Ocular Immunology and Inflammation最新文献_第6页

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-24 DOI: 10.1080/09273948.2025.2504581

Nicolas Kitic, Adélaïde Toutee, Isabelle Audo, Alexandre Le Joncour, Dimitri Psimaras, Valérie Touitou

{"title":"There's Always a Bigger Fish.","authors":"Nicolas Kitic, Adélaïde Toutee, Isabelle Audo, Alexandre Le Joncour, Dimitri Psimaras, Valérie Touitou","doi":"10.1080/09273948.2025.2504581","DOIUrl":"10.1080/09273948.2025.2504581","url":null,"abstract":"Purpose: To report a rare case of cancer-associated retinopathy (CAR) presenting initially as a bilateral acute vision loss in a 72-year-old female patient with a history of tongue carcinoma. Systemic work-up revealed a metastatic uterine neuroendocrine carcinoma.Methods: Case report describing clinical presentation and diagnostic work up in a patient with CAR syndrome.Results: A 72-year-old female patient was referred for bilateral acute severe vision loss immediately after axillary node dissection in the context of a tongue carcinoma. Ophthalmological examination revealed rapidly evolutive outer retinal atrophy, with acute severe vision loss to light perception in both eyes within a few days. CAR-syndrome was suspected in this patient with tongue carcinoma and a positive sentinel lymph node. However, a systemic work-up revealed a metastatic tumor of the uterine body.Despite high-dose systemic corticosteroids, plasmapheresis, and chemotherapy, she did not present any functional recovery.Conclusion: CAR-syndrome may precede the diagnosis of the associated tumor. Thorough medical history, extensive work-up is the key in order not to miss the primitive lesion causative of the CAR syndrome, even in patients with another known malignancy.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-3"},"PeriodicalIF":2.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Clinical Characteristics Among Herpetic Retinitis: Acute Retinal Necrosis and Cytomegalovirus Retinitis. 疱疹性视网膜炎的临床特点：急性视网膜坏死与巨细胞病毒性视网膜炎的比较。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-24 DOI: 10.1080/09273948.2025.2522955

Hiromasa Hirai, Daiki Kuraoka, Tetsuo Ueda, Satoru Kase

{"title":"Comparison of Clinical Characteristics Among Herpetic Retinitis: Acute Retinal Necrosis and Cytomegalovirus Retinitis.","authors":"Hiromasa Hirai, Daiki Kuraoka, Tetsuo Ueda, Satoru Kase","doi":"10.1080/09273948.2025.2522955","DOIUrl":"https://doi.org/10.1080/09273948.2025.2522955","url":null,"abstract":"Purpose: To compare the characteristics of patients with herpetic retinitis, specifically acute retinal necrosis (ARN) and cytomegalovirus retinitis (CMVR).Methods: This retrospective study included patients who visited Nara Medical University Hospital between 2014 and 2024. A total of 38 patients (53 eyes) diagnosed with ARN or CMVR based on the diagnostic criteria were enrolled.Results: The ARN group (11 patients, 14 eyes) showed more anterior inflammation and peripheral lesions than the CMVR group (27 patients, 39 eyes). Although initial best-corrected visual acuity (BCVA) was similar between groups, the CMVR group demonstrated significantly better BCVA at the final visit (p = 0.004). Among eyes with poor initial BCVA (≥0.3 logMAR), significant post-treatment improvement was observed in the CMVR group but not in the ARN group (p = 0.006, p = 0.30, respectively). Subgroup analysis of CMVR revealed that HIV-positive patients were all male and significantly younger than HIV-negative patients (p = 0.029). HIV-negative patients were further classified based on having either hematologic disease or receiving immunosuppressive therapy. The hematologic disease subgroup had more bilateral involvement (p = 0.0498) and higher cytomegalovirus antigen-positive cell count on the cytomegalovirus antigenemia test (C7HRP, p = 0.049).Conclusion: Although both ARN and CMVR are caused by herpesviruses, they exhibit distinct clinical features and disease progression. CMVR subtypes can also be differentiated based on patient background and laboratory findings. Appropriate evaluation of the patient's background and clinical presentation is essential for management of herpetic retinitis.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OCT Characterization and Monitoring of Fusarium solani Chorioretinitis Lesions. 茄枯菌性脉络膜视网膜炎病变的OCT特征与监测。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-23 DOI: 10.1080/09273948.2025.2522954

María Aramberri Araiz, Estibaliz Alcalde Del Río, Sofía Uncetabarrenechea Larrucea, Joseba Artaraz Beobide, Alex Fonollosa

{"title":"OCT Characterization and Monitoring of Fusarium solani Chorioretinitis Lesions.","authors":"María Aramberri Araiz, Estibaliz Alcalde Del Río, Sofía Uncetabarrenechea Larrucea, Joseba Artaraz Beobide, Alex Fonollosa","doi":"10.1080/09273948.2025.2522954","DOIUrl":"10.1080/09273948.2025.2522954","url":null,"abstract":"Purpose: To report a case of chorioretinitis caused by Fusarium in an immunosuppressed 34-year-old patient in the context of an acute lymphoblastic leukemia and to describe its management based on optical coherence tomography (OCT) findings of the inflammatory lesions.Methods: Case report.Results: A 34-year-old man developed a bilateral multifocal chorioretinitis caused by Fusarium solani during the induction chemotherapy for acute lymphoblastic leukemia diagnosed three months earlier. At the time of ophthalmological diagnosis, the patient already presented a disseminated fungal infection involving skin, nasal mucosa, and lungs. The patient was treated with systemic antifungal agents (intravenous voriconazole and liposomal amphotericin B) and five intravitreal injections of voriconazole (100 µg/0.1 mL). The clinical outcome was favorable, with resolution of the lesions and a final best-corrected visual acuity of 20/20 in both eyes. Chorioretinal inflammatory lesions were monitored using OCT, enabling the evaluation and characterization of different stages of lesion evolution.Conclusions: OCT may be useful for monitoring the evolution of inflammatory lesions in Fusarium chorioretinitis and may assist in therapeutic decision-making.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Subretinal Abscess Secondary to Methicillin-Sensitive Staphylococcus aureus Bacteremia. 罕见的甲氧西林敏感性金黄色葡萄球菌菌血症继发视网膜下脓肿1例。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-23 DOI: 10.1080/09273948.2025.2519845

Elaine Ju Yen Gan, Jun Fai Yap, Sylves Patrick, Caroline Binson, Sheena Mary Alexander

{"title":"A Rare Case of Subretinal Abscess Secondary to Methicillin-Sensitive Staphylococcus aureus Bacteremia.","authors":"Elaine Ju Yen Gan, Jun Fai Yap, Sylves Patrick, Caroline Binson, Sheena Mary Alexander","doi":"10.1080/09273948.2025.2519845","DOIUrl":"https://doi.org/10.1080/09273948.2025.2519845","url":null,"abstract":"Purpose: Subretinal abscess is a rare but vision-threatening manifestation of endogenous endophthalmitis, accounting for approximately 5% of cases. It typically occurs in immunocompromised individuals and may be caused by a variety of microbial pathogens. We aim to highlight the importance of early recognition of subretinal abscess in a patient with preserved vision and minimal ocular symptoms.Methods: We report a case of acute subretinal abscess secondary to Methicillin-Sensitive Staphylococcus aureus bacteremia in a 55-year-old man with previously undiagnosed diabetes mellitus. The patient presented with floaters in the left eye one day after undergoing incision and drainage of a lip abscess.Results: Visual acuity remained 6/6 in both eyes. Fundus examination of the left eye revealed a superotemporal subretinal abscess with surrounding hemorrhage and Roth spots. Blood and pus cultures confirmed methicillin-sensitive Staphylococcus aureus. The patient was treated with a single dose of intravitreal vancomycin and ceftazidime, along with systemic antibiotics including intravenous cloxacillin, cefazolin, and oral ciprofloxacin. Pars plana vitrectomy was deemed unnecessary due to the lesion's favorable location, size, and good presenting visual acuity. The lesion resolved with choroidoretinal scarring, and vision was preserved.Conclusion: Subretinal abscess is an uncommon ocular complication of systemic infections that may be overlooked due to its subtle presentation. This case highlights the need for thorough ocular evaluation in patients with bacteremia, even in the presence of minimal visual symptoms. Early diagnosis and targeted antimicrobial therapy are crucial in preventing serious ocular morbidity and preserving vision.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paradoxical Exacerbation of Birdshot Retinochoroiditis Following Rituximab. 利妥昔单抗后鸟射性视网膜脉络膜炎的矛盾加重。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2519869

Anamika Patel, Chi Yun Doreen Ho, William Tucker, Carlos Pavesio, Ilaria Testi

{"title":"Paradoxical Exacerbation of Birdshot Retinochoroiditis Following Rituximab.","authors":"Anamika Patel, Chi Yun Doreen Ho, William Tucker, Carlos Pavesio, Ilaria Testi","doi":"10.1080/09273948.2025.2519869","DOIUrl":"https://doi.org/10.1080/09273948.2025.2519869","url":null,"abstract":"Purpose: We report a case of exacerbated ocular inflammation following rituximab treatment in a patient with Birdshot Retinochoroiditis.Method: Retrospective single case report.Result: Following rituximab administration for Birdshot Retinochoroiditis, the patient developed bilateral increase in choroidal thickness with retinal pigment epithelium undulations and subretinal fluid on enhanced depth imaging optical coherence tomography (EDI-OCT). Indocyanine green angiography (ICGA) demonstrated bilateral fuzzy and obscured choroidal vessels with diffuse late hyperfluorescence. Electroretinography (ERG) showed delayed amplitudes, indicating retinal dysfunction. The patient was rescued with intravenous methylprednisolone, followed by high-dose oral steroids. Rituximab was discontinued, and abatacept was initiated.Conclusion: This case highlights a potential paradoxical exacerbation of intraocular inflammation following rituximab in Birdshot Retinochoroiditis, an observation already reported in other areas but rarely seen in ophthalmology.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic Therapy for the Management of Lipid Keratopathy Secondary to Herpetic Keratitis. 光动力疗法治疗疱疹性角膜炎继发的脂性角膜病变。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2513509

Margarita Zamorano, Carlos Solera de Andres, Natalia Pastora Salvador, Almudena Del Hierro Zarzuelo, Paola Vázquez Colomo, Ana Martin-Ucero, Ana Boto de Los Bueis

{"title":"Photodynamic Therapy for the Management of Lipid Keratopathy Secondary to Herpetic Keratitis.","authors":"Margarita Zamorano, Carlos Solera de Andres, Natalia Pastora Salvador, Almudena Del Hierro Zarzuelo, Paola Vázquez Colomo, Ana Martin-Ucero, Ana Boto de Los Bueis","doi":"10.1080/09273948.2025.2513509","DOIUrl":"https://doi.org/10.1080/09273948.2025.2513509","url":null,"abstract":"Purpose: To report the quantitative effectiveness of photodynamic therapy (PDT) with verteporfin in reducing corneal neovascularization (CNV) and lipid keratopathy (LK) in patients with herpetic interstitial keratitis.Methods: We retrospectively evaluated patients with secondary LK due to herpetic keratitis who underwent PDT with Verteporfin. We analyzed before and after PDT, visual acuity (VA) and the percentage of CNV, LK, and total pathological corneal areas. The number of stromal neo-vessels and its activity, and the severity of the corneal opacity were also analyzed.Results: We studied nine consecutive patients. The CNV area, LK extent, pathological area, vessel count, vessel activity and corneal opacity all exhibited a statistically significant decrease (p < 0.05) in all patients following PDT. A second PDT was required in 3 patients. Complete vascular occlusion was observed in 5 eyes (55.5%), and partial occlusion in 3 eyes (33.5%). The mean post-treatment VA was 0.76 ± 0.32. VA improved by more than 1 line in 5 eyes (55.5%), with more than 2 line-improvement observed in 4 eyes (44.4%). It remain unchanged in 3 eyes (33.3%), while one patient (11%) worsened. No adverse effects were detected after a mean of 14.9 ± 3.9 years follow-up. There was no relapse of herpetic keratitis after discharging 88,8% patients (follow-up after discharged 8.1 ± 4.6 years).Conclusion: PDT with verteporfin is a safe and effective treatment of herpetic CNV and LK, with long lasting efficacy. Additionally, after the treatment, our cases had a lower incidence of herpetic recurrences than expected.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Rise of Syphilitic Placoid Chorioretinitis: A Literature Review with Data from 286 Published Cases. 梅毒样斑脉络膜视网膜炎的兴起：对286例已发表病例的文献回顾。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2511129

Nicholas Jones, Eleftherios Agorogiannis

{"title":"The Rise of Syphilitic Placoid Chorioretinitis: A Literature Review with Data from 286 Published Cases.","authors":"Nicholas Jones, Eleftherios Agorogiannis","doi":"10.1080/09273948.2025.2511129","DOIUrl":"https://doi.org/10.1080/09273948.2025.2511129","url":null,"abstract":"Purpose: To investigate all published reports of acute syphilitic posterior placoid chorioretinitis (ASPPC) and to analyse demographic, clinical and management features to clarify trends in presentation, diagnosis and outcome.Methods: A comprehensive review of literature relating to ASPPC including examples within published series of ocular syphilis, case series limited to ASPPC and case reports.Results: A total of 128 publications included 286 patients with 387 eyes affected by ASPPC. This is increasing in frequency and since 2020 accounts for 26% of ocular syphilis in case series; it appears most common in countries where the predominant Treponema pallidum subclade is SS14 Omega. Visual symptoms were the first in 81%. The mean age at onset was 47.0 yrs (range 23-81), 84% were male and these were more likely to be men who had sex with men (MSM)(p = 0.001). Risk was not increased by HIV positivity. Recovery to LogMAR 0.3 or better was achieved in 85%.Conclusions: Men are particularly affected by ASPPC, especially MSM. It is associated with otosyphilis. Optic nerve involvement is less common in ASPPC, compared to other forms of ocular syphilis. Visual outcomes were very good unless treatment onset was delayed and were equally good for HIV+ and HIV- patients; IV penicillin, IM penicillin and IV ceftriaxone were equally effective. Data quality on systemic steroid usage was too poor to permit analysis. The aetiology of ASPPC remains unknown but geographical disparity supports the possibility of an association between ASPPC and particular treponemal subclade(s).","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-11"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remdesivir Treatment Outcomes of Subacute Sclerosing Panencephalitis Presenting with Macular Necrotizing Retinitis: A Case Report. 瑞德西韦治疗以黄斑坏死性视网膜炎为表现的亚急性硬化性全脑炎的疗效：1例报告。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2521370

Aseel Gebara, Mohammed Homeidat, Tarek Keadan, Tamar Fisher-Negev, Esther Oiknine-Djian, Dana G Wolf, Hadas Mechoulam, Dana Ekstein, Radgonde Amer

{"title":"Remdesivir Treatment Outcomes of Subacute Sclerosing Panencephalitis Presenting with Macular Necrotizing Retinitis: A Case Report.","authors":"Aseel Gebara, Mohammed Homeidat, Tarek Keadan, Tamar Fisher-Negev, Esther Oiknine-Djian, Dana G Wolf, Hadas Mechoulam, Dana Ekstein, Radgonde Amer","doi":"10.1080/09273948.2025.2521370","DOIUrl":"https://doi.org/10.1080/09273948.2025.2521370","url":null,"abstract":"Purpose: Subacute sclerosing panencephalitis (SSPE) is a fatally progressive neurodegenerative disorder caused by persistent measles virus infection of the CNS. We report on the visual and neurological outcomes of SSPE in a patient who presented with necrotizing retinitis three decades after measles infection.Methods: Descriptive case report.Results: A 31-year-old woman presented with sudden blurred vision of the right eye (RE). Visual acuity (VA) was finger counting in RE and 0.8 in the left eye (LE). Funduscopy revealed RE multifocal macular yellowish lesions, LE peripheral retinal atrophic scar and bilateral optic disc edema. OCT of RE showed \"moth-eaten\" macula. Elevated anti-measles IgG and positive oligoclonal bands were detected in the cerebrospinal fluid (CSF). Aqueous PCR was positive for Measles. Brain MRI showed mild hyperintense FLAIR signal in the parieto-occipital white matter. Electroencephalogram revealed mild generalized and left temporal focal slowing. Treatment with remdesivir was instituted in combination with intravenous immunoglobulins. Subsequently, intrathecal interferon-ɑ was administered. Macular necrosis progressed relentlessly. Remdesivir lowered measles IgG titer in CSF and serum and the titer re-increased once remdesivir was discontinued. The patient was well one-year later.Conclusion: While remdesivir failed to arrest measles-associated macular necrosis, it may have prevented disease progression in the contralateral eye and in the CNS. To our knowledge, this is the first case of measles-associated necrotizing retinitis that was confirmed by a positive aqueous PCR. In the absence of an established treatment, vaccination remains the most effective modality. Further investigation of remdesivir as a potential treatment of SSPE is required.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathologically Proven IgG4-Related Orbital Disease: A Two-Tertiary Center Study from Turkiye. 组织病理学证实igg4相关眼窝疾病：来自土耳其的两三级中心研究

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2518255

Burak Ulas, Altan Atakan Özcan, Melis Palamar, Banu Yaman, Arbil Acikalin

{"title":"Histopathologically Proven IgG4-Related Orbital Disease: A Two-Tertiary Center Study from Turkiye.","authors":"Burak Ulas, Altan Atakan Özcan, Melis Palamar, Banu Yaman, Arbil Acikalin","doi":"10.1080/09273948.2025.2518255","DOIUrl":"https://doi.org/10.1080/09273948.2025.2518255","url":null,"abstract":"Aim: The purpose of this study was to evaluate the clinical features and symptoms of IgG4-related orbital disease (IgG4-ROD) cases from two ophthalmology clinics.Methods: The medical records of 20 patients with histopathologically proven IgG4-ROD diagnosed at 2 tertiary referral university hospitals in Turkey were retrospectively reviewed. The demographic profiles, clinical findings, and ocular symptoms of the patients were analyzed.Results: The mean patient age was 40.9 ± 20.1 (5-67) years (65% female, 35% male). IgG4-ROD involvement was bilateral in 25% of cases. The involvement sites were lacrimal gland (84.2%), orbital soft tissues (52.6%), conjunctiva (15.8%). Multiple ophthalmic sites of involvement were detected in seven patients. Lacrimal gland involvement was the most frequent ophthalmic manifestation of IgG4-ROD. The most common complaints of the patients were swelling and redness of the eyelids. All patients responded to glucocorticoid treatment. However, one patient (5.3%) relapsed and required long-term corticosteroid and immunosupressive agent use.Conclusion: IgG4-ROD can present with overlapping features of clinical history, physical examination, and imaging findings. Therefore, in any orbital involvement - especially with eyelid swelling and redness, it is important to suspect IgG4-ROD and to perform biopsy to achieve the accurate diagnose.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-7"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tocilizumab for Silicone Oil-Induced Recalcitrant Cystoid Macular Edema in a Patient with Recurrent Acute Retinal Necrosis-Associated Retinal Detachment. 托珠单抗治疗复发性急性视网膜坏死相关视网膜脱离患者硅油诱导的顽固性囊样黄斑水肿。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-18 DOI: 10.1080/09273948.2025.2519849

Warren W Pan, Mahsaw Mansoor, David Riccardi, Jacqueline A Madison, Thomas J Wubben, Shilpa Kodati, Jason Miller

{"title":"Tocilizumab for Silicone Oil-Induced Recalcitrant Cystoid Macular Edema in a Patient with Recurrent Acute Retinal Necrosis-Associated Retinal Detachment.","authors":"Warren W Pan, Mahsaw Mansoor, David Riccardi, Jacqueline A Madison, Thomas J Wubben, Shilpa Kodati, Jason Miller","doi":"10.1080/09273948.2025.2519849","DOIUrl":"10.1080/09273948.2025.2519849","url":null,"abstract":"Purpose: We report a case of refractory silicone oil-induced cystoid macular edema in a patient with recurrent acute retinal necrosis-related retinal detachments successfully treated with tocilizumab without silicone oil removal nor reactivation of the acute retinal necrosis.Methods: Single-patient case report.Results: A monocular patient with recurrent acute retinal necrosis-related retinal detachments necessitating indefinite silicone oil tamponade developed intractable cystoid macular edema immediately after silicone oil placement that was unresponsive to multiple therapies over nearly a year. After a single dose of tocilizumab, the patient demonstrated significant clinical improvement with resolution of the macular edema and reduction in petaloid macular leakage on fluorescein angiography. With continued tocilizumab treatment, silicone oil tamponade could be maintained, and no reactivation of acute-retinal necrosis was noted.Conclusion: This case represents the first documented successful use of tocilizumab in treating silicone oil-induced recalcitrant cystoid macular edema. When silicone oil cannot be removed from an eye and when steroids risk reactivating viral retinal disease, tocilizumab may offer a safe and effective treatment alternative for such macular edema.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0