Ocular Immunology and Inflammation最新文献

{"title":"The Quality of Life Impact of Acute Uveitis: A Prospective Study.","authors":"Juliana Rocha de Mendonça da Silva, Ana Luiza Biancardi, Henrique Maciel Vieira de Moraes, Haroldo Vieira de Moraes","doi":"10.1080/09273948.2025.2518253","DOIUrl":"https://doi.org/10.1080/09273948.2025.2518253","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact on quality of life of acute uveitis diagnosis and management.</p><p><strong>Design: </strong>50 patients with acute uveitis were followed prospectively for three months in a tertiary hospital in Rio de Janeiro, Brazil. Vision-related (VR-) and health-related (HR-) quality of life (QoL) were respectively assessed by NEI-VFQ-25 and SF-36 questionnaires at the initial consultation and after three months. Associations between the questionnaire's subscale item scores with clinical/demographical data were assessed.</p><p><strong>Results: </strong>After generalized linear models, in the initial QoL evaluation lower visual acuity (VA) and unemployment/retirement were associated with lower scores in both questionnaires, while bilateral uveitis was associated with NEI-VFQ-25 questionnaire only and older age with SF-36 only. At the three-month QoL evaluation lower VA and older age were associated with lower scores and VA improvement with higher scores in both questionnaires and unemployment/retirement was associated with lower SF-36 score only. When evaluating the variation between the initial QoL scores and those after three months, older age was associated with lower VR- and HR-QoL improvement, while short interval between referral and the first appointment, higher final VA and VA improvement were associated with VR-QoL upgrade. Bilateral uveitis was associated with lower HR-QoL improvement.</p><p><strong>Conclusion: </strong>Older age and worse VA have a significant negative impact on VR-QoL and HR-QoL, while VA improvement has positive impact. Anatomic classification and etiology of uveitis did not seem to impact on variation of QoL during diagnosis and treatment of acute uveitis, as well as education level and self-reported color.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the COTS Calculator for Tubercular Uveitis: Predictive Performance and Diagnostic Utility in an Indian Cohort.","authors":"Janakiraman Palani, Carlos Cifuentes Gonzalez, Gazal Patnaik, William Rojas-Carabali, Ludi Zhang, Zheng Xian Thng, Bernett Lee, Rupesh Agrawal, Jyotirmay Biswas","doi":"10.1080/09273948.2025.2517309","DOIUrl":"https://doi.org/10.1080/09273948.2025.2517309","url":null,"abstract":"<p><strong>Purpose: </strong>Diagnosing ocular tuberculosis (OTB) is clinically challenging due to its paucibacillary nature and lack of definitive diagnostic tests. The Collaborative Ocular Tuberculosis Study (COTS) Calculator was developed as a clinical decision-support tool to guide anti-tubercular therapy (ATT) initiation. This study externally validates the COTS Calculator in a high-burden Indian cohort and assesses the additive value of radiological and immunological testing.</p><p><strong>Methods: </strong>This retrospective cohort study included 196 OTB patients treated between 2015 and 2022 at a tertiary eye care center in South India. Inclusion required complete diagnostic workup, ≥6-month follow-up post-ATT, and at least one supportive test (TST, IGRA, CT, or CXR). Two thresholds were evaluated: M4I1 (median ≥ 4) and M4I2 (median ≥ 4, IQR ≤ 2). Treatment response and recurrence were primary outcomes. Diagnostic performance was measured using AUC, sensitivity, specificity, PPV, and NPV. Composite scores (CT+CXR and TST+IGRA) were also analyzed.</p><p><strong>Results: </strong>The M4I2 threshold yielded higher sensitivity (83%) than M4I1 (60%) with comparable AUC (0.60 vs 0.58), though at lower specificity (38% vs 56%). Both thresholds achieved high PPV (94%) but poor NPV (11-17%). Composite testing showed similar high PPV (93%) and poor NPV (9-11%). Higher COTS scores and multiple positive tests correlated with favorable treatment response.</p><p><strong>Conclusions: </strong>The COTS Calculator, particularly the M4I2 model, provides a useful clinical tool to guide ATT decisions in OTB. While limited in ruling out TB, its integration with radiological and immunological testing supports early treatment decisions in TB-endemic settings. Prospective validation is warranted.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Upadacitinib in Adolescents with Idiopathic Chronic Panuveitis Who Lost Response to Adalimumab.","authors":"Kailei Guo, Xiaomin Zhang","doi":"10.1080/09273948.2025.2519852","DOIUrl":"https://doi.org/10.1080/09273948.2025.2519852","url":null,"abstract":"<p><strong>Purpose: </strong>This report highlights the administration of upadacitinib in four adolescents with idiopathic chronic refractory panuveitis who showed an inadequate response to systemic glucocorticoids, immunosuppressive agents, and anti-TNF biologic therapy.</p><p><strong>Methods: </strong>We present four cases: two 13-year-old boys, one 15-year-old boy, and one 14-year-old girl, each with a history of idiopathic panuveitis that persisted for 4, 8, 4, and 5 years, respectively.</p><p><strong>Results: </strong>Upadacitinib effectively reduced ocular inflammation in all four cases during the first month of treatment. Following upadacitinib treatment, adalimumab was discontinued or extended, and the immunosuppressive agents were gradually tapered. In two cases, it led to complete resolution of the anterior segment and vitreous inflammation and significant improvement in the posterior segment. However, two patients developed upper respiratory tract symptoms at the second and fifth months, respectively, both of which were associated with recurrence of ocular inflammation and required high-dose glucocorticoids for control. No other serious adverse events were documented in the four patients during the nine to ten months follow-up period.</p><p><strong>Conclusions: </strong>These cases indicate that upadacitinib may be an effective treatment strategy for adolescents with idiopathic chronic refractory panuveitis. However, the potential risk of infections should be considered and monitored.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Evanescent White Dot Syndrome as Epiphenomenon of Infectious Chorioretinopathies.","authors":"Luca De Simone, Vanessa Ferraro, Elena Bolletta, Fabrizio Gozzi, Pietro Gentile, Francesca Ceccarelli, Carlo Nucci, Mario Romano, Luca Cimino","doi":"10.1080/09273948.2025.2514987","DOIUrl":"https://doi.org/10.1080/09273948.2025.2514987","url":null,"abstract":"<p><strong>Purpose: </strong>Multiple evanescent white dot syndrome (MEWDS) is a rare idiopathic ocular disorder often affecting young adults. Recently, a secondary form, epiphenomenon MEWDS (Epi-MEWDS), has been described in association with pre-existing retinal conditions. However, its correlation with infectious diseases remains poorly documented.</p><p><strong>Methods: </strong>A retrospective review of six patients with infectious chorioretinopathies who developed Epi-MEWDS was conducted. Clinical presentations, imaging findings, and disease progression were analyzed.</p><p><strong>Results: </strong>This study presents a case series of six patients who developed Epi-MEWDS secondary to infectious chorioretinopathies, highlighting its distinct clinical features. Cases included Epi-MEWDS following Candida endophthalmitis, tubercular multifocal serpiginous-like choroiditis, ocular syphilis, and recurrent toxoplasmosis. Fundus autofluorescence and optical coherence tomography confirmed hyperautofluorescent lesions and outer retinal disruption in all cases. Patients were managed conservatively, and in all cases, imaging abnormalities resolved within a few weeks.</p><p><strong>Conclusion: </strong>This case series emphasizes the role of infectious disease-related immune responses in triggering Epi-MEWDS. In these cases disruptions in the outer blood-retinal barrier, leading to photoreceptor antigen exposure, appear to contribute to disease pathogenesis. Recognizing these cases can enhance understanding of post-infectious retinal immune responses and guide appropriate clinical management.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Pigment Epithelium Undulations in Primary Vitreoretinal Lymphoma: An Under-Recognised OCT Biomarker.","authors":"Khushboo Chauhan, Lauren Dalvin, Mohit Dogra, Vishal Raval","doi":"10.1080/09273948.2025.2519848","DOIUrl":"https://doi.org/10.1080/09273948.2025.2519848","url":null,"abstract":"<p><strong>Objective: </strong>To determine the significance of retinal pigment epithelium (RPE) undulations in primary vitreoretinal lymphoma (PVRL) and evaluate the association of RPE undulations, intraretinal infiltration, and sub-RPE/subretinal lesions with severity indicators, including partial regression, subsequent central nervous system (CNS) involvement, and recurrence.</p><p><strong>Methods: </strong>It is a multicentred, retrospective observational study which included 134 biopsy-proven PVRL eyes from Asian and American populations. Regression analysis was used to determine the association between various OCT biomarkers of PVRL and disease severity indicators.</p><p><strong>Results: </strong>A total of 134 eyes from 77 patients with biopsy-confirmed PVRL were included. The median age of the patients was 67 years (range 59-71), and the sex distribution was 72 females (54%) and 62 males (46%). On OCT, 35 (26%) eyes showed RPE undulations, which were more common in Asians (61%) than in the American population (16%). In addition, 67 (50%) eyes exhibited sub-RPE/subretinal hyperreflective lesions, and 45 (34%) eyes had intraretinal lesions. Multivariate regression analysis showed an association between RPE undulations and partial regression odds ratio (OR) of 4.032 (95% CI: 1.518-10.71), (<i>p</i> = 0.005), and likelihood ratio of 8.418, and intraretinal lesions were associated with CNS involvement OR of 2.597 (95% CI: 1.14-5.876), (<i>p</i> = 0.01), and likelihood ratio of 5.26.</p><p><strong>Conclusion: </strong>RPE undulation is more common in Asians than in the American population. It is a marker of disease severity associated with partial regression of the disease, whereas intraretinal lesions are associated with an increased risk of subsequent CNS involvement.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Effectiveness and Safety of Weekly Adalimumab in Refractory Non-Infectious Uveitis.","authors":"Abdülcemal Gürpınar, Mertcan Esenkaya, Bilge Eraydin, Hilal Eser-Ozturk, Yüksel Süllü","doi":"10.1080/09273948.2025.2516826","DOIUrl":"https://doi.org/10.1080/09273948.2025.2516826","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the efficacy and safety of weekly adalimumab after dose escalation in patients with chronic refractory non-infectious uveitis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients aged 18 years and older with persistent chronic uveitis despite bi-weekly adalimumab treatment. Data collected included uveitis diagnosis, anatomical site of involvement, history of immunosuppressive treatments, relapse frequency, and other relevant clinical parameters.</p><p><strong>Results: </strong>This study included 30 patients (18 females and 12 males) with a median age of 33.5 (22-57) years and a mean follow-up period of 62.6 ± 25.2 months. Median visual acuity was 0.29 logMAR (0.22-0.40) with bi-weekly adalimumab treatment and improved to 0.20 logMAR (0.10-0.36) with weekly adalimumab treatment (<i>p</i> = 0.009). A significant reduction in central macular thickness was observed with weekly adalimumab treatment compared to the bi-weekly regimen (259.67 µm vs. 336.47 µm, <i>p</i> = 0.001). The frequency of relapses was 1.9 ± 0.66 with bi-weekly treatment and 0.53 ± 0.33 with weekly treatment (<i>p</i> = 0.001). The proportion of patients exhibiting active ocular inflammation requiring systemic steroids was 60% in the bi-weekly treatment, compared to 24.3% in the weekly treatment. In terms of adverse effect profile, both treatment modalities exhibited similar characteristics. Weekly adalimumab is associated with a significantly reduced risk of relapse compared with bi-weekly ADA (HR = 0.267, <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Weekly adalimumab treatment is a viable option for managing inflammation in refractory uveitis, providing enhanced efficacy to the standard dose in terms of visual and anatomical outcomes, while maintaining a comparable side effect profile.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Between Behçet's Uveitis Patients with Immunologically Positive and Immunologically Negative Tuberculosis Test.","authors":"Alaa Abdulrahman Almogahed, Maha M Youssef, Magda Salaheldin Abdelaziz, Esraa El-Mayah","doi":"10.1080/09273948.2025.2509717","DOIUrl":"https://doi.org/10.1080/09273948.2025.2509717","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical features of patients with Behçet's Uveitis in the presence or absence of latent tuberculosis infection (LTBI).</p><p><strong>Methods: </strong>A retrospective comparative study was carried out, examining patients with Behçet's disease who visited the Uveitis subspecialty clinic at Kasr Al-Ainy Hospital, Cairo University Hospitals. A total of 20 consecutive patients with positive tuberculosis immunology (group 1) and 20 consecutive patients with negative tuberculosis immunology (group 2) were included.</p><p><strong>Results: </strong>Patients in group 2 showed a higher incidence of macular edema (<i>p</i> value = 0.013) and were more likely to receive systemic corticosteroids compared to group 1 (<i>p</i> value = 0.011). Conversely, vascular occlusion was more prevalent among group 1 patients (<i>p</i> value = 0.044). There was a significant increase in the use of systemic corticosteroids, immunosuppressive drugs, biologics, and anti-TB medications from the initial visit to the last visit (<i>p</i> value < 0.001). Genital ulcers, oral ulcers, GIT ulcers, and nodular erythema decreased significantly by the last visit compared to the initial presentation (<i>p</i> value < 0.05). Significant differences in laboratory findings such as anemia, high ESR, high C-reactive protein, and high HBA1c were observed between the two groups (<i>p</i> value < 0.001).</p><p><strong>Conclusion: </strong>Patients with immunologically negative TB tests were more likely to develop macular edema, whereas those with immunologically positive TB tests had a higher risk of vascular occlusion. Additionally, patients who have immunologically positive TB tests often present with elevated inflammatory markers like high ESR and C-reactive protein.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-11"},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Simultaneous Bilateral Corneal Perforations in Chronic Ocular Graft-Versus-Host Disease.","authors":"Anna Marmalidou, Leena Surapaneni, Sotiria Palioura","doi":"10.1080/09273948.2025.2516828","DOIUrl":"https://doi.org/10.1080/09273948.2025.2516828","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical course and management of a patient with bilateral, simultaneous corneal perforations associated with chronic graft-versus-host disease (GVHD) and subsequent phacolytic glaucoma, highlighting the role of cyanoacrylate glue, amniotic membrane transplantation, and anterior segment optical coherence tomography (AS-OCT) in disease monitoring.</p><p><strong>Methods: </strong>Case report and literature review.</p><p><strong>Results: </strong>A 58-year-old male with chronic ocular and skin GVHD presented with bilateral corneal perforations, confirmed via slit-lamp examination and AS-OCT. Initial visual acuity was light perception in both eyes. Immediate surgical management involved cyanoacrylate glue application and amniotic membrane transplantation, followed by medical therapy with systemic corticosteroids, topical antibiotics, autologous serum tears, and bandage contact lenses. Postoperatively, the patient's ocular surface stabilized, with corneal healing confirmed on AS-OCT. The patient later developed phacolytic glaucoma due to intumescent white cataracts, requiring endoillumination-assisted phacoemulsification. At 2.5 years, visual acuity had improved to 20/60 OD and 20/125 OS, with normal intraocular pressures and controlled ocular GVHD.</p><p><strong>Conclusion: </strong>While corneal perforation is a rare but sight-threatening complication of chronic ocular GVHD, simultaneous bilateral corneal perforations are exceptionally uncommon, with only one previously documented case in the literature. Cyanoacrylate glue and amniotic membrane transplantation provided effective stabilization, while AS-OCT facilitated precise monitoring of corneal healing. This case underscores the importance of prompt surgical intervention, interdisciplinary management, and vigilant long-term monitoring. Early identification and management of secondary complications, including phacolytic glaucoma, contributed to visual rehabilitation.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Ophthalmologist in the Prompt Diagnosis of Syphilis: Unmasking the Great Mimicker.","authors":"Luca De Simone, Francesca Ceccarelli, Pietro Gentile, Elena Bolletta, Fabrizio Gozzi, Vanessa Ferraro, Mario Romano, Carlo Nucci, Luca Cimino","doi":"10.1080/09273948.2025.2516082","DOIUrl":"https://doi.org/10.1080/09273948.2025.2516082","url":null,"abstract":"<p><strong>Purpose: </strong>Syphilis is a systemic sexually transmitted infection that often mimics autoimmune and neurological disorders, which can lead to diagnostic delays. We describe a series of four patients affected by ocular syphilis initially misdiagnosed as a systemic inflammatory condition to highlight the ophthalmologist's role in early detection and management, thereby preventing irreversible visual impairment.</p><p><strong>Methods: </strong>We retrospectively reviewed four cases of ocular syphilis from 2022 to 2024, which were initially misdiagnosed as autoimmune or neurological diseases and thus inappropriately treated with immunosuppressive therapy. The patients underwent a full ophthalmic examination, including best-corrected visual acuity, slit-lamp biomicroscopy, fundus imaging, optical coherence tomography, and retinal angiography. Syphilis serologies were performed, and treatment included intravenous penicillin G or ceftriaxone (for penicillin-allergic patients).</p><p><strong>Results: </strong>All patients tested positive for syphilis, with negative HIV screening. Initial misdiagnoses included systemic sarcoidosis, multiple sclerosis, psoriasis-like skin lesions, or unknown inflammatory conditions and were treated with unnecessary immunosuppressive therapy. Ocular findings varied from granulomatous panuveitis to retinal vasculitis, placoid chorioretinitis, and macular edema. Antibiotic therapy led to significant clinical improvement, but patients exhibited irreversible damage, such as decreased visual acuity, persistent color vision loss, retinal atrophy, and irreversible photoreceptor damage.</p><p><strong>Conclusion: </strong>Syphilis remains a great mimicker, frequently misdiagnosed as non-infectious systemic disease. Ophthalmologists play a critical role in identifying ocular manifestations and initiating appropriate serological testing. A delayed diagnosis increases the risk of irreversible damage. Given the rising incidence, greater awareness and interdisciplinary collaboration are essential to ensure timely diagnosis and management.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacovigilance Analysis of Lifitegrast-Associated Adverse Events Using the FDA Adverse Event Reporting System (FAERS) Database.","authors":"Dongzhi Wu, Zhijing Liu, Tao Zhang, Wenhui He, Chengjie Ke, Maohua Chen","doi":"10.1080/09273948.2025.2518257","DOIUrl":"https://doi.org/10.1080/09273948.2025.2518257","url":null,"abstract":"<p><strong>Background: </strong>Lifitegrast is the first lymphocyte function-associated antigen-1 antagonist approved by the United States Food and Drug Administration (FDA) for the treatment of the signs and symptoms of dry eye disease. Its safety has not been fully elucidated in a real-world analysis. Thus, we conducted a pharmacovigilance analysis using data on lifitegrast-associated adverse events (AEs) from the FDA's adverse event reporting system (FAERS).</p><p><strong>Methods: </strong>A comprehensive search of the FAERS database was conducted to extract all available data on lifitegrast from the time of its initial market release (July 2016) until March 2024. Signals of lifitegrast-associated AEs were quantified by calculating reporting odds ratio, proportional reporting ratio, information component, and empirical Bayesian geometric mean.</p><p><strong>Results: </strong>In total 12 929,815 AE reports were collected from the FAERS database. Lifitegrast was deemed the primary suspect in 12 390 of these reports. Comprehensive analysis using four algorithms resulted in the identification and retention of 179 preferred terms exhibiting significant disproportionality. In addition to known AEs, unexpected and novel AEs, such as hypoacusis, instillation site infection, temporomandibular joint syndrome, and reduced blood folate levels, were identified.</p><p><strong>Conclusion: </strong>Most lifitegrast-related AEs identified in this study were consistent with those described on the drug label, but some other signals potentially associated with lifitegrast were identified. Prospective studies are needed to verify and clarify these AEs' relationship to lifitegrast.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}