Ocular Immunology and Inflammation最新文献

OCT Characterization and Monitoring of Fusarium solani Chorioretinitis Lesions. 茄枯菌性脉络膜视网膜炎病变的OCT特征与监测。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-23 DOI: 10.1080/09273948.2025.2522954

María Aramberri Araiz, Estibaliz Alcalde Del Río, Sofía Uncetabarrenechea Larrucea, Joseba Artaraz Beobide, Alex Fonollosa

{"title":"OCT Characterization and Monitoring of Fusarium solani Chorioretinitis Lesions.","authors":"María Aramberri Araiz, Estibaliz Alcalde Del Río, Sofía Uncetabarrenechea Larrucea, Joseba Artaraz Beobide, Alex Fonollosa","doi":"10.1080/09273948.2025.2522954","DOIUrl":"https://doi.org/10.1080/09273948.2025.2522954","url":null,"abstract":"Purpose: To report a case of chorioretinitis caused by Fusarium in an immunosuppressed 34-year-old patient in the context of an acute lymphoblastic leukemia and to describe its management based on optical coherence tomography (OCT) findings of the inflammatory lesions.Methods: Case report.Results: A 34-year-old man developed a bilateral multifocal chorioretinitis caused by Fusarium solani during the induction chemotherapy for acute lymphoblastic leukemia diagnosed three months earlier. At the time of ophthalmological diagnosis, the patient already presented a disseminated fungal infection involving skin, nasal mucosa, and lungs. The patient was treated with systemic antifungal agents (intravenous voriconazole and liposomal amphotericin B) and five intravitreal injections of voriconazole (100 µg/0.1 mL). The clinical outcome was favorable, with resolution of the lesions and a final best-corrected visual acuity of 20/20 in both eyes. Chorioretinal inflammatory lesions were monitored using OCT, enabling the evaluation and characterization of different stages of lesion evolution.Conclusions: OCT may be useful for monitoring the evolution of inflammatory lesions in Fusarium chorioretinitis and may assist in therapeutic decision-making.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paradoxical Exacerbation of Birdshot Retinochoroiditis Following Rituximab. 利妥昔单抗后鸟射性视网膜脉络膜炎的矛盾加重。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2519869

Anamika Patel, Chi Yun Doreen Ho, William Tucker, Carlos Pavesio, Ilaria Testi

{"title":"Paradoxical Exacerbation of Birdshot Retinochoroiditis Following Rituximab.","authors":"Anamika Patel, Chi Yun Doreen Ho, William Tucker, Carlos Pavesio, Ilaria Testi","doi":"10.1080/09273948.2025.2519869","DOIUrl":"https://doi.org/10.1080/09273948.2025.2519869","url":null,"abstract":"Purpose: We report a case of exacerbated ocular inflammation following rituximab treatment in a patient with Birdshot Retinochoroiditis.Method: Retrospective single case report.Result: Following rituximab administration for Birdshot Retinochoroiditis, the patient developed bilateral increase in choroidal thickness with retinal pigment epithelium undulations and subretinal fluid on enhanced depth imaging optical coherence tomography (EDI-OCT). Indocyanine green angiography (ICGA) demonstrated bilateral fuzzy and obscured choroidal vessels with diffuse late hyperfluorescence. Electroretinography (ERG) showed delayed amplitudes, indicating retinal dysfunction. The patient was rescued with intravenous methylprednisolone, followed by high-dose oral steroids. Rituximab was discontinued, and abatacept was initiated.Conclusion: This case highlights a potential paradoxical exacerbation of intraocular inflammation following rituximab in Birdshot Retinochoroiditis, an observation already reported in other areas but rarely seen in ophthalmology.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic Therapy for the Management of Lipid Keratopathy Secondary to Herpetic Keratitis. 光动力疗法治疗疱疹性角膜炎继发的脂性角膜病变。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2513509

Margarita Zamorano, Carlos Solera de Andres, Natalia Pastora Salvador, Almudena Del Hierro Zarzuelo, Paola Vázquez Colomo, Ana Martin-Ucero, Ana Boto de Los Bueis

{"title":"Photodynamic Therapy for the Management of Lipid Keratopathy Secondary to Herpetic Keratitis.","authors":"Margarita Zamorano, Carlos Solera de Andres, Natalia Pastora Salvador, Almudena Del Hierro Zarzuelo, Paola Vázquez Colomo, Ana Martin-Ucero, Ana Boto de Los Bueis","doi":"10.1080/09273948.2025.2513509","DOIUrl":"https://doi.org/10.1080/09273948.2025.2513509","url":null,"abstract":"Purpose: To report the quantitative effectiveness of photodynamic therapy (PDT) with verteporfin in reducing corneal neovascularization (CNV) and lipid keratopathy (LK) in patients with herpetic interstitial keratitis.Methods: We retrospectively evaluated patients with secondary LK due to herpetic keratitis who underwent PDT with Verteporfin. We analyzed before and after PDT, visual acuity (VA) and the percentage of CNV, LK, and total pathological corneal areas. The number of stromal neo-vessels and its activity, and the severity of the corneal opacity were also analyzed.Results: We studied nine consecutive patients. The CNV area, LK extent, pathological area, vessel count, vessel activity and corneal opacity all exhibited a statistically significant decrease (p < 0.05) in all patients following PDT. A second PDT was required in 3 patients. Complete vascular occlusion was observed in 5 eyes (55.5%), and partial occlusion in 3 eyes (33.5%). The mean post-treatment VA was 0.76 ± 0.32. VA improved by more than 1 line in 5 eyes (55.5%), with more than 2 line-improvement observed in 4 eyes (44.4%). It remain unchanged in 3 eyes (33.3%), while one patient (11%) worsened. No adverse effects were detected after a mean of 14.9 ± 3.9 years follow-up. There was no relapse of herpetic keratitis after discharging 88,8% patients (follow-up after discharged 8.1 ± 4.6 years).Conclusion: PDT with verteporfin is a safe and effective treatment of herpetic CNV and LK, with long lasting efficacy. Additionally, after the treatment, our cases had a lower incidence of herpetic recurrences than expected.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Rise of Syphilitic Placoid Chorioretinitis: A Literature Review with Data from 286 Published Cases. 梅毒样斑脉络膜视网膜炎的兴起：对286例已发表病例的文献回顾。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2511129

Nicholas Jones, Eleftherios Agorogiannis

{"title":"The Rise of Syphilitic Placoid Chorioretinitis: A Literature Review with Data from 286 Published Cases.","authors":"Nicholas Jones, Eleftherios Agorogiannis","doi":"10.1080/09273948.2025.2511129","DOIUrl":"https://doi.org/10.1080/09273948.2025.2511129","url":null,"abstract":"Purpose: To investigate all published reports of acute syphilitic posterior placoid chorioretinitis (ASPPC) and to analyse demographic, clinical and management features to clarify trends in presentation, diagnosis and outcome.Methods: A comprehensive review of literature relating to ASPPC including examples within published series of ocular syphilis, case series limited to ASPPC and case reports.Results: A total of 128 publications included 286 patients with 387 eyes affected by ASPPC. This is increasing in frequency and since 2020 accounts for 26% of ocular syphilis in case series; it appears most common in countries where the predominant Treponema pallidum subclade is SS14 Omega. Visual symptoms were the first in 81%. The mean age at onset was 47.0 yrs (range 23-81), 84% were male and these were more likely to be men who had sex with men (MSM)(p = 0.001). Risk was not increased by HIV positivity. Recovery to LogMAR 0.3 or better was achieved in 85%.Conclusions: Men are particularly affected by ASPPC, especially MSM. It is associated with otosyphilis. Optic nerve involvement is less common in ASPPC, compared to other forms of ocular syphilis. Visual outcomes were very good unless treatment onset was delayed and were equally good for HIV+ and HIV- patients; IV penicillin, IM penicillin and IV ceftriaxone were equally effective. Data quality on systemic steroid usage was too poor to permit analysis. The aetiology of ASPPC remains unknown but geographical disparity supports the possibility of an association between ASPPC and particular treponemal subclade(s).","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-11"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remdesivir Treatment Outcomes of Subacute Sclerosing Panencephalitis Presenting with Macular Necrotizing Retinitis: A Case Report. 瑞德西韦治疗以黄斑坏死性视网膜炎为表现的亚急性硬化性全脑炎的疗效：1例报告。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2521370

Aseel Gebara, Mohammed Homeidat, Tarek Keadan, Tamar Fisher-Negev, Esther Oiknine-Djian, Dana G Wolf, Hadas Mechoulam, Dana Ekstein, Radgonde Amer

{"title":"Remdesivir Treatment Outcomes of Subacute Sclerosing Panencephalitis Presenting with Macular Necrotizing Retinitis: A Case Report.","authors":"Aseel Gebara, Mohammed Homeidat, Tarek Keadan, Tamar Fisher-Negev, Esther Oiknine-Djian, Dana G Wolf, Hadas Mechoulam, Dana Ekstein, Radgonde Amer","doi":"10.1080/09273948.2025.2521370","DOIUrl":"https://doi.org/10.1080/09273948.2025.2521370","url":null,"abstract":"Purpose: Subacute sclerosing panencephalitis (SSPE) is a fatally progressive neurodegenerative disorder caused by persistent measles virus infection of the CNS. We report on the visual and neurological outcomes of SSPE in a patient who presented with necrotizing retinitis three decades after measles infection.Methods: Descriptive case report.Results: A 31-year-old woman presented with sudden blurred vision of the right eye (RE). Visual acuity (VA) was finger counting in RE and 0.8 in the left eye (LE). Funduscopy revealed RE multifocal macular yellowish lesions, LE peripheral retinal atrophic scar and bilateral optic disc edema. OCT of RE showed \"moth-eaten\" macula. Elevated anti-measles IgG and positive oligoclonal bands were detected in the cerebrospinal fluid (CSF). Aqueous PCR was positive for Measles. Brain MRI showed mild hyperintense FLAIR signal in the parieto-occipital white matter. Electroencephalogram revealed mild generalized and left temporal focal slowing. Treatment with remdesivir was instituted in combination with intravenous immunoglobulins. Subsequently, intrathecal interferon-ɑ was administered. Macular necrosis progressed relentlessly. Remdesivir lowered measles IgG titer in CSF and serum and the titer re-increased once remdesivir was discontinued. The patient was well one-year later.Conclusion: While remdesivir failed to arrest measles-associated macular necrosis, it may have prevented disease progression in the contralateral eye and in the CNS. To our knowledge, this is the first case of measles-associated necrotizing retinitis that was confirmed by a positive aqueous PCR. In the absence of an established treatment, vaccination remains the most effective modality. Further investigation of remdesivir as a potential treatment of SSPE is required.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathologically Proven IgG4-Related Orbital Disease: A Two-Tertiary Center Study from Turkiye. 组织病理学证实igg4相关眼窝疾病：来自土耳其的两三级中心研究

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2518255

Burak Ulas, Altan Atakan Özcan, Melis Palamar, Banu Yaman, Arbil Acikalin

{"title":"Histopathologically Proven IgG4-Related Orbital Disease: A Two-Tertiary Center Study from Turkiye.","authors":"Burak Ulas, Altan Atakan Özcan, Melis Palamar, Banu Yaman, Arbil Acikalin","doi":"10.1080/09273948.2025.2518255","DOIUrl":"https://doi.org/10.1080/09273948.2025.2518255","url":null,"abstract":"Aim: The purpose of this study was to evaluate the clinical features and symptoms of IgG4-related orbital disease (IgG4-ROD) cases from two ophthalmology clinics.Methods: The medical records of 20 patients with histopathologically proven IgG4-ROD diagnosed at 2 tertiary referral university hospitals in Turkey were retrospectively reviewed. The demographic profiles, clinical findings, and ocular symptoms of the patients were analyzed.Results: The mean patient age was 40.9 ± 20.1 (5-67) years (65% female, 35% male). IgG4-ROD involvement was bilateral in 25% of cases. The involvement sites were lacrimal gland (84.2%), orbital soft tissues (52.6%), conjunctiva (15.8%). Multiple ophthalmic sites of involvement were detected in seven patients. Lacrimal gland involvement was the most frequent ophthalmic manifestation of IgG4-ROD. The most common complaints of the patients were swelling and redness of the eyelids. All patients responded to glucocorticoid treatment. However, one patient (5.3%) relapsed and required long-term corticosteroid and immunosupressive agent use.Conclusion: IgG4-ROD can present with overlapping features of clinical history, physical examination, and imaging findings. Therefore, in any orbital involvement - especially with eyelid swelling and redness, it is important to suspect IgG4-ROD and to perform biopsy to achieve the accurate diagnose.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tocilizumab for Silicone Oil-Induced Recalcitrant Cystoid Macular Edema in a Patient with Recurrent Acute Retinal Necrosis-Associated Retinal Detachment. 托珠单抗治疗复发性急性视网膜坏死相关视网膜脱离患者硅油诱导的顽固性囊样黄斑水肿。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2519849

Warren W Pan, Mahsaw Mansoor, David Riccardi, Jacqueline A Madison, Thomas J Wubben, Shilpa Kodati, Jason Miller

{"title":"Tocilizumab for Silicone Oil-Induced Recalcitrant Cystoid Macular Edema in a Patient with Recurrent Acute Retinal Necrosis-Associated Retinal Detachment.","authors":"Warren W Pan, Mahsaw Mansoor, David Riccardi, Jacqueline A Madison, Thomas J Wubben, Shilpa Kodati, Jason Miller","doi":"10.1080/09273948.2025.2519849","DOIUrl":"https://doi.org/10.1080/09273948.2025.2519849","url":null,"abstract":"Purpose: We report a case of refractory silicone oil-induced cystoid macular edema in a patient with recurrent acute retinal necrosis-related retinal detachments successfully treated with tocilizumab without silicone oil removal nor reactivation of the acute retinal necrosis.Methods: Single-patient case report.Results: A monocular patient with recurrent acute retinal necrosis-related retinal detachments necessitating indefinite silicone oil tamponade developed intractable cystoid macular edema immediately after silicone oil placement that was unresponsive to multiple therapies over nearly a year. After a single dose of tocilizumab, the patient demonstrated significant clinical improvement with resolution of the macular edema and reduction in petaloid macular leakage on fluorescein angiography. With continued tocilizumab treatment, silicone oil tamponade could be maintained, and no reactivation of acute-retinal necrosis was noted.Conclusion: This case represents the first documented successful use of tocilizumab in treating silicone oil-induced recalcitrant cystoid macular edema. When silicone oil cannot be removed from an eye and when steroids risk reactivating viral retinal disease, tocilizumab may offer a safe and effective treatment alternative for such macular edema.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Quality of Life Impact of Acute Uveitis: A Prospective Study. 急性葡萄膜炎对生活质量影响的前瞻性研究。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-17 DOI: 10.1080/09273948.2025.2518253

Juliana Rocha de Mendonça da Silva, Ana Luiza Biancardi, Henrique Maciel Vieira de Moraes, Haroldo Vieira de Moraes

{"title":"The Quality of Life Impact of Acute Uveitis: A Prospective Study.","authors":"Juliana Rocha de Mendonça da Silva, Ana Luiza Biancardi, Henrique Maciel Vieira de Moraes, Haroldo Vieira de Moraes","doi":"10.1080/09273948.2025.2518253","DOIUrl":"https://doi.org/10.1080/09273948.2025.2518253","url":null,"abstract":"Purpose: To evaluate the impact on quality of life of acute uveitis diagnosis and management.Design: 50 patients with acute uveitis were followed prospectively for three months in a tertiary hospital in Rio de Janeiro, Brazil. Vision-related (VR-) and health-related (HR-) quality of life (QoL) were respectively assessed by NEI-VFQ-25 and SF-36 questionnaires at the initial consultation and after three months. Associations between the questionnaire's subscale item scores with clinical/demographical data were assessed.Results: After generalized linear models, in the initial QoL evaluation lower visual acuity (VA) and unemployment/retirement were associated with lower scores in both questionnaires, while bilateral uveitis was associated with NEI-VFQ-25 questionnaire only and older age with SF-36 only. At the three-month QoL evaluation lower VA and older age were associated with lower scores and VA improvement with higher scores in both questionnaires and unemployment/retirement was associated with lower SF-36 score only. When evaluating the variation between the initial QoL scores and those after three months, older age was associated with lower VR- and HR-QoL improvement, while short interval between referral and the first appointment, higher final VA and VA improvement were associated with VR-QoL upgrade. Bilateral uveitis was associated with lower HR-QoL improvement.Conclusion: Older age and worse VA have a significant negative impact on VR-QoL and HR-QoL, while VA improvement has positive impact. Anatomic classification and etiology of uveitis did not seem to impact on variation of QoL during diagnosis and treatment of acute uveitis, as well as education level and self-reported color.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the COTS Calculator for Tubercular Uveitis: Predictive Performance and Diagnostic Utility in an Indian Cohort. 结核性葡萄膜炎的COTS计算器的验证：在印度队列中的预测性能和诊断效用。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-16 DOI: 10.1080/09273948.2025.2517309

Janakiraman Palani, Carlos Cifuentes Gonzalez, Gazal Patnaik, William Rojas-Carabali, Ludi Zhang, Zheng Xian Thng, Bernett Lee, Rupesh Agrawal, Jyotirmay Biswas

{"title":"Validation of the COTS Calculator for Tubercular Uveitis: Predictive Performance and Diagnostic Utility in an Indian Cohort.","authors":"Janakiraman Palani, Carlos Cifuentes Gonzalez, Gazal Patnaik, William Rojas-Carabali, Ludi Zhang, Zheng Xian Thng, Bernett Lee, Rupesh Agrawal, Jyotirmay Biswas","doi":"10.1080/09273948.2025.2517309","DOIUrl":"https://doi.org/10.1080/09273948.2025.2517309","url":null,"abstract":"Purpose: Diagnosing ocular tuberculosis (OTB) is clinically challenging due to its paucibacillary nature and lack of definitive diagnostic tests. The Collaborative Ocular Tuberculosis Study (COTS) Calculator was developed as a clinical decision-support tool to guide anti-tubercular therapy (ATT) initiation. This study externally validates the COTS Calculator in a high-burden Indian cohort and assesses the additive value of radiological and immunological testing.Methods: This retrospective cohort study included 196 OTB patients treated between 2015 and 2022 at a tertiary eye care center in South India. Inclusion required complete diagnostic workup, ≥6-month follow-up post-ATT, and at least one supportive test (TST, IGRA, CT, or CXR). Two thresholds were evaluated: M4I1 (median ≥ 4) and M4I2 (median ≥ 4, IQR ≤ 2). Treatment response and recurrence were primary outcomes. Diagnostic performance was measured using AUC, sensitivity, specificity, PPV, and NPV. Composite scores (CT+CXR and TST+IGRA) were also analyzed.Results: The M4I2 threshold yielded higher sensitivity (83%) than M4I1 (60%) with comparable AUC (0.60 vs 0.58), though at lower specificity (38% vs 56%). Both thresholds achieved high PPV (94%) but poor NPV (11-17%). Composite testing showed similar high PPV (93%) and poor NPV (9-11%). Higher COTS scores and multiple positive tests correlated with favorable treatment response.Conclusions: The COTS Calculator, particularly the M4I2 model, provides a useful clinical tool to guide ATT decisions in OTB. While limited in ruling out TB, its integration with radiological and immunological testing supports early treatment decisions in TB-endemic settings. Prospective validation is warranted.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Upadacitinib in Adolescents with Idiopathic Chronic Panuveitis Who Lost Response to Adalimumab. Upadacitinib在对阿达木单抗失去反应的青少年特发性慢性全葡萄膜炎中的治疗潜力

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-14 DOI: 10.1080/09273948.2025.2519852

Kailei Guo, Xiaomin Zhang

{"title":"Therapeutic Potential of Upadacitinib in Adolescents with Idiopathic Chronic Panuveitis Who Lost Response to Adalimumab.","authors":"Kailei Guo, Xiaomin Zhang","doi":"10.1080/09273948.2025.2519852","DOIUrl":"https://doi.org/10.1080/09273948.2025.2519852","url":null,"abstract":"Purpose: This report highlights the administration of upadacitinib in four adolescents with idiopathic chronic refractory panuveitis who showed an inadequate response to systemic glucocorticoids, immunosuppressive agents, and anti-TNF biologic therapy.Methods: We present four cases: two 13-year-old boys, one 15-year-old boy, and one 14-year-old girl, each with a history of idiopathic panuveitis that persisted for 4, 8, 4, and 5 years, respectively.Results: Upadacitinib effectively reduced ocular inflammation in all four cases during the first month of treatment. Following upadacitinib treatment, adalimumab was discontinued or extended, and the immunosuppressive agents were gradually tapered. In two cases, it led to complete resolution of the anterior segment and vitreous inflammation and significant improvement in the posterior segment. However, two patients developed upper respiratory tract symptoms at the second and fifth months, respectively, both of which were associated with recurrence of ocular inflammation and required high-dose glucocorticoids for control. No other serious adverse events were documented in the four patients during the nine to ten months follow-up period.Conclusions: These cases indicate that upadacitinib may be an effective treatment strategy for adolescents with idiopathic chronic refractory panuveitis. However, the potential risk of infections should be considered and monitored.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0