Ocular Immunology and Inflammation最新文献

{"title":"Analysis of Serum microRNAs During the Development of Experimental Autoimmune Uveoretinitis in Rats.","authors":"Shoko Saito, Hiroshi Keino, Ichiro Takasaki, Takayo Watanabe, Annabelle A Okada","doi":"10.1080/09273948.2025.2483430","DOIUrl":"https://doi.org/10.1080/09273948.2025.2483430","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate alterations in circulating microRNAs (miRNAs) in the development of experimental autoimmune uveoretinitis (EAU) in rats.</p><p><strong>Methods: </strong>Lewis rats were immunized with interphotoreceptor retinoid binding protein (IRBP) peptide (R14) and EAU clinical scores were assessed on day 0 (baseline), and days 7, 14, and 21 after immunization. Total RNA was isolated from serum at the same timepoints and used for microarray analysis.</p><p><strong>Results: </strong>The clinical score of EAU peaked on day 14 and decreased on day 21. Hierarchical cluster analysis and principal component analysis (PCA) of serum miRNA expression displayed distinctly different miRNA profiles between baseline and days 7, 14, and 21 after immunization. Microarray analysis revealed significantly increased expression of 5 (day 7), 9 (day 14), and 10 (day 21) miRNAs, and significantly decreased expression of 19 (day 7), 20 (day 14), and 19 (day 21) miRNAs compared to baseline. Of note, the expression of miRNA-146a-5p, known to be involved in EAU, and miRNA-150-5p was significantly elevated on days 14 and 21. Bioinformatics analysis revealed that mucin type O-glycan biosynthesis and cell adhesion molecules were major pathways affected during the development of EAU.</p><p><strong>Conclusions: </strong>Hierarchical cluster analysis and PCA showed distinctly different miRNA profiles at baseline versus after IRBP immunization. Upregulation of serum miRNA-146a-5p and miRNA-150-5p was observed in the effector and resolution phases of EAU. Analysis of circulating miRNAs may help to delineate systemic epigenetic changes occurring in the development of EAU, and may lead to new insights in our understanding of human uveitis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Intravitreal Dexamethasone Implant in the Treatment of Immune Recovery Uveitis.","authors":"Hakan Koc, Ugur Bayram","doi":"10.1080/09273948.2025.2496977","DOIUrl":"https://doi.org/10.1080/09273948.2025.2496977","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of intravitreal dexamethasone in immune recovery uveitis (IRU) diagnosed with worsening of visual symptoms after recovery of cytomegalovirus (CMV) retinitis caused by acquired immunodeficiency syndrome (AIDS).</p><p><strong>Methods: </strong>A single case report was obtained from a tertiary referral center and retrospectively evaluated.</p><p><strong>Results: </strong>A 53-year-old male patient with known AIDS was admitted to our clinic with vision loss that started 1 month before and was diagnosed with CMV retinitis based on clinical findings (CD4  +  T lymphocyte count 38 cells/μL). Two months after CMV retinitis regressed with treatment, the patient presented with decreased vision and had isolated bilateral cystoid macular edema, but no retinitis focus was observed. Considering the patient's CD4  +  T lymphocyte count of 528 cells/μL and the fact that he was receiving HAART treatment, the patient was diagnosed with immune recovery uveitis. Intravitreal dexamethasone was administered to the patient who did not respond to three repeated doses of subtenon triamcinolone. After the intravitreal dexamethasone implant, the patient's clinical findings and bilateral cystoid macular edema regressed. No reactivation or side effects were observed.</p><p><strong>Conclusions: </strong>Intravitreal dexamethasone therapy can be an effective and safe treatment for immune recovery uveitis that occurs after immune system recovery in AIDS patients and is resistant to topical or subtenon steroid treatment.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Optical Coherence Tomography Angiography Biomarkers with Fluorescein Angiography Retinal Inflammation Scores in Behcet's Retinal Vasculitis.","authors":"Mohammad Javad Ghanbarnia, Ghazal Ghochani, Elias Khalili Pour, Afsaneh Moghadam, Mohammad Zarei, Ramak Roohipourmoallai, Parichehr Ghahari, Nazanin Ebrahimiadib","doi":"10.1080/09273948.2025.2491568","DOIUrl":"https://doi.org/10.1080/09273948.2025.2491568","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association of macular vessel density (VD) and foveal avascular zone (FAZ) parameters with the severity of retinal inflammation in patients with Behcet's retinal vasculitis.</p><p><strong>Methods: </strong>In this prospective study, consecutive patients with Behcet's uveitis who had fluorescein angiography (FA)-proven retinal vasculitis underwent concurrent OCTA and FA imaging. Severity of retinal inflammation was quantitatively evaluated using our previously devised FA scoring system. Fovea-centered 6 × 6 mm spectral-domain OCTA scans were acquired, and VD of superficial vascular complex (SVC), deep vascular complex (DVC) and retina were measured for different measurement zones based on the ETDRS grid. FAZ area and perimeter were also measured.</p><p><strong>Results: </strong>In total 54 eyes with mean age of 34.94 (±11.85) years were included. Mean best corrected visual acuity (BCVA) was 0.18 (±0.23) LogMAR. Mean FA score was 9.54 (±9.56). FAZ area and perimeter were not significantly associated with FA scores (<i>p</i> > 0.05). There was a significant negative association between superficial, deep and retina VD in all measurement zones except the fovea, with FA scores. This negative association was stronger in the DVC. Accordingly, greater deep VD in parafovea (B = -0.93; 95% CI -1.34 to -0.53), perifovea (B = -0.70; 95% CI -1.06 to -0.34) and whole ETDRS grid (B = -0.80; 95% CI -1.18 to -0.41) were associated with lower FA retinal inflammation scores.</p><p><strong>Conclusion: </strong>Greater macular vessel density is associated with lower retinal inflammation in patients with Behcet's retinal vasculitis in non-ischemic stages. The deep vascular complex is more severely affected in these patients. OCTA biomarkers have shown promising results for detecting microvascular changes in retinal inflammation.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory Nodular Scleritis as a Presenting Sign of Colorectal Cancer.","authors":"Rahime Duran, Yiğit Kıran, Kübra Özdemir Yalçınsoy, Ertuğrul Çağrı Bölek, Abdulsamet Erden","doi":"10.1080/09273948.2025.2495069","DOIUrl":"https://doi.org/10.1080/09273948.2025.2495069","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a rare case of recurrent anterior nodular scleritis as the initial manifestation of paraneoplastic syndrome in a patient with colorectal cancer.</p><p><strong>Methods: </strong>A case report of a 47-year-old female with a history of acute lymphoblastic leukemia who presented with ocular pain, redness, and blurred vision in her right eye. Despite treatment with corticosteroids and methotrexate, the patient experienced monthly recurrences of scleritis. A comprehensive work-up was conducted to investigate the underlying systemic disease.</p><p><strong>Results: </strong>Laboratory investigations revealed iron deficiency anemia and elevated inflammatory markers. Abdominal CT, followed by colonoscopy, revealed an ulcerovegetative mass at the splenic flexure. The patient underwent a left hemicolectomy. Pathological examination of the resected specimen confirmed the diagnosis of a mucinous adenocarcinoma. No recurrence of scleritis was observed after surgery.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering paraneoplastic syndrome in the differential diagnosis of unexplained or refractory scleritis, especially in elderly patients. A multidisciplinary diagnostic approach is essential to identify and manage such paraneoplastic manifestations.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Unilateral Multifocal Choroiditis and Retinal Vasculitis Following Presumed West Nile Virus Infection.","authors":"Noah L Carey, Breanna M Tracey, Tejaswini Matsyaraja, Matthew Trese, Sandeep Randhawa, Boonkit Purt, Shilpa Kodati","doi":"10.1080/09273948.2025.2495829","DOIUrl":"https://doi.org/10.1080/09273948.2025.2495829","url":null,"abstract":"<p><strong>Purpose: </strong>We report a case of an atypical multifocal choroiditis with retinal vasculitis associated with positive West Nile serology.</p><p><strong>Methods: </strong>Retrospective case report.</p><p><strong>Results: </strong>A healthy 18-year-old man presented with floaters in the left eye that started while backpacking in Wyoming. Examination and testing revealed numerous chorioretinal lesions in the left eye, as well as retinal vasculitis and evidence of branch retinal vein occlusion. Serology was positive for West Nile Virus.</p><p><strong>Conclusion: </strong>West Nile virus may be a trigger for development of multifocal choroiditis in susceptible individuals.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Factors of Treatment Failure with First-Line Corticosteroid-Sparing Agents in Patients with Birdshot Chorioretinopathy: A Retrospective Study.","authors":"Paul Goupillou, Mathilde Leclercq, Marc Muraine, Nicolas Girszyn, Julie Gueudry","doi":"10.1080/09273948.2025.2491570","DOIUrl":"https://doi.org/10.1080/09273948.2025.2491570","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate prognostic factors of treatment failure with first-line corticosteroid-sparing agents in patients with birdshot chorioretinopathy (BCR).</p><p><strong>Methods: </strong>This retrospective single center study recruited patients with HLA A29-positive BCR between 2004 and 2023. First-line treatment consisted in oral corticosteroids (prednisone) and mycophenolate mofetil (MMF) or interferon alpha-2a (IFN). Second-line treatment consisted in biologics, i.e. anti-TNFα or tocilizumab (TCZ). At baseline, the characteristics of patients treated with MMF/IFN and patients requiring biologics were compared.</p><p><strong>Results: </strong>Forty-three patients (86 eyes) were included. Mean follow-up duration was 7.9 +/- 5.6 years. All patients were treated with prednisone. MMF/IFN was successful in 22 patients, while 21 patients required biologics. At baseline, clinical papillitis and angiographic leakage of the optical nerve were statistically more frequent in patients requiring biologics compared to patients treated with MMF/IFN, <i>p</i> = 0.004 and <i>p</i> = 0.003 respectively. At baseline, retinal nerve fiber layer (RNFL) thickness was elevated in patients requiring biologics (153 vs 117 μm; <i>p</i> = 0.02). At baseline, mean deviation evaluated by automatized visual field was significantly worse in patients requiring biologics (-7.85 vs - 4.87 ; <i>p</i> = 0.04). Among 11 patients treated sequentially with MMF, anti-TNFα and TCZ, mean prednisone dose significantly decreased with anti-TNFα compared to MMF (13.2 vs 21.9 mg/day, <i>p</i> = 0.002), TCZ compared to MMF (5.7 vs 21.9, <i>p</i> < 0.001) and TCZ compared to anti-TNFα (5.7 vs 13.2, <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>At baseline, clinical papillitis, angiographic papillary leakage, RNFL thickness and mean deviation could be prognostic factors of treatment failure with first-line corticosteroid-sparing agents in patients with BCR.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Mycophenolate Mofetil in the Treatment of Non-Infectious Uveitis and Sclerouveitis in Japanese Patients: A Feasibility Study.","authors":"Tomona Hiyama, Kaori Komatsu, Yosuke Harada","doi":"10.1080/09273948.2025.2492773","DOIUrl":"https://doi.org/10.1080/09273948.2025.2492773","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the incidence rate and severity of adverse events associated with mycophenolate mofetil (MMF) in the treatment of non-infectious uveitis and sclerouveitis in Japanese patients.</p><p><strong>Methods: </strong>This open-label, single-centre feasibility study was performed at Hiroshima University Hospital (jRCTs061220030). Patients started MMF at 1000 mg/day, increasing up to 3000 mg/day. Primary endpoints were the incidence rate and severity of adverse events associated with MMF. Secondary endpoints were the overall rate of treatment success (defined as controlled ocular inflammation according to the Standardization of Uveitis Nomenclature criteria for uveitis and standardised grading system for sclerouveitis in patients on oral prednisolone at ≤ 5 mg/day and/or topical betamethasone 0.1% up to twice daily) and the reason for discontinuation. Patients were followed up for 12 months.</p><p><strong>Results: </strong>Ten patients (7 women; median age, 54.5 years) with Vogt-Koyanagi-Harada disease (<i>n</i> = 4), retinal vasculitis (<i>n</i> = 3) sarcoidosis (<i>n</i> = 1), sympathetic ophthalmia (<i>n</i> = 1), or sclerouveitis (<i>n</i> = 1) were enrolled. At 12 months, treatment was successful in 7 of the 10 patients. The reasons for treatment failure were lack of safety (<i>n</i> = 1) and insufficient therapeutic effect (<i>n</i> = 2). One patient discontinued MMF due to elevated liver enzymes. No serious adverse events (death, hospitalization, life-threatening events) or systemic symptoms (gastrointestinal issues, headache, fatigue) occurred. The median MMF dose was 2500 mg/day, with a maximum of 3000 mg/day.</p><p><strong>Conclusion: </strong>MMF may be safely used as a steroid-sparing agent in Japanese patients with non-infectious uveitis or sclerouveitis.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active Juxtapapillary Toxoplasmic Retinochoroiditis Presenting with Henle Fiber Hemorrhages.","authors":"Antônio Pedro de Britto Pereira Fortuna, Laura Gomes Nunes de Melo, Ricardo Lima de Almeida Neves, Raul Nunes Galvarro Vianna","doi":"10.1080/09273948.2025.2493358","DOIUrl":"https://doi.org/10.1080/09273948.2025.2493358","url":null,"abstract":"<p><p>To report an atypical presentation of ocular toxoplasmosis manifesting as juxtapapillary toxoplasmic retinochoroiditis with Henle fiber layer (HFL) hemorrhages. Observational case report. A 56-year-old HIV-positive female from the southeast region of Brazil presented with unilateral juxtapapillary toxoplasmic retinochoroiditis and HFL hemorrhages at fundus examination. Multimodal imaging systems, such as optical coherence tomography (OCT), were used for diagnosis and monitoring. The patient had a satisfactory clinical response to medical treatment, with ocular toxoplasmosis being the main etiological diagnosis based on clinical data, imaging, and laboratory. HFL hemorrhages represent, as far as the author's knowledge goes, a novel finding in ocular toxoplasmosis, adding to the understanding of HFL hemorrhages, specifically in their pathophysiology and etiologies.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Presentation of Frosted Branch Angiitis due to Ocular Toxoplasmosis: A Case Report.","authors":"Laura Daniela Rodríguez-Camelo, María Triana-Cavelier, Laura Inés Rojas-Serrano, Germán Mejía-Salgado, Camilo Andrés Gómez-Durán, Juanita Cardona-López, Claudia Eugenia Durán-Merino, Alejandra de-la-Torre","doi":"10.1080/09273948.2025.2493791","DOIUrl":"https://doi.org/10.1080/09273948.2025.2493791","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of Frosted Branch Angiitis (FBA) secondary to ocular toxoplasmosis in a patient with a retinochoroidal scar in the contralateral eye (OD) and a late active retinochoroiditis in the OS and to compare it with previous reports.</p><p><strong>Case description: </strong>A 25-year-old female experienced sudden vision loss and eye redness in the left eye (OS). During the initial examination, the best-corrected visual acuity was 20/20 in the right eye (OD) and counting fingers in the OS. Ophthalmological examination of the OD showed a 1-disc diameter scar in the lower nasal mid-periphery. At the same time, OS revealed 2+ cellularity in the anterior chamber and retinal vasculitis with perivascular sheathing, indicative of FBA. Initial treatment included antiviral and corticosteroid therapy (oral and topical), with partial improvement. Aqueous humor polymerase chain reaction confirmed toxoplasmosis as the etiology, necessitating a shift to specific anti-Toxoplasma therapy, which led to clinical improvement.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering in the differential diagnosis of FBA, even in patients with retinochoroidal scars in the contralateral eye. Close follow-up is essential after FBA resolution, as new lesions may develop. Prompt anti- therapy and corticosteroid treatment are critical for preserving visual outcomes, as delays in diagnosis and treatment can lead to significant complications.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Ocular Post-Transplant Lymphoproliferative Disorder with Obinutuzumab in an 8-Year-Old Boy Following Kidney Transplant: A Case Report.","authors":"Charlotte Lussier, Cynthia L Larche, Julie Vadboncoeur","doi":"10.1080/09273948.2025.2495070","DOIUrl":"https://doi.org/10.1080/09273948.2025.2495070","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of an eight-year-old boy who developed an intraocular recurrence of lymphoproliferative disorder following a kidney transplant.</p><p><strong>Methods: </strong>Retrospective single case report.</p><p><strong>Results: </strong>The patient initially presented with systemic post-transplant lymphoproliferative disorder (PTLD), which later recurred as a masquerade syndrome with iris nodules and granulomatous uveitis. Initial treatment with systemic rituximab led to recurrence after 6 months. Complete recurrence resolution of both ocular and systemic disease was achieved with obinutuzumab.</p><p><strong>Conclusion: </strong>This case highlights the importance of early recognition and multidisciplinary management in PTLD. It also emphasizes the delicate balance between immunosuppression and antitumor therapy in transplant recipients, aiming to preserve graft function while effectively treating PTLD.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}