Utilizing the IRIS® Registry (Intelligent Research in Sight) to Characterize Cases of Acanthamoeba Keratitis in the United States.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-09-24 DOI:10.1080/09273948.2025.2565462

Jennifer L Patnaik, Alan G Palestine, Anne M Lynch, Nicolas Neumeister, Flora Lum, Karen L Christopher

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引用次数: 0

Abstract

Purpose: The purpose of this study was to utilize data from a large national registry to characterize patients diagnosed with acanthamoeba keratitis (AK) and compare with cases at our institution.

Methods: Cases of AK were identified in the IRIS® Registry (Intelligent Research in Sight) from October 2015 through December 2019 and at University of Colorado Hospital (UCH) from October 2015 through June 2024. Outcomes were corneal transplant and visual acuity within 3-24 months after diagnosis.

Results: A total of 356 eyes with AK from 292 patients were identified in the IRIS Registry and 31 eyes from 27 patients at UCH. Corneal transplant following AK diagnosis was performed in 39 (11.2%) eyes in the IRIS Registry and 10 (32.3%) of UCH eyes. Patient eyes undergoing corneal transplant were on average older, mean of 52 years in the IRIS Registry (standard deviation (SD): 18) compared to 42 (SD: 20) for those not undergoing this procedure (p = 0.002). Having a final follow-up visual acuity of worse than 20/200 occurred in 28.2% of eyes in the IRIS Registry and 31.3% at UCH. Older age was associated with poor follow-up visual acuity in the IRIS Registry (p < 0.0001) and in the UCH cohort (p = 0.114), but was not significant in the UCH cohort likely due to small sample size.

Conclusions: This large cohort of AK cases shows that Big Data such as the IRIS Registry is useful for research, but some details will differ from institutional chart review due to limitations in coding precision and verification.

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利用IRIS®注册表（视觉智能研究）来描述美国棘阿米巴角膜炎病例。

目的：本研究的目的是利用来自大型国家登记处的数据来描述诊断为棘阿米巴角膜炎（AK）的患者，并与我们机构的病例进行比较。方法：2015年10月至2019年12月在IRIS®登记处（Intelligent Research in Sight）和2015年10月至2024年6月在科罗拉多大学医院（University of Colorado Hospital， UCH）发现AK病例。结果为角膜移植和诊断后3-24个月内视力恢复。结果：在IRIS Registry中发现292例患者中有356只眼存在AK，在UCH中有27例患者中有31只眼存在AK。在IRIS登记的39只眼（11.2%）和10只眼（32.3%）进行了AK诊断后的角膜移植。接受角膜移植的患者的平均年龄为52岁，IRIS登记处的平均年龄（标准差（SD）： 18），而未接受该手术的患者的平均年龄为42岁（SD: 20）（p = 0.002）。最终随访视力低于20/200的有28.2%的IRIS和31.3%的UCH。在IRIS登记中，年龄较大与随访视力差相关（p p = 0.114），但由于样本量小，在UCH队列中不显著。结论：大量AK病例表明，像IRIS这样的大数据对研究是有用的，但由于编码精度和验证的限制，一些细节将与机构图表审查有所不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.