in vivo confocal microscopic(IVCM) changes in patients with systemic sclerosis(SSc).</p><p><strong>Methods: </strong>This study with a prospective design included 52 eyes of 26 patients with SSc and 56 eyes of 28 healthy participants. Corneal tomography (Sirius dual imaging) provided keratometric data, corneal and anterior chamber parameters, and aberration values for all participants. An ocular response analyzer (Reichert Ophthalmic Instruments) was used to measure corneal biomechanics, while IVCM (Confoscan 4.0) assessed corneal subbasal nerve plexus, endothelium, and epithelium morphology. Presence of dry eye was examined using the tear break-up time(BUT) and ocular surface disease index(OSDI).</p><p><strong>Results: </strong>The mean follow-up period for the patients with SSc was 84 ± 84 (6-360 months) months. In the SSc group, tomographic measurements revealed significantly lower mean central corneal thickness, corneal volume, anterior chamber angle, and anterior chamber depth, alongside higher anterior elevation, trefoil, and spherical aberrations(<i>p</i> < 0.05 for all). There were no significant differences between the groups in terms of mean corneal biomechanical parameters (<i>p</i> > 0.05 for all). The IVCM measurements in the SSc group showed lower corneal subbasal nerve fiber length and density, nerve branch density, endothelial cell hexagonality, and intermediate epithelial cell count (<i>p</i> < 0.05 for all) when compared to the healthy subjects. The mean TBUT was lower, and the OSDI score was higher in the SSc group (<i>p</i> < 0.001 for both).</p><p><strong>Conclusion: </strong>This study demonstrated some changes in subbasal nerve plexus and endothelial cell morphology in patients with SSc along with decreased corneal thickness, volume, anterior chamber angle and depth, and increased higher order aberrations. Subjective and objective dry eye tests further showed dry eye in SSc patients.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1703-1711"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Sequential Herpes Simplex Type 2 Panophthalmitis in an Adult with a Toll-Like Receptor 4 Mutation.","authors":"Shiao W Wong, Sasa Pockar, Laura R Steeples, Felipe Dhawahir-Scala, Salma Babiker, Nicholas P Jones","doi":"10.1080/09273948.2025.2524586","DOIUrl":"10.1080/09273948.2025.2524586","url":null,"abstract":"<p><strong>Purpose: </strong>To present the first reported case of bilateral sequential Herpes Simplex Virus Type 2 (HSV-2) panophthalmitis causing severe vision loss in a young adult with a toll-like receptor 4 (TLR-4) mutation, with a review of previously reported cases of HSV-2 panophthalmitis.</p><p><strong>Methods: </strong>Retrospective case report.</p><p><strong>Results: </strong>A 29-year-old man presented with a severely painful, swollen left eye and vision loss. Visual acuity was no light perception in both eyes. Six years earlier, he had developed right panophthalmitis, the cause confirmed as Herpes Simplex Virus Type 2 (HSV-2) by polymerase chain reaction (PCR) on aqueous humour (AH) sampling, with a poor outcome. At current presentation, PCR of AH and vitreous samples again confirmed HSV-2 infection. A poor initial response to high-dose intravenous antiviral led to the addition of high-dose systemic corticosteroid. Subsequent phacovitrectomy enabled partial visual recovery. Genetic testing revealed TLR-4 mutation rs4986790 A/G.</p><p><strong>Conclusion: </strong>HSV-2 panophthalmitis is rare and visually destructive, and we present the first reported case of bilateral disease. We hypothesise that TLR-4 mutation, not previously reported in association with HSV ocular inflammation, may have contributed to excessive inflammation and severe ocular damage. We suggest comprehensive immunological evaluation in all patients with severe viral intraocular inflammation. Prompt diagnosis with PCR and immediate high-dose antiviral therapy is critical and immune abnormality may require amended management.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1886-1889"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Case Report of Successful Use of ILM Peeling, Inverted Flap and PRGF-Endoret® in Bilateral Macular Hole in Behçet's Disease.","authors":"Yann Bertolani, Julia Angrill Valls, Tetiana Goncharova, Eric Kirkegaard-Biosca, Laura Distefano, Claudia Garcia-Arumi, Jose Garcia-Arumi","doi":"10.1080/09273948.2025.2486363","DOIUrl":"10.1080/09273948.2025.2486363","url":null,"abstract":"<p><strong>Purpose: </strong>To report the successful use of internal limiting membrane peeling, inverted flap and plasma rich in growth factors in bilateral full-thickness macular hole in Behçet's disease.</p><p><strong>Methods: </strong>A comprehensive multimodal ophthalmological examination, including optical coherence tomography, fluorescein angiography and indocyanine angiography, was conducted along with a multidisciplinary approach. An individualized systemic immunosuppressive treatment was initiated, and surgical treatment was planned in both eyes.</p><p><strong>Results: </strong>A 29-year-old patient with bilateral full thickness macular hole was eventually diagnosed with Behçet's disease based on recurrent oral and genital ulcers and bilateral vitritis. Best corrected visual acuity at presentation was 20/400 in the right eye and 20/200 in the left eye. Treatment with steroids and azathioprine was initiated with an appropriate clinical response. Finally, a bilateral 25-G pars plana vitrectomy with internal limiting membrane peeling, inverted flap and application of plasma rich in growth factors (Endoret®) with C3F8 tamponade was performed. Successful bilateral closure was achieved and visual acuity improved to 20/100 in both eyes.</p><p><strong>Conclusion: </strong>Full thickness macular hole in young patients may be a sign of occult or uncontrolled Behçet's disease. The use of plasma rich in growth factors (Endoret®), ILM peeling and inverted flap may be a useful surgical approach in these cases.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1794-1798"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Anterior Uveitis Following Cataract Surgery.","authors":"Victoria Marks, Aleksandra M Golos, Mohsain Gill, Daniel Henick, Katie Li, Brian DeBroff, Ninani Kombo","doi":"10.1080/09273948.2025.2509716","DOIUrl":"10.1080/09273948.2025.2509716","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the incidence of and risk factors for persistent anterior uveitis following cataract surgery.</p><p><strong>Methods: </strong>This was a retrospective cohort study of patients who underwent cataract surgery at a tertiary referral center in Connecticut, USA. Those with prior uveitis, complex ocular pathology, concurrent procedures, and surgical complications were excluded. The outcome was development of persistent anterior uveitis, defined as anterior chamber cell grade ≥ 0.5+ and steroid treatment beyond two months. Patients who did and did not develop persistent anterior uveitis were compared using univariate and multivariate analysis.</p><p><strong>Results: </strong>Of 3341 patients (5419 eyes), 45 (61) developed persistent anterior uveitis (1.1% incidence). Cases were significantly younger (64.6 years vs. 69.6 years, <i>p</i> < 0.001), and there were significantly higher proportions of female (73.8% compared to 58.5%, <i>p</i> = 0.016) and Black or African American (54.1% vs. 15.5%, <i>p</i> < 0.001) patients, as well as those with age-related macular degeneration (9.8% vs. 1.5%, <i>p</i> < 0.001), previous intravitreal injections (14.8% vs. 6.0%, <i>p</i> = 0.004), and diabetes (18.0% vs. 8.9%, <i>p</i> = 0.013). In multivariate analysis, older age was associated with a significantly lower likelihood of persistent anterior uveitis (adjusted odds ratio (AOR) = 0.963, 95% confidence interval (CI)=[0.942, 0.984]), whereas Black race (AOR = 9.102, 95% CI = [4.836, 17.133]) and wet age-related macular degeneration (AOR = 37.700, 95% CI = [6.408, 221.792]) were associated with a significantly higher likelihood.</p><p><strong>Conclusions: </strong>In this study, 1.1% of eyes developed persistent anterior uveitis following cataract surgery. Younger age, Black race, and wet age-related macular degeneration should be investigated as potential risk factors to improve its prophylaxis, identification, and management.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1618-1623"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune Retinopathy in a Patient with Common Variable Immunodeficiency.","authors":"Chiara Muzio, Giuseppe Casalino, Chiara Mapelli, Marco Nassisi, Laura Dell'Arti, Alfredo Pece, Federica Fossataro, Giovanna Fabio, Maria Carrabba, Francesco Viola","doi":"10.1080/09273948.2025.2507712","DOIUrl":"10.1080/09273948.2025.2507712","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a rare case of posterior ocular involvement consistent with an autoimmune retinopathy (AIR) on multimodal retinal imaging in a patient with common variable immunodeficiency (CVID).</p><p><strong>Methods: </strong>Observational case report.</p><p><strong>Results: </strong>A 34-year-old male patient with a recent diagnosis of CVID was referred to our clinic following the incidental finding of retinal lesions in his eyes. He was asymptomatic and his best-corrected visual acuity (BCVA) was 20/20 in both eyes. Multimodal retinal imaging including optical coherence tomography and fundus autofluorescence revealed peripapillary and mid-peripheral hyperautofluorescent lesions associated with outer nuclear layer thinning and ellipsoid/interdigitation zones disruption in both eyes.PET/CT imaging ruled out systemic inflammation or malignancy and a diagnosis of a possible non-paraneoplastic AIR was established.During follow-up BCVA was stable, the patient remained asymptomatic, and the retinal imaging findings showed no progression. At 12 months, the patient reported new-onset occasional photopsias described as \"shimmering lights.\" Despite these symptoms, BCVA and retinal imaging remained stable.</p><p><strong>Conclusion: </strong>This case supports a potential association between CVID and immune-mediated retinal pathology, highlighting the importance of comprehensive ophthalmic evaluation and multimodal retinal imaging in CVID patients and further research into this association.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1811-1815"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Clinical Characteristics Among Herpetic Retinitis: Acute Retinal Necrosis and Cytomegalovirus Retinitis.","authors":"Hiromasa Hirai, Daiki Kuraoka, Tetsuo Ueda, Satoru Kase","doi":"10.1080/09273948.2025.2522955","DOIUrl":"10.1080/09273948.2025.2522955","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the characteristics of patients with herpetic retinitis, specifically acute retinal necrosis (ARN) and cytomegalovirus retinitis (CMVR).</p><p><strong>Methods: </strong>This retrospective study included patients who visited Nara Medical University Hospital between 2014 and 2024. A total of 38 patients (53 eyes) diagnosed with ARN or CMVR based on the diagnostic criteria were enrolled.</p><p><strong>Results: </strong>The ARN group (11 patients, 14 eyes) showed more anterior inflammation and peripheral lesions than the CMVR group (27 patients, 39 eyes). Although initial best-corrected visual acuity (BCVA) was similar between groups, the CMVR group demonstrated significantly better BCVA at the final visit (<i>p</i> = 0.004). Among eyes with poor initial BCVA (≥0.3 logMAR), significant post-treatment improvement was observed in the CMVR group but not in the ARN group (<i>p</i> = 0.006, <i>p</i> = 0.30, respectively). Subgroup analysis of CMVR revealed that HIV-positive patients were all male and significantly younger than HIV-negative patients (<i>p</i> = 0.029). HIV-negative patients were further classified based on having either hematologic disease or receiving immunosuppressive therapy. The hematologic disease subgroup had more bilateral involvement (<i>p</i> = 0.0498) and higher cytomegalovirus antigen-positive cell count on the cytomegalovirus antigenemia test (C7HRP, <i>p</i> = 0.049).</p><p><strong>Conclusion: </strong>Although both ARN and CMVR are caused by herpesviruses, they exhibit distinct clinical features and disease progression. CMVR subtypes can also be differentiated based on patient background and laboratory findings. Appropriate evaluation of the patient's background and clinical presentation is essential for management of herpetic retinitis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1679-1687"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous Candida Endophthalmitis: An Update on Epidemiological, Pathogenetic, Clinical, and Therapeutic Aspects.","authors":"Pietro Gentile, E Ragusa, R Bruno, F Ceccarelli, C Adani, E Bolletta, L De Simone, F Gozzi, L Cimino","doi":"10.1080/09273948.2025.2524013","DOIUrl":"10.1080/09273948.2025.2524013","url":null,"abstract":"<p><p>Endogenous Candida endophthalmitis (ECE) is a rare intraocular infection that poses a significant clinical challenge due to its potential to cause permanent visual impairment. ECE is caused by Candida spreading to the uvea and the retina during candidemia, in absence of recent ocular trauma. Candida <i>albicans</i> is the species most frequently involved, although in recent years non-<i>albicans</i> species have been on the rise, with distribution differences depending on the geographical area. The diagnosis is primarily based on the presence of specific risk factors (especially recent surgical interventions, diabetes, and immunosuppression) and on the clinical presentation, which is usually highly suggestive. Among imaging techniques, optical coherence tomography (OCT), with the typical \"rain-cloud\" sign, has notably improved diagnostic capability. Laboratory tests performed on ocular fluids, instead, have low sensitivity, so they often do not contribute to the diagnostic process. Therapeutic strategies are primarily based on systemic antifungal therapy, mainly fluconazole and amphotericin B (AmB), accompanied by vitrectomy and intravitreal injections of voriconazole or AmB in cases of significant vitreous involvement. The increase in Candida species resistant to currently available antifungal drugs necessitates a more appropriate use of these medications as well as the development of new drugs capable of eradicating the most challenging infections. This review examines the existing literature on ECE, covering its epidemiology, pathogenesis, diagnosis, prognosis, and management approaches.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1777-1793"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis.","authors":"Mahsa Pourmahdi-Boroujeni, Bahareh Abtahi-Naeini, Fereshte Rastegarnasab, Kimia Afshar, Mohammadreza Akhlaghi, Mohsen Pourazizi","doi":"10.1080/09273948.2025.2530144","DOIUrl":"10.1080/09273948.2025.2530144","url":null,"abstract":"<p><strong>Purpose: </strong>To systematically review and analyze reported cases of herpes zoster ophthalmicus (HZO)-related optic neuritis (ON) without retinal involvement, a potentially sight-threatening complication of varicella-zoster virus (VZV).</p><p><strong>Methods: </strong>A PRISMA-guided search of online databases from inception to January 31, 2025, identified case reports and series describing HZO-related ON without retinal involvement. Study quality was assessed using Joanna Briggs Institute checklists. Data on demographics, clinical features, diagnostics, treatments, and outcomes were analyzed using SPSS.</p><p><strong>Results: </strong>Thirty-two studies (1919-2025) comprising 38 patients were included. The mean patient age was 52.6 years (ranging from 6 to 82), with a near-equal gender distribution. Comorbid conditions such as human immunodeficiency virus (HIV) infection, diabetes, and autoimmune disorders were noted in one-third of cases. ON most commonly presented unilaterally and ipsilateral to the dermatome of HZO. The mean interval from HZO onset to ON was approximately 22 days (ranging from 10 days prior to 150 days afterward). Blurred vision and eye pain were the most frequent symptoms. Common signs include visual field defect, congestion, mydriasis, and ophthalmoplegia. Keratitis was the most common observation in slit-lamp examination (62.8% (22 of 35 cases)). Corticosteroid therapy, including high-dose and pulse regimens, was administered in a third-fourth (28 of 38) of patients. In outcome assessment, 52.8% (19 of 36) achieved mild or no impairment, while 36.3% (12 of 36) experienced clinical blindness.</p><p><strong>Conclusions: </strong>HZO-related ON is an uncommon but significant sight-threatening complication in HZO. Timely diagnosis and appropriate antiviral treatment along with corticosteroid therapy may improve the visual prognosis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1732-1747"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}