Ocular Immunology and Inflammation最新文献

{"title":"Prognostic Factors of Treatment Failure with First-Line Corticosteroid-Sparing Agents in Patients with Birdshot Chorioretinopathy: A Retrospective Study.","authors":"Paul Goupillou, Mathilde Leclercq, Marc Muraine, Nicolas Girszyn, Julie Gueudry","doi":"10.1080/09273948.2025.2491570","DOIUrl":"10.1080/09273948.2025.2491570","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate prognostic factors of treatment failure with first-line corticosteroid-sparing agents in patients with birdshot chorioretinopathy (BCR).</p><p><strong>Methods: </strong>This retrospective single center study recruited patients with HLA A29-positive BCR between 2004 and 2023. First-line treatment consisted in oral corticosteroids (prednisone) and mycophenolate mofetil (MMF) or interferon alpha-2a (IFN). Second-line treatment consisted in biologics, i.e. anti-TNFα or tocilizumab (TCZ). At baseline, the characteristics of patients treated with MMF/IFN and patients requiring biologics were compared.</p><p><strong>Results: </strong>Forty-three patients (86 eyes) were included. Mean follow-up duration was 7.9 +/- 5.6 years. All patients were treated with prednisone. MMF/IFN was successful in 22 patients, while 21 patients required biologics. At baseline, clinical papillitis and angiographic leakage of the optical nerve were statistically more frequent in patients requiring biologics compared to patients treated with MMF/IFN, <i>p</i> = 0.004 and <i>p</i> = 0.003 respectively. At baseline, retinal nerve fiber layer (RNFL) thickness was elevated in patients requiring biologics (153 vs 117 μm; <i>p</i> = 0.02). At baseline, mean deviation evaluated by automatized visual field was significantly worse in patients requiring biologics (-7.85 vs - 4.87 ; <i>p</i> = 0.04). Among 11 patients treated sequentially with MMF, anti-TNFα and TCZ, mean prednisone dose significantly decreased with anti-TNFα compared to MMF (13.2 vs 21.9 mg/day, <i>p</i> = 0.002), TCZ compared to MMF (5.7 vs 21.9, <i>p</i> < 0.001) and TCZ compared to anti-TNFα (5.7 vs 13.2, <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>At baseline, clinical papillitis, angiographic papillary leakage, RNFL thickness and mean deviation could be prognostic factors of treatment failure with first-line corticosteroid-sparing agents in patients with BCR.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1298-1302"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Mycophenolate Mofetil in the Treatment of Non-Infectious Uveitis and Sclerouveitis in Japanese Patients: A Feasibility Study.","authors":"Tomona Hiyama, Kaori Komatsu, Yosuke Harada","doi":"10.1080/09273948.2025.2492773","DOIUrl":"10.1080/09273948.2025.2492773","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the incidence rate and severity of adverse events associated with mycophenolate mofetil (MMF) in the treatment of non-infectious uveitis and sclerouveitis in Japanese patients.</p><p><strong>Methods: </strong>This open-label, single-centre feasibility study was performed at Hiroshima University Hospital (jRCTs061220030). Patients started MMF at 1000 mg/day, increasing up to 3000 mg/day. Primary endpoints were the incidence rate and severity of adverse events associated with MMF. Secondary endpoints were the overall rate of treatment success (defined as controlled ocular inflammation according to the Standardization of Uveitis Nomenclature criteria for uveitis and standardised grading system for sclerouveitis in patients on oral prednisolone at ≤ 5 mg/day and/or topical betamethasone 0.1% up to twice daily) and the reason for discontinuation. Patients were followed up for 12 months.</p><p><strong>Results: </strong>Ten patients (7 women; median age, 54.5 years) with Vogt-Koyanagi-Harada disease (<i>n</i> = 4), retinal vasculitis (<i>n</i> = 3) sarcoidosis (<i>n</i> = 1), sympathetic ophthalmia (<i>n</i> = 1), or sclerouveitis (<i>n</i> = 1) were enrolled. At 12 months, treatment was successful in 7 of the 10 patients. The reasons for treatment failure were lack of safety (<i>n</i> = 1) and insufficient therapeutic effect (<i>n</i> = 2). One patient discontinued MMF due to elevated liver enzymes. No serious adverse events (death, hospitalization, life-threatening events) or systemic symptoms (gastrointestinal issues, headache, fatigue) occurred. The median MMF dose was 2500 mg/day, with a maximum of 3000 mg/day.</p><p><strong>Conclusion: </strong>MMF may be safely used as a steroid-sparing agent in Japanese patients with non-infectious uveitis or sclerouveitis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1303-1312"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Topical Fumagillin 0.007% in the Management of Microsporidial Stromal Keratitis: Interventional Pilot Study with Literature Review.","authors":"Amrita Mohanty, Savitri Sharma, Lakshminarayanan Gowtham, Bhupesh Bagga","doi":"10.1080/09273948.2025.2501028","DOIUrl":"10.1080/09273948.2025.2501028","url":null,"abstract":"<p><strong>Purpose: </strong>The standard management of Microsporidial Stromal Keratitis (MSK) traditionally involves therapeutic penetrating keratoplasty, often accompanied by complications. This pilot study investigated medical management, evaluating outcomes using topical fumagillin alone or in combination with topical voriconazole and oral albendazole.</p><p><strong>Methods: </strong>Mild to moderate MSK cases (January 2019-2024) with informed consent were included. The diagnosis was confirmed by microsporidial spores on smear (potassium hydroxide with calcofluor white, Gram, or modified Ziehl-Neelsen stain). Patients received 0.007% topical fumagillin (Sigma-Aldrich, F6771) alone or with topical voriconazole and oral albendazole.</p><p><strong>Results: </strong>Five patients (six eyes, 17.2%) of 29 MSK cases were enrolled, all males, with a mean age of 52.4 ± 12.3 years (37-74). Symptoms lasted 5.2 ± 3.8 months (1-12) before presentation. The mean IOP was 27.6 ± 7.6 mmHg; two were on anti-glaucoma medications. Corneal infiltrates measured 3.4 ± 0.8 mm (horizontal) and 3.4 ± 1.4 mm (vertical). Three patients received additional topical voriconazole 1% (Vozole) and oral albendazole 400 mg daily for 1 month. Clinical resolution occurred in all cases after 9.4 ± 5.2 months of treatment, with no recurrence over a 12.6 ± 3.4-month follow-up.</p><p><strong>Conclusion: </strong>The findings of this study support the potential of medical management for MSK, suggesting that topical fumagillin 0.007% may offer a viable treatment option for mild to moderate cases.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1501-1505"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Outcome of Cataract in Eyes with Scleritis and Episcleritis.","authors":"Michelle J Sun, Bernard A Rosner, Craig W Newcomb, Kurt A Dreger, Pichaporn Artornsombudh, Srishti Kothari, Abhishek R Payal, Siddharth S Pujari, Grace A Levy-Clarke, H Nida Sen, Eric B Suhler, Jennifer E Thorne, Nirali P Bhatt, C Stephen Foster, Douglas A Jabs, James T Rosenbaum, Jeanine M Buchanich, Sylvia L Groth, Gui-Shuang Ying, Sapna S Gangaputra, John H Kempen","doi":"10.1080/09273948.2025.2453878","DOIUrl":"10.1080/09273948.2025.2453878","url":null,"abstract":"<p><strong>Purpose: </strong>To estimate the incidence and predictive factors for cataract in eyes with episcleritis and scleritis, and to evaluate the outcome of cataract surgery in those eyes.</p><p><strong>Design: </strong>Retrospective cohort study at uveitis subspecialty centers.</p><p><strong>Methods: </strong>One thousand three hundred eighty-four eyes with non-infectious scleritis and episcleritis at risk of cataract were included. Predictive factors for cataract development were assessed by multivariable Cox regression. The main outcomes were development of cataract, defined as the first reduction of presenting visual acuity <20/40 attributed to cataract or else occurrence of cataract surgery itself. A second cohort of eyes with episcleritis and scleritis that underwent cataract surgery was evaluated for postoperative outcomes. Logistic regression was utilized to assess variables associated with visual acuity 20/40 or better one year after cataract surgery.</p><p><strong>Results: </strong>Seventy-six eyes developed cataract (incidence = 0.025/eye-year, 95% confidence interval: 0.019-0.031). Age ≥65 years, elevated intraocular pressure ≥30 mmHg, use of oral corticosteroids at the preceding visit, and anterior chamber inflammatory activity were associated with increased cataract incidence. Race/ethnicity, type of scleritis, and bilaterality were unassociated with cataract risk after adjustment. Among 79 cataractous eyes that underwent cataract surgery, median presenting visual acuity improved by 6 ETDRS lines. Pre-operative factors including duration of inflammation, immunotherapy use, and corticosteroid use were not significantly associated with odds of post-operative visual acuity 20/40 or better.</p><p><strong>Conclusions: </strong>Under subspecialty management, the incidence of cataract was low in eyes with episcleritis and scleritis. Cataract surgery was associated with large and sustained improvements in visual acuity.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1227-1234"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to Adherence with Clinic Visits in Patients with Uveitis.","authors":"Karen Sun, Rayna Marshall, Michael Frankland, Amal Taylor, Cynthia Montana, Eric Crowell, Karen R Armbrust, Laura Kopplin, Meghan Berkenstock","doi":"10.1080/09273948.2025.2456641","DOIUrl":"10.1080/09273948.2025.2456641","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the patient barriers to adherence with appointment follow-up in patients with ocular inflammatory disorders across the United States.</p><p><strong>Methods: </strong>This was a multicenter study of adult and pediatric patients at the Wilmer Eye Institute, University of Texas at Austin, University of Wisconsin-Madison, University of Minnesota, Minneapolis Veterans Administration Hospital, and Washington University of St. Louis. The primary outcome was self-reported adherence to follow-up visits. Secondary outcomes were the reasons for missing follow-up including sub analyses of patient demographics. Eligible patients completed a self-reporting survey to assess barriers to attending follow-up visits.</p><p><strong>Results: </strong>The survey was fully completed by 210 subjects and partially by 40 (250 in total), of whom were 67% white, 59% female, and 51% had a college or advanced degree. Most patients had bilateral (68%), anterior (51%) uveitis. Patients were treated with topical corticosteroids (33%), immunosuppressive agents (23%), or both (22%). Most patients (79%) did not miss or cancel appointments. Ninety-seven percent of patients had medical insurance and some paid (39%) more than 40 dollars for their copay. Copay costs limited the number of visits patients could attend in 7% of patients. Eight percent of patients missed appointments due to inability to take off time from work and 5% missed visits due to lack of transportation.</p><p><strong>Conclusion: </strong>Most patients with ocular inflammation reported good adherence to follow-up appointments. Insurance type, copay costs, transportation, patient scheduling, and patient understanding were all minimally reported to effect patient visit attendance.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1243-1247"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Density Analysis of Subretinal Fluid in Vogt Koyanagi Harada Disease, Posterior Scleritis and Acute Central Serous Chorioretinopathy.","authors":"Berru Yargı Özkoçak, Sakir Ariman, Cigdem Altan, Burcu Kemer Atik, Berna Basarir","doi":"10.1080/09273948.2025.2487161","DOIUrl":"10.1080/09273948.2025.2487161","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the diagnostic/prognostic utility of the Optical Density (OD) from subretinal fluid (SRF) analyses across Vogt-Koyanagi-Harada disease (VKH), posterior scleritis (PS) and acute central serous chorioretinopathy (CSCR).</p><p><strong>Methods: </strong>This study was conducted in treatment-naive patients with VKH, PS and CSCR presented with SRF. Optical coherence tomography (OCT) images were analysed using ImageJ. OD ratios (ODR) were calculated as the ratio of OD of SRF to OD of vitreous (ODR1-2), retinal pigment epithelium (ODR3) and retinal nerve fibre layer (ODR4). Associations between demographics, ocular findings, OCT findings, best corrected visual acuity (BCVA) change and OD were analysed.</p><p><strong>Results: </strong>The study comprised 64 patients/81 eyes. ODR1 and ODR2 were found significantly higher in CSCR than VKH (<i>p</i> = 0.004 and 0.031). ODR4 showed significantly higher in PS than VKH (<i>p</i> = 0.013). With an increase in the anterior chamber reaction, there was a significant increase in OD of SRF and ODR3 in the PS (<i>p</i> = 0.034 and 0.016). BCVA showed a significant improvement in all groups at 12-month follow-up (<i>p</i> < 0.05). In the VKH, the OD of vitreous and ODR3 positively correlated with baseline BCVA (<i>p</i> = 0.006 and < 0.001) and ODR4 with 12^th-month BCVA (<i>p</i> = 0.03).</p><p><strong>Conclusion: </strong>This study demonstrates that OD has the potential to serve as a non-invasive, objective, and easily interpretable method for differentiating between VKH, PS, and CSCR. The OD can be used as a valuable method for prognostic evaluation in relation to visual acuity outcomes, especially in the VKH group.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1269-1276"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcomes of Intravitreal Aflibercept for Uveitic Macular Edema.","authors":"Enny Oyeniran, Sanjeeb Bhandari, Ali Amir, Matias Soifer, Sunil Bellur, Susan Vitale, H Nida Sen, Shilpa Kodati","doi":"10.1080/09273948.2024.2344709","DOIUrl":"10.1080/09273948.2024.2344709","url":null,"abstract":"<p><strong>Background/aims: </strong>To evaluate the efficacy of intravitreal aflibercept for UME (uveitic macular).</p><p><strong>Methods: </strong>A retrospective review of records of patients that received aflibercept for UME from January 2017 to August 2022 was conducted. The primary outcomes were mean change in visual acuity (VA) and central subfield thickness (CST) 6 and 12 months from the start of aflibercept treatment.</p><p><strong>Results: </strong>A total of 16 eyes of 12 patients were included. Indications for treatment included eyes that had previously demonstrated a history of elevated intraocular pressure secondary to a steroid response (<i>n</i> = 10) or a history of non-response or partial response to local corticosteroids (<i>n</i> = 6). Fifteen eyes (94%) demonstrated a reduction in CST after their initial injection. At 6-months, mean VA gain was 2.6 ± 7.7 letters (<i>p</i> = 0.24) from a mean VA of 67.8 ± 10.7 letters at baseline and mean CST improved by 97.6 ± 113.5 μm (<i>p</i> = 0.004) from 458.6 ± 123.1 μm at baseline. Fourteen eyes had 12-months of follow up and received a median of 4 injections over 12 visits. The mean VA at 12-months remained stable compared to baseline (mean change of -1.4 ± 12.5 letters (<i>p</i> = 0.87)) while the CST improved by a mean of 90.9 ± 114.6 μm (<i>p</i> = 0.053) compared to baseline.</p><p><strong>Conclusion: </strong>Intravitreal aflibercept injections resulted in reduced central subfield thickness at all time-points. It appears to be an effective treatment alternative for UME, particularly for patients who are not responsive to local corticosteroids or who have contraindications to corticosteroid treatment.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1145-1152"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There's Always a Bigger Fish.","authors":"Nicolas Kitic, Adélaïde Toutee, Isabelle Audo, Alexandre Le Joncour, Dimitri Psimaras, Valérie Touitou","doi":"10.1080/09273948.2025.2504581","DOIUrl":"10.1080/09273948.2025.2504581","url":null,"abstract":"<p><strong>Purpose: </strong>To report a rare case of cancer-associated retinopathy (CAR) presenting initially as a bilateral acute vision loss in a 72-year-old female patient with a history of tongue carcinoma. Systemic work-up revealed a metastatic uterine neuroendocrine carcinoma.</p><p><strong>Methods: </strong>Case report describing clinical presentation and diagnostic work up in a patient with CAR syndrome.</p><p><strong>Results: </strong>A 72-year-old female patient was referred for bilateral acute severe vision loss immediately after axillary node dissection in the context of a tongue carcinoma. Ophthalmological examination revealed rapidly evolutive outer retinal atrophy, with acute severe vision loss to light perception in both eyes within a few days. CAR-syndrome was suspected in this patient with tongue carcinoma and a positive sentinel lymph node. However, a systemic work-up revealed a metastatic tumor of the uterine body.Despite high-dose systemic corticosteroids, plasmapheresis, and chemotherapy, she did not present any functional recovery.</p><p><strong>Conclusion: </strong>CAR-syndrome may precede the diagnosis of the associated tumor. Thorough medical history, extensive work-up is the key in order not to miss the primitive lesion causative of the CAR syndrome, even in patients with another known malignancy.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1506-1508"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Hyaloid Adhesion as an Optical Coherence Tomography Biomarker of Active Toxoplasma Retinochoroiditis.","authors":"Kiran Chandra, Rajeev Reddy Pappuru, Shabtab Nasir, Sucheta Ireni, Soumyava Basu, SriniVas Sadda, Hasnat Ali, Mudit Tyagi","doi":"10.1080/09273948.2025.2486366","DOIUrl":"10.1080/09273948.2025.2486366","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the utility of Posterior Hyaloid Adhesions (PHA) as an Optical Coherence Tomography (OCT) biomarker of toxoplasma retinochoroiditi.</p><p><strong>Methods: </strong>A retrospective review of OCT scans of infective retinitis cases to evaluate the presence of PHA at the time of presentation.</p><p><strong>Results: </strong>Ninety-seven eyes of active toxoplasma retinochoroiditis and 125 eyes of retinitis of other etiologies were included. OCT feature of PHA was present in 70 eyes (72%) in the toxoplasmosis group as compared to other retinitis where it was present in 32 eyes (26%). Univariate analysis revealed that PHA was significantly more prevalent in toxoplasma retinochoroiditis compared to other retinitis. Multivariate analysis, adjusted for age and sex, revealed an odds ratio of finding PHA was 5.22 in patients with toxoplasma retinochoroiditis as compared to other retinitis. (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>PHA to a retinitis lesion can serve as a diagnostic OCT biomarker for active toxoplasma retinochoroiditis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1264-1268"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Nervous System Involvement in Patients with Endogenous Endophthalmitis: A Retrospective Study.","authors":"Dalbert Chen, Sam Karimaghaei, Rupak Dhoot, Alex Wright, Rohan Samant, Eric Crowell, Alice Chuang, Ore-Ofe Adesina","doi":"10.1080/09273948.2025.2489528","DOIUrl":"10.1080/09273948.2025.2489528","url":null,"abstract":"<p><strong>Purpose: </strong>The detrimental effects of endogenous endophthalmitis on visual acuity have been well studied; however, other complications of the central nervous system have not been robustly investigated. Our objective was to investigate central nervous system involvement associated with endogenous endophthalmitis.</p><p><strong>Methods: </strong>We analyzed hospitalized patients with endogenous endophthalmitis in two hospitals from January 2010 to November 2020. We documented patient characteristics and outcomes related to endogenous endophthalmitis, including relevant neurologic complications. A neuroradiologist reviewed any available central nervous system imaging.</p><p><strong>Results: </strong>A total of 62 patients were included (42 [68%] males and 20 [32%] female). Of those included, 14 patients (23%) had at least one neurologic complication associated with the central nervous system. Of those 14 patients, 8 (57%) had ischemic/embolic brain infarction(s), 7 (50%) had encephalopathy, 4 (29%) had cerebral hemorrhage(s), 2 (14%) had meningitis, 1 (7%) had a brain abscess, and 1 (7%) had an anoxic brain injury. Of the patients who had central nervous system complications, a majority of eight patients (57%) had positive blood cultures, two (14%) had positive intraocular cultures, while two (14%) were positive in both. There was no statistically significant difference in demographics, comorbidities, source of infection, or organism between patients with and without central nervous system complications.</p><p><strong>Conclusion: </strong>The incidence of comorbid central nervous system disease in our cohort was higher than previously reported in the literature. Although we identified no specific risk factors for the development of central nervous system disease in endogenous endophthalmitis, we found that cases with more severe central nervous system complications were associated with culture positivity.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1285-1290"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}