Photodynamic Therapy for the Management of Lipid Keratopathy Secondary to Herpetic Keratitis.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI:10.1080/09273948.2025.2513509

Margarita Zamorano, Carlos Solera de Andres, Natalia Pastora Salvador, Almudena Del Hierro Zarzuelo, Paola Vázquez Colomo, Ana Martin-Ucero, Ana Boto de Los Bueis

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引用次数: 0

Abstract

Purpose: To report the quantitative effectiveness of photodynamic therapy (PDT) with verteporfin in reducing corneal neovascularization (CNV) and lipid keratopathy (LK) in patients with herpetic interstitial keratitis.

Methods: We retrospectively evaluated patients with secondary LK due to herpetic keratitis who underwent PDT with Verteporfin. We analyzed before and after PDT, visual acuity (VA) and the percentage of CNV, LK, and total pathological corneal areas. The number of stromal neo-vessels and its activity, and the severity of the corneal opacity were also analyzed.

Results: We studied nine consecutive patients. The CNV area, LK extent, pathological area, vessel count, vessel activity and corneal opacity all exhibited a statistically significant decrease (p < 0.05) in all patients following PDT. A second PDT was required in 3 patients. Complete vascular occlusion was observed in 5 eyes (55.5%), and partial occlusion in 3 eyes (33.5%). The mean post-treatment VA was 0.76 ± 0.32. VA improved by more than 1 line in 5 eyes (55.5%), with more than 2 line-improvement observed in 4 eyes (44.4%). It remain unchanged in 3 eyes (33.3%), while one patient (11%) worsened. No adverse effects were detected after a mean of 14.9 ± 3.9 years follow-up. There was no relapse of herpetic keratitis after discharging 88,8% patients (follow-up after discharged 8.1 ± 4.6 years).

Conclusion: PDT with verteporfin is a safe and effective treatment of herpetic CNV and LK, with long lasting efficacy. Additionally, after the treatment, our cases had a lower incidence of herpetic recurrences than expected.

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光动力疗法治疗疱疹性角膜炎继发的脂性角膜病变。

目的：报道椎泊芬光动力疗法（PDT）在减少疱疹性间质性角膜炎患者角膜新生血管（CNV）和脂质性角膜病变（LK）中的定量效果。方法：我们回顾性评估了因疱疹性角膜炎而接受维替波芬PDT治疗的继发性LK患者。我们分析了PDT前后、视力（VA）、CNV百分比、LK百分比和总病理角膜面积。分析角膜间质新生血管的数量、活性及角膜混浊程度。结果：我们连续研究了9例患者。CNV面积、LK范围、病理面积、血管计数、血管活性、角膜混浊度均有统计学意义的降低(p)。结论：椎泊芬联合PDT治疗疱疹性CNV和LK安全有效，疗效持久。此外，治疗后，我们的病例疱疹复发的发生率低于预期。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.