Ocular Immunology and Inflammation最新文献

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Specific Skin Lesions of Sarcoidosis in the Diagnosis of Ocular Sarcoidosis. 结节病特异性皮肤病变在眼部结节病诊断中的应用。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-12 DOI: 10.1080/09273948.2025.2553873
Olga Garcia-Garcia, Joaquim Marcoval, Adriana Iriarte, Gemma Rocamora, Juan Mañá
{"title":"Specific Skin Lesions of Sarcoidosis in the Diagnosis of Ocular Sarcoidosis.","authors":"Olga Garcia-Garcia, Joaquim Marcoval, Adriana Iriarte, Gemma Rocamora, Juan Mañá","doi":"10.1080/09273948.2025.2553873","DOIUrl":"https://doi.org/10.1080/09273948.2025.2553873","url":null,"abstract":"<p><strong>Purpose: </strong>To analyse the clinical forms of specific skin lesions in OS patients, their potential relationship with ocular manifestations, and their diagnostic utility.</p><p><strong>Methods: </strong>A retrospective analyses of specific skin lesions in patients with OS diagnosed in our hospital between 1980 and 2022.</p><p><strong>Results: </strong>Among 85 patients diagnosed with OS, 28 (33%) also had specific skin lesions (19 women and 9 men, mean age 45.11 years, SD 14.474). Ocular lesions included anterior uveitis (9 cases), intermediate uveitis (3), posterior uveitis (1), panuveitis (6), granulomatous conjunctivitis (7), and granulomatous lacrimal infiltration (2). Skin lesions comprised plaques (14 cases), maculopapules (7), subcutaneous sarcoidosis (4), lupus pernio (1), and scar sarcoidosis (2). Plaques were the most frequent form of cutaneous lesions observed in patient with OS and were more frequently associated with anterior uveitis and panuveitis. Maculopapules were less common in our patients with OS and were mainly observed in patients with anterior uveitis. Skin lesions were present at the onset of ocular symptoms in most patients with OS (23/28 cases, 82%) and their biopsy was useful to confirm the diagnosis of sarcoidosis.</p><p><strong>Conclusion: </strong>When OS is suspected, clinicians should actively assess for specific cutaneous lesions, particularly plaques, since their biopsy may facilitate earlier diagnosis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angular Sign of Henle Fiber Layer Hyperreflectivity (ASHH) in Cancer-Associated Retinopathy. 癌症相关性视网膜病变中Henle纤维层高反射率(ASHH)的角度征象。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-12 DOI: 10.1080/09273948.2025.2552925
Alessandro Feo, Marko M Popovic, Edmund Tsui
{"title":"Angular Sign of Henle Fiber Layer Hyperreflectivity (ASHH) in Cancer-Associated Retinopathy.","authors":"Alessandro Feo, Marko M Popovic, Edmund Tsui","doi":"10.1080/09273948.2025.2552925","DOIUrl":"https://doi.org/10.1080/09273948.2025.2552925","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the longitudinal multimodal imaging findings of two patients with cancer-associated retinopathy (CAR) presenting with the angular sign of Henle fiber layer hyperreflectivity (ASHH) on spectral-domain optical coherence tomography (SD-OCT).</p><p><strong>Methods: </strong>Retrospective case series.</p><p><strong>Results: </strong>A total of two patients (an 88-year-old woman and a 63-year-old man, respectively) with systemic malignancy (endometrial cancer and metastatic prostate cancer, respectively) presented with bilateral ASHH lesions on OCT in the setting of rapidly progressive vision loss. Baseline visual acuity (VA) ranged from 20/30 to 20/60. In both cases, ASHH lesions preceded the development of extensive ellipsoid zone (EZ) loss and outer retinal atrophy with granular hyperreflectivity. Despite systemic therapy and local steroid injections, both patients showed poor anatomical and functional outcomes, with final VA ranging from 20/30 to light perception, and significant visual field constriction.</p><p><strong>Conclusion: </strong>CAR eyes in our series who presented with ASHH lesions demonstrated a rapidly progressive course, culminating in severe EZ loss and outer retinal atrophy with characteristic hyperreflective granularity on OCT. The presence of ASHH lesions may serve as an early OCT biomarker of photoreceptor toxicity in paraneoplastic retinopathy and is a poor prognostic factor.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors for Development of Uveitis and Cystoid Macular Edema After Cataract Surgery. 白内障术后葡萄膜炎和黄斑囊样水肿的危险因素。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-11 DOI: 10.1080/09273948.2025.2551262
Jihwan Albert Hwang, Gavin Li, Sumayya Ahmad, Janek Klawe, Carl Wilkins
{"title":"Risk Factors for Development of Uveitis and Cystoid Macular Edema After Cataract Surgery.","authors":"Jihwan Albert Hwang, Gavin Li, Sumayya Ahmad, Janek Klawe, Carl Wilkins","doi":"10.1080/09273948.2025.2551262","DOIUrl":"https://doi.org/10.1080/09273948.2025.2551262","url":null,"abstract":"<p><strong>Purpose: </strong>To identify risk factors for the development of uveitis and CME after cataract surgery.</p><p><strong>Methods: </strong>Medicare patients with no known history of uveitis receiving cataract surgery between 2012 and 2015 (<i>n</i> = 146,536) were identified from a 5% nationwide sample of Medicare beneficiaries. Multivariable regression assessed the association between demographic factors, history of rheumatic, ocular, and systemic disease, and prior ocular procedures with the risks of postoperative anterior uveitis, panuveitis, posterior uveitis, and CME.</p><p><strong>Results: </strong>Black patients had higher odds of developing anterior uveitis (OR 4.58, 95% CI [4.01-5.22]) and CME (OR 1.70, 95% CI [1.48-1.93]) compared to White patients. Patients with primary open angle glaucoma (OR 1.66, 95% CI [1.43-1.91]) and CME (OR 1.18, 95% CI [1.04-1.33]) and closed angle glaucoma had higher odds of developing anterior uveitis (OR 1.57, 95% CI [1.14-2.10]) and CME (OR 1.37, 95% CI [1.04-1.78]). Patients with a history of retinal detachment repair had higher odds of developing posterior uveitis (OR 20.42, 95% CI [1.53-119.28]) and CME (OR 2.01, 95% CI [1.25-3.20]). Patients with a history of vitrectomy had higher odds of developing posterior uveitis (OR 6.02, 95% CI [1.24-19.80]) and CME (OR 4.43, 95% CI [3.64-5.36]).</p><p><strong>Conclusion: </strong>Black race, open and closed angle glaucoma, and a history of retinal detachment repair and vitrectomy were risk factors for developing uveitis and CME after cataract surgery. These findings should inform postoperative management approaches for at-risk populations.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Candidate Cytokine Biomarkers for the Diagnosis of Ocular- and Neurosyphilis. 诊断眼梅毒和神经梅毒的候选细胞因子生物标志物。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-10 DOI: 10.1080/09273948.2025.2552919
Suret Engelbrecht, Laurie W van der Merwe, Candice I Snyders, Martin Kidd, Gerhard Walzl, Novel N Chegou, Derrick P Smit
{"title":"Candidate Cytokine Biomarkers for the Diagnosis of Ocular- and Neurosyphilis.","authors":"Suret Engelbrecht, Laurie W van der Merwe, Candice I Snyders, Martin Kidd, Gerhard Walzl, Novel N Chegou, Derrick P Smit","doi":"10.1080/09273948.2025.2552919","DOIUrl":"https://doi.org/10.1080/09273948.2025.2552919","url":null,"abstract":"<p><strong>Purpose: </strong>To describe differences in the expression of selected host biomarkers, by analysing the aqueous humour (AH), cerebrospinal fluid (CSF) and serum of patients with ocular syphilis, both with and without neurosyphilis and HIV infection, to support the diagnosis of ocular syphilis.</p><p><strong>Methods: </strong>A prospective observational descriptive study was conducted at Tygerberg Academic Hospital in Cape Town, South Africa, from February 1, 2018, to January 31, 2021. The study included all patients aged 18 years or older who presented to the eye clinic with ocular syphilis, provided they had a positive serum Treponema pallidum antibodies (TPA) test, an RPR titre of ≥ 8 and confirmed ocular inflammation. The HIV status of each patient was determined and the CRP, IL-2, IL-6, IL-10, IL-12 p70, MIP-1<math><mi>β</mi></math> and IFN-<math><mi>γ</mi></math> were measured in their AH, CSF and serum samples using a multiplex immunoassay platform. All patients received treatment.</p><p><strong>Results: </strong>The mean concentrations of biomarkers IL-2, IL-10, MIP-1<math><mi>β</mi></math>, IL-6, IL-12 p70 and IFN-<math><mi>γ</mi></math> were consistently higher in the AH compared to the CSF and serum in patients with ocular syphilis, irrespective of their HIV status and the presence or absence of concurrent neurosyphilis.</p><p><strong>Conclusion: </strong>Our findings showed significant differences in certain cytokine levels across the AH, CSF, and serum, with notably higher concentrations in the AH. This indicates that ocular syphilis triggers a unique immune response within the eye. As a result, further analysis of AH biomarkers is needed to determine if these may enhance the diagnosis of ocular and neurosyphilis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-14"},"PeriodicalIF":2.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperreflective, Pyramidal-Like Lesions of the Outer Retina and Retinal Pigmented Epithelium in Non-Syphilitic Uveitis: A Case Series. 非梅毒性葡萄膜炎的外视网膜和视网膜色素上皮高反射锥体样病变:一个病例系列。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-07 DOI: 10.1080/09273948.2025.2556905
Sunil Bellur, Nam V Nguyen, Matias Soifer, Shilpa Kodati
{"title":"Hyperreflective, Pyramidal-Like Lesions of the Outer Retina and Retinal Pigmented Epithelium in Non-Syphilitic Uveitis: A Case Series.","authors":"Sunil Bellur, Nam V Nguyen, Matias Soifer, Shilpa Kodati","doi":"10.1080/09273948.2025.2556905","DOIUrl":"https://doi.org/10.1080/09273948.2025.2556905","url":null,"abstract":"<p><strong>Purpose: </strong>To report pyramidal-like, hyperreflective changes of the outer retina and retinal pigmented epithelium (RPE) in three patients with an atypical non-syphilitic outer retinopathy.</p><p><strong>Study design/materials and methods: </strong>Single institutional case series conducted at the National Eye Institute, National Institutes of Health.</p><p><strong>Results: </strong>Hyperreflective, pyramidal lesions of the outer retina and RPE have been described in patients with syphilitic posterior segment uveitis. We report three patients with an atypical posterior segment involving uveitis who were found to have pyramidal-like, hyperreflective lesions extending from the RPE to the outer nuclear layer in combination with associated ellipsoid zone (EZ) loss on optical coherence tomography. All cases had associated choroidopathy and antecedent infectious symptoms. Extensive laboratory investigation including syphilis testing was negative. All cases had an excellent response to corticosteroid treatment with improvements in vision, EZ reconstitution, and resolution of the pyramidal changes.</p><p><strong>Conclusion: </strong>Hyperreflective, pyramidal-like lesions of the outer retina and RPE can be found in cases of non-syphilitic uveitis. Anti-inflammatory treatment can result in significant anatomic and visual acuity improvements.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.0,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenoviral Retinitis: A Rare Case Presentation of a Common Virus. 腺病毒性视网膜炎:一种罕见的常见病毒。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-05 DOI: 10.1080/09273948.2025.2555379
Nyaish Mansoor, Emma A Davies, Dominic A Haigh, Michael Dennis, Assad Jalil, Shiao Wei Wong
{"title":"Adenoviral Retinitis: A Rare Case Presentation of a Common Virus.","authors":"Nyaish Mansoor, Emma A Davies, Dominic A Haigh, Michael Dennis, Assad Jalil, Shiao Wei Wong","doi":"10.1080/09273948.2025.2555379","DOIUrl":"https://doi.org/10.1080/09273948.2025.2555379","url":null,"abstract":"<p><strong>Purpose: </strong>To report a rare case of bilateral necrotising retinitis caused by a potentially novel human adenovirus D (HAdV-D) in a post-bone marrow transplant patient and to highlight the diagnostic challenges and therapeutic role of intravenous cidofovir, alongside a review of previously reported cases of human adenovirus (HAdV) retinitis.</p><p><strong>Methods: </strong>Retrospective case report.</p><p><strong>Results: </strong>A 60-year-old man with a history of acute myeloid leukaemia, in remission post-bone marrow transplant, presented with bilateral hypertensive granulomatous panuveitis and necrotising retinitis. Repeated aqueous polymerase chain reaction (PCR) testing for herpes simplex virus, varicella-zoster virus, cytomegalovirus, syphilis and <i>Toxoplasma gondii</i> was negative and the patient showed a poor response to multiple empirical antiviral therapies. This led to expanded PCR testing which detected high HAdV loads in both aqueous and vitreous samples. Genomic sequencing confirmed the presence of a potentially novel HAdV-D. The patient received intravenous cidofovir with close renal monitoring. Serial aqueous PCR demonstrated a substantial reduction in HAdV load, with corresponding clinical improvement and complete resolution of active retinitis, replaced by retinal scarring. Final best-corrected visual acuities were 0.4 LogMAR in the right eye and hand movements in the left eye.</p><p><strong>Conclusion: </strong>HAdV retinitis, though rare, should be considered in immunocompromised patients with progressive necrotising retinitis that is unresponsive to conventional antivirals, particularly when associated with repeatedly negative PCR for herpes viruses, syphilis and <i>Toxoplasma gondii</i>. Intravenous cidofovir may be an effective off-label treatment. A multidisciplinary approach is essential, and serial aqueous PCR is useful for monitoring treatment response.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of Ophthalmologic Comorbidities in Hidradenitis Suppurativa Patients. 化脓性汗腺炎患者眼部合并症的风险。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-04 DOI: 10.1080/09273948.2025.2550487
Jason J Jo, Hannah Verma, Omar Alani, Anisha Kasi, Mahaa Ayub, Nicholas Gulati, Sumayya Ahmad
{"title":"Risk of Ophthalmologic Comorbidities in Hidradenitis Suppurativa Patients.","authors":"Jason J Jo, Hannah Verma, Omar Alani, Anisha Kasi, Mahaa Ayub, Nicholas Gulati, Sumayya Ahmad","doi":"10.1080/09273948.2025.2550487","DOIUrl":"10.1080/09273948.2025.2550487","url":null,"abstract":"<p><strong>Purpose: </strong>To assess associations between hidradenitis suppurativa (HS) and inflammatory and infectious eye diseases.</p><p><strong>Methods: </strong>We created a matched cohort of adults with and without a diagnosis of HS and calculated relative risk (RR) ratios for inflammatory and infectious eye diseases using the Global TriNetX Database. We also calculated RR ratios for infectious and inflammatory eye diseases in HS patients based on the use of biologic medications.</p><p><strong>Results: </strong>Based on our cohort of 57,749 adults with HS, we found an increased risk for corneal ulcers (RR: 1.66, <i>p</i> = 0.001), marginal corneal ulcers (RR: 2.82, <i>p</i> = 0.002), and scleritis (RR: 1.89, <i>p</i> = 0.009) and a decreased risk for conjunctivitis (RR: 0.75, <i>p</i> < 0.001), acute atopic conjunctivitis (RR: 0.78; <i>p</i> < 0.001), and mucopurulent conjunctivitis (RR: 0.71, <i>p</i> < 0.001) in HS patients compared to healthy controls. Subgroup analysis showed a decreased risk for conjunctivitis (RR: 0.62, <i>p</i> < 0.001) in adults with HS treated with adalimumab or secukinumab compared to adults with HS not treated with biologics.</p><p><strong>Conclusion: </strong>This study found an increased risk for corneal ulcers, marginal corneal ulcers, and scleritis in adults with HS. Use of biologics was associated with a reduced risk of conjunctivitis in patients with HS compared to patients who did not have biologic exposure.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Posterior Multifocal Placoid Pigment Epitheliopathy-Like Panuveitis Following Mpox Vaccination. m痘疫苗接种后的急性多灶性后斑Placoid epithelial opathy- like Panuveitis。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-04 DOI: 10.1080/09273948.2025.2551802
Lucy M Lu, Priya D Samalia, Rachael L Niederer
{"title":"Acute Posterior Multifocal Placoid Pigment Epitheliopathy-Like Panuveitis Following Mpox Vaccination.","authors":"Lucy M Lu, Priya D Samalia, Rachael L Niederer","doi":"10.1080/09273948.2025.2551802","DOIUrl":"https://doi.org/10.1080/09273948.2025.2551802","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of APMPPE-like panuveitis following mpox vaccination.</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 37-year-old Chinese man presented with bilateral anterior and intermediate uveitis, retinal vasculitis and unilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) 2 weeks following JYNNEOS mpox vaccination. Investigations excluded infectious and systemic inflammatory causes. Multi-modal imaging revealed features consistent with APMPPE in the left eye. His symptoms and clinical signs improved with topical and systemic corticosteroid therapy with no recurrence off treatment over a 9-month follow-up.</p><p><strong>Conclusion: </strong>Clinicians should be aware of the possibility of APMPPE-like panuveitis as a rare ocular complication following the mpox vaccine.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semi-Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography in Cataract Surgery Patients. 白内障手术患者前房炎症的光谱域光学相干断层半自动化分析。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-03 DOI: 10.1080/09273948.2025.2551801
Naveen Karthik, Sunil K Srivastava, Richard Gans, Kimberly Baynes, Emily Fisher, Cindy Chen, Peter K Kaiser, Arthi Venkat, Careen Y Lowder, Sumit Sharma
{"title":"Semi-Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography in Cataract Surgery Patients.","authors":"Naveen Karthik, Sunil K Srivastava, Richard Gans, Kimberly Baynes, Emily Fisher, Cindy Chen, Peter K Kaiser, Arthi Venkat, Careen Y Lowder, Sumit Sharma","doi":"10.1080/09273948.2025.2551801","DOIUrl":"10.1080/09273948.2025.2551801","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the feasibility of using anterior segment optical coherence tomography (AS-OCT) to image and objectively quantify anterior chamber (AC) inflammation after cataract surgery.</p><p><strong>Methods: </strong>Prospective case series of patients who underwent cataract surgery by one surgeon at a single academic center. AC volume scans were obtained using AS-OCT (Avanti, Optovue Inc, Fremont, CA) at postoperative day 0 or 1 (POD0/1), postoperative week 1 (POW1), and postoperative month 1 (POM1) after cataract surgery. AS-OCT images were analyzed by a semi-automated algorithm, which identified AC hyper-reflective spots.</p><p><strong>Results: </strong>155 eyes from 117 patients who underwent cataract surgery were included. The average patient age was 69.2 years (range: 44-91 years). The average fluid density (spots per mm<sup>3</sup>) was 51.52 at POD0, 26.81 at POD1, 5.15 at POW1, and 1.78 at POM1. The average fluid density correlated with clinical grading of masked uveitis specialists but not with grading of the cataract surgeon. Brown irises had significantly higher average fluid density compared to blue at POW1 (4.47 ± 8.87 vs. 2.11 ± 1.80, <i>p</i> = 0.04) and POM1 (2.01 ± 3.50 vs. 0.75 ± 0.72, <i>p</i> = 0.01). A significant difference was noted in average fluid density between uveitic and non-uveitic eyes at POD0/POD1 (19.4 ± 16.1 vs. 46.9 ± 70.1, <i>p</i> < 0.001). Femtosecond laser-assisted surgery eyes had significantly lower average fluid density compared to traditional cataract surgery eyes at POM1 (0.66 ± 0.55 vs. 2.11 ± 5.77 spots/mm<sup>3</sup>, <i>p</i> = 0.02).</p><p><strong>Conclusions: </strong>AS-OCT can be used to grade AC inflammation in cataract surgery patients and may be more reliable compared to clinical grading. Further investigation of this technology in larger, multi-institutional cohorts is warranted.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Secondary Glaucoma Associated with Congenital Herpes Simplex Virus Keratitis: A Case Report and Review of the Literature. 先天性单纯疱疹病毒性角膜炎伴双侧继发性青光眼1例报告及文献复习。
IF 2 4区 医学
Ocular Immunology and Inflammation Pub Date : 2025-09-03 DOI: 10.1080/09273948.2025.2555382
Rohan Shah, Inae Jang Kim, Lewis Oh, Javaneh Abbasian, Asim V Farooq
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