Ocular Manifestations of Psoriasis: A Systematic Review.

Abstract

Purpose: Psoriasis, a chronic inflammatory skin disease, manifests itself by an array of immunological and inflammatory alterations. Ocular involvement can occur through a variety of pathways, notably direct interaction with psoriatic plaques or psoriasis-associated inflammatory responses. The present systematic review was intended to more effectively comprehend and describe the prevalent nature of psoriasis ocular symptoms by tracking all relevant studies published over the last decade and carefully synthesizing their findings.

Methods: This systematic review was performed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for study selection, synthesis, and reporting of results. The PubMed, Cochrane, and Scopus databases were used to search for evidence-based research papers on psoriasis ocular symptoms published between January 2012 and August 2023.

Results: The prevalence of ocular manifestations in psoriasis varied between the studies ranging from 81.4% to 10%. The increase in the ocular symptoms with prolonged duration of psoriasis was statistically significant. Dry eye condition is the most prevalent clinical ocular alteration related to psoriasis. Blepharitis, conjunctivitis, keratopathy, and uveitis were common in psoriasis patients. Higher intraocular pressure and glaucoma were reported.

Conclusion: Physicians should keep in mind and look for ocular associations in Psoriasis patients. Addressing the crucial stages in the pathophysiology of ocular alterations is essential for targeted efforts for immunotherapeutic management. Interventions are shifting away from broad immunosuppression towards the administration of particular biologicals that target specific components of the immune response.