Ocular Immunology and Inflammation最新文献

Bilateral Acute Occlusive Retinal Vasculitis in Pediatric Patients: A Report of Two Cases.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-14 DOI: 10.1080/09273948.2025.2533423

Chengzhi Liu, Yuezhu Lu, Guangda Deng, Jinghua Liu

{"title":"Bilateral Acute Occlusive Retinal Vasculitis in Pediatric Patients: A Report of Two Cases.","authors":"Chengzhi Liu, Yuezhu Lu, Guangda Deng, Jinghua Liu","doi":"10.1080/09273948.2025.2533423","DOIUrl":"https://doi.org/10.1080/09273948.2025.2533423","url":null,"abstract":"Purpose: To present two rare pediatric cases of bilateral acute occlusive retinal vasculitis (ORV) associated with respiratory viral infections.Methods: This retrospective review of two cases included a comprehensive clinical evaluation and detailed examinations, including wide-field RetCam color fundus photography, fundus fluorescein angiography, B-ultrasound imaging, aqueous humor cytokine analysis, and laboratory testing for viral infections. Treatments consisted of antivirals, corticosteroids, and anti-VEGF therapy.Results: Both patients presented with severe vision loss, retinal hemorrhages, retinal vascular occlusion, and exudative detachment. Elevated intraocular VEGF and IL-6 suggested an immune-mediated response. Despite treatment, both had poor visual recovery with optic atrophy and retinal vessel attenuation.Conclusion: Respiratory viral infections may trigger severe pediatric ORV via immune-mediated inflammation. In these two cases, early diagnosis, viral screening, and prompt treatment were applied, but the prognosis remains poor. Further research is needed to refine management strategies.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Sequential Herpes Simplex Type 2 Panophthalmitis in an Adult with a Toll-Like Receptor 4 Mutation.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-14 DOI: 10.1080/09273948.2025.2524586

Shiao W Wong, Sasa Pockar, Laura R Steeples, Felipe Dhawahir-Scala, Salma Babiker, Nicholas P Jones

{"title":"Bilateral Sequential Herpes Simplex Type 2 Panophthalmitis in an Adult with a Toll-Like Receptor 4 Mutation.","authors":"Shiao W Wong, Sasa Pockar, Laura R Steeples, Felipe Dhawahir-Scala, Salma Babiker, Nicholas P Jones","doi":"10.1080/09273948.2025.2524586","DOIUrl":"https://doi.org/10.1080/09273948.2025.2524586","url":null,"abstract":"Purpose: To present the first reported case of bilateral sequential Herpes Simplex Virus Type 2 (HSV-2) panophthalmitis causing severe vision loss in a young adult with a toll-like receptor 4 (TLR-4) mutation, with a review of previously reported cases of HSV-2 panophthalmitis.Methods: Retrospective case report.Results: A 29-year-old man presented with a severely painful, swollen left eye and vision loss. Visual acuity was no light perception in both eyes. Six years earlier, he had developed right panophthalmitis, the cause confirmed as Herpes Simplex Virus Type 2 (HSV-2) by polymerase chain reaction (PCR) on aqueous humour (AH) sampling, with a poor outcome. At current presentation, PCR of AH and vitreous samples again confirmed HSV-2 infection. A poor initial response to high-dose intravenous antiviral led to the addition of high-dose systemic corticosteroid. Subsequent phacovitrectomy enabled partial visual recovery. Genetic testing revealed TLR-4 mutation rs4986790 A/G.Conclusion: HSV-2 panophthalmitis is rare and visually destructive, and we present the first reported case of bilateral disease. We hypothesise that TLR-4 mutation, not previously reported in association with HSV ocular inflammation, may have contributed to excessive inflammation and severe ocular damage. We suggest comprehensive immunological evaluation in all patients with severe viral intraocular inflammation. Prompt diagnosis with PCR and immediate high-dose antiviral therapy is critical and immune abnormality may require amended management.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral Keratitis in Chronic Ocular Graft-Versus-Host Disease: Virus Species and Clinical Characteristics.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-14 DOI: 10.1080/09273948.2025.2524589

Yunke Ma, Yinghan Zhao, Rongmei Peng, Gege Xiao, Yi Qu, Jinghao Qu, Yaning Zhao, Xiaozhen Liu, Jing Hong

{"title":"Viral Keratitis in Chronic Ocular Graft-Versus-Host Disease: Virus Species and Clinical Characteristics.","authors":"Yunke Ma, Yinghan Zhao, Rongmei Peng, Gege Xiao, Yi Qu, Jinghao Qu, Yaning Zhao, Xiaozhen Liu, Jing Hong","doi":"10.1080/09273948.2025.2524589","DOIUrl":"https://doi.org/10.1080/09273948.2025.2524589","url":null,"abstract":"Purpose: To investigate the virus species, risk factors and clinical characteristics of viral keratitis in patients with chronic ocular graft-versus-host disease (coGVHD).Methods: A chart review of patients with coGVHD who visited Peking University Third Hospital between May 2020 and September 2024 was conducted. Demographic and clinical characteristics and laboratory test results were collected. Multivariate logistic regression was performed to explore the risk factors for viral keratitis. The results of viral DNA polymerase chain reaction of aqueous humor or corneal tissue were reviewed to determine the infecting virus species.Results: A total of 373 patients with coGVHD were included. The prevalence of viral keratitis was 4.6%. The most frequent infecting virus was cytomegalovirus (64.7%). Topical steroid use (odds ratio (OR) 8.88, 95% confidence interval (CI) 1.15-68.80; p = 0.037), systemic steroid use (OR 3.15, 95% CI 1.10-0.02; p = 0.032), and eyelid margin irregularities (OR 13.36, 95% CI 1.73-102.94; p = 0.013) were risk factors for viral keratitis. CoGVHD patients with viral keratitis presented with persistent epithelial defects, corneal ulcers and even corneal perforation. Corneal edema, keratic precipitates and neovascularization were observed. Fourteen patients underwent keratoplasty, and 4 of them had to undergo repeat keratoplasty due to corneal perforation or graft dissolution.Conclusions: CMV was the most frequent infecting virus in coGVHD patients with viral keratitis. Topical and systemic steroid use and eyelid margin irregularities were identified as risk factors for viral keratitis. Viral keratitis in coGVHD patients can cause devastating vision damage, even when keratoplasty is performed.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravitreal versus Subcutaneous Adalimumab in Active Non-Infectious Uveitis: A Randomized Non-Inferiority Trial. 玻璃体内与皮下阿达木单抗治疗活动性非感染性葡萄膜炎：一项随机非劣效性试验。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-13 DOI: 10.1080/09273948.2025.2526692

Mahdi M Hassoun, Ziyad R Mahfoud, Rachid Istambouli, Ahmad M Mansour, Haytham Salti, Souha Allam, Alaa Bou Ghannam, Rola N Hamam

{"title":"Intravitreal versus Subcutaneous Adalimumab in Active Non-Infectious Uveitis: A Randomized Non-Inferiority Trial.","authors":"Mahdi M Hassoun, Ziyad R Mahfoud, Rachid Istambouli, Ahmad M Mansour, Haytham Salti, Souha Allam, Alaa Bou Ghannam, Rola N Hamam","doi":"10.1080/09273948.2025.2526692","DOIUrl":"https://doi.org/10.1080/09273948.2025.2526692","url":null,"abstract":"Purpose: To compare the clinical effectiveness and safety of subcutaneous adalimumab (SCA) versus intravitreal adalimumab (IVA) in treating active non-infectious uveitis (NIU).Methods: This single-center, phase 2 non-inferiority randomized controlled trial included patients with active NIU assigned to receive either SCA (80 mg loading dose, then 40 mg every 2 weeks) or IVA (1.5 mg at baseline, then every 4 weeks). Follow-ups occurred weekly for the first 2 weeks, then every 4 weeks until 26 weeks. Primary outcomes were changes in anterior chamber cell (AC) and vitreous haze (VH) grades at 26 weeks (non-inferiority margin: 0.5). Secondary outcomes included best-corrected visual acuity (BCVA), central retinal thickness (CRT), fluorescein angiography (FA) score, and oral prednisone dose.Results: A total of 23 patients (43 eyes) were randomized into the SCA (n = 12) or IVA (n = 11) treatment group. IVA was found to be non-inferior to SCA. The upper limit of the 90% confidence interval (CI) for the difference in AC grade change (-0.33 [-0.79 to 0.38], p = 0.440) and VH grade change (-0.34 [-1.15 to 0.47], p = 0.490) remained below the noninferiority margin of + 0.5 grade. No significant differences were found between the two treatment groups for secondary outcomes, including changes in BCVA (p = 0.594), CRT (p = 0.607), FA score (p = 0.318), and oral prednisone dose (p = 0.881). No serious systemic or ocular adverse events (AE) were observed. SCA resulted in a higher number of non-serious systemic AE (21) compared to IVA (5).Conclusions: IVA was non-inferior to SCA in treating active NIU and resulted in fewer systemic adverse events.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroretinogram as an Early Diagnostic Biomarker for Acute Retinal Necrosis: A Multicenter Comparative Study.

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-13 DOI: 10.1080/09273948.2025.2532049

Shunichi Fukuyama, Kazuichi Maruyama, Masaaki Yoshida, Hiroaki Ushida, Kazuki Hashimoto, Satoko Fujimoto, Takuya Shunto, Nobuhiko Shiraki, Toru Nakazawa, Martine J Jager, Koji M Nishiguchi, Kohji Nishida

{"title":"Electroretinogram as an Early Diagnostic Biomarker for Acute Retinal Necrosis: A Multicenter Comparative Study.","authors":"Shunichi Fukuyama, Kazuichi Maruyama, Masaaki Yoshida, Hiroaki Ushida, Kazuki Hashimoto, Satoko Fujimoto, Takuya Shunto, Nobuhiko Shiraki, Toru Nakazawa, Martine J Jager, Koji M Nishiguchi, Kohji Nishida","doi":"10.1080/09273948.2025.2532049","DOIUrl":"https://doi.org/10.1080/09273948.2025.2532049","url":null,"abstract":"Purpose: Acute retinal necrosis (ARN) is a rare but severe ocular condition that often results in significant visual impairment or blindness. We aimed to determine whether ARN exhibits a distinct electroretinogram (ERG) waveform compared with other infectious and non-infectious uveitis forms.Methods: This retrospective observational multicenter study included a total of 73 patients; 21 with ARN, 9 with bacterial endophthalmitis, 16 with other types of infectious uveitis, and 27 with non-infectious uveitis. Full-field electroretinography was performed at the initial examination to evaluate retinal function. Additionally, initial and post-treatment visual acuity were recorded. The a- and b-wave amplitudes were measured and compared between the groups.Results: Patients with ARN had significantly reduced a- and b-wave amplitudes than the other types of infectious and non-infectious uveitis at the first visit (p < 0.01). Receiver operating characteristic analysis showed that an a-wave amplitude reduction of more than 73% discriminated ARN from other infectious uveitis with 75% sensitivity and 90% specificity (area under the curve [AUC] = 0.84), while a reduction greater than 49% discriminated ARN from non-infectious uveitis with 89% sensitivity and 76% specificity (AUC = 0.83). Pre-treatment visual acuity was the strongest predictor of visual prognosis.Conclusions: ERG response is significantly reduced in the early stages of ARN. Therefore, ERG may serve as a valuable diagnostic tool for ARN, particularly when specialist examination or definitive diagnosis based on clinical findings is delayed. Given that early treatment improves the prognosis of ARN, this finding highlights the critical role of early diagnosis in preventing vision loss.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous Candida Endophthalmitis: An Update on Epidemiological, Pathogenetic, Clinical, and Therapeutic Aspects. 内源性念珠菌眼内炎：流行病学、发病、临床和治疗方面的最新进展。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-10 DOI: 10.1080/09273948.2025.2524013

Pietro Gentile, E Ragusa, R Bruno, F Ceccarelli, C Adani, E Bolletta, L De Simone, F Gozzi, L Cimino

{"title":"Endogenous Candida Endophthalmitis: An Update on Epidemiological, Pathogenetic, Clinical, and Therapeutic Aspects.","authors":"Pietro Gentile, E Ragusa, R Bruno, F Ceccarelli, C Adani, E Bolletta, L De Simone, F Gozzi, L Cimino","doi":"10.1080/09273948.2025.2524013","DOIUrl":"https://doi.org/10.1080/09273948.2025.2524013","url":null,"abstract":"Endogenous Candida endophthalmitis (ECE) is a rare intraocular infection that poses a significant clinical challenge due to its potential to cause permanent visual impairment. ECE is caused by Candida spreading to the uvea and the retina during candidemia, in absence of recent ocular trauma. Candida albicans is the species most frequently involved, although in recent years non-albicans species have been on the rise, with distribution differences depending on the geographical area. The diagnosis is primarily based on the presence of specific risk factors (especially recent surgical interventions, diabetes, and immunosuppression) and on the clinical presentation, which is usually highly suggestive. Among imaging techniques, optical coherence tomography (OCT), with the typical \"rain-cloud\" sign, has notably improved diagnostic capability. Laboratory tests performed on ocular fluids, instead, have low sensitivity, so they often do not contribute to the diagnostic process. Therapeutic strategies are primarily based on systemic antifungal therapy, mainly fluconazole and amphotericin B (AmB), accompanied by vitrectomy and intravitreal injections of voriconazole or AmB in cases of significant vitreous involvement. The increase in Candida species resistant to currently available antifungal drugs necessitates a more appropriate use of these medications as well as the development of new drugs capable of eradicating the most challenging infections. This review examines the existing literature on ECE, covering its epidemiology, pathogenesis, diagnosis, prognosis, and management approaches.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-17"},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anterior Uveitis Associated with ASIA Syndrome: A Distinct Clinical Entity? 前葡萄膜炎与亚洲综合征相关：一个独特的临床实体？

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-10 DOI: 10.1080/09273948.2025.2530131

Şule Barman Kakil, Mete Pekdiker, Talip Akikol

{"title":"Anterior Uveitis Associated with ASIA Syndrome: A Distinct Clinical Entity?","authors":"Şule Barman Kakil, Mete Pekdiker, Talip Akikol","doi":"10.1080/09273948.2025.2530131","DOIUrl":"https://doi.org/10.1080/09273948.2025.2530131","url":null,"abstract":"Purpose: To investigate whether anterior uveitis developing after BNT162b2 COVID-19 vaccination-classified as Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA)-exhibits distinct clinical features compared to idiopathic uveitis.Methods: This single-center retrospective study analyzed records of patients diagnosed with non-infectious anterior uveitis between June 1, 2021, and December 31, 2022. Patients were categorized into two groups: post-vaccine ASIA-related uveitis (Group 1) and idiopathic uveitis (Group 2).Results: A total of 62 patients were included: 12 in Group 1 and 50 in Group 2. The mean age was similar (33.8 ± 10.4 vs. 35.1 ± 10.8 years; p = 0.547), with male predominance in both groups (61.1% vs. 58.5%). Group 1 had significantly milder anterior chamber inflammation (1.94 ± 0.64 vs. 2.85 ± 0.94; p < 0.001) and fewer ocular complications (16.7% vs. 60.0%; p = 0.003). All Group 1 cases responded to topical corticosteroids alone, while 32.3% in Group 2 required systemic immunosuppressants (p = 0.004). Best corrected visual acuity improved in both groups over time, but recovery was faster and more complete in Group 1 (p < 0.001 for time × group interaction).Conclusion: Anterior uveitis associated with ASIA syndrome post-vaccination appears to follow a milder, self-limiting course, with better visual outcomes and less aggressive treatment needs than idiopathic uveitis. These findings offer important insight into the clinical behavior of vaccine-associated ocular inflammation.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PCR-Based Evaluation of Viral Load Reduction in Adenoviral Conjunctivitis: A Comparative Study of Ganciclovir and Povidone-Iodine. 基于pcr的评估腺病毒性结膜炎病毒载量降低：更昔洛韦和聚维酮碘的比较研究。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-10 DOI: 10.1080/09273948.2025.2530768

Fahri Onur Aydin, Semra Akkaya Turhan, Ayfer Güner, Rabia Can Sarınoğlu, Ayşegül Karahasan, Ebru Toker

{"title":"PCR-Based Evaluation of Viral Load Reduction in Adenoviral Conjunctivitis: A Comparative Study of Ganciclovir and Povidone-Iodine.","authors":"Fahri Onur Aydin, Semra Akkaya Turhan, Ayfer Güner, Rabia Can Sarınoğlu, Ayşegül Karahasan, Ebru Toker","doi":"10.1080/09273948.2025.2530768","DOIUrl":"https://doi.org/10.1080/09273948.2025.2530768","url":null,"abstract":"Purpose: To evaluate the efficacy of topical ganciclovir (GCV), povidone-iodine (PVP-I), and their combination with loteprednol etabonate (LE) in reducing viral load and improving clinical outcomes in adenoviral conjunctivitis.Methods: This single-centered, controlled study enrolled patients diagnosed with adenoviral conjunctivitis, confirmed by the Rapid Pathogen Screening Adeno-Detector Plus test. Participants were assigned to five treatment groups: artificial tears (AT) as the control group, and the treatment groups included PVP-I, GCV, PVP-I/LE, and GCV/LE. Treatment efficacy was assessed by viral load, clinical sign and symptom scores, and complications (subepithelial infiltrates and pseudomembranes). The early phase encompassed days 0-7, and the late phase covered days 8-14.Results: Seventy-five eyes were included. Adenovirus type 8 was the most common pathogen (95%). At baseline, clinical signs and symptoms were similar among groups (p > 0.05), but viral loads differed significantly (p = 0.036). The greatest reduction in viral load in the early phase was observed in the PVP-I group (p < 0.05). The fastest improvement of the clinical signs and symptoms was observed in the PVP-I/LE and the GCV/LE group (p < 0.05). Subepithelial infiltrates were significantly less frequent in the PVP-I/LE group (p = 0.014).Conclusions: The combination of PVP-I/LE effectively reduced viral load and improved clinical outcomes in adenoviral conjunctivitis. PVP-I significantly decreased viral load in the early phase, while PVP-I/LE and GCV/LE combinations led to faster clinical improvement. Subepithelial infiltrates were significantly lower in the PVP-I/LE group, suggesting this combination may help prevent complications and offer an effective treatment option.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Orbital Inflammation as the Initial Manifestation of Eosinophilic Granulomatosis with Polyangiitis Following Dupilumab administration, Successfully Treated with Mepolizumab. 杜匹单抗治疗后眼眶炎症为嗜酸性肉芽肿病合并多血管炎的初始表现一例，Mepolizumab成功治疗。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-08 DOI: 10.1080/09273948.2025.2529342

Haruka Aya, Kaoru Araki-Sasaki, Yoshiki Kobayashi, Ken Fukuda, Hisanori Imai

{"title":"A Case of Orbital Inflammation as the Initial Manifestation of Eosinophilic Granulomatosis with Polyangiitis Following Dupilumab administration, Successfully Treated with Mepolizumab.","authors":"Haruka Aya, Kaoru Araki-Sasaki, Yoshiki Kobayashi, Ken Fukuda, Hisanori Imai","doi":"10.1080/09273948.2025.2529342","DOIUrl":"https://doi.org/10.1080/09273948.2025.2529342","url":null,"abstract":"Purpose: We report a case of eosinophilic granulomatosis with polyangiitis (EGPA), manifesting as orbital cellulitis and scleritis following anti-interleukin (IL)-4 receptor α antibody dupilumab treatment, which was successfully treated with anti-IL-5 antibody mepolizumab.Methods: Slit-lamp examination, diagnostic imaging, and biopsy were performed.Results: A 53-year-old male patient presented with sudden swelling of the left eyelid, severe conjunctival edema, and hyperemia. He had received dupilumab for 6 months for refractory nasal polyps. On initial examination, slit-lamp examination and computed tomography of the orbit revealed the orbital cellulitis and scleritis in his left eye. Although orbital swelling resolved by the administration of systemic steroids, scleritis persisted. Six months after initial presentation, the patient developed abdominal pain, vomiting, diarrhea, and skin rashes. Biopsy of upper gastrointestinal tract and skin revealed eosinophilic infiltration surrounding the blood vessel with an increase in peripheral blood eosinophil count. The patient was diagnosed with EGPA and subsequently started on subcutaneous anti-IL-5 antibody mepolizumab with systemic steroid. Following initiation of mepolizumab, his eosinophil counts normalized, gastroenteritis symptoms resolved, and refractory scleritis disappeared within a month. Topical and systemic steroids were discontinued after mepolizumab administration without recurrence.Conclusions: This case highlights that physicians should be aware of the potential ocular side effects associated with biologics administration, such as those associated with EGPA.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-3"},"PeriodicalIF":2.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Efficacy of Infliximab Therapy in Idiopathic Retinal vasculitis, Aneurysms and Neuroretinitis (IRVAN) Syndrome. 英夫利昔单抗治疗特发性视网膜血管炎、动脉瘤和神经视网膜炎（IRVAN）综合征的长期疗效。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-08 DOI: 10.1080/09273948.2025.2530134

Rahaf Abdullah Mandura, Ghislain Opdenakker, Ahmed Abu El-Asrar

{"title":"Long-Term Efficacy of Infliximab Therapy in Idiopathic Retinal vasculitis, Aneurysms and Neuroretinitis (IRVAN) Syndrome.","authors":"Rahaf Abdullah Mandura, Ghislain Opdenakker, Ahmed Abu El-Asrar","doi":"10.1080/09273948.2025.2530134","DOIUrl":"https://doi.org/10.1080/09273948.2025.2530134","url":null,"abstract":"Purpose: Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is a rare inflammatory vision-threatening retinal disease of unknown origin. If untreated, it can lead to severe vision loss from exudative maculopathy and neovascular sequelae of retinal ischaemia. Detailed IRVAN case reporting may help to provide new insights.Methods: Successful treatment of a pediatric patient with infliximab.Results: A 12-year-old girl with IRVAN syndrome received immunosuppressive and laser photocoagulation therapy without improvements. A shift to treatment with infliximab not only reversed disease symptoms on short term, but also led to a complete and long-term cure of the disease. The patient was followed-up for a period of 3 years and infliximab resulted in complete resolution of retinal and optic nerve head aneurysmal dilations, retinal vasculitis and optic disc swelling, and complete resorption of retinal exudation.Conclusion: Infliximab is safe and effective and should be considered as a primary first-line therapy for IRVAN syndrome.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0