Retinal Pigment Epithelium Undulations in Primary Vitreoretinal Lymphoma: An Under-Recognised OCT Biomarker.

IF 2.6 4区 医学 Q2 OPHTHALMOLOGY
Khushboo Chauhan, Lauren Dalvin, Mohit Dogra, Vishal Raval
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引用次数: 0

Abstract

Objective: To determine the significance of retinal pigment epithelium (RPE) undulations in primary vitreoretinal lymphoma (PVRL) and evaluate the association of RPE undulations, intraretinal infiltration, and sub-RPE/subretinal lesions with severity indicators, including partial regression, subsequent central nervous system (CNS) involvement, and recurrence.

Methods: It is a multicentred, retrospective observational study which included 134 biopsy-proven PVRL eyes from Asian and American populations. Regression analysis was used to determine the association between various OCT biomarkers of PVRL and disease severity indicators.

Results: A total of 134 eyes from 77 patients with biopsy-confirmed PVRL were included. The median age of the patients was 67 years (range 59-71), and the sex distribution was 72 females (54%) and 62 males (46%). On OCT, 35 (26%) eyes showed RPE undulations, which were more common in Asians (61%) than in the American population (16%). In addition, 67 (50%) eyes exhibited sub-RPE/subretinal hyperreflective lesions, and 45 (34%) eyes had intraretinal lesions. Multivariate regression analysis showed an association between RPE undulations and partial regression odds ratio (OR) of 4.032 (95% CI: 1.518-10.71), (p = 0.005), and likelihood ratio of 8.418, and intraretinal lesions were associated with CNS involvement OR of 2.597 (95% CI: 1.14-5.876), (p = 0.01), and likelihood ratio of 5.26.

Conclusion: RPE undulation is more common in Asians than in the American population. It is a marker of disease severity associated with partial regression of the disease, whereas intraretinal lesions are associated with an increased risk of subsequent CNS involvement.

原发性玻璃体视网膜淋巴瘤的视网膜色素上皮波动:一个未被识别的OCT生物标志物。
目的:探讨视网膜色素上皮(RPE)波动在原发性玻璃体视网膜淋巴瘤(PVRL)中的意义,并评价RPE波动、视网膜内浸润、RPE亚/视网膜下病变与严重程度指标的关系,包括部分消退、随后的中枢神经系统(CNS)受累和复发。方法:这是一项多中心、回顾性观察性研究,包括来自亚洲和美国人群的134只活检证实的PVRL眼睛。采用回归分析确定PVRL各OCT生物标志物与疾病严重程度指标之间的相关性。结果:共纳入77例活检证实的PVRL患者134只眼。患者年龄中位数为67岁(59 ~ 71岁),性别分布为女性72例(54%),男性62例(46%)。在OCT上,35只(26%)眼睛显示RPE波动,亚洲人(61%)比美国人(16%)更常见。此外,67只(50%)眼表现为rpe下/视网膜下高反射病变,45只(34%)眼表现为视网膜内病变。多因素回归分析显示,RPE波动与部分回归相关的比值比(OR)为4.032 (95% CI: 1.518-10.71), (p = 0.005),似然比为8.418;视网膜内病变与中枢神经系统受累相关的比值比(OR)为2.597 (95% CI: 1.14-5.876), (p = 0.01),似然比为5.26。结论:RPE波动在亚洲人群中比美国人群更常见。它是与疾病部分消退相关的疾病严重程度的标志,而视网膜内病变与随后中枢神经系统受累的风险增加相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.20
自引率
15.20%
发文量
285
审稿时长
6-12 weeks
期刊介绍: Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.
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