Ocular Immunology and Inflammation最新文献_第2页

Tattoo-Associated Uveitis: An African Case Series. 纹身相关葡萄膜炎：非洲病例系列。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-07 DOI: 10.1080/09273948.2025.2564770

Paola Saboya-Galindo, Alejandra de-la-Torre, Rupesh Agrawal, John H Kempen, Getahun Tabor Emebet

{"title":"Tattoo-Associated Uveitis: An African Case Series.","authors":"Paola Saboya-Galindo, Alejandra de-la-Torre, Rupesh Agrawal, John H Kempen, Getahun Tabor Emebet","doi":"10.1080/09273948.2025.2564770","DOIUrl":"https://doi.org/10.1080/09273948.2025.2564770","url":null,"abstract":"Purpose: Tattoo-associated uveitis is a rare condition often linked to sarcoidosis. Its presentation in African individuals has not been previously documented, and, in the cases we report, it exhibited an unusual pattern characterized by the absence of evident systemic involvement.Methods: We report three cases of Ethiopian patients with tattoo-associated uveitis. None of the patients showed signs of sarcoidosis on chest X-ray or clinical examination, although systemic sarcoidosis was not completely ruled out by biopsy or chest CT. The absence of chest CT or biopsy represents a limitation of this study, due to resource constraints. All developed inflammatory skin reactions in their black-ink tattoos, followed by ocular inflammation. Uveitis resolved with systemic corticosteroid therapy in all cases, with only one patient experiencing a relapse requiring methotrexate.Results: Unlike previous reports primarily involving African American patients, this series highlights the presence of tattoo-associated uveitis in African individuals without clinical or radiographic evidence of systemic sarcoidosis. Black tattoo pigments appeared to be a common factor, potentially triggering localized immune responses that may extend to ocular structures.Conclusion: This case series expands the clinical spectrum of tattoo-associated uveitis beyond its usual association with sarcoidosis. In these African patients, no systemic involvement was evident during evaluation. Clinicians should consider tattoo inspection in unexplained uveitis, including non- granulomatous cases, which were also observed in our series.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Clinical Characteristics and Posterior Segment Parameters in Multiple Sclerosis-Associated Uveitis with Optical Coherence Tomography Angiography. 光学相干断层血管造影分析多发性硬化相关性葡萄膜炎的临床特征和后段参数。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-07 DOI: 10.1080/09273948.2025.2568646

Nurtaç Yeşilyaprak, Ali Mert Koçer, Hayat Güven, Bülent Güven, Fatma Avşar Ertürk, Pınar Çakar Özdal

{"title":"Analysis of Clinical Characteristics and Posterior Segment Parameters in Multiple Sclerosis-Associated Uveitis with Optical Coherence Tomography Angiography.","authors":"Nurtaç Yeşilyaprak, Ali Mert Koçer, Hayat Güven, Bülent Güven, Fatma Avşar Ertürk, Pınar Çakar Özdal","doi":"10.1080/09273948.2025.2568646","DOIUrl":"https://doi.org/10.1080/09273948.2025.2568646","url":null,"abstract":"Purpose: To describe the clinical characteristics of multiple sclerosis-associated uveitis (MSAU), to examine its relationship with multiple sclerosis (MS), using optical coherence tomography angiography (OCT-A) and spectral-domain optical coherence tomography (SD-OCT) parameters of patients.Methods: The study included 58 eyes of 29 patients with MSAU, 102 eyes of 55 patients with MS, and 41 eyes of 41 healthy controls (HC). The eyes were divided into four subgroups depending on history of optic neuritis (MSON+, MSAUON+, MSON-, MSAUON-). All underwent OCT-A and SD-OCT. The data collected from MS, MSAU and control groups was compared.Results: In MS patients, intermediate uveitis was the most common type of uveitis (41.4%). In unilateral MSON+ patients; a significant decrease was observed in the radial peripapillary capillary plexus (RPC), superficial capillary plexus (SCP), pRNFL and macular thickness in the ON+ eye compared to the healthy eye (p < 0.05). In ON- eyes, SCP density was found as control group, MS, and MSAU, respectively, from highest to lowest (p < 0.005). In the MSAUON- group; SCP, deep capillary plexus density (DCP) were significantly decreased compared to MS and control groups (p < 0.005). Macular thickness was decreased in the MSON- group compared to the control group (p < 0.005).Conclusion: Intermediate uveitis is the most common form of uveitis in MS patients. Optic neuritis causes a decrease in SCP, RPC, RNFL, and macular thickness, it does not create a significant change in DCP. The diffuse reduction in all retinal capillary plexus layers in MSAU may accelerate the neurodegenerative process in ganglion cells.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-8"},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suprachoroidal Proliferative Membrane in Uveal Effusion Syndrome with Nanophthalmos: Incidental Finding During Sclerectomy. 葡萄膜积液综合征伴纳米眼的脉络膜上增生膜：巩膜切除术时偶然发现。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 DOI: 10.1080/09273948.2025.2563168

Ying Tian, Jingyi Shi, Fuxiao Luan, Xiaofeng Hu, Li Chen, Yong Tao

{"title":"Suprachoroidal Proliferative Membrane in Uveal Effusion Syndrome with Nanophthalmos: Incidental Finding During Sclerectomy.","authors":"Ying Tian, Jingyi Shi, Fuxiao Luan, Xiaofeng Hu, Li Chen, Yong Tao","doi":"10.1080/09273948.2025.2563168","DOIUrl":"https://doi.org/10.1080/09273948.2025.2563168","url":null,"abstract":"Purpose: To report the identification and histopathological analysis of a suprachoroidal proliferative membrane in a patient with uveal effusion syndrome (UES) and nanophthalmos, highlighting its potential role in the pathophysiology of the condition.Methods: A comprehensive ophthalmological examination, including fundus examination IOL-Master biometry, and B-scan ultrasound, was performed on a 52-year-old female patient presenting with blurred vision. Sclerectomy was conducted, during which a white strand-like substance was extracted from the suprachoroidal space. Histopathological and immunohistochemical analyses were carried out to characterize the substance.Results: The patient presented with hand motion visual acuity in the right eye and a best-corrected visual acuity of 0.4 in the left eye. Fundus examination revealed a spherical bulge of the retina in the right eye, and IOL-Master confirmed nanophthalmos with axial lengths of 18.2 mm (right) and 18.5 mm (left). B-scan ultrasound showed a retinal and choroidal detachment in the right eye. During sclerectomy, a 3 cm white strand-like substance was extracted from the suprachoroidal space of the right eye. Histopathological analysis identified it as a collagen-rich proliferative membrane, with immunohistochemical staining showing strong positivity for collagen type I and moderate positivity for CD68. Post-surgery, with topical corticosteroids, the uveal effusion resolved, the retina flattened, and visual acuity improved to 0.02 in the right eye.Conclusion: The discovery of a suprachoroidal proliferative membrane rich in fibroblasts and macrophages in a patient with UES and nanophthalmos suggests an inflammatory component in the pathophysiology of nanophthalmic UES, providing new insights into its mechanism and potential therapeutic targets.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Biomarkers for Uveitis: Serum BAFF and CXCL9 in Differentiating Ocular Sarcoidosis, Tuberculosis and Other Entities with Implication for QuantiFERON-Positive Uveitis. 葡萄膜炎的诊断生物标志物：血清BAFF和CXCL9在鉴别眼结节病、结核病和其他与quantiferon阳性葡萄膜炎相关的实体中的作用

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-04-17 DOI: 10.1080/09273948.2025.2493357

Ikhwanuliman Putera, Rina La Distia Nora, Josianne C E M Ten Berge, Nicole M A Nagtzaam, Sigrid M A Swagemakers, Saskia M Rombach, P Martin van Hagen, Willem A Dik

{"title":"Diagnostic Biomarkers for Uveitis: Serum BAFF and CXCL9 in Differentiating Ocular Sarcoidosis, Tuberculosis and Other Entities with Implication for QuantiFERON-Positive Uveitis.","authors":"Ikhwanuliman Putera, Rina La Distia Nora, Josianne C E M Ten Berge, Nicole M A Nagtzaam, Sigrid M A Swagemakers, Saskia M Rombach, P Martin van Hagen, Willem A Dik","doi":"10.1080/09273948.2025.2493357","DOIUrl":"10.1080/09273948.2025.2493357","url":null,"abstract":"Purpose: To evaluate serum B cell activating factor (BAFF) and CXCL9 as diagnostic biomarkers for ocular sarcoidosis and ocular tuberculosis (TB). We also explore their role in the stratification of patients with QuantiFERON (QFT)-positive uveitis without another identifiable cause.Methods: Eighty uveitis patients with various entities were included: 10 with ocular sarcoidosis, 35 with TB-related uveitis (including 11 confirmed (ocular TB) and 24 QFT-positive uveitis of unknown cause) and 35 with other uveitis entities. Levels of serum BAFF and CXCL9 were measured.Results: Serum BAFF was higher in ocular sarcoidosis compared to other groups (area under the curve (AUC) = 0.74; 95% CI: 0.53-0.96, p = 0.017). At an optimal serum BAFF cut-off point of 772.3 pg/ml, the sensitivity was 70.0% (95% CI: 39.7-89.2) and the specificity was 89.1% (95% CI: 77.0-95.3). Serum CXCL9 was comparable between ocular sarcoidosis and confirmed ocular TB but was significantly higher in these groups compared to other uveitis entities (AUC = 0.71, 95% CI: 0.57-0.86, p = 0.011). To differentiate ocular sarcoidosis and TB from other uveitis entities, CXCL9 (cutoff: 105.5 pg/ml) showed a sensitivity of 88.9% (95% CI: 67.2-98.0) and a specificity of 54.3% (95% CI: 38.2-69.5). High CXCL9 TB-related uveitis patients demonstrated a higher proportion of uveitis resolution when fully treated with antitubercular treatment (ATT) (p = 0.027).Conclusions: Serum BAFF and CXCL9 serve as potential diagnostic biomarkers for differentiating ocular sarcoidosis, ocular TB and other uveitis entities. These might identify QFT-positive uveitis who are most in need of ATT.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1548-1560"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Rise of Syphilitic Placoid Chorioretinitis: A Literature Review with Data from 286 Published Cases. 梅毒样斑脉络膜视网膜炎的兴起：对286例已发表病例的文献回顾。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-18 DOI: 10.1080/09273948.2025.2511129

Nicholas Jones, Eleftherios Agorogiannis

{"title":"The Rise of Syphilitic Placoid Chorioretinitis: A Literature Review with Data from 286 Published Cases.","authors":"Nicholas Jones, Eleftherios Agorogiannis","doi":"10.1080/09273948.2025.2511129","DOIUrl":"10.1080/09273948.2025.2511129","url":null,"abstract":"Purpose: To investigate all published reports of acute syphilitic posterior placoid chorioretinitis (ASPPC) and to analyse demographic, clinical and management features to clarify trends in presentation, diagnosis and outcome.Methods: A comprehensive review of literature relating to ASPPC including examples within published series of ocular syphilis, case series limited to ASPPC and case reports.Results: A total of 128 publications included 286 patients with 387 eyes affected by ASPPC. This is increasing in frequency and since 2020 accounts for 26% of ocular syphilis in case series; it appears most common in countries where the predominant Treponema pallidum subclade is SS14 Omega. Visual symptoms were the first in 81%. The mean age at onset was 47.0 yrs (range 23-81), 84% were male and these were more likely to be men who had sex with men (MSM)(p = 0.001). Risk was not increased by HIV positivity. Recovery to LogMAR 0.3 or better was achieved in 85%.Conclusions: Men are particularly affected by ASPPC, especially MSM. It is associated with otosyphilis. Optic nerve involvement is less common in ASPPC, compared to other forms of ocular syphilis. Visual outcomes were very good unless treatment onset was delayed and were equally good for HIV+ and HIV- patients; IV penicillin, IM penicillin and IV ceftriaxone were equally effective. Data quality on systemic steroid usage was too poor to permit analysis. The aetiology of ASPPC remains unknown but geographical disparity supports the possibility of an association between ASPPC and particular treponemal subclade(s).","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1757-1767"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Evanescent White Dot Syndrome as Epiphenomenon of Infectious Chorioretinopathies. 传染性脉络膜视网膜病变伴发的多发性消失性白点综合征。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-13 DOI: 10.1080/09273948.2025.2514987

Luca De Simone, Vanessa Ferraro, Elena Bolletta, Fabrizio Gozzi, Pietro Gentile, Francesca Ceccarelli, Carlo Nucci, Mario Romano, Luca Cimino

{"title":"Multiple Evanescent White Dot Syndrome as Epiphenomenon of Infectious Chorioretinopathies.","authors":"Luca De Simone, Vanessa Ferraro, Elena Bolletta, Fabrizio Gozzi, Pietro Gentile, Francesca Ceccarelli, Carlo Nucci, Mario Romano, Luca Cimino","doi":"10.1080/09273948.2025.2514987","DOIUrl":"10.1080/09273948.2025.2514987","url":null,"abstract":"Purpose: Multiple evanescent white dot syndrome (MEWDS) is a rare idiopathic ocular disorder often affecting young adults. Recently, a secondary form, epiphenomenon MEWDS (Epi-MEWDS), has been described in association with pre-existing retinal conditions. However, its correlation with infectious diseases remains poorly documented.Methods: A retrospective review of six patients with infectious chorioretinopathies who developed Epi-MEWDS was conducted. Clinical presentations, imaging findings, and disease progression were analyzed.Results: This study presents a case series of six patients who developed Epi-MEWDS secondary to infectious chorioretinopathies, highlighting its distinct clinical features. Cases included Epi-MEWDS following Candida endophthalmitis, tubercular multifocal serpiginous-like choroiditis, ocular syphilis, and recurrent toxoplasmosis. Fundus autofluorescence and optical coherence tomography confirmed hyperautofluorescent lesions and outer retinal disruption in all cases. Patients were managed conservatively, and in all cases, imaging abnormalities resolved within a few weeks.Conclusion: This case series emphasizes the role of infectious disease-related immune responses in triggering Epi-MEWDS. In these cases disruptions in the outer blood-retinal barrier, leading to photoreceptor antigen exposure, appear to contribute to disease pathogenesis. Recognizing these cases can enhance understanding of post-infectious retinal immune responses and guide appropriate clinical management.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1841-1846"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic Therapy for the Management of Lipid Keratopathy Secondary to Herpetic Keratitis. 光动力疗法治疗疱疹性角膜炎继发的脂性角膜病变。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-18 DOI: 10.1080/09273948.2025.2513509

Margarita Zamorano, Carlos Solera de Andres, Natalia Pastora Salvador, Almudena Del Hierro Zarzuelo, Paola Vázquez Colomo, Ana Martin-Ucero, Ana Boto de Los Bueis

{"title":"Photodynamic Therapy for the Management of Lipid Keratopathy Secondary to Herpetic Keratitis.","authors":"Margarita Zamorano, Carlos Solera de Andres, Natalia Pastora Salvador, Almudena Del Hierro Zarzuelo, Paola Vázquez Colomo, Ana Martin-Ucero, Ana Boto de Los Bueis","doi":"10.1080/09273948.2025.2513509","DOIUrl":"10.1080/09273948.2025.2513509","url":null,"abstract":"Purpose: To report the quantitative effectiveness of photodynamic therapy (PDT) with verteporfin in reducing corneal neovascularization (CNV) and lipid keratopathy (LK) in patients with herpetic interstitial keratitis.Methods: We retrospectively evaluated patients with secondary LK due to herpetic keratitis who underwent PDT with Verteporfin. We analyzed before and after PDT, visual acuity (VA) and the percentage of CNV, LK, and total pathological corneal areas. The number of stromal neo-vessels and its activity, and the severity of the corneal opacity were also analyzed.Results: We studied nine consecutive patients. The CNV area, LK extent, pathological area, vessel count, vessel activity and corneal opacity all exhibited a statistically significant decrease (p < 0.05) in all patients following PDT. A second PDT was required in 3 patients. Complete vascular occlusion was observed in 5 eyes (55.5%), and partial occlusion in 3 eyes (33.5%). The mean post-treatment VA was 0.76 ± 0.32. VA improved by more than 1 line in 5 eyes (55.5%), with more than 2 line-improvement observed in 4 eyes (44.4%). It remain unchanged in 3 eyes (33.3%), while one patient (11%) worsened. No adverse effects were detected after a mean of 14.9 ± 3.9 years follow-up. There was no relapse of herpetic keratitis after discharging 88,8% patients (follow-up after discharged 8.1 ± 4.6 years).Conclusion: PDT with verteporfin is a safe and effective treatment of herpetic CNV and LK, with long lasting efficacy. Additionally, after the treatment, our cases had a lower incidence of herpetic recurrences than expected.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1830-1833"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Pigment Epithelium Undulations in Primary Vitreoretinal Lymphoma: An Under-Recognised OCT Biomarker. 原发性玻璃体视网膜淋巴瘤的视网膜色素上皮波动：一个未被识别的OCT生物标志物。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-13 DOI: 10.1080/09273948.2025.2519848

Khushboo Chauhan, Lauren Dalvin, Mohit Dogra, Vishal Raval

{"title":"Retinal Pigment Epithelium Undulations in Primary Vitreoretinal Lymphoma: An Under-Recognised OCT Biomarker.","authors":"Khushboo Chauhan, Lauren Dalvin, Mohit Dogra, Vishal Raval","doi":"10.1080/09273948.2025.2519848","DOIUrl":"10.1080/09273948.2025.2519848","url":null,"abstract":"Objective: To determine the significance of retinal pigment epithelium (RPE) undulations in primary vitreoretinal lymphoma (PVRL) and evaluate the association of RPE undulations, intraretinal infiltration, and sub-RPE/subretinal lesions with severity indicators, including partial regression, subsequent central nervous system (CNS) involvement, and recurrence.Methods: It is a multicentred, retrospective observational study which included 134 biopsy-proven PVRL eyes from Asian and American populations. Regression analysis was used to determine the association between various OCT biomarkers of PVRL and disease severity indicators.Results: A total of 134 eyes from 77 patients with biopsy-confirmed PVRL were included. The median age of the patients was 67 years (range 59-71), and the sex distribution was 72 females (54%) and 62 males (46%). On OCT, 35 (26%) eyes showed RPE undulations, which were more common in Asians (61%) than in the American population (16%). In addition, 67 (50%) eyes exhibited sub-RPE/subretinal hyperreflective lesions, and 45 (34%) eyes had intraretinal lesions. Multivariate regression analysis showed an association between RPE undulations and partial regression odds ratio (OR) of 4.032 (95% CI: 1.518-10.71), (p = 0.005), and likelihood ratio of 8.418, and intraretinal lesions were associated with CNS involvement OR of 2.597 (95% CI: 1.14-5.876), (p = 0.01), and likelihood ratio of 5.26.Conclusion: RPE undulation is more common in Asians than in the American population. It is a marker of disease severity associated with partial regression of the disease, whereas intraretinal lesions are associated with an increased risk of subsequent CNS involvement.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1670-1678"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory Therapy Discontinuation for Reasons Other Than Efficacy in the Treatment of Ocular Inflammation. 眼炎治疗中因非疗效原因而停止免疫调节治疗。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-05-21 DOI: 10.1080/09273948.2025.2506806

Jenny Shunyakova, Jennifer L Patnaik, Julia Xia, Lynn M Hassman, Paula E Pecen, Alan G Palestine, Amit K Reddy

{"title":"Immunomodulatory Therapy Discontinuation for Reasons Other Than Efficacy in the Treatment of Ocular Inflammation.","authors":"Jenny Shunyakova, Jennifer L Patnaik, Julia Xia, Lynn M Hassman, Paula E Pecen, Alan G Palestine, Amit K Reddy","doi":"10.1080/09273948.2025.2506806","DOIUrl":"10.1080/09273948.2025.2506806","url":null,"abstract":"Purpose: Immunomodulatory therapy (IMT) is commonly used in the treatment of chronic ocular inflammation. While there is substantial data on their efficacy, comparatively little data is available on their relative tolerability and safety. Here, we compare the discontinuation rates for reasons other than efficacy for both conventional IMT (cIMT) - methotrexate, mycophenolate, and azathioprine - and biologic IMT (bIMT) - adalimumab and infliximab - in the treatment of ocular inflammation.Methods: A retrospective cohort study was performed for patients treated with IMT for ocular inflammation between 2013 and 2024 at the University of Colorado Hospital. Data collected for each patient use of a relevant IMT agent included patient sex, race/ethnicity, age, ocular and systemic inflammation diagnosis, duration of therapy, and reason for IMT discontinuation. The primary outcomes were discontinuation rates and time to discontinuation of IMT by reason, which was separated into tolerability; safety; insurance changes, excessive cost, or patient preference; lack of efficacy for ocular inflammation; lack of efficacy for systemic inflammation; or to evaluate for drug-free remission.Results: 455 patients with 760 unique patient-drug records were included. Discontinuation rates for any reason differed between the five drugs (p = 0.005), and specifically differed for reason of tolerability (p < 0.0001). The time to discontinuation for reasons other than efficacy was significantly shorter for cIMT as compared to bIMT (p < 0.0001).Conclusions: Similar to findings in other inflammatory diseases, bIMT was better tolerated than cIMT in the treatment of ocular inflammation.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1807-1810"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remdesivir Treatment Outcomes of Subacute Sclerosing Panencephalitis Presenting with Macular Necrotizing Retinitis: A Case Report. 瑞德西韦治疗以黄斑坏死性视网膜炎为表现的亚急性硬化性全脑炎的疗效：1例报告。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-18 DOI: 10.1080/09273948.2025.2521370

Aseel Gebara, Mohammed Homeidat, Tarek Keadan, Tamar Fisher-Negev, Esther Oiknine-Djian, Dana G Wolf, Hadas Mechoulam, Dana Ekstein, Radgonde Amer

{"title":"Remdesivir Treatment Outcomes of Subacute Sclerosing Panencephalitis Presenting with Macular Necrotizing Retinitis: A Case Report.","authors":"Aseel Gebara, Mohammed Homeidat, Tarek Keadan, Tamar Fisher-Negev, Esther Oiknine-Djian, Dana G Wolf, Hadas Mechoulam, Dana Ekstein, Radgonde Amer","doi":"10.1080/09273948.2025.2521370","DOIUrl":"10.1080/09273948.2025.2521370","url":null,"abstract":"Purpose: Subacute sclerosing panencephalitis (SSPE) is a fatally progressive neurodegenerative disorder caused by persistent measles virus infection of the CNS. We report on the visual and neurological outcomes of SSPE in a patient who presented with necrotizing retinitis three decades after measles infection.Methods: Descriptive case report.Results: A 31-year-old woman presented with sudden blurred vision of the right eye (RE). Visual acuity (VA) was finger counting in RE and 0.8 in the left eye (LE). Funduscopy revealed RE multifocal macular yellowish lesions, LE peripheral retinal atrophic scar and bilateral optic disc edema. OCT of RE showed \"moth-eaten\" macula. Elevated anti-measles IgG and positive oligoclonal bands were detected in the cerebrospinal fluid (CSF). Aqueous PCR was positive for Measles. Brain MRI showed mild hyperintense FLAIR signal in the parieto-occipital white matter. Electroencephalogram revealed mild generalized and left temporal focal slowing. Treatment with remdesivir was instituted in combination with intravenous immunoglobulins. Subsequently, intrathecal interferon-ɑ was administered. Macular necrosis progressed relentlessly. Remdesivir lowered measles IgG titer in CSF and serum and the titer re-increased once remdesivir was discontinued. The patient was well one-year later.Conclusion: While remdesivir failed to arrest measles-associated macular necrosis, it may have prevented disease progression in the contralateral eye and in the CNS. To our knowledge, this is the first case of measles-associated necrotizing retinitis that was confirmed by a positive aqueous PCR. In the absence of an established treatment, vaccination remains the most effective modality. Further investigation of remdesivir as a potential treatment of SSPE is required.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1873-1876"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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