Ocular Immunology and Inflammation最新文献_第3页

Corneal Perforation Associated with Pembrolizumab - A Case Report with Literature Review. Pembrolizumab相关的角膜穿孔- 1例报告并文献复习。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-01-30 DOI: 10.1080/09273948.2025.2456647

Dharshini Balasubaramaniam, Lim Yi Wen, Nurul Najieha Amir, Sujaya Singh

{"title":"Corneal Perforation Associated with Pembrolizumab - A Case Report with Literature Review.","authors":"Dharshini Balasubaramaniam, Lim Yi Wen, Nurul Najieha Amir, Sujaya Singh","doi":"10.1080/09273948.2025.2456647","DOIUrl":"10.1080/09273948.2025.2456647","url":null,"abstract":"Purpose: To shed light on one of the ocular adverse effects related to pembrolizumab.Method: Case report and literature review.Result: A 53-year-old gentleman with underlying Stage III B renal cell carcinoma with lung metastasis and gout presented in June 2021 with bilateral red eyes following Coronavirus disease (COVID-19) vaccination. He had undergone a nephrectomy for renal cell carcinoma and was on Pembrolizumab therapy for 5 years. Examination showed right eye injected conjunctiva with diffuse punctate epithelial erosions over the cornea, which was treated with topical steroids. The left eye is suspected to have infective keratitis, which is treated with topical antibiotics and subsequently steroids for the ocular surface inflammation. However, he developed a left eye paracentral sterile corneal melt which rapidly progressed to perforation measuring 1 mm in size. The perforation was temporarily sealed with tissue glue, but he eventually required a full thickness corneal patch graft. Patient has been doing well post-operatively for the last 3 years.Conclusion: The diagnosis and management of irAEs are challenging and necessitate continuously updated diagnostic and monitoring tools. As checkpoint inhibitors become more promising in the management of malignancies, it is crucial for both the oncologist and ophthalmologist to be aware of the potential ocular adverse effects of these drugs.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"868-870"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic Photoreceptoritis: An Unusual Variant of Outer Retinopathy. 特发性光感受器炎：一种不同寻常的外视网膜病变。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-02-12 DOI: 10.1080/09273948.2025.2461241

Yoo-Ri Chung, Adélaïde Toutée, Chérif Titah, Isabelle Audo, Michel Paques, Sarah Mrejen, Alain Gaudric, Bahram Bodaghi, Sara Touhami

{"title":"Idiopathic Photoreceptoritis: An Unusual Variant of Outer Retinopathy.","authors":"Yoo-Ri Chung, Adélaïde Toutée, Chérif Titah, Isabelle Audo, Michel Paques, Sarah Mrejen, Alain Gaudric, Bahram Bodaghi, Sara Touhami","doi":"10.1080/09273948.2025.2461241","DOIUrl":"10.1080/09273948.2025.2461241","url":null,"abstract":"Purpose: To report an unusual case of progressive photoreceptor disruption following a herpetic labial infection.Method: Case report of a patient with severe idiopathic photoreceptoritis.Results: A 46-year-old female patient presented with blurred vision and inferior photopsia in her right eye one week after a herpetic labial eruption. Initial examination revealed mild vitreous inflammation and focal photoreceptor alterations in the superior periphery of the right retina. Despite oral valaciclovir, the disease progressed rapidly, prompting referral to a tertiary care center. Autofluorescence and optical coherence tomography showed diffuse photoreceptor damage with impending foveal involvement. Extensive workup, including viral markers, was inconclusive. Given the temporal association with the herpetic infection and the sight-threatening progression, treatment was escalated to intravenous acyclovir and subsequently foscarnet for 2 weeks, which slowed down disease progression. The frontal margin of retinal foci stabilized with no further progression, while ellipsoid zone restoration was achieved following systemic corticosteroids and interferon alpha-2a.Conclusion: The term \"photoreceptoritis\" describes conditions involving diffuse photoreceptor damage, predominantly unilateral, without primary choriocapillaritis. This case highlights a severe form of photoreceptoritis with diffuse photoreceptors loss, likely triggered by a herpetic labial infection. The disease was stabilized with antiviral therapy, while structural recovery of the photoreceptors was achieved through anti-inflammatory and immunosuppressive treatments. This report underscores the importance of a multidisciplinary approach to managing atypical retinal inflammatory disorders.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"875-878"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes After Silicone Oil Removal in Patients with Acute Retinal Necrosis Who Underwent Vitrectomy. 玻璃体切除术后急性视网膜坏死患者硅油去除后的疗效。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-03-27 DOI: 10.1080/09273948.2025.2477193

Boya Lei, Xin Chen, Min Zhou, Ting Zhang, Ruiping Gu, Qinmeng Shu, Qing Chang, Gezhi Xu, Rui Jiang

{"title":"Outcomes After Silicone Oil Removal in Patients with Acute Retinal Necrosis Who Underwent Vitrectomy.","authors":"Boya Lei, Xin Chen, Min Zhou, Ting Zhang, Ruiping Gu, Qinmeng Shu, Qing Chang, Gezhi Xu, Rui Jiang","doi":"10.1080/09273948.2025.2477193","DOIUrl":"10.1080/09273948.2025.2477193","url":null,"abstract":"Purpose: To investigate the outcomes after silicone oil removal (SOR) in patients with acute retinal necrosis (ARN).Methods: Retrospective case series. Patients diagnosed with ARN-associated retinal detachment (RD) who underwent vitrectomy and silicone oil tamponade and subsequent SOR between January 2013 and December 2021 who were followed up for ≥1 year after SOR were included. The medical records before and after SOR were reviewed.Results: Fifty-three eyes from 52 patients were included. SOR was conducted at 201.3 ± 104.1 days (range, 63‒547) after vitrectomy. The duration of follow-up after SOR was 1266.8 ± 797.2 days (range, 384-3865). The logMAR BCVA before SOR, at 1 year after SOR, and at the last follow-up were 1.249 ± 0.816, 1.086 ± 0.791, and 1.488 ± 0.961. The intraocular pressure (IOP) at the corresponding times were 13.2 ± 3.6, 10.9 ± 3.4, and 10.4 ± 3.5 mmHg. Seven patients (13.5%) experienced recurrent RD at 81.0 ± 46.7 days (range, 18‒154) after SOR. At 1 year after SOR, 4 eyes (7.5%) had hypotony and 26 (49.1%) had macular edema; the corresponding numbers were 7 (13.5%) and 27 (51.9%) at the last follow-up. The IOP at the time of SOR (r = -0.438, p = 0.001) was the risk factor for the occurrence of hypotony after SOR (area under the ROC curve: 0.873; cutoff value: 11.30 mmHg).Conclusion: The BCVA and IOP continued to change after SOR in ARN patients. Ocular complications mostly occurred within the first year after SOR. IOP at the time of SOR was a main predictor of the clinical outcomes after SOR.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"751-758"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Understanding the Causes, Management and Outcomes of Acute Retinal Necrosis. 急性视网膜坏死的病因、治疗和预后的研究进展。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-06-24 DOI: 10.1080/09273948.2025.2508115

Derrick P Smit, Jennifer E Thorne, Ilknur Tugal-Tutkun

引用次数: 0

Acute Retinal Necrosis Caused by Varicella Zoster Virus and Cytomegalovirus Co-Infection. 水痘带状疱疹病毒和巨细胞病毒合并感染引起的急性视网膜坏死

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2024-09-25 DOI: 10.1080/09273948.2024.2404092

Maria Paola Dolci, Caterina Donà, Chiara Mapelli, Marco Nassisi, Federico Zicarelli, Alessandro Invernizzi, Alessandra Lombardi, Giuseppe Casalino, Francesco Viola

{"title":"Acute Retinal Necrosis Caused by Varicella Zoster Virus and Cytomegalovirus Co-Infection.","authors":"Maria Paola Dolci, Caterina Donà, Chiara Mapelli, Marco Nassisi, Federico Zicarelli, Alessandro Invernizzi, Alessandra Lombardi, Giuseppe Casalino, Francesco Viola","doi":"10.1080/09273948.2024.2404092","DOIUrl":"10.1080/09273948.2024.2404092","url":null,"abstract":"Purpose: To report the clinical course of two cases of acute retinal necrosis (ARN) caused by varicella zoster virus (VZV) and cytomegalovirus (CMV) co-infection detected by polymerase chain reaction (PCR) on aqueous tap.Methods: Observational case reports.Results: Two patients presented to our services with unilateral panuveitis suggestive of ARN complicated by hemorrhagic vasculitis and started empirical therapy. Aqueous PCR was performed on the same day and showed double positivity for VZV and CMV, which guided treatment. At follow-up, wide-field color fundus imaging and high-resolution optical coherence tomography showed resolution of active retinitis.Conclusion: Our cases suggest that ARN complicated by hemorrhagic vasculitis may be secondary to CMV and VZV co-infection, both in patients with an unremarkable clinical history and in those with immunodeficiency. In our cases, aqueous PCR testing was of paramount importance to determine the aetiology of ARN and to adjust the antiviral therapy accordingly.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"713-717"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular Manifestations of Psoriasis: A Systematic Review. 银屑病的眼部表现：系统综述。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-02-17 DOI: 10.1080/09273948.2025.2459710

Atheer G Almutairi, Leena I Aloraini, Rahaf R Almutairi, Alanoud A Alfaqih, Shahad A Alruwaili, Sara Aljefri

{"title":"Ocular Manifestations of Psoriasis: A Systematic Review.","authors":"Atheer G Almutairi, Leena I Aloraini, Rahaf R Almutairi, Alanoud A Alfaqih, Shahad A Alruwaili, Sara Aljefri","doi":"10.1080/09273948.2025.2459710","DOIUrl":"10.1080/09273948.2025.2459710","url":null,"abstract":"Purpose: Psoriasis, a chronic inflammatory skin disease, manifests itself by an array of immunological and inflammatory alterations. Ocular involvement can occur through a variety of pathways, notably direct interaction with psoriatic plaques or psoriasis-associated inflammatory responses. The present systematic review was intended to more effectively comprehend and describe the prevalent nature of psoriasis ocular symptoms by tracking all relevant studies published over the last decade and carefully synthesizing their findings.Methods: This systematic review was performed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for study selection, synthesis, and reporting of results. The PubMed, Cochrane, and Scopus databases were used to search for evidence-based research papers on psoriasis ocular symptoms published between January 2012 and August 2023.Results: The prevalence of ocular manifestations in psoriasis varied between the studies ranging from 81.4% to 10%. The increase in the ocular symptoms with prolonged duration of psoriasis was statistically significant. Dry eye condition is the most prevalent clinical ocular alteration related to psoriasis. Blepharitis, conjunctivitis, keratopathy, and uveitis were common in psoriasis patients. Higher intraocular pressure and glaucoma were reported.Conclusion: Physicians should keep in mind and look for ocular associations in Psoriasis patients. Addressing the crucial stages in the pathophysiology of ocular alterations is essential for targeted efforts for immunotherapeutic management. Interventions are shifting away from broad immunosuppression towards the administration of particular biologicals that target specific components of the immune response.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"827-835"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential Macular Hole Formation as a Rare Complication of Rickettsia Post Fever Retinitis. 继发性黄斑裂孔形成是立克次体发热后视网膜炎的罕见并发症。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2024-12-26 DOI: 10.1080/09273948.2024.2446408

Sai Bhakti Mishra, Gaurang Sehgal, Naresh Kumar Yadav, Ankush Kawali, Padmamalini Mahendradas

{"title":"Sequential Macular Hole Formation as a Rare Complication of Rickettsia Post Fever Retinitis.","authors":"Sai Bhakti Mishra, Gaurang Sehgal, Naresh Kumar Yadav, Ankush Kawali, Padmamalini Mahendradas","doi":"10.1080/09273948.2024.2446408","DOIUrl":"10.1080/09273948.2024.2446408","url":null,"abstract":"Purpose: We describe a rare complication of macular hole formation in rickettsia post-fever retinitis.Patients and methods: Retrospective observational case report of a patient who presented with post-fever retinitis and cystoid macular edema that later progressed to a macular hole. Clinical record and multimodal imaging including fundus photography, fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT) were analyzed.Results: Initial examination revealed multifocal retinitis lesions with vitritis associated with disc and macular edema, consistent with a diagnosis of post-fever retinitis. During the course of her treatment, she developed a full-thickness macular hole, complicating the management and requiring surgical intervention.Conclusion: Continued monitoring and management are essential to address potential sequelae and ensure minimised long-term ocular morbidity in affected patients. Further reports are needed to precise and characterize this clinical relationship and its management.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"841-844"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of AQP4-IgG Neuromyelitis Optica Presenting with Orbital Inflammatory Syndrome. AQP4-IgG视神经脊髓炎伴眼眶炎症综合征1例。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-01-30 DOI: 10.1080/09273948.2022.2075762

Lucy A Bailey, Roy F Riascos, Ore-Ofe O Adesina

引用次数: 0

Bilateral Acute Myopia: Do Not Overlook Bilateral Uveal Effusion. 双侧急性近视：不要忽视双侧葡萄膜积液。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-02-03 DOI: 10.1080/09273948.2025.2456639

Tetiana Goncharova, Marta Garrido-Marin, Yann Bertolani, David Oliver-Gutierrez, Elena Ros-Sanchez, Paul Gerard Buck, Jaime Rigo, Nieves Martin

{"title":"Bilateral Acute Myopia: Do Not Overlook Bilateral Uveal Effusion.","authors":"Tetiana Goncharova, Marta Garrido-Marin, Yann Bertolani, David Oliver-Gutierrez, Elena Ros-Sanchez, Paul Gerard Buck, Jaime Rigo, Nieves Martin","doi":"10.1080/09273948.2025.2456639","DOIUrl":"10.1080/09273948.2025.2456639","url":null,"abstract":"Purpose: To describe an atypical case of bilateral uveal effusion, presumably triggered by amoxicillin, in a 10-year-old child with pneumonia.Methods: A comprehensive ophthalmological evaluation and imaging studies, including anterior segment and macular optical coherence tomography, ultrasound biomicroscopy, and B-mode ultrasonography, were performed to assess anatomical changes and confirm the diagnosis.Results: A 10-year-old boy presented with an acute, painless loss of visual acuity in both eyes, primarily affecting distance vision. He had a recent history of pneumonia, which had been treated with amoxicillin. Ophthalmic examination revealed bilateral acute myopia, significant refractive error, and shallow anterior chambers in both eyes. Ultrasound biomicroscopy and anterior segment optical coherence tomography revealed fluid in the supraciliary space and anterior rotation of the ciliary processes, suggestive of uveal effusion. Based on these findings, uveal effusion was suspected, prompting the discontinuation of amoxicillin. The patient was treated with topical dexamethasone, cyclopentolate, and oral azithromycin. After stopping amoxicillin and initiating treatment, the patient's myopia resolved, anterior chamber depth normalized, and the uveal effusion was resolved within three days. The patient remained asymptomatic during a 6-month follow-up period.Conclusion: This case suggests a possible link between amoxicillin use and bilateral uveal effusion, a relationship not previously reported. Healthcare professionals should consider uveal effusion in the differential diagnosis of patients presenting with bilateral acute myopia, particularly when associated with recent medication use. Further research is needed to explore the potential role of amoxicillin in inducing uveal effusion.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"859-863"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Panuveitis as a Manifestation of a Novel PIK3CD Gene Mutation: A Diagnostic and Management Challenge. 复发性全葡萄膜炎是一种新的PIK3CD基因突变的表现：诊断和管理的挑战。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-02-11 DOI: 10.1080/09273948.2025.2461240

Vipin Rana, Ankur Jindal, Vamshi Krishna, Mohit Dogra, Amit Nandan Tripathi, Sanghamitra Machhua

{"title":"Recurrent Panuveitis as a Manifestation of a Novel PIK3CD Gene Mutation: A Diagnostic and Management Challenge.","authors":"Vipin Rana, Ankur Jindal, Vamshi Krishna, Mohit Dogra, Amit Nandan Tripathi, Sanghamitra Machhua","doi":"10.1080/09273948.2025.2461240","DOIUrl":"10.1080/09273948.2025.2461240","url":null,"abstract":"Purpose: To present a unique case of recurrent panuveitis in a young patient associated with a novel pathogenic variant in the PIK3CD gene, expanding the clinical spectrum of Activated PIK3 delta syndrome (APDS), a primary immunodeficiency that predisposes individuals to infections, autoimmunity, and malignancies.Methods: We evaluated a 15-year-old boy with refractory panuveitis, recurrent infections, and lymphadenopathy with Hodgkin lymphoma. Ophthalmic assessment and ultra-wide field fundus fluorescein angiography were conducted. Whole exome sequencing identified a novel heterozygous pathogenic variant in the PIK3CD gene. Immunological and histopathological evaluations further supported the diagnosis of APDS.Results: The patient experienced progressive vision loss despite immunosuppressive therapy with prednisolone, methotrexate, and mycophenolate mofetil. Genetic testing revealed a novel PIK3CD pathogenic variant (c.1002C>G;p.Asn334Lys), confirmed via Sanger sequencing and predicted by in-silico tools to be pathogenic. Initial improvement was observed with steroids, but frequent relapses upon tapering underscored the chronicity of his inflammatory condition.Conclusion: This case underscores the importance of genetic testing in diagnosing complex, treatment-resistant uveitis in children. The novel PIK3CD pathogenic variant expands the genetic landscape of APDS, indicating the need to consider underlying genetic causes in cases with recurrent systemic inflammation and infections. Managing APDS requires a careful balance of immunosuppressive treatment and monitoring for potential malignancies, emphasizing a multidisciplinary approach to optimize patient outcomes.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"871-874"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0