Anterior Segment Optical Coherence Tomography in Endophthalmitis.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-09-30 DOI:10.1080/09273948.2025.2555615

Luca Mautone, Laura Ponti, Pierre Sanchis, Vasyl Druchkiv, Christos Skevas, Johannes Birtel, Martin S Spitzer

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引用次数: 0

Abstract

Purpose: Anterior Segment Optical Coherence Tomography (AS-OCT) can assess anterior chamber's (AC) changes. This study aims to describe AC changes in eyes with endophthalmitis using AS-OCT.

Methods: Electronic patient records, slit lamp photography and anterior segment infrared imaging were reviewed in this retrospective single-center cohort study and correlated to swept-source AS-OCT scans of eyes with endophthalmitis.

Results: Fourteen eyes of 14 patients with postoperative (n = 6 after cataract surgery; n = 6 after anti-VGEF-injection) and endogenous (n = 2) endophthalmitis were included. The visual acuity was light perception (n = 3), hand movement (n = 7) and ≥1.30 LogMar (n = 4). On slit lamp examination, hypopyon (n = 13) and fibrin (n = 5) were seen. AS-OCT detected hypopyon (n = 13) and fibrin formations (n = 10); hypopyon appeared as a hyperreflective level at the bottom of the AC and showed a hyperreflective lamellar prolongation on the corneal endothelium. Fibrin had the shape of hyperreflective filaments and presented in four patterns: single-stranded, stork-nest-like, cloth-like, or with a mixed phenotype.

Conclusion: AS-OCT imaging may visualize inflammatory activity of the AC in endophthalmitis and enable a morphological characterization of fibrin formation. Characteristic findings are also seen in cases with reduced corneal transparency.

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眼内炎的前段光学相干断层扫描。

目的：利用前段光学相干断层扫描（AS-OCT）评估前房病变。本研究旨在用AS-OCT描述眼内炎患者眼内AC的变化。方法：回顾性单中心队列研究回顾了电子病历、裂隙灯摄影和前段红外成像，并与眼内炎眼睛的扫描源AS-OCT扫描相关联。结果：14例白内障术后（n = 6，抗vgef注射后n = 6）和内源性眼内炎（n = 2）患者共14眼。视力分别为光感（n = 3）、手部运动（n = 7）和≥1.30 LogMar （n = 4）。裂隙灯检查见hypohypon （n = 13）和fibrin （n = 5）。AS-OCT检测到hypopyon （n = 13）和fibrin formations (n = 10)；hypoyon在AC底部表现为高反射水平，并在角膜内皮上表现为高反射的板层延长。纤维蛋白具有高反射细丝的形状，并以四种模式呈现：单链，鹳巢状，布状或混合表型。结论：AS-OCT成像可以显示眼内炎AC的炎症活动，并能对纤维蛋白形成进行形态学表征。特征性表现也见于角膜透明度降低的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.