Ocular Immunology and Inflammation最新文献

Subconjunctival Adalimumab for Noninfectious Uveitis: A Prospective Pilot Study. 结膜下阿达木单抗治疗非感染性葡萄膜炎：一项前瞻性试点研究。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-27 DOI: 10.1080/09273948.2025.2512170

Soumyava Basu, Sucheta Ireni, Mudit Tyagi, Thomas H Dohlman, Eleftherios I Paschalis

{"title":"Subconjunctival Adalimumab for Noninfectious Uveitis: A Prospective Pilot Study.","authors":"Soumyava Basu, Sucheta Ireni, Mudit Tyagi, Thomas H Dohlman, Eleftherios I Paschalis","doi":"10.1080/09273948.2025.2512170","DOIUrl":"https://doi.org/10.1080/09273948.2025.2512170","url":null,"abstract":"Aim: To evaluate the safety and preliminary efficacy of low-dose subconjunctival adalimumab in patients with non-infectious uveitis (NIU), refractory to conventional immunomodulatory therapy (IMT).Methods: Prospective, noncomparative, interventional case series. Five patients with bilateral panuveitis (four post-therapeutic vitrectomy) and persistent intraocular inflammation on conventional IMT for > 2 years received three doses of subconjunctival adalimumab 5 mg/0.1 mL at two-week intervals and followed up for 24 weeks.Results: No cases of persistent conjunctival congestion, corneal erosions or infection, or intraocular pressure > 21 mmHg were noted. Improvement in inflammatory scores and best-corrected visual acuity (BCVA) were noted in three patients each and worsening in none. None of the three patients who showed initial improvement in visual acuity had any baseline cystoid macular edema or vitreous haze to account for the improvement in BCVA.Conclusion: Subconjunctival administration of 5 mg adalimumab is a safe and effective therapy for NIU refractory to conventional IMT.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-3"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular and Periocular Leprosy Confirmed by Polymerase Chain Reaction and Histopathology with Therapeutic Insights. 经聚合酶链反应和组织病理学证实的眼部和眼周麻风病的治疗见解。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-24 DOI: 10.1080/09273948.2025.2509719

Smitha Kuthyar Shambu, Kavya Nagaraj, Santosh Ramesh, Nashra Alma, Shruthi Mysore Krishna, Madhusmita Das

{"title":"Ocular and Periocular Leprosy Confirmed by Polymerase Chain Reaction and Histopathology with Therapeutic Insights.","authors":"Smitha Kuthyar Shambu, Kavya Nagaraj, Santosh Ramesh, Nashra Alma, Shruthi Mysore Krishna, Madhusmita Das","doi":"10.1080/09273948.2025.2509719","DOIUrl":"https://doi.org/10.1080/09273948.2025.2509719","url":null,"abstract":"Purpose: Mycobacterium leprae commonly affects organs such as skin, peripheral nerves, joints and eyes. However, its intraocular presence has not been documented before. Through our retrospective case report, we aim to raise the awareness of the possibility of intraocular invasion by Mycobacterium leprae.Methods: A 56-year-old male, diagnosed with left periocular leprosy at our medical centre, developed pain, redness, and diminution of vision while still on Multi-Drug Therapy (MDT). On examination, he had corneal ulceration, corneal melt, and endophthalmitis. He underwent emergent therapeutic keratoplasty with lateral tarsorrhaphy and multiple intravitreal injections.Results: Histopathological examination of cornea using Ziehl-Neelsen and Fite-Faraco staining techniques revealed the presence of acid-fast bacilli in the corneal epithelium and anterior stroma. The Descemet's membrane was intact with an adherent endothelial plaque-like hypopyon, which also showed positivity for Lepra bacilli on special stains. The corneal button, hypopyon, and vitreous sample tested positive for Mycobacterium leprae detected via polymerase-chain reaction (PCR). He was started on topical fortified imipenem drops & intravitreal Vancomycin + Imipenem + Dexamethasone. USG-B scan after 48 h showed marked improvement with a few moderate dot echoes. Intravitreal injections were repeated every 48 h for 2 weeks, with serial USG B scans showing significant reduction in vitreous echoes.Conclusion: This case report thus provides evidence that Mycobacterium leprae can indeed penetrate the ocular coats despite a good immune response & Multi-Drug Therapy. Intravitreal injection Imipenem seems to be an effective drug choice in the management of Mycobacterium leprae endophthalmitis.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Function and Intraocular Pressure Outcomes Following Surgical Intervention in Pediatric Patients with Inflammatory Glaucoma. 儿童炎症性青光眼手术干预后的视功能和眼压预后。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-23 DOI: 10.1080/09273948.2025.2508408

Abhiram R Manda, Xiangyu Ji, Jordan Comstock, Stephen J Kim, Qingxia Chen, Karen Joos, Sapna S Gangaputra

{"title":"Visual Function and Intraocular Pressure Outcomes Following Surgical Intervention in Pediatric Patients with Inflammatory Glaucoma.","authors":"Abhiram R Manda, Xiangyu Ji, Jordan Comstock, Stephen J Kim, Qingxia Chen, Karen Joos, Sapna S Gangaputra","doi":"10.1080/09273948.2025.2508408","DOIUrl":"https://doi.org/10.1080/09273948.2025.2508408","url":null,"abstract":"Purpose: This study evaluates the outcomes of pediatric uveitic glaucoma eyes that received surgery compared to non-surgical pediatric uveitis eyes.Methods: A retrospective chart review was performed of patients diagnosed with inflammatory glaucoma before the age of 18 years. Outcomes, including intraocular pressure (IOP), visual acuity (VA), and inflammatory activity were assessed over two years.Results: Thirty-six eyes (18 surgically managed, 18 non-surgical) were included in this study. At baseline the surgical eyes had significantly higher median IOP than the non-surgical pediatric uveitis eyes (31.5 mmHg versus 15.0 mmHg; p < 0.001). Two years later, the median IOP between the surgical eyes and non-surgical eyes was not significantly different (12.0 mmHg versus 13.5 mmHg; p = 0.14). Median visual acuity (VA) was not significantly different between surgically managed eyes (logMAR 0.35 [IQR: 0.10-0.50] and non-surgical eyes 0.10 [IQR: 0.03-0.85]; p = 0.92) at baseline. At two years, the median VA in surgical eyes improved to 0.30 (IQR: 0.12-0.70), while the non-surgical eyes maintained a stable median VA of 0.10 (IQR: 0.00-0.20). The mean number of glaucoma medications in the surgical eyes decreased considerably from 3.2 ± 1.6 medications at baseline to 0.67 ± 1.1 at two years.Conclusion: Our data showcases that glaucoma surgery in patients with well controlled uveitis, can provide significant benefit to patients that are refractory to medical management, by reducing IOP and glaucoma medication burden, with excellent visual outcomes at two years.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpetic Eye Disease During the COVID-19 Pandemic at an Urban Hospital System. 2019冠状病毒病大流行期间城市医院系统的疱疹性眼病

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-23 DOI: 10.1080/09273948.2025.2508405

Amy Song, Lydia Lin, Ann-Marie Lobo-Chan

{"title":"Herpetic Eye Disease During the COVID-19 Pandemic at an Urban Hospital System.","authors":"Amy Song, Lydia Lin, Ann-Marie Lobo-Chan","doi":"10.1080/09273948.2025.2508405","DOIUrl":"https://doi.org/10.1080/09273948.2025.2508405","url":null,"abstract":"Purpose: To report and compare the incidence, prevalence, and presentation of herpetic eye disease (HED) before and during the COVID-19 pandemic in an urban hospital system and assess related COVID-19 infection or vaccination prior to presentation.Methods: A retrospective chart review of patients with herpes simplex virus (HSV) keratitis and HSV uveitis based on ICD-10 diagnosis codes at the University of Illinois Hospitals from before the COVID-19 pandemic (May 1, 2018, to February 29, 2020) and during the COVID-19 pandemic (March 1, 2020, to December 31, 2021) was performed. For each patient, demographic and clinical information was recorded. For patients seen during the pandemic, any history of COVID-19 infection or vaccination prior to HED presentation was recorded. For patients who presented with a history of COVID-19 infection or vaccination, further chart review was performed.Results: Seventy-one patients (0.024%) out of 299,201 patients seen at the University of Illinois Hospitals presented with active HED in the period before the pandemic. Sixty-four patients (0.008%) out of 841,173 patients seen at the University of Illinois Hospitals presented with active HED in the period during the pandemic. Seventeen (26.6%) patients who presented during the pandemic had a history of COVID-19 infection or vaccination within 60 days prior to presentation.Conclusion: Understanding the potential relationship between new presentations and recurrences of HED following COVID-19 exposure is important to consider with future COVID-19 infections and booster vaccinations. Providers should be aware of possible development of HED after COVID-19 vaccination or infection and should counsel patients accordingly.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent Anterior Uveitis Following Cataract Surgery. 白内障手术后持续性前葡萄膜炎。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-22 DOI: 10.1080/09273948.2025.2509716

Victoria Marks, Aleksandra M Golos, Mohsain Gill, Daniel Henick, Katie Li, Brian DeBroff, Ninani Kombo

{"title":"Persistent Anterior Uveitis Following Cataract Surgery.","authors":"Victoria Marks, Aleksandra M Golos, Mohsain Gill, Daniel Henick, Katie Li, Brian DeBroff, Ninani Kombo","doi":"10.1080/09273948.2025.2509716","DOIUrl":"https://doi.org/10.1080/09273948.2025.2509716","url":null,"abstract":"Purpose: To determine the incidence of and risk factors for persistent anterior uveitis following cataract surgery.Methods: This was a retrospective cohort study of patients who underwent cataract surgery at a tertiary referral center in Connecticut, USA. Those with prior uveitis, complex ocular pathology, concurrent procedures, and surgical complications were excluded. The outcome was development of persistent anterior uveitis, defined as anterior chamber cell grade ≥ 0.5+ and steroid treatment beyond two months. Patients who did and did not develop persistent anterior uveitis were compared using univariate and multivariate analysis.Results: Of 3341 patients (5419 eyes), 45 (61) developed persistent anterior uveitis (1.1% incidence). Cases were significantly younger (64.6 years vs. 69.6 years, p < 0.001), and there were significantly higher proportions of female (73.8% compared to 58.5%, p = 0.016) and Black or African American (54.1% vs. 15.5%, p < 0.001) patients, as well as those with age-related macular degeneration (9.8% vs. 1.5%, p < 0.001), previous intravitreal injections (14.8% vs. 6.0%, p = 0.004), and diabetes (18.0% vs. 8.9%, p = 0.013). In multivariate analysis, older age was associated with a significantly lower likelihood of persistent anterior uveitis (adjusted odds ratio (AOR) = 0.963, 95% confidence interval (CI)=[0.942, 0.984]), whereas Black race (AOR = 9.102, 95% CI = [4.836, 17.133]) and wet age-related macular degeneration (AOR = 37.700, 95% CI = [6.408, 221.792]) were associated with a significantly higher likelihood.Conclusions: In this study, 1.1% of eyes developed persistent anterior uveitis following cataract surgery. Younger age, Black race, and wet age-related macular degeneration should be investigated as potential risk factors to improve its prophylaxis, identification, and management.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exogenous Fungal Endophthalmitis: A 20-Year Experience at a Tertiary Referral Centre in North China. 外源性真菌性眼内炎：中国北方某三级转诊中心20年的经验。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-22 DOI: 10.1080/09273948.2025.2509715

Yan Qi, Fang Liu, Lingxiao Lun, Yan Gao, Xiaoli Xing, Kunkun Zheng, Lei Wan

{"title":"Exogenous Fungal Endophthalmitis: A 20-Year Experience at a Tertiary Referral Centre in North China.","authors":"Yan Qi, Fang Liu, Lingxiao Lun, Yan Gao, Xiaoli Xing, Kunkun Zheng, Lei Wan","doi":"10.1080/09273948.2025.2509715","DOIUrl":"https://doi.org/10.1080/09273948.2025.2509715","url":null,"abstract":"Purpose: To report the epidemiological characteristics, causative pathogens, treatment approaches, and outcomes of culture-proven exogenous fungal endophthalmitis (EFE).Methods: This retrospective, interventional case series analysed the data of 112 patients with culture-positive EFE treated at a tertiary centre in North China between 2001 and 2020. The medical data of patients were extracted from hospital records.Results: EFE was associated with fungal keratitis, penetrating trauma, and intraocular surgery in 67 (59.8%), 39 (34.8%), and six eyes (5.4%), respectively. The primary cause of infection was mould (106/112, 94.6%), followed by yeast infection (6/112, 5.4%). Most keratitis cases were caused by Fusarium (32/67, 47.8%). Moreover, Aspergillus was the predominant species associated with penetrating trauma (15/39, 38.5%). Furthermore, Fusarium accounted for 50% (3/6) of postoperative cases. More than half of the eyes (89/112, 79.5%) were preserved through penetrating keratoplasty, vitrectomy, or intravitreal antifungal injections. However, 23 eyes (20.5%) were eviscerated, including 16 with fungal keratitis and seven with penetrating trauma.Conclusion: Fusarium and Aspergillus were the predominant pathogens in EFE, with fungal keratitis as the leading cause. Visual prognosis varied, with keratitis-associated cases showing the poorest outcomes, underscoring the need for early diagnosis and timely intervention.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroretinitis: Diagnostic Associations and Management Approach. 神经性视网膜炎：诊断关联和治疗方法。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-22 DOI: 10.1080/09273948.2025.2508399

Raneem Jannadi, Moustafa S Magliyah, Hanan Al Shalan, Doaa Milibari, Hassan Al Dhibi

{"title":"Neuroretinitis: Diagnostic Associations and Management Approach.","authors":"Raneem Jannadi, Moustafa S Magliyah, Hanan Al Shalan, Doaa Milibari, Hassan Al Dhibi","doi":"10.1080/09273948.2025.2508399","DOIUrl":"https://doi.org/10.1080/09273948.2025.2508399","url":null,"abstract":"Purpose: To describe the clinical presentation, management, visual outcomes, and prognosis of neuroretinitis in a cohort who had neuroretinitis associated with different etiologies.Methods: A retrospective review of the medical records of 10 patients diagnosed with neuroretinitis from a period of 2014 to March 2024 and reporting the clinical features, management, and prognosis.Results: The study included 12 eyes from 10 patients. Seven were males and three were females. The mean age on presentation was 26.5 ± 12.8 years. The Mean duration of follow up was 15.25 ± 14.3 months. The Mean LogMAR visual acuity on presentation was 0.4 ± 0.4 (Snellen = 20/50). Six patients were diagnosed with Behcet's disease, one patient with ocular cat-scratch disease, one patient diagnosed with ocular toxoplasmosis and two patients had idiopathic neuroretinitis. Three patients were initially treated with intravenous methylprednisolone, 5 patients were treated with oral prednisolone, one patient was treated with oral doxycycline and one patient was treated with oral sulfamethoxazole/trimethoprim. The average duration for resolution of first attack was 1.2 ± 0.6 months. Three patients who were diagnosed with Behcet's disease had recurrent neuroretinitis for which treatment regimens were modified. The mean visual acuity on last follow-up was 0.1 ± 0.2 (Snellen = 20/25).Conclusion: Proper management of neuroretinitis involves establishing the accurate diagnosis. In cases with neuroretinitis due to Behcet's disease, the TNFa inhibitors need to be initiated as early as possible to achieve better control and reduce the risk of recurrent attacks of neuroretinitis.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory Therapy Discontinuation for Reasons Other Than Efficacy in the Treatment of Ocular Inflammation. 眼炎治疗中因非疗效原因而停止免疫调节治疗。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-21 DOI: 10.1080/09273948.2025.2506806

Jenny Shunyakova, Jennifer L Patnaik, Julia Xia, Lynn M Hassman, Paula E Pecen, Alan G Palestine, Amit K Reddy

{"title":"Immunomodulatory Therapy Discontinuation for Reasons Other Than Efficacy in the Treatment of Ocular Inflammation.","authors":"Jenny Shunyakova, Jennifer L Patnaik, Julia Xia, Lynn M Hassman, Paula E Pecen, Alan G Palestine, Amit K Reddy","doi":"10.1080/09273948.2025.2506806","DOIUrl":"https://doi.org/10.1080/09273948.2025.2506806","url":null,"abstract":"Purpose: Immunomodulatory therapy (IMT) is commonly used in the treatment of chronic ocular inflammation. While there is substantial data on their efficacy, comparatively little data is available on their relative tolerability and safety. Here, we compare the discontinuation rates for reasons other than efficacy for both conventional IMT (cIMT) - methotrexate, mycophenolate, and azathioprine - and biologic IMT (bIMT) - adalimumab and infliximab - in the treatment of ocular inflammation.Methods: A retrospective cohort study was performed for patients treated with IMT for ocular inflammation between 2013 and 2024 at the University of Colorado Hospital. Data collected for each patient use of a relevant IMT agent included patient sex, race/ethnicity, age, ocular and systemic inflammation diagnosis, duration of therapy, and reason for IMT discontinuation. The primary outcomes were discontinuation rates and time to discontinuation of IMT by reason, which was separated into tolerability; safety; insurance changes, excessive cost, or patient preference; lack of efficacy for ocular inflammation; lack of efficacy for systemic inflammation; or to evaluate for drug-free remission.Results: 455 patients with 760 unique patient-drug records were included. Discontinuation rates for any reason differed between the five drugs (p = 0.005), and specifically differed for reason of tolerability (p < 0.0001). The time to discontinuation for reasons other than efficacy was significantly shorter for cIMT as compared to bIMT (p < 0.0001).Conclusions: Similar to findings in other inflammatory diseases, bIMT was better tolerated than cIMT in the treatment of ocular inflammation.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Masquerade Syndrome Revealing a Vitreous Metastasis from Adenosquamous Lung Carcinoma in a Patient Treated with Pembrolizumab. 假面综合征在接受派姆单抗治疗的患者中显示腺鳞肺癌的玻璃体转移。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-21 DOI: 10.1080/09273948.2025.2509711

Léo Olory-Garnotel, Sarah Gabison, Malek Hamzaoui, Camille Boulagnon-Rombi, Carl Arndt

{"title":"Masquerade Syndrome Revealing a Vitreous Metastasis from Adenosquamous Lung Carcinoma in a Patient Treated with Pembrolizumab.","authors":"Léo Olory-Garnotel, Sarah Gabison, Malek Hamzaoui, Camille Boulagnon-Rombi, Carl Arndt","doi":"10.1080/09273948.2025.2509711","DOIUrl":"https://doi.org/10.1080/09273948.2025.2509711","url":null,"abstract":"Purpose: To describe the case of a 71-year-old man presenting with an isolated vitreous metastasis of an adenosquamous lung carcinoma treated with pembrolizumab.Case report: The patient initially presented with a unilateral visual loss (20/200) due to a dense vitritis. First-line treatment with oral corticosteroids 1 mg/kg was ineffective. A diagnostic vitrectomy was conducted, and cytological analyses were positive for malignancy with focal expression of TTF1 marker, confirming a secondary localization of his lung cancer. Adjunctive external radiotherapy (20 Gy/5 fractions) was performed due to an early recurrence and retinal extension. The evolution was marked by a neovascular glaucoma and a rapid progression of cataract. The patient underwent a combined surgery to remove the lens, apply pan-retinal photocoagulation, and fill the vitreous cavity with silicone oil. Six months after the surgery and the removal of the silicone oil, no metastatic recurrence occurred, and VA improved to 20/32.Discussion: Vitreous metastasis is a rare condition, and vitreous metastatic extension of a lung cancer is even less frequent. We assume that Pembrolizumab, given to its high molecular weight and unaltered blood retinal barriers, failed to prevent the development of this secondary lesion. The origin of the lesion, choroidal or ciliary, remains unclear.Conclusion: Masquerade syndrome uveitis can may delay diagnosis and worsen outcomes. In case of failure of anti-inflammatory treatment, a cytological analysis should be conducted to confirm a tumoral origin.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune Retinopathy in a Patient with Common Variable Immunodeficiency. 常见可变免疫缺陷患者的自身免疫性视网膜病变

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-20 DOI: 10.1080/09273948.2025.2507712

Chiara Muzio, Giuseppe Casalino, Chiara Mapelli, Marco Nassisi, Laura Dell'Arti, Alfredo Pece, Federica Fossataro, Giovanna Fabio, Maria Carrabba, Francesco Viola

{"title":"Autoimmune Retinopathy in a Patient with Common Variable Immunodeficiency.","authors":"Chiara Muzio, Giuseppe Casalino, Chiara Mapelli, Marco Nassisi, Laura Dell'Arti, Alfredo Pece, Federica Fossataro, Giovanna Fabio, Maria Carrabba, Francesco Viola","doi":"10.1080/09273948.2025.2507712","DOIUrl":"https://doi.org/10.1080/09273948.2025.2507712","url":null,"abstract":"Purpose: To describe a rare case of posterior ocular involvement consistent with an autoimmune retinopathy (AIR) on multimodal retinal imaging in a patient with common variable immunodeficiency (CVID).Methods: Observational case report.Results: A 34-year-old male patient with a recent diagnosis of CVID was referred to our clinic following the incidental finding of retinal lesions in his eyes. He was asymptomatic and his best-corrected visual acuity (BCVA) was 20/20 in both eyes. Multimodal retinal imaging including optical coherence tomography and fundus autofluorescence revealed peripapillary and mid-peripheral hyperautofluorescent lesions associated with outer nuclear layer thinning and ellipsoid/interdigitation zones disruption in both eyes.PET/CT imaging ruled out systemic inflammation or malignancy and a diagnosis of a possible non-paraneoplastic AIR was established.During follow-up BCVA was stable, the patient remained asymptomatic, and the retinal imaging findings showed no progression. At 12 months, the patient reported new-onset occasional photopsias described as \"shimmering lights.\" Despite these symptoms, BCVA and retinal imaging remained stable.Conclusion: This case supports a potential association between CVID and immune-mediated retinal pathology, highlighting the importance of comprehensive ophthalmic evaluation and multimodal retinal imaging in CVID patients and further research into this association.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0