Ocular Immunology and Inflammation最新文献_第6页

Bilateral Alternate Orbital and Ocular Manifestations in a VEXAS Syndrome Patient. 一名VEXAS综合征患者的双侧眼眶和眼部交替表现。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-05-19 DOI: 10.1080/09273948.2025.2507713

A Chierigo, M Akyol, B Sharma, J Michaels, F Afshar, V Joganathan, D Lorenzano

{"title":"Bilateral Alternate Orbital and Ocular Manifestations in a VEXAS Syndrome Patient.","authors":"A Chierigo, M Akyol, B Sharma, J Michaels, F Afshar, V Joganathan, D Lorenzano","doi":"10.1080/09273948.2025.2507713","DOIUrl":"10.1080/09273948.2025.2507713","url":null,"abstract":"Purpose: VEXAS syndrome, caused by somatic UBA1 gene mutations, is a recently described autoinflammatory disorder characterized by systemic inflammation and hematologic abnormalities. Ocular involvement occurs in 28-40% of cases. This report describes a unique case of VEXAS syndrome with recurrent bilateral orbital and ocular inflammation, including the first documented concurrent ocular and orbital disease in the same patient, as well as of vitritis.Methods: A 79-year-old male presented with recurrent bilateral orbital and ocular inflammation, featuring periorbital oedema, dacryoadenitis, fibrinous anterior uveitis, vitritis, and macular oedema. He also developed fatigue, malaise, weight loss, dry cough, shortness of breath, joint and muscle pain, and chest pain and was followed for over one year.Results: Diagnostic work-up included multimodal ophthalmic imaging, CT orbits and serologic testing. The diagnosis was confirmed by genetic testing for UBA1 mutation and bone marrow biopsy. Treatment with oral corticosteroids led to complete resolution of symptoms, both ophthalmologically and systemically, and tocilizumab was later added as a second line immunosuppression steroid-sparing agent.Conclusions: This case emphasises the importance of considering VEXAS syndrome in the diagnosis of patients with recurrent orbital and ocular inflammation. It also reiterates the effectiveness of corticosteroids and tocilizumab association in managing this complex condition, contributing to the growing understanding of VEXAS syndrome and its ophthalmological features.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1816-1820"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Intravitreal Onchocerciasis Associated with Panuveitis: A Case Report. 双侧玻璃体内盘尾丝虫病合并全葡萄膜炎1例。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-05-19 DOI: 10.1080/09273948.2025.2508409

Huseyin Baran Ozdemir, Benay Karabulut, Funda Dogruman Al, Ihsan Gokhan Gürelik

引用次数: 0

Association of Optical Coherence Tomography Angiography Biomarkers with Fluorescein Angiography Retinal Inflammation Scores in Behcet's Retinal Vasculitis. 光学相干断层扫描血管造影生物标志物与荧光素血管造影视网膜炎症评分在Behcet视网膜血管炎中的关联。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-04-23 DOI: 10.1080/09273948.2025.2491568

Mohammad Javad Ghanbarnia, Ghazal Ghochani, Elias Khalili Pour, Afsaneh Moghadam, Mohammad Zarei, Ramak Roohipourmoallai, Parichehr Ghahari, Nazanin Ebrahimiadib

{"title":"Association of Optical Coherence Tomography Angiography Biomarkers with Fluorescein Angiography Retinal Inflammation Scores in Behcet's Retinal Vasculitis.","authors":"Mohammad Javad Ghanbarnia, Ghazal Ghochani, Elias Khalili Pour, Afsaneh Moghadam, Mohammad Zarei, Ramak Roohipourmoallai, Parichehr Ghahari, Nazanin Ebrahimiadib","doi":"10.1080/09273948.2025.2491568","DOIUrl":"10.1080/09273948.2025.2491568","url":null,"abstract":"Purpose: To investigate the association of macular vessel density (VD) and foveal avascular zone (FAZ) parameters with the severity of retinal inflammation in patients with Behcet's retinal vasculitis.Methods: In this prospective study, consecutive patients with Behcet's uveitis who had fluorescein angiography (FA)-proven retinal vasculitis underwent concurrent OCTA and FA imaging. Severity of retinal inflammation was quantitatively evaluated using our previously devised FA scoring system. Fovea-centered 6 × 6 mm spectral-domain OCTA scans were acquired, and VD of superficial vascular complex (SVC), deep vascular complex (DVC) and retina were measured for different measurement zones based on the ETDRS grid. FAZ area and perimeter were also measured.Results: In total 54 eyes with mean age of 34.94 (±11.85) years were included. Mean best corrected visual acuity (BCVA) was 0.18 (±0.23) LogMAR. Mean FA score was 9.54 (±9.56). FAZ area and perimeter were not significantly associated with FA scores (p > 0.05). There was a significant negative association between superficial, deep and retina VD in all measurement zones except the fovea, with FA scores. This negative association was stronger in the DVC. Accordingly, greater deep VD in parafovea (B = -0.93; 95% CI -1.34 to -0.53), perifovea (B = -0.70; 95% CI -1.06 to -0.34) and whole ETDRS grid (B = -0.80; 95% CI -1.18 to -0.41) were associated with lower FA retinal inflammation scores.Conclusion: Greater macular vessel density is associated with lower retinal inflammation in patients with Behcet's retinal vasculitis in non-ischemic stages. The deep vascular complex is more severely affected in these patients. OCTA biomarkers have shown promising results for detecting microvascular changes in retinal inflammation.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1534-1541"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison Between Behçet's Uveitis Patients with Immunologically Positive and Immunologically Negative Tuberculosis Test. behaperet葡萄膜炎患者结核试验免疫阳性与免疫阴性的比较。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-13 DOI: 10.1080/09273948.2025.2509717

Alaa Abdulrahman Almogahed, Maha M Youssef, Magda Salaheldin Abdelaziz, Esraa El-Mayah

{"title":"Comparison Between Behçet's Uveitis Patients with Immunologically Positive and Immunologically Negative Tuberculosis Test.","authors":"Alaa Abdulrahman Almogahed, Maha M Youssef, Magda Salaheldin Abdelaziz, Esraa El-Mayah","doi":"10.1080/09273948.2025.2509717","DOIUrl":"10.1080/09273948.2025.2509717","url":null,"abstract":"Purpose: To evaluate the clinical features of patients with Behçet's Uveitis in the presence or absence of latent tuberculosis infection (LTBI).Methods: A retrospective comparative study was carried out, examining patients with Behçet's disease who visited the Uveitis subspecialty clinic at Kasr Al-Ainy Hospital, Cairo University Hospitals. A total of 20 consecutive patients with positive tuberculosis immunology (group 1) and 20 consecutive patients with negative tuberculosis immunology (group 2) were included.Results: Patients in group 2 showed a higher incidence of macular edema (p value = 0.013) and were more likely to receive systemic corticosteroids compared to group 1 (p value = 0.011). Conversely, vascular occlusion was more prevalent among group 1 patients (p value = 0.044). There was a significant increase in the use of systemic corticosteroids, immunosuppressive drugs, biologics, and anti-TB medications from the initial visit to the last visit (p value < 0.001). Genital ulcers, oral ulcers, GIT ulcers, and nodular erythema decreased significantly by the last visit compared to the initial presentation (p value < 0.05). Significant differences in laboratory findings such as anemia, high ESR, high C-reactive protein, and high HBA1c were observed between the two groups (p value < 0.001).Conclusion: Patients with immunologically negative TB tests were more likely to develop macular edema, whereas those with immunologically positive TB tests had a higher risk of vascular occlusion. Additionally, patients who have immunologically positive TB tests often present with elevated inflammatory markers like high ESR and C-reactive protein.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1523-1533"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Subretinal Abscess Secondary to Methicillin-Sensitive Staphylococcus aureus Bacteremia. 罕见的甲氧西林敏感性金黄色葡萄球菌菌血症继发视网膜下脓肿1例。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-23 DOI: 10.1080/09273948.2025.2519845

Elaine Ju Yen Gan, Jun Fai Yap, Sylves Patrick, Caroline Binson, Sheena Mary Alexander

{"title":"A Rare Case of Subretinal Abscess Secondary to Methicillin-Sensitive Staphylococcus aureus Bacteremia.","authors":"Elaine Ju Yen Gan, Jun Fai Yap, Sylves Patrick, Caroline Binson, Sheena Mary Alexander","doi":"10.1080/09273948.2025.2519845","DOIUrl":"10.1080/09273948.2025.2519845","url":null,"abstract":"Purpose: Subretinal abscess is a rare but vision-threatening manifestation of endogenous endophthalmitis, accounting for approximately 5% of cases. It typically occurs in immunocompromised individuals and may be caused by a variety of microbial pathogens. We aim to highlight the importance of early recognition of subretinal abscess in a patient with preserved vision and minimal ocular symptoms.Methods: We report a case of acute subretinal abscess secondary to Methicillin-Sensitive Staphylococcus aureus bacteremia in a 55-year-old man with previously undiagnosed diabetes mellitus. The patient presented with floaters in the left eye one day after undergoing incision and drainage of a lip abscess.Results: Visual acuity remained 6/6 in both eyes. Fundus examination of the left eye revealed a superotemporal subretinal abscess with surrounding hemorrhage and Roth spots. Blood and pus cultures confirmed methicillin-sensitive Staphylococcus aureus. The patient was treated with a single dose of intravitreal vancomycin and ceftazidime, along with systemic antibiotics including intravenous cloxacillin, cefazolin, and oral ciprofloxacin. Pars plana vitrectomy was deemed unnecessary due to the lesion's favorable location, size, and good presenting visual acuity. The lesion resolved with choroidoretinal scarring, and vision was preserved.Conclusion: Subretinal abscess is an uncommon ocular complication of systemic infections that may be overlooked due to its subtle presentation. This case highlights the need for thorough ocular evaluation in patients with bacteremia, even in the presence of minimal visual symptoms. Early diagnosis and targeted antimicrobial therapy are crucial in preventing serious ocular morbidity and preserving vision.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1865-1868"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Orbital Inflammation as the Initial Manifestation of Eosinophilic Granulomatosis with Polyangiitis Following Dupilumab Administration, Successfully Treated with Mepolizumab. 杜匹单抗治疗后眼眶炎症为嗜酸性肉芽肿病合并多血管炎的初始表现一例，Mepolizumab成功治疗。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-07-08 DOI: 10.1080/09273948.2025.2529342

Haruka Aya, Kaoru Araki-Sasaki, Yoshiki Kobayashi, Ken Fukuda, Hisanori Imai

{"title":"A Case of Orbital Inflammation as the Initial Manifestation of Eosinophilic Granulomatosis with Polyangiitis Following Dupilumab Administration, Successfully Treated with Mepolizumab.","authors":"Haruka Aya, Kaoru Araki-Sasaki, Yoshiki Kobayashi, Ken Fukuda, Hisanori Imai","doi":"10.1080/09273948.2025.2529342","DOIUrl":"10.1080/09273948.2025.2529342","url":null,"abstract":"Purpose: We report a case of eosinophilic granulomatosis with polyangiitis (EGPA), manifesting as orbital cellulitis and scleritis following anti-interleukin (IL)-4 receptor α antibody dupilumab treatment, which was successfully treated with anti-IL-5 antibody mepolizumab.Methods: Slit-lamp examination, diagnostic imaging, and biopsy were performed.Results: A 53-year-old male patient presented with sudden swelling of the left eyelid, severe conjunctival edema, and hyperemia. He had received dupilumab for 6 months for refractory nasal polyps. On initial examination, slit-lamp examination and computed tomography of the orbit revealed the orbital cellulitis and scleritis in his left eye. Although orbital swelling resolved by the administration of systemic steroids, scleritis persisted. Six months after initial presentation, the patient developed abdominal pain, vomiting, diarrhea, and skin rashes. Biopsy of upper gastrointestinal tract and skin revealed eosinophilic infiltration surrounding the blood vessel with an increase in peripheral blood eosinophil count. The patient was diagnosed with EGPA and subsequently started on subcutaneous anti-IL-5 antibody mepolizumab with systemic steroid. Following initiation of mepolizumab, his eosinophil counts normalized, gastroenteritis symptoms resolved, and refractory scleritis disappeared within a month. Topical and systemic steroids were discontinued after mepolizumab administration without recurrence.Conclusions: This case highlights that physicians should be aware of the potential ocular side effects associated with biologics administration, such as those associated with EGPA.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1894-1896"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous Endophthalmitis and Subretinal Abscess Following Rituximab Therapy in Myasthenia Gravis: A Report of Two Cases. 利妥昔单抗治疗重症肌无力后并发内源性眼内炎和视网膜下脓肿2例报告。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-28 DOI: 10.1080/09273948.2025.2524010

Sherina Thomas, Vaishnavi Prasad Rao, Suneetha Nithyanandanam, Vybhavi Rao, Dimple Shaji, Savitha Nagaraj, Merin Ann Raju

{"title":"Endogenous Endophthalmitis and Subretinal Abscess Following Rituximab Therapy in Myasthenia Gravis: A Report of Two Cases.","authors":"Sherina Thomas, Vaishnavi Prasad Rao, Suneetha Nithyanandanam, Vybhavi Rao, Dimple Shaji, Savitha Nagaraj, Merin Ann Raju","doi":"10.1080/09273948.2025.2524010","DOIUrl":"10.1080/09273948.2025.2524010","url":null,"abstract":"Purpose: Endogenous endophthalmitis is a serious vision-threatening condition commonly associated with immunosuppression and is invariably linked to a systemic focus. Rituximab infusion is one of the treatment options for refractory Myasthenia Gravis but can become a double-edged sword, increasing susceptibility to serious infections. This study reports the occurrence and management of Endogenous endophthalmitis in two patients after rituximab infusion given for refractory Myasthenia Gravis. Endogenous endophthalmitis post Rituximab has not been reported.Method: A retrospective review of patients' records was done.Results: Case 1 is a 55-year-old male, on treatment with Rituximab for refractory Myasthenia Gravis, presented with painful loss of vision in left eye for 5 days. The patient had right upper limb cellulitis, cavitary bronchopneumonia with septicaemia, 10 days prior. Left eye showed 4+ cells in the anterior chamber with fibrinous exudates and dense vitritis, confirmed on B-scan ultrasonography. Blood culture isolated Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA) sensitive to meropenem and vancomycin. The patient was administered systemic and intravitreal antibiotics along with vitrectomy. Case 2 is a 45-year-old male with a similar history and presentation to case 1, involving the right eye. Blood culture isolated Nocardia farcinia with sensitivity to amikacin and meropenem. This patient also received systemic and intravitreal antibiotics with vitrectomy. Complete resolution of the infection was noted with improvement in vision in both patients.Conclusion: With the increasing use of Rituximab, EE incidence is likely to increase. Hence, an awareness of this uncommon complication will help in early recognition and treatment, leading to good outcomes.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1882-1885"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behçet Disease Uveitis: Insights into Epigenetic and Environmental Factors, Retinal Imaging, and Treatment. 视网膜病变葡萄膜炎：对表观遗传和环境因素、视网膜成像和治疗的见解。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-10-07 DOI: 10.1080/09273948.2025.2544496

Ilknur Tugal-Tutkun, Derrick P Smit, Jennifer E Thorne

引用次数: 0

Atypical Unilateral Multifocal Choroiditis and Retinal Vasculitis Following Presumed West Nile Virus Infection. 疑似西尼罗病毒感染后的非典型单侧多灶性脉络膜炎和视网膜血管炎。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-04-23 DOI: 10.1080/09273948.2025.2495829

Noah L Carey, Breanna M Tracey, Tejaswini Matsyaraja, Matthew Trese, Sandeep Randhawa, Boonkit Purt, Shilpa Kodati

引用次数: 0

Treatment Impact on the Long-Term Ocular Outcomes in Behçet's-Related Uveitis. 治疗对贝赫切特相关性葡萄膜炎长期眼部疗效的影响

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2024-06-20 DOI: 10.1080/09273948.2024.2366906

Hilmi Altıntaş, Esra Kardeş

{"title":"Treatment Impact on the Long-Term Ocular Outcomes in Behçet's-Related Uveitis.","authors":"Hilmi Altıntaş, Esra Kardeş","doi":"10.1080/09273948.2024.2366906","DOIUrl":"10.1080/09273948.2024.2366906","url":null,"abstract":"Purpose: To examine the demographic characteristics, findings and complication rates in patients with Behçet's uveitis (BU) and to investigate the effect of early biological therapy on the development of complications.Methods: Medical records of 94 patients with BU were retrospectively reviewed. Demographic data, ocular findings and complications at presentation, complications during follow-up, and treatments received during follow-up were analyzed. Patients who were followed for at least 24 months were divided into two groups according to the time of presentation as Group 1 (between 2009 and 2015) and Group 2 (between 2016 and 2021). Complications at the time of presentation and during follow-up, and treatments were compared.Results: We enrolled 94 patients with a male-to-female ratio of 1.94 with a mean age of 30 ± 12 years. Median follow-up was 58.1(12-163) months. There were 35 patients (66 eyes) in Group 1 and 33 patients (61 eyes) in Group 2. At the time of presentation, end-stage disease, cataract, epiretinal membrane, and optic atrophy were significantly more common in Group 1 than in Group 2 (p < 0.05). A significantly higher proportion of eyes in Group 1 developed macular edema, cataract, epiretinal membrane, and macular atrophy during-follow-up (p < 0.05). Median time to initiation of biological treatment was 17.29 months in Group 1 and 3.33 months in Group 2 (p < 0.001). The overall complication rate was significantly lower in Group 2.Conclusions: Prognosis of BU is improved after the introduction of biological treatment. Early use of biological agents in BU is effective in decreasing sight-threatening ocular complications.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1542-1547"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0