Ocular Immunology and Inflammation最新文献_第7页

Ocular Complications of Intermediate Uveitis. 中度葡萄膜炎的眼部并发症。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-07-18 DOI: 10.1080/09273948.2024.2378370

Radgonde Amer, Yael Sharon

{"title":"Ocular Complications of Intermediate Uveitis.","authors":"Radgonde Amer, Yael Sharon","doi":"10.1080/09273948.2024.2378370","DOIUrl":"10.1080/09273948.2024.2378370","url":null,"abstract":"Intermediate uveitis (IU) in an intraocular inflammation that predominantly affects the vitreous. It typically manifests as chronic low-grade inflammation, mainly affecting children and young adults. Uncontrolled chronic intraocular inflammation carries a high risk of visual loss. IU, despite being a low-grade inflammation, is among the sight-threatening conditions owing to its intrinsically-associated vision-robbing ocular complications. It can cause early and late-onset ocular complications affecting the anterior and posterior segments of the eye. 40-60% of the patients who suffer from IU will develop at least one ocular complication during the disease course. Prompt management and long-term monitoring are vital for the early detection of ocular complications and timely intervention. Proactive screening programs are essential in children because of the occult nature of IU in the pediatric age group and the high prevalence of complications at the initial visit. This review provides a comprehensive panorama of anterior segment complications, namely, band keratopathy, corneal endotheliopathy, posterior synechiae, and cataract as well as of posterior segment complications including macular edema, retinoschisis, retinal detachment, vitreous hemorrhage, vasoproliferative tumor, optic neuritis, and papillitis, in addition to glaucoma and hypotony.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"548-555"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Vascular Changes in Vitiligo: A Novel Approach Using OCTA. 白癜风视网膜血管改变：一种新的OCTA方法。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-12-05 DOI: 10.1080/09273948.2024.2431195

Kübra Özata Gündoğdu, Emine Doğan, Reyhan Çetinkaya, Gürsoy Alagöz

{"title":"Retinal Vascular Changes in Vitiligo: A Novel Approach Using OCTA.","authors":"Kübra Özata Gündoğdu, Emine Doğan, Reyhan Çetinkaya, Gürsoy Alagöz","doi":"10.1080/09273948.2024.2431195","DOIUrl":"10.1080/09273948.2024.2431195","url":null,"abstract":"Purpose: This study aimed to the detect of structural and functional changes in the retina and choroid in patients with vitiligo using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).Materials and methods: Thirty patients with vitiligo and 30 healthy participants were enrolled in the study. Central macular thickness (CMT), retina nerve fiber layer (RNFL) thickness, choroidal thickness (CT), foveal avascular zone (FAZ) area, and superficial and deep vascular density (VD) ratios were compared between the groups.Results: The mean age was 43.32 ± 12.13 and 45.90 ± 7.50 years, respectively (p = 0.435). CMT, RNFL thicknesses (except temporal quadrant), CT, superficial and deep VD, and FAZ area were similar between the two groups (p > 0.05 for all). Temporal RNFL thicknesses were lower in vitiligo patients than in control groups (p = 0.005). There was a moderate negative correlation between the duration of vitiligo disease and the mean RNFL thickness, inferior RNFL thickness, superficial total, superior, superior inner, outer, and superior outer VD values. No correlation was found between the VASI (Vitiligo area scoring index) score in vitiligo patients and OCT and OCTA values.Conclusion: Although it is known that vitiligo causes melanocyte loss in ocular tissues, there was no significant effect of vitiligo on superficial and deep retinal VD. Further comprehensive studies with a larger and more diverse population of vitiligo patients are needed to explore this further.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"627-632"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indolent Nonprogressive Multifocal Choroidal Lesions: A Review of Literature and Case Report Based on Similarity. 无痛性非进展性多灶脉络膜病变：基于相似性的文献回顾与病例报告。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-12-06 DOI: 10.1080/09273948.2024.2435471

Nicolas Nicolaou, Despina Nicolaou, Constantinos Nicolaou

{"title":"Indolent Nonprogressive Multifocal Choroidal Lesions: A Review of Literature and Case Report Based on Similarity.","authors":"Nicolas Nicolaou, Despina Nicolaou, Constantinos Nicolaou","doi":"10.1080/09273948.2024.2435471","DOIUrl":"10.1080/09273948.2024.2435471","url":null,"abstract":"Purpose: To present a case of indolent, nonprogressive multifocal choroidal lesions and contribute to the limited reports aiding this diagnosis, supplemented by a review of the literature.Methods: Clinical records of a patient were reviewed alongside relevant literature from PubMed, Cochrane, and Google Scholar.Results: A male in late 50s presented with a 10-year history of unilateral yellow-white asymptomatic fundus lesions in the left eye. Extensive multimodal imaging and workup for systemic lymphoma, sarcoidosis, autoimmune diseases, birdshot chorioretinopathy, and related infections yielded negative results. Indocyanine Green Angiography (ICGA) revealed hypofluorescent spots in the mid-late frames and fluorescence blockage consistent with fundus lesions. Enhanced-depth OCT revealed choroidal thickening and hyporeflective spaces within the outer choroid corresponding to the lesions. During Fluorescein angiography, the lesions became more iso-fluorescent and stained minimally in the late phase, indicating they are not full thickness and spare the inner choroid. Short-wave autofluorescence was normal. B-scan ultrasound revealed two shallow, lesions without retinal infiltration. Partial lesion regression and progression were observed over time. Steroid treatment aimed at reducing lesion choroidal thickening had a mild effect. Despite discontinuation, the patient remained asymptomatic without vision impairment or intraocular inflammation. The right eye remained unaffected.Conclusion: Indolent, nonprogressive, multifocal, and choroidal lesions likely represent benign lymphocytic infiltrates localised within the outer choroid. Mild steroid response suggests a non-inflammatory process. The lack of reports presents a gap in ophthalmology. Diagnosis of this case is based on similar presentation of other cases. Surveillance rather than biopsy or treatment is recommended for asymptomatic patients.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"705-709"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers to Adherence with Immunosuppressive Therapy in Patients with Uveitis. 葡萄膜炎患者坚持免疫抑制疗法的障碍。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-11-26 DOI: 10.1080/09273948.2024.2430709

Karen Sun, Rayna Marshall, Michael Frankland, Amal Taylor, Cynthia Montana, Eric Crowell, Karen R Armbrust, Laura Kopplin, Meghan Berkenstock

{"title":"Barriers to Adherence with Immunosuppressive Therapy in Patients with Uveitis.","authors":"Karen Sun, Rayna Marshall, Michael Frankland, Amal Taylor, Cynthia Montana, Eric Crowell, Karen R Armbrust, Laura Kopplin, Meghan Berkenstock","doi":"10.1080/09273948.2024.2430709","DOIUrl":"10.1080/09273948.2024.2430709","url":null,"abstract":"Purpose: To evaluate the barriers to adherence with immunomodulatory therapy (IMT) for patients with uveitis across multiple regions of the United States.Methods: A multi-center survey of adult and pediatric patients with ocular inflammatory diseases undergoing treatment with IMT was conducted between September 2021 and August 2022. Participating sites included Johns Hopkins Wilmer Eye Institute, Wong Eye Institute of the University of Texas at Austin, University of Wisconsin-Madison, University of Minnesota, Veterans Affairs Hospital of Minneapolis, and Washington University of St. Louis. Each patient completed a self-reporting survey to identify barriers to adherence.Results: The survey was completed by 98 subjects, of whom were 71% white, 67% female, and 61% had a college or advanced degree. Nearly half (49%) were on two or more IMTs of which the most common were methotrexate (38%), mycophenolate (36%), or adalimumab (36%). Nearly half (52%) of patients required reminders to take their medications and 20% found it difficult to take IMT regularly, with 12% struggling to take medications multiple times a day. A lack of refills resulted in 15% of patients missing doses. Limitations to completing laboratory studies to monitor for drug-related side-effects included finding time (10%) and cost (22%).Conclusion: Barriers to IMT treatment include laboratory study cost, difficulty with medication administration, and adhering to medication schedules. Monthly cost of medication was high for some, but no patients were unable to take IMT due to insurance loss. Addressing these barriers may improve IMT adherence for uveitis patients and better clinical outcomes.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"619-626"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vogt-Koyanagi-Harada Disease Presenting as Papillitis vs. Classic Serous Retinal Detachment: A Comparative Analysis of Outcomes. 表现为乳头炎的 Vogt-Koyanagi-Harada 病与典型浆液性视网膜脱离：疗效对比分析

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-11-08 DOI: 10.1080/09273948.2024.2424475

Raul E Ruiz-Lozano, Eugenia M Ramos-Dávila, Eduardo Camacho-Martinez, Carlos Alvarez-Guzman, Angelina Espino Barros Palau, Alejandro Rodriguez-Garcia

{"title":"Vogt-Koyanagi-Harada Disease Presenting as Papillitis vs. Classic Serous Retinal Detachment: A Comparative Analysis of Outcomes.","authors":"Raul E Ruiz-Lozano, Eugenia M Ramos-Dávila, Eduardo Camacho-Martinez, Carlos Alvarez-Guzman, Angelina Espino Barros Palau, Alejandro Rodriguez-Garcia","doi":"10.1080/09273948.2024.2424475","DOIUrl":"10.1080/09273948.2024.2424475","url":null,"abstract":"Background: To compare the treatment outcome and visual prognosis of Vogt-Koyanagi-Harada (VKH) disease presenting as papillitis vs. serous retinal detachment (SRD).Methods: Retrospective comparative cohort study of 35 patients with previously unknown VKH diagnosis, followed-up for ≥6 months. Outcomes measured: (1) time to achieve inflammatory control; (2) VKH relapse; (3) ocular complications (glaucoma, sunset glow fundus, cataract, and vision loss ≥2 Snellen lines); and (4) chances for developing a chronic-recurrent disease.Results: Females predominated in both groups: 12/16 (75%) papillitis and 18/19 (94.7%) SRD. The mean age at presentation was 29 ± 12 years in the papillitis and 36 ± 14 years in the SRD group (p = 0.119), with an overall median follow-up of 26 months (6-180 months). The papillitis-onset VKH group's mean time elapsed between symptoms onset and initial treatment was shorter (2.9 ± 1.0 vs. 4.6 ± 2.8 weeks, p = 0.024). Anterior segment inflammation was lower (56% vs. 79%, p = 0.018), requiring a shorter corticosteroids treatment duration (12.8 ± 16.1 vs. 32.7 ± 34.1 months, p = 0.040), achieving an earlier inflammatory control (1.9 ± 0.6 vs. 4.1 ± 3.2 months, p <0.001) with fewer ocular complications (13% vs. 74%, p <0.001), including sunset glow fundus (SGF) (0% vs. 63%, p <0.001). Conversely, SRD-onset VKH was a risk factor for developing disease relapse (HR: 4.53; 95% CI: 1.31-15.69, p = 0.017), ocular complications (OR: 19.60, 95% CI: 3.24-118.50, p = 0.001), and chronic-recurrent disease (OR: 20.63; 95% CI: 2.24-189.84, p = 0.008).Conclusion: Mexican-mestizo VKH patients with papillitis-onset VKH disease showed earlier inflammatory control, fewer recurrences, and better visual and ocular complication outcomes.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"570-577"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Incidence of Uveitis in Korean Patients with Sarcoidosis: A Population-Based Study. 韩国肉样瘤病患者葡萄膜炎的患病率和发病率：基于人群的研究

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-11-25 DOI: 10.1080/09273948.2024.2430708

Daehwan Shin, Seongho Kim, Mingui Kong, Bo Hee Kim, Su Jeong Song

{"title":"Prevalence and Incidence of Uveitis in Korean Patients with Sarcoidosis: A Population-Based Study.","authors":"Daehwan Shin, Seongho Kim, Mingui Kong, Bo Hee Kim, Su Jeong Song","doi":"10.1080/09273948.2024.2430708","DOIUrl":"10.1080/09273948.2024.2430708","url":null,"abstract":"Purpose: Sarcoidosis is a systemic granulomatous inflammatory disease with varying clinical presentations, including sarcoid uveitis, which is the most prevalent ocular manifestation of sarcoidosis and differs by region and ethnicity. This study aims to determine the incidence and prevalence of sarcoidosis-related uveitis in South Korea, providing essential epidemiological data.Methods: This nationwide, population-based retrospective study used the Korean Health Insurance Review and Assessment database from 2010 to 2019. It included all individuals diagnosed with sarcoidosis (ICD-10 code D86) and focused on those with newly developed uveitis. We assessed annual incidence, prevalence, gender-specific trends, age at diagnosis, treatment patterns, and recurrence. Cases were categorized as single episode or recurrent/chronic based on treatment duration and interval before recurrence.Results: Among 9,485 patients with sarcoidosis, 2,730 (28.8%) had sarcoidosis-related uveitis, with 2,413 (88.4%) being recurrent/chronic. Anterior uveitis was the most common presentation (78.0%), with posterior segment in/civolvement in 22.0% of cases. The peak age of onset was 50-59 years for both genders. The incidence rate was 0.33 and 0.64 per 100,000 for men and women, respectively. The prevalence was 0.18 and 0.35 per 100,000 for men and women, respectively. Among sarcoidosis patients, 32.9% with uveitis used three or more combinations of systemic steroids and immunosuppressants, compared to 11.1% without uveitis.Conclusion: The high prevalence of sarcoid uveitis in sarcoidosis patients necessitates regular ophthalmic examinations. Our findings highlight the need for comprehensive eye care in managing sarcoidosis and suggest that uveitis may increase disease severity, warranting tailored treatment and enhanced monitoring protocols in Korea.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"613-618"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Vitamin D Levels in Patients with Vernal Keratoconjunctivitis: A Systematic Review and Meta-Analysis. 春性角膜结膜炎患者血清维生素D水平：系统回顾和荟萃分析

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-12-05 DOI: 10.1080/09273948.2024.2431663

Kimia Daneshvar, Samira Chaibakhsh, Shila Iranpour, Elham Rahmanipour, Sara Ghorbani, Mohsen Pourazizi, Alireza Peyman

{"title":"Serum Vitamin D Levels in Patients with Vernal Keratoconjunctivitis: A Systematic Review and Meta-Analysis.","authors":"Kimia Daneshvar, Samira Chaibakhsh, Shila Iranpour, Elham Rahmanipour, Sara Ghorbani, Mohsen Pourazizi, Alireza Peyman","doi":"10.1080/09273948.2024.2431663","DOIUrl":"10.1080/09273948.2024.2431663","url":null,"abstract":"Purpose: To conduct a systematic review and meta-analysis to provide an outline of available data on the association between serum vitamin D levels and vernal keratoconjunctivitis (VKC) and to determine the possible relationship in children.Methods: Systematic research on all articles published until July 2023 was conducted in PubMed, SCOPUS, Web of Science, and Embase. All observational-analytical studies that measured vitamin D levels in patients with VKC were included. Extracted data were included in two separate meta-analyses: 1) a meta-analysis on the standardized mean difference (SMD) of vitamin D levels between VKC patients and the control group and 2) a meta-analysis on the prevalence of vitamin D deficiency in VKC patients.Results: Seven relevant studies that included 316 patients, with the mean age of 10.8 3 ± 1.14 years, with VKC were included in this meta-analysis. The mean serum vitamin D level was significantly lower in the patients with VKC as compared with the control group (SMD: -0.92; 95% CI -1.15, -0.69, p < 0.001). The overall prevalence of vitamin D deficiency among VKC patients was 63.7% (95% CI 42.5%-80.7%, p < 0.001). VKC patients spent significantly less time outdoors during daylight compared to healthy individuals (SMD = -0.90, 95%CI -1.28, -0.52, p < 0.001).Conclusion: VKC patients have lower serum vitamin D than healthy controls. This finding underscores the potential role of vitamin D in the immunopathogenesis of VKC.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"633-640"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Outcomes of Pediatric Pars Planitis: Retrospective Cohort from a Single Tertiary Center in Turkey. 小儿扁桃体旁炎的长期疗效：土耳其一家三级医院的回顾性队列研究

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-11-04 DOI: 10.1080/09273948.2024.2421386

Aslıhan Yılmaz Çebi, Oğuzhan Kılıçarslan, Didar Uçar

{"title":"Long-Term Outcomes of Pediatric Pars Planitis: Retrospective Cohort from a Single Tertiary Center in Turkey.","authors":"Aslıhan Yılmaz Çebi, Oğuzhan Kılıçarslan, Didar Uçar","doi":"10.1080/09273948.2024.2421386","DOIUrl":"10.1080/09273948.2024.2421386","url":null,"abstract":"Purpose: To retrospectively analyze long-term outcomes of pediatric pars planitis (PP).Methods: PP was defined as vitreal inflammation with snowbank or snowball formation in the absence of a related disease. Eighty-five eyes of 44 patients were included in this study. Demographic and clinical characteristics were obtained from medical records.Results: Approximately 70% of the patients were males; the mean patient age was 10.4 ± 3.6 years at presentation, and the mean follow-up time was 42.8 ± 27.9 months. At presentation, the mean best corrected visual acuity (BCVA, logMAR) was 0.17 ± 0.27 in the right eyes and 0.27 ± 0.33 in the left eyes. Common symptoms included blurry vision (29 eyes, 65%), redness (17, 38%), pain (8, 18%), and floaters (5, 11%). Sight-threatening complications included optic disc edema/hyperemia (26, 30%), cataracts (16, 18%), macular edema (16, 18%), and glaucoma (15, 17%). All 38 patients who initially required systemic treatment received corticosteroids. During the follow-up, 24 patients were treated with azathioprine, 20 with methotrexate, 11 with cyclosporine, 20 with adalimumab, and 8 with infliximab. At the final examination, the mean BCVA of the right and left eyes improved significantly (0.08 ± 0.23 and 0.06 ± 0.17, p = 0.006 and p < 0.001, respectively). The severities of vitritis, anterior chamber inflammation, snowbank/snowball formation, and endotheliitis decreased (all p < 0.001). Thirty-one patients remained on systemic treatment, with only four patients still receiving corticosteroids. No life-threatening adverse effects were reported.Conclusion: Despite pediatric PP's mild course, severe vision-threatening complications can occur. Immunomodulatory or biologic agents are important for controlling inflammation and tapering corticosteroids. Further research could enhance understanding of optimal treatments.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"556-560"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNAs as Biomarkers for Uveitis in Juvenile Idiopathic Arthritis. 作为幼年特发性关节炎葡萄膜炎生物标志物的微RNAs

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-11-19 DOI: 10.1080/09273948.2024.2428417

Yael Sharon, Gil Ben-David, Yael Nisgav, Gil Amarilyo, Guy Shapira, Ifat Israel-Elgali, Shani Pillar, Nir Pillar, Noam Shomron, Michal Kramer

{"title":"MicroRNAs as Biomarkers for Uveitis in Juvenile Idiopathic Arthritis.","authors":"Yael Sharon, Gil Ben-David, Yael Nisgav, Gil Amarilyo, Guy Shapira, Ifat Israel-Elgali, Shani Pillar, Nir Pillar, Noam Shomron, Michal Kramer","doi":"10.1080/09273948.2024.2428417","DOIUrl":"10.1080/09273948.2024.2428417","url":null,"abstract":"Purpose: Uveitis associated with juvenile idiopathic arthritis (JIA-U) is a clinically silent vision-impairing disease. Early detection and aggressive treatment are crucial for optimal visual outcome. Alterations in levels of microRNAs (miRNAs) are characteristic of autoimmune diseases. The present clinical study sought to explore the expression of miRNAs in JIA-U and their potential role as a predictive biomarker.Methods: MiRNA expression profiling was performed on peripheral blood mononuclear cells derived from pediatric patients with JIA, JIA-U, or other types of uveitis using the high-throughput small-RNA sequencing (on Next Generation Sequencing (NGS)). Patient- and disease-related data were retrieved from the medical files. Main outcome measure was the differential expression of miRNAs among the groups.Results: The cohort included 35 patients; 20 children with JIA-U (8 with active disease), 10 with JIA without ocular involvement, and 5 with other types of uveitis (4 with active disease). Mean age was 8.6 years; 83% were female. Nineteen patients (54%) received immunomodulatory treatment. The expression of miR-4485-3p was significantly increased in patients with JIA-U compared to patients with JIA alone (p < 0.05), with no difference between patients with active or inactive uveitis. The expression in patients with uveitis of other etiologies was similar to the expression in JIA-U patients.Conclusions: This study demonstrates a differential expression profile of a specific miRNA in JIA patients with and without uveitis. If verified in larger studies, the findings may assist to identify JIA patients at risk to develop uveitis and to improve early detection of disease activity.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"589-595"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-05-01 Epub Date: 2024-11-25 DOI: 10.1080/09273948.2024.2432554

Matthaeus Ware, Yasmin Motekalem, Kirill Zaslavsky, Miguel Cruz-Pimentel, Vishal Kukreti, Alexander J Kaplan, Peng Yan

{"title":"CMV-Related Hemorrhagic Retinal Vasculitis in a Multiple Myeloma Patient on Daratumumab Therapy: A Case Report.","authors":"Matthaeus Ware, Yasmin Motekalem, Kirill Zaslavsky, Miguel Cruz-Pimentel, Vishal Kukreti, Alexander J Kaplan, Peng Yan","doi":"10.1080/09273948.2024.2432554","DOIUrl":"10.1080/09273948.2024.2432554","url":null,"abstract":"Purpose: To report a case of cytomegalovirus (CMV)-related hemorrhagic retinal vasculitis in a patient with multiple myeloma (MM) on daratumumab, a trial cereblon E3 ligase modulatory drug (CELMoD), dexamethasone, and acyclovir, and discuss clinical implications for CMV prophylaxis.Methods: Case report, narrative review of CMV reactivation risk in MM patients on daratumumab and antiviral agent efficacy for CMV prophylaxis.Results: A 63-year-old female presented with 3 days of progressive unilateral vision loss in the right eye to the level of counting fingers. She had a history of relapsed and refractory MM and autologous stem cell transplant (ASCT). At the time of presentation, she was receiving daratumumab, a trial CELMoD, dexamethasone, and acyclovir. Posterior segment exam demonstrated trace vitreous cells (0.5+ vitritis as per SUN criteria) and scattered hemorrhages with multifocal intraluminal vascular whitening, aligned with infectious posterior uveitis and suggestive of panretinal occlusive vasculitis. Optical coherence tomography showed inner macular edema and epiretinal membrane formation. CMV reactivation was confirmed with PCR of anterior chamber fluid and blood.Conclusion: Patients with MM on daratumumab are at increased risk of opportunistic reactivations including CMV, potentially due to daratumumab's immunomodulatory side effects. Our patient developed CMV-related hemorrhagic retinal vasculitis despite low-dose acyclovir, which provides limited protection against CMV reactivation in CMV seropositive individuals. This case report therefore offers casuistic support for ophthalmic screening for CMV reactivation or CMV prophylaxis with letermovir in this patient population.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"701-704"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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