Ocular Immunology and Inflammation最新文献

{"title":"Incidence, Mechanisms, and Clinical Characteristics of Traumatic Iritis: A Population-Based Analysis.","authors":"Kenny Y Wang, B Michelle Kim, Timothy T Xu, Margaret M Reynolds, David O Hodge, Wendy M Smith","doi":"10.1080/09273948.2024.2413899","DOIUrl":"10.1080/09273948.2024.2413899","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the incidence, mechanisms, and clinical characteristics of patients diagnosed with traumatic iritis in a U.S. Midwestern county population.</p><p><strong>Methods: </strong>Retrospective population-based cohort of all residents of Olmsted County, Minnesota diagnosed with traumatic iritis from January 1, 2006, to December 31, 2015. The medical records of patients with traumatic iritis were identified using the Rochester Epidemiology Project database, which contains virtually all medical care in the county. Medical records were reviewed for demographics, presentation, and follow-up data. Incidence rates were calculated per 100,000 per year.</p><p><strong>Results: </strong>There were 156 incident diagnoses of traumatic iritis during the 10-year study period, yielding an age- and sex-adjusted incidence rate of 10.7 per 100,000 per year. Traumatic iritis disproportionately occurred in male (<i>p</i> < 0.001) and Black (<i>p</i> < 0.001) patients. The mean age of diagnosis was 33 years (range: 4-96 years), mean number of traumatic iritis-specific follow-up visits was 2.1 (range: 0-26), and median duration of traumatic iritis-specific follow-up was 11 days (range: 1 day-1.6 years). There were 155 (99.4%) patients with unilateral disease. The most frequent mechanisms of traumatic iritis were sports-related (<i>N</i> = 29, 18.6%), assault-related (<i>N</i> = 23, 14.7%), scratch (<i>N</i> = 22, 14.1%), and work-related (<i>N</i> = 21, 13.5%) injuries. The mean initial and final best-corrected visual acuity (BCVA) of the affected eye was 20/40 and 20/30, respectively. Loss of follow-up was more frequently observed in Black patients (<i>p</i> < 0.001) and patients with smoking history (<i>p</i> = 0.004).</p><p><strong>Conclusion: </strong>Traumatic iritis was most frequently observed in younger males and Black patients. Common mechanisms included sports, assault, scratch, and work-related injuries.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"378-384"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveal Effusion Syndrome Due to WNT10A Mutation.","authors":"Gazal Patnaik, Sujatha Jagadeesh, Muna Bhende, Jyotirmay Biswas","doi":"10.1080/09273948.2024.2413903","DOIUrl":"10.1080/09273948.2024.2413903","url":null,"abstract":"<p><strong>Purpose: </strong>Uveal effusion syndrome (UES) is an exudative detachment of ciliary body, retina and choroid. Various underlying causes leads to UES-like drugs (topiramate), inflammation and hypotony. Wnt gene involvement has never been associated with UES. We report a case of bilateral UES being misdiagnosed as Vogt-Koyanagi-Harada syndrome (VKH), with Wnt gene dysfunction as the underlying trigger.</p><p><strong>Observations: </strong>A 32-year-old male presented with diminution of vision in his left eye. He was found to have choroidal detachment with retinal detachment in his left eye. Choroidal detachment was noted in the right eye. Various ocular imaging including fundus fluorescein angiography and ocular coherence tomography was done. He was misdiagnosed as a case of VKH syndrome, for which he was treated with systemic immunomodulatory therapy. However, a subclinical response was made to revisit the diagnosis. Ultrasound biomicroscopy showed supraciliary effusion. Systemic and genetic evaluation led to the detection of Wnt10A pathway mutation.</p><p><strong>Conclusions: </strong>UES is an entity of diagnostic challenge. Careful and thorough systemic evaluation is required to clinch the diagnosis. We reported the first case of bilateral UES recalcitrant to corticosteroids, with Wnt10A gene mutation.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"492-496"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Evanescent White Dot Syndrome (MEWDS) Secondary to Acute Retinal Pigment Epitheliitis: Possible Atypical Presentation of MEWDS?","authors":"Jacobo Emilio Enríquez-Fuentes, Fiorella Katherine Cuba-Sulluchuco, Juan Donate-López, José Ignacio Fernández-Vigo, Alicia Valverde-Megías","doi":"10.1080/09273948.2024.2416524","DOIUrl":"10.1080/09273948.2024.2416524","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of possible multiple evanescent white dot syndrome secondary (MEWDS) to acute retinal pigment epitheliitis (ARPE).</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 16-year-old female presented to the ophthalmology emergency department with a 5-day history of blurred vision in the left eye (OS). Initial examination revealed a visual acuity (VA) of 89 letters on the Early Treatment Diabetic Retinopathy Study (ETDRS)(-0.08 logMAR) chart in the right eye (OD) and 53 letters(0.64 logMAR) in the OS. Anterior segment biomicroscopy was normal, with no evidence of inflammation in the anterior chamber. Evaluation of the posterior pole revealed an alteration in the retinal pigment epithelium (RPE) in the OS. Optical coherence tomography (OCT) at the macular level showed disruption at the external limiting membrane (ELM), ellipsoid zone (EZ), interdigitation zone (IZ), and the RPE-Bruch's membrane (RPE-Bm) complex. Fundus autofluorescence (FAF) demonstrated hypofluorescent areas in the peripapillary region. No treatment was indicated. After two weeks, there was an improvement in VA, with 90 ETDRS letters(-0.1 logMAR) in the OD and 85 letters(0.0 logMAR) in the OS, as well as improvement in the OCT at the level of the ELM and EZ. However, a marked increase in white spots was observed throughout the posterior pole. By 5-months post-onset, a complete resolution of retinal alterations was observed in both OCT and FAF.</p><p><strong>Conclusion: </strong>ARPE and MEWDS exhibit overlapping clinical features, which can sometimes complicate differentiation. This case is consistent with MEWDS secondary to ARPE, although an atypical presentation of MEWDS cannot be ruled out.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"482-484"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Syphilis: The Resurgence of an Old Disease Experience of a Tertiary Centre in Portugal.","authors":"Celso Costa, Telma Machado, André Zhu, Rosa Sá, Fernando Rodrigues, Pedro Fonseca, João Gonçalo, Carolina Torres, Cristina Fonseca","doi":"10.1080/09273948.2024.2413902","DOIUrl":"10.1080/09273948.2024.2413902","url":null,"abstract":"<p><strong>Purpose: </strong>To estimate the number of ocular syphilis (OS) cases diagnosed in a tertiary care centre in Portugal, correlate with increasing syphilis diagnoses and characterize the OS population.</p><p><strong>Materials and methods: </strong>Retrospective, observational, single-center study that included patients diagnosed with OS between 2015 and 2023 at the local health unit of Coimbra. Demographic data were collected, and a complete ophthalmological examination was performed with multimodal imaging acquisition. Data on syphilis reports from the National System of Epidemiologic Surveillance were correlated with OS data.</p><p><strong>Results: </strong>Fifty-four patients with OS were observed; mean age was 54.17 ± 14.46 years, 38 (70.37%) were male and 18 (47.37%) men who have sex with men. The proportion of OS in syphilis patients per year ranged from 0% to 10.34%. One-quarter were co-infected with HIV. Forty-nine patients (91.84%) complained of decreased visual acuity on presentation. Twenty-two (40.74%) had systemic findings (mostly skin rash). Two-thirds had bilateral disease and half presented with anterior segment involvement. Eighty-five percent had posterior segment involvement, mostly placoid chorioretinitis. Forty-one percent had optic nerve involvement. All patients were admitted and underwent 2-week treatment with intravenous penicillin. Visual acuity improved from logMAR 0.70 to logMAR 0.26 (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Ocular syphilis is a heterogeneous disease with a wide range of presentations. The incidence is on the rise and therefore OS must be considered in every patient with anterior and posterior uveitis, panuveitis and optic neuritis, with or without systemic manifestations.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"385-395"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Findings in Corneal Endothelium by Confocal and Specular Microscopy in Patients with Fuchs Uveitis Syndrome Undergoing Phacoemulsification.","authors":"Miguel O Ibanez-Esparza, Roberto González-Salinas, Luz-Elena Concha-Del-Río, Patricia Navarro-López","doi":"10.1080/09273948.2024.2416531","DOIUrl":"10.1080/09273948.2024.2416531","url":null,"abstract":"<p><strong>Purpose: </strong>To compare corneal endothelial changes in patients with Fuchs Uveitis Syndrome (FUS) undergoing phacoemulsification surgery using confocal and specular microscopy.</p><p><strong>Methods: </strong>We included 14 patients with unilateral FUS and cataracts who underwent phacoemulsification surgery in a Mexican referral center for inflammatory eye diseases. Preoperative confocal and specular microscopies were conducted, establishing baseline images for subsequent analyses. Surgery on the FUS eye was performed by a single surgeon and an intraocular lens was implanted in all cases. Both specular and confocal microscopy were repeated 6 months after FUS eye surgery and compared with baseline images. We used Image J to do a manual segmentation of KP and determine their density for further analysis hence developing a new tool for confocal microscopy image analysis.</p><p><strong>Results: </strong>All patients underwent uneventful phacoemulsification surgery in the FUS eye. There was no significant change in endothelial cell density (ECD) from 2257 (±508.2) cells/mm2 preoperatively to 2214 (±535.1) cells/mm2 postoperatively (<i>p</i> = 0.809). Confocal microscopy revealed a decrease in Keratic Precipitate Density (KPD) from a median of 1413 (±2809.7) KPs/mm2 preoperatively to a median of 685.5 (1527.9) KPs/mm2 postoperatively (<i>p</i> = 0.036).</p><p><strong>Conclusions: </strong>Phacoemulsification surgery in patients with FUS produces no significant loss of endothelial cells and morphological changes that can be detected by confocal and specular microscopy. We found a reduction in KPD 6 months after surgery on confocal microscopy. Additionally, our manual segmentation technique for KPs utilizing Image J offers a novel and practical approach for confocal microscopy image analysis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"432-438"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Perceived Difficulty in Job Performance by Working Patients with Uveitis: Global Assessment and by Subscales of Work Demands.","authors":"Juan Luis Sánchez Sevila, José Rosas, José María Ramada Rodilla, Mar Seguí-Crespo","doi":"10.1080/09273948.2024.2415539","DOIUrl":"10.1080/09273948.2024.2415539","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate a worker's self-perceived difficulty in job performance as a whole and by subscales of job demands in a sample of working patients with uveitis and to analyze the relationship with sociodemographic, occupational, and clinical variables.</p><p><strong>Methods: </strong>A cross-sectional, cross-association study was conducted. Participants completed the Work Role Functioning Questionnaire (WRFQ) to assess self-perceived difficulty in job performance. Clinical data were collected from the patients' medical records or instruments used to evaluate clinical parameters in practice. Two clinical groups were established for this study. Bivariate and multivariate analyses were performed to assess associations between variables.</p><p><strong>Results: </strong>Sixty participants were included in the study. In the multivariate linear regression analysis, active uveitis was significantly associated with a worse WRFQ total score (coefficient, -25.1; 95% CI, -36.6 to -13.6; <i>p</i> < 0.001). Acute course uveitis was significantly associated with a better total score than recurrent and chronic uveitis (coefficient, 17.7; 95% CI, 3.7 to 31.7; <i>p</i> = 0.014). In bivariate analysis, patients with active uveitis also scored worse on all subscales and on the total score.</p><p><strong>Conclusions: </strong>Patients with active uveitis presented with greater self-perceived difficulty in the performance of their work as a whole and in all subscales of work demands. Patients with acute uveitis presented with less difficulty than those with recurrent and chronic uveitis. Early and correct treatment of uveitis in specialized units may reduce its impact on patients' work impairment.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"423-431"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Kytococcus schroeteri</i> Chronic Post-Operative Endophthalmitis After Cataract Surgery: The First Report of Ocular <i>Kytococcus</i> Infection.","authors":"Lewis Karapanos, Shivesh Varma, Penelope Allen","doi":"10.1080/09273948.2024.2417799","DOIUrl":"10.1080/09273948.2024.2417799","url":null,"abstract":"<p><strong>Purpose: </strong>To report the first case of <i>Kytococcus schroeteri</i> ocular infection manifesting as chronic post-operative endophthalmitis (CPOE) following routine phacoemulsification with intraocular lens (IOL) implantation. This gram-positive bacterium is recognised as a cause of hardware infections in immunocompetent hosts, such as prosthetic cardiac valves, ventriculoperitoneal shunts, and orthopaedic hardware, often necessitating surgical removal of the infected prostheses for cure.</p><p><strong>Methods: </strong>Case report and literature review.</p><p><strong>Results: </strong>A 64-year-old male with a history of uncomplicated cataract extraction and IOL insertion had multiple presentations over 6 years, with relapsing-remitting intraocular inflammation with multiple negative vitreous cultures treated as non-infectious panuveitis. An eventual positive vitreous culture for <i>K. schroeteri</i> led to a diagnosis of CPOE, which was successfully treated with vitrectomy, removal of IOL, and intravitreal vancomycin injections. However, advanced vision loss occurred due to secondary glaucoma.</p><p><strong>Conclusion: </strong><i>K. schroeteri</i> is a novel cause of CPOE, which is typically attributed to other low virulence organisms. As with infections of non-ocular implanted hardware by <i>K. schroeteri</i>, surgical removal of the infected IOL-capsule complex was required for cure. The CPOE diagnosis requires a combination of high index of suspicion and culture of vitreous and capsular material. The role of IOL removal for the treatment of CPOE is discussed.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"485-487"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Endothelial Changes in Chinese Patients with Fuchs' Uveitis Syndrome.","authors":"Yanlin Pu, Wanyun Zhang, Xinle Zhang, Lan Xia, Peizeng Yang","doi":"10.1080/09273948.2024.2417187","DOIUrl":"10.1080/09273948.2024.2417187","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the changes of corneal endothelial cells in Chinese patients with unilateral Fuchs' uveitis syndrome (FUS) and investigate the factors relevant to these changes.</p><p><strong>Methods: </strong>Bilateral specular microscopic examination was performed in 459 Chinese patients with unilateral FUS from April 2008 to April 2023. The affected eyes constituted the study group, while the contralateral eyes served as controls.</p><p><strong>Results: </strong>The median values of endothelial cell density (ECD), cell count, total cell size, and hexagonality were significantly lower in the FUS eyes compared to the control eyes (<i>p</i> < 0.001). The median values of average cell size, maximum cell size, SD of cell size, and CV were significantly higher in the FUS eyes compared to the control eyes (<i>p</i> < 0.001). Central ECD showed a negative correlation with age (<i>r</i> =  -0.339; <i>p</i> < 0.001), maximum IOP (<i>r</i> =  -0.127; <i>p</i> = 0.006), and the interval since symptom onset (<i>r</i> =  -0.172; <i>p</i> < 0.001). The ECD was lower in eyes with ocular hypertension compared to those without ocular hypertension (<i>p</i> < 0.001). Eyes with KPs distributed on the central corneal endothelium had a significantly lower ECD than those with KPs distributed diffusely or KPs distributed triangularly on the inferior corneal endothelium (<i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>Our findings suggest decreased ECD, increased cell size, and morphological alterations in the affected eyes of Chinese patients with FUS. The reduction in ECD is correlated with age, elevated IOP, the interval since symptom onset, and the distribution of KPs.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"439-445"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Ray of Hope in the Treatment of Seasonal Hyperacute Panuveitis: Could Intravitreal Triple Combination Therapy of an Antibiotic with Dual Steroids Play a Pivotal Role?","authors":"Ranju Kharel Sitaula, Pratap Karki, Haramaya Gurung, Eliya Shrestha, Hira Nath Dahal, Ananda K Sharma, Madan Prasad Upadhaya, Sagun Narayan Joshi","doi":"10.1080/09273948.2024.2414918","DOIUrl":"10.1080/09273948.2024.2414918","url":null,"abstract":"<p><strong>Introduction: </strong>Seasonal Hyperacute Panuveitis (SHAPU) is a blinding disease in Nepal with unknown aetiology. Henceforth, we proposed to study the treatment outcome of a triple intravitreal combination therapy of dual steroids triamcinolone (long-acting steroid) and dexamethasone (short-acting steroid) along with antibiotic moxifloxacin for patients with severe stage of SHAPU.</p><p><strong>Methods: </strong>A prospective study was conducted among the SHAPU patients presenting in severe stages during the September to December 2023 outbreak. Intravitreal injection of 4-mg preservative-free triamcinolone acetonide (4 mg/0.1 ml) with intravitreal dexamethasone injection (0.4 mg/0.1 ml) and 0.5 mg/0.1 ml of moxifloxacin was given in the operating theatre. Best corrected visual acuity, intraocular pressure measurements, vitreous haze and fundus evaluation, were assessed to determine the treatment outcome on examination on day 7 and day 30 following intravitreal combination therapy.</p><p><strong>Result: </strong>A total of 6 patients (2 female and 4 male) were enrolled. At presentation, the mean BCVA was 2.40 ± 0.30 logMAR, mean intraocular pressure was 12.8 mmHg and vitreous haze was 4+ haze in all cases. The evaluation on the 7^th day and 30^th after injection showed significant improvement in BCVA (<i>p</i> value = 0.039; <i>p</i> value = 0.040, respectively). The change in the IOP at day 7 (<i>p</i> value = 0.85) was insignificant. However, the IOP change was significant at day 30 (<i>p</i> value = 0.5). Similarly, there was a marked reduction in the vitreous haze with better fundus visibility after treatment.</p><p><strong>Conclusion: </strong>This study depicted that steroids prevent the dreaded complication of hypotony due to ciliary shutdown by combating severe inflammation, thus adding new hope to the armamentarium of SHAPU management.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"418-422"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Dutta Majumder et al.'s 2019 'Ocular Syphilis: An Update'.","authors":"Nicolas Nicolaou, Matthew Valentino, Despina Nicolaou","doi":"10.1080/09273948.2024.2414232","DOIUrl":"10.1080/09273948.2024.2414232","url":null,"abstract":"<p><p>The article <i>'Ocular Syphilis: An Update (2019)'</i> provides a thorough review of the challenges in diagnosing ocular syphilis. However, our research on 'Dermatological and Ocular Manifestations of Syphilis,' identifies a significant gap in both literature and clinical practice: the lack of recognition of dermatological signs during ophthalmological assessments. Ocular syphilis often mimics other conditions and can remain undiagnosed for months or years. Detecting dermatological signs, such as the characteristic palmar rash of secondary syphilis and extragenital chancres, could prompt earlier investigation and serological testing, reducing unnecessary diagnostic workups and inappropriate management. Early recognition would facilitate timely administration of Penicillin G, helping prevent vision loss, which is often reversible with prompt treatment. We urge <i>Ocular Immunology and Inflammation</i> to highlight the importance of incorporating dermatological assessments in future ocular syphilis publications to improve diagnostic protocols and patient outcomes.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"497-498"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}