Ocular Immunology and Inflammation最新文献

{"title":"Clinical Features, Multimodal Imaging, and Neurological Differential Diagnoses in Recurrent Susac Syndrome.","authors":"Aaminah Haq, Saruban Pasu, Gillian Watson, Anastasia Pilat","doi":"10.1080/09273948.2026.2735419","DOIUrl":"https://doi.org/10.1080/09273948.2026.2735419","url":null,"abstract":"<p><strong>Background: </strong>Susac's syndrome (SuS) is a rare microangiopathy, often consisting of a classic, pathognomonic, clinical triad of sensorineural hearing impairment, encephalopathy, and retinal arterial occlusions. The variable presentation of SuS leads to underdiagnosis, despite the syndrome standing as an important differential in a variety of ophthalmic, neurological, and psychiatric presentations. Low case numbers and a fast progressive clinical course add to the difficulty of early recognition and treatment.</p><p><strong>Methods: </strong>We report on a case of Susac's syndrome in a 40-year-old woman with the classic clinical triad. We report multimodal imaging findings in a patient with recurrent Susac syndrome and discuss these findings in the context of the existing literature. Particular emphasis is placed on neurological differential diagnosis, especially differentiation from multiple sclerosis and other causes of retinal vascular occlusion with nervous system involvement.We summarise the literature of other conditions that can present with retinal vascular occlusion, their associated central nervous system involvement, and imaging changes.</p><p><strong>Results: </strong>Multimodal imaging demonstrated branch retinal artery occlusion (BRAO) with corresponding retinal ischaemic changes on optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA), together with characteristic corpus callosal lesions on magnetic resonance imaging (MRI). The combination of retinal vascular occlusion and central corpus callosal involvement is useful in distinguishing Susac syndrome from important neurological differentials such as multiple sclerosis.</p><p><strong>Conclusions: </strong>This case illustrates an example of how combined ophthalmic and neuroimaging findings may support recognition of recurrent Susac syndrome and facilitate distinction from other neurological disorders presenting with retinal vascular occlusion, particularly multiple sclerosis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>HLA-DRB1*15:01</i> Paediatric Uveitis: Ophthalmological Presentation and Follow-Up.","authors":"Jytte Hendrikse, Viera Kalinina Ayuso, Annette Ossewaarde-van Norel, Joke H de Boer","doi":"10.1080/09273948.2026.2734577","DOIUrl":"https://doi.org/10.1080/09273948.2026.2734577","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to describe the clinical presentation of the <i>HLA-DRB1*15:01</i> positive non-anterior uveitis phenotype in paediatric uveitis and to determine if early markers that may indicate a possible risk of MS, white matter lesions on brain MRI and OCT RNFL or GCL thinning, are present in this subgroup.</p><p><strong>Methods: </strong>In a cohort of 65 patients with non-infectious non-anterior paediatric uveitis patients we retrospectively characterized the uveitis phenotype based on underlying <i>HLA-DRB1*15:01</i> genotype and described the clinical parameters on OCT and FA of 87 <i>HLA-DRB1*15:01</i> negative and 37 <i>HLA-DRB1*15:01</i> positive eyes.</p><p><strong>Results: </strong><i>HLA-DRB1*15:01</i> positive patients had intermediate uveitis almost three times as often as <i>HLA-DRB1*15:01</i> negative patients with uveitis (70.0% versus 24.4% respectively, <i>p</i> = 0.001). Cells in the anterior chamber were seen less often in <i>HLA-DRB1*15:01</i> positive patients compared to in <i>HLA-DRB1*15:01</i> negative patients (55.0% versus 90.7% respectively, <i>p</i> = 0.001). Meanwhile, vitreous floaters were found more frequently in <i>HLA-DRB1*15:01</i>-positive compared to -negative cases (80.0% versus 53.3% respectively, <i>p</i> = 0.041). Also, fern-like capillary leakage was almost twice as common in <i>HLA-DRB1*15:01</i> positive compared to <i>HLA-DRB1*15:01</i> negative patients (64.7% versus 34.1% respectively, <i>p</i> = 0.032). Multiple sclerosis developed in one <i>HLA-DRB1*15:01</i> positive patient (5.0%), 15 years after intermediate uveitis was diagnosed.</p><p><strong>Conclusion: </strong>The <i>HLA-DRB1*15:01</i> allele is associated with intermediate uveitis in children, with absence of anterior chamber cells, presence of vitreous floaters and peripheral capillary fern-like leakage as distinct clinical features. At this point the usefulness of <i>HLA-DRB1*15:01</i> typing for predicting the risk of multiple sclerosis is yet to be determined.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Macrophage-Stimulating Protein (MSP) and RON Receptor Are Potential Novel Angiogenic Biomarkers in Proliferative Diabetic Retinopathy.","authors":"Ahmed Abu El-Asrar, Mohd Nawaz, Ajmal Ahmad, Mairaj Siddiquei, Eef Allegaert, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker","doi":"10.1080/09273948.2026.2734573","DOIUrl":"https://doi.org/10.1080/09273948.2026.2734573","url":null,"abstract":"<p><strong>Purpose: </strong>Macrophage-stimulating protein (MSP) as a crucial cytokine of the Hippo pathway mediates its activity via the tyrosine kinase receptor RON and functions in activating macrophages. We investigated the expression of the MSP/RON protein couple in the intraocular microenvironment of patients with proliferative diabetic retinopathy (PDR).</p><p><strong>Methods: </strong>Epiretinal fibrovascular membranes from 12 patients, vitreous fluid samples from 32 PDR and 25 nondiabetic patients, rat retinas, human retinal microvascular endothelial cells (HRMECs) and human retinal Müller glial cells were studied by ELISA, Western blot analysis and immunohistochemistry.</p><p><strong>Results: </strong>MSP and vascular endothelial growth factor (VEGF) levels were significantly higher in vitreous fluid samples from patients with PDR than in nondiabetic control patients (<i>p</i> < 0.001 for both comparisons). MSP levels in PDR patients with active neovascularization were significantly higher than those in involuted PDR patients (<i>p</i> < 0.001). Levels of MSP correlated significantly with those of VEGF. In epiretinal membranes, immunohistochemical analysis revealed MSP expression in CD68-expressing monocytes/ macrophages, vascular endothelial cells and myofibroblasts. RON expression was limited to monocytes/ macrophages. Significant positive correlations were detected between the numbers of blood vessels expressing CD31, reflecting angiogenic activity of PDR, and the numbers of blood vessels expressing MSP and stromal cells expressing MSP and RON. Western blot analysis demonstrated MSP expression in rat retinas, HRMECs and Müller cells.</p><p><strong>Conclusions: </strong>MSP and RON represent potential new biomarkers of angiogenesis in PDR.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Outcomes in Immune Checkpoint Inhibitor-Associated Uveitis.","authors":"Justin S Yun, Alessandro Feo, Leila Chew, Jeffrey Feng, Elizabeth Hutchins, Ashley F Stein-Merlob, Eric H Yang, Melissa G Lechner, Edmund Tsui","doi":"10.1080/09273948.2026.2735418","DOIUrl":"https://doi.org/10.1080/09273948.2026.2735418","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize clinical features and longitudinal outcomes in eyes with immune checkpoint inhibitor (ICI)-associated uveitis.</p><p><strong>Methods: </strong>Retrospective cohort study at a tertiary academic center (2015-2024). Eyes developing uveitis after ICI initiation were identified using ICD-9/10 codes and chart review. Baseline and final follow-up anatomic location of uveitis, SUN grades of inflammation, best-corrected visual acuity (BCVA) in logMAR, intraocular pressure, and treatment were collected.</p><p><strong>Results: </strong>Among 5,966 patients, 29 (50 eyes; 0.49%) developed uveitis, bilateral in 21 (72.4%). Most associated agents were pembrolizumab (27 patients, 93.1%), nivolumab (19, 65.5%), and ipilimumab (9, 31.0%). Anterior uveitis occurred in 22 patients (75.9%), posterior uveitis in 2 (6.9%), and panuveitis in 5 (17.2%); cystoid macular edema in 11 (37.9%). Median follow-up was 438 days (IQR: 101-921). Topical corticosteroids were used in 23 patients (79.3%) and intravitreal corticosteroid implants in 3 (10.3%). Baseline BCVA was ≤ 0.3 logMAR in 21/50 eyes (42.0%) and ≥1.0 in 8/50 (16.0%). Anterior chamber cells ≥ 1+ were present in 32/50 (64.0%), flare ≥ 1+ in 10/50 (20.0%), anterior vitreous cells ≥ 1+ in 11/50 (22.0%), and vitreous haze ≥ 1+ in 7/50 (14.0%). At final follow-up, BCVA ≤ 0.3 logMAR increased to 33/50 (66.0%) while 7/50 (14.0%) worsened to ≥1.0; median logMAR was 0.36 at baseline and 0.18 at final follow-up overall, without a statistically significant change. Anatomic subgroups also did not have statistically significant changes.</p><p><strong>Conclusions: </strong>ICI-associated uveitis often involved clinically significant inflammation and reduced vision. When promptly recognized and managed with appropriate therapy and close follow-up, long-term visual acuity was generally stable.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Adalimumab Initiation in Non-Infectious Uveitis: A Propensity Score Matched Analysis.","authors":"Cylvin Sim, William Rojas-Carabali, Carlos Cifuentes-Gonzalez, Zheng Xian Thng, Su Ling Ho, Bernard Yu-Hor Thong, Manisha Agarwal, Alok Sen, Jyotirmay Biswas, Ranju Kharel, Rina La Distia Nora, Anna Utami, Anadi Khatri, Padmamalini Mahendradas, Ariel Schlaen, Chitaranjan Mishra, Yan Guex-Crosier, Edmund Tsui, John H Kempen, Vishali Gupta, Alejandra de-la-Torre, Rupesh Agrawal","doi":"10.1080/09273948.2026.2734580","DOIUrl":"https://doi.org/10.1080/09273948.2026.2734580","url":null,"abstract":"<p><strong>Purpose: </strong>To identify factors associated with adalimumab initiation in non-infectious uveitis.</p><p><strong>Methods: </strong>This was a retrospective case-control study using multicentric data of 3204 patients. The primary outcome was whether adalimumab was initiated, and the secondary outcome was time to initiation. To investigate factors influencing the primary outcome, propensity score matching (1:3) of adalimumab recipients (<i>n</i> = 53, cases) to non-recipients (<i>n</i> = 159, controls) was done to reduce confounding by age, sex, race, anatomical category of disease, and follow-up time. Subsequently, subgroup analysis was performed among adalimumab recipients to investigate factors influencing time to initiation. Statistical methods included logistic regression and survival analysis of time to adalimumab initiation.</p><p><strong>Results: </strong>Factors which predicted for the primary outcome of adalimumab initiation included mixed autoimmune-autoinflammatory etiologies (multivariable OR = 3.97, CI: 1.37-12.21, <i>p</i> = 0.012) such as juvenile idiopathic arthritis (JIA), psoriasis and Behcet's disease, as well as the presence of retinal vasculitis (univariable OR = 2.10; CI: 1.06-4.09). Secondarily, among the 53 patients initiated on adalimumab, bilateral disease (adjusted survival HR = 2.07; CI: 1.08-3.98) and posterior uveitis (adjusted univariable logistic OR = 9.44; CI: 1.01-88.18) were associated with earlier adalimumab initiation, while the presence of keratic precipitates showed association with late adalimumab initiation (adjusted univariable OR = 0.18, CI: 0.03-0.93).</p><p><strong>Conclusion: </strong>Uveitis patients with underlying mixed autoimmune-autoinflammatory etiologies (specifically JIA, and likely Behcet's disease and psoriasis), and those with retinal vasculitis were more likely to be initiated on adalimumab. Bilateral or posterior disease may also influence earlier adalimumab initiation. Therefore, clinicians who encounter these phenotypes at patients' first presentation may wish to anticipate early escalation to adalimumab.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes in Toxoplasmic Retinochoroiditis: Comparing Intravitreal Clindamycin with and Without Adjunctive Steroids.","authors":"Sophia S Lam, Amanda Wong, Carl S Wilkins","doi":"10.1080/09273948.2026.2737310","DOIUrl":"https://doi.org/10.1080/09273948.2026.2737310","url":null,"abstract":"<p><strong>Purpose: </strong>The goal was to compare the clinical characteristics and visual outcomes of patients treated with intravitreal clindamycin with and without adjunctive steroids for vision-threatening toxoplasmic retinochoroiditis.</p><p><strong>Methods: </strong>A single-center retrospective cohort study of all toxoplasmic retinochoroiditis cases from January 1, 2013 to December 31, 2024 treated with intravitreal clindamycin was reviewed. Patients with vision-threatening disease and ≥3 months of follow-up data were included. Data collected included best-corrected visual acuity (BCVA), retinitis zone, aqueous and/or vitreous tap polymerase chain reaction results, number and type of intravitreal injections and systemic medications, complications and recurrence rates.</p><p><strong>Results: </strong>A total of 21 eyes from 20 patients were included. All patients were placed on oral antibiotic treatment. About 28.6% of eyes (6/21) received oral steroids, 28.6% of eyes (6/21) received adjunctive intravitreal dexamethasone injections, 23.8% of eyes (5/21) received both, and four eyes did not receive any adjunctive steroids. A mean of 3.2 intravitreal clindamycin injections were administered from initial to last follow-up visit. There was a statistically significant improvement of 0.54 logMAR in visual acuity regardless of treatment regimen (<i>p</i> < 0.008). Adjunctive corticosteroid exposure did not have a statistically significant difference in BCVA in this small retrospective cohort (<i>p</i> = 0.47).</p><p><strong>Conclusions: </strong>Patients with toxoplasmic retinochoroiditis treated with intravitreal clindamycin had significantly improved BCVA. The addition of intravitreal or oral steroids did not have a statistically significant difference on vision or complication rates in this small retrospective cohort. No cases of injection-related endophthalmitis or lens injury were observed, but the small sample size limits conclusions regarding safety.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recalcitrant infectious crystalline keratopathy caused by <i>Acanthamoeba</i> and <i>Fusarium</i> coinfection.","authors":"Doh Hoon Chung, Yang Kyung Cho","doi":"10.1080/09273948.2026.2744582","DOIUrl":"https://doi.org/10.1080/09273948.2026.2744582","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of successful resolution of infectious crystalline keratopathy caused by <i>Acanthamoeba</i> and <i>Fusarium</i> coinfection.</p><p><strong>Methods: </strong>A 56-year-old man with a history of topical corticosteroid and antiviral treatment presented with severe ocular pain and progressive visual loss in the right eye. Clinical findings, microbiological investigations, treatment, and outcomes were reviewed.</p><p><strong>Results: </strong>At the initial visit, the patient had decreased visual acuity, intense pain, and tearing in the right eye. Slit-lamp examination revealed a corneal infiltrate with an irregular margin of crystalline shape, epithelial defects, and hypopyon. Corneal smear with Gram stain showed <i>Acanthamoeba</i> cysts, and <i>Fusarium</i> growth was observed in cultures. Treatment with 0.5% moxifloxacin, 0.3% tobramycin, 1% voriconazole, and 0.04% chlorhexidine ophthalmic solution every hour was initiated. Corneal infiltration decreased and the hypopyon disappeared, but during a course of tapering eye drops, there was a recurrence of a crystalline corneal infiltrate, which eventually involved the central cornea. With extended aggressive treatment, the corneal infiltration decreased. The best-corrected visual acuity improved to 20/100 during the 6-month follow-up period.</p><p><strong>Conclusions: </strong><i>Acanthamoeba</i> and <i>Fusarium</i> coinfection can cause infectious crystalline keratopathy. Treatment was difficult due to the crystalline keratopathy itself and the concurrent coinfection. To prevent recurrent progression of infectious crystalline keratopathy caused by <i>Acanthamoeba</i> and <i>Fusarium</i> coinfection, vigilant follow-up with long-term aggressive medical treatment may be necessary, even when an early clinical improvement is observed.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal Tuberculosis in Miliary Disease: A Multimodal Imaging Spectrum Across Iatrogenic and Disease-Mediated Immunosuppression.","authors":"Anamika Patel, Ilaria Testi, William Tucker, Carlos Pavesio","doi":"10.1080/09273948.2026.2739467","DOIUrl":"https://doi.org/10.1080/09273948.2026.2739467","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the multimodal imaging findings of choroidal tuberculosis in two cases of miliary tuberculosis occurring in the setting of distinct forms of immunosuppression.</p><p><strong>Method: </strong>Retrospective analysis of four eyes with miliary choroidal tuberculosis.</p><p><strong>Results: </strong>Case 1 was a young male with newly diagnosed HIV infection and a CD4 count of 23 cells/μL presenting with bilateral multifocal choroidal lesions at first ophthalmic evaluation. Case 2 was a 41-year-old male with psoriatic arthritis on long-term methotrexate and adalimumab, with prior treated latent tuberculosis, who presented with a unilateral unifocal choroidal granuloma subsequently progressing to bilateral multifocal choroiditis following miliary dissemination. In both cases, ocular involvement was exclusively choroidal with no anterior chamber inflammation, vitritis, retinal vasculitis, capillaritis, or disc leakage in any eye. Indocyanine green angiography (ICGA) demonstrated the greatest lesion burden, identifying hypofluorescent foci not apparent on fundus fluorescein angiography or autofluorescence. Optical coherence tomography revealed a spectrum from subtle stromal lesions with minimal ellipsoid zone changes to large granulomas with subretinal fluid and choriocapillaris compression. Both cases responded to anti-tubercular therapy; adjunctive intravitreal bevacizumab facilitated resolution of subfoveal subretinal fluid in Case 2.</p><p><strong>Conclusions: </strong>Findings from these two cases support the possibility of choroidal involvement in miliary tuberculosis despite absent accompanying intraocular inflammation. ICGA may improve lesion detection and characterization of lesion burden in immunocompromised patients with otherwise unexplained choroidal lesions. These observations also support excluding tuberculosis before initiating empiric corticosteroid therapy, given the potential risk of precipitating systemic dissemination.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory Radiomic Analysis of Anterior Segment OCT Images in Patients with Vitreoretinal Lymphoma.","authors":"Fabrizio Gozzi, Marco Bertolini, Massimo Vicentini, Emanuele Ragusa, Valeria Trojani, Pamela Mancuso, Laura Verzellesi, Pietro Gentile, Luca De Simone, Elena Bolletta, Letizia Bartolini, Lucia Belloni, Alessandro Zerbini, Davide Nicoli, Enrico Farnetti, Stefano Ricci, Riccardo Valli, Magda Zanelli, Alberto Cavazza, Alberto Bavieri, Fiorella Ilariucci, Stefano Luminari, Francesco Merli, Martina Fantuzzi, Emma Celeo, Mirco Braghiroli, Michele De Maria, Areti Kosmarikou, Matteo Belpoliti, Marco Vecchi, Stefania Croci, Mauro Iori, Paolo Giorgi Rossi, Luca Cimino","doi":"10.1080/09273948.2026.2739454","DOIUrl":"https://doi.org/10.1080/09273948.2026.2739454","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the ability of a radiomics-based classification model of identifying anterior segment optical coherence tomography (AS-OCT) image features compatible with active vitreoretinal lymphoma (VRL). The secondary aim was to investigate the possible association between these image features and aqueous humour molecular biomarkers used in VRL assessment.</p><p><strong>Methods: </strong>We conducted a retrospective single-centre study of patients with biopsy-proven VRL, and at least one series of baseline or follow-up AS-OCT image scans and an aqueous tap. We extracted radiomic features from a manually delineated region of interest (ROI) in anterior vitreous AS-OCT images, five were selected and trained XGBoost classifiers with leave-two-patients-out cross-validation (L2PO) to distinguish active from inactive disease, using AUC-ROC as performance metric. If present, interleukin (IL)-10:IL-6 ratios were correlated with imaging features using logistic regression analyses.</p><p><strong>Results: </strong>Eight patients (22 visits total, 43 eyes) were analysed. From the L2PO analysis, we obtained an AUC metric of 0.74 with a 95% confidence interval (CI) of 0.68-0.81. GLRLM_LRLGE was the feature most consistently associated with disease activity. When IL-10:IL-6 > 1 was used as the outcome, the association weakened (all <i>p</i>-values > 0.05), though mean and median values showed the same direction of effect.</p><p><strong>Conclusions: </strong>This pilot study explored the potential innovative role of radiomics to analyse VRL activity status using AS-OCT images. Although it is currently far from being a clinical tool, radiomic analysis could be the subject of future investigations aiming to refine non-invasive monitoring strategies. Prospective studies with standardized, simultaneous serial imaging and aqueous tap are required.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between vascular risk factors and the presence of uveitic macular edema in non-infectious uveitis: A retrospective cohort study in a southern Spain population.","authors":"Irene Temblador-Barba, Javier Benitez-Del-Castillo, Alfredo Michan-Doña, Alejo Rodriguez-Suarez","doi":"10.1080/09273948.2026.2739453","DOIUrl":"https://doi.org/10.1080/09273948.2026.2739453","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the effect of age and other vascular risk factors (VRFs) - arterial hypertension (AHT), hypercholesterolemia, diabetes mellitus (DM), smoking, and obesity defined by a high body mass index (BMI) - on the presence of uveitic macular edema (UME) in patients with uveitis.</p><p><strong>Methods: </strong>A retrospective observational cohort study of 390 patients with non-infectious uveitis treated at the University Hospital of Jerez from 2015 to 2021 was carried out. Data collected included age, sex, follow-up time (months), AHT, hypercholesterolemia, DM, smoking, and BMI. Patients were divided into those with UME (<i>n</i> = 84) and those without UME (<i>n</i> = 306). Univariable and multivariable logistic regression models were applied to assess the association between VRFs and the presence of UME.</p><p><strong>Results: </strong>A total of 84 patients presented with UME (21.5%). Patients with a high BMI were 2.031 times more likely to develop UME (OR 2.031, 95% CI 1.238-3.331, <i>p</i> = 0.005) compared to those with normal weight. Smokers had a 1.681-fold increased risk compared to non-smokers (OR 1.681, 95% CI 1.003-2.817, <i>p</i> = 0.04).</p><p><strong>Conclusions: </strong>History of smoking and high BMI were significantly associated with a higher likelihood of UME in patients with uveitis. These findings may have important clinical implications, as smoking and high BMI are potentially modifiable factors. Recognizing and addressing these factors may contribute to improved risk management and disease control in patients with uveitis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}