{"title":"Retinal Pigment Epithelium Undulations in Primary Vitreoretinal Lymphoma: An Under-Recognised OCT Biomarker.","authors":"Khushboo Chauhan, Lauren Dalvin, Mohit Dogra, Vishal Raval","doi":"10.1080/09273948.2025.2519848","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine the significance of retinal pigment epithelium (RPE) undulations in primary vitreoretinal lymphoma (PVRL) and evaluate the association of RPE undulations, intraretinal infiltration, and sub-RPE/subretinal lesions with severity indicators, including partial regression, subsequent central nervous system (CNS) involvement, and recurrence.</p><p><strong>Methods: </strong>It is a multicentred, retrospective observational study which included 134 biopsy-proven PVRL eyes from Asian and American populations. Regression analysis was used to determine the association between various OCT biomarkers of PVRL and disease severity indicators.</p><p><strong>Results: </strong>A total of 134 eyes from 77 patients with biopsy-confirmed PVRL were included. The median age of the patients was 67 years (range 59-71), and the sex distribution was 72 females (54%) and 62 males (46%). On OCT, 35 (26%) eyes showed RPE undulations, which were more common in Asians (61%) than in the American population (16%). In addition, 67 (50%) eyes exhibited sub-RPE/subretinal hyperreflective lesions, and 45 (34%) eyes had intraretinal lesions. Multivariate regression analysis showed an association between RPE undulations and partial regression odds ratio (OR) of 4.032 (95% CI: 1.518-10.71), (<i>p</i> = 0.005), and likelihood ratio of 8.418, and intraretinal lesions were associated with CNS involvement OR of 2.597 (95% CI: 1.14-5.876), (<i>p</i> = 0.01), and likelihood ratio of 5.26.</p><p><strong>Conclusion: </strong>RPE undulation is more common in Asians than in the American population. It is a marker of disease severity associated with partial regression of the disease, whereas intraretinal lesions are associated with an increased risk of subsequent CNS involvement.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ocular Immunology and Inflammation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09273948.2025.2519848","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To determine the significance of retinal pigment epithelium (RPE) undulations in primary vitreoretinal lymphoma (PVRL) and evaluate the association of RPE undulations, intraretinal infiltration, and sub-RPE/subretinal lesions with severity indicators, including partial regression, subsequent central nervous system (CNS) involvement, and recurrence.
Methods: It is a multicentred, retrospective observational study which included 134 biopsy-proven PVRL eyes from Asian and American populations. Regression analysis was used to determine the association between various OCT biomarkers of PVRL and disease severity indicators.
Results: A total of 134 eyes from 77 patients with biopsy-confirmed PVRL were included. The median age of the patients was 67 years (range 59-71), and the sex distribution was 72 females (54%) and 62 males (46%). On OCT, 35 (26%) eyes showed RPE undulations, which were more common in Asians (61%) than in the American population (16%). In addition, 67 (50%) eyes exhibited sub-RPE/subretinal hyperreflective lesions, and 45 (34%) eyes had intraretinal lesions. Multivariate regression analysis showed an association between RPE undulations and partial regression odds ratio (OR) of 4.032 (95% CI: 1.518-10.71), (p = 0.005), and likelihood ratio of 8.418, and intraretinal lesions were associated with CNS involvement OR of 2.597 (95% CI: 1.14-5.876), (p = 0.01), and likelihood ratio of 5.26.
Conclusion: RPE undulation is more common in Asians than in the American population. It is a marker of disease severity associated with partial regression of the disease, whereas intraretinal lesions are associated with an increased risk of subsequent CNS involvement.
期刊介绍:
Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.