Anamika Patel, Chi Yun Doreen Ho, William Tucker, Carlos Pavesio, Ilaria Testi
{"title":"利妥昔单抗后鸟射性视网膜脉络膜炎的矛盾加重。","authors":"Anamika Patel, Chi Yun Doreen Ho, William Tucker, Carlos Pavesio, Ilaria Testi","doi":"10.1080/09273948.2025.2519869","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>We report a case of exacerbated ocular inflammation following rituximab treatment in a patient with Birdshot Retinochoroiditis.</p><p><strong>Method: </strong>Retrospective single case report.</p><p><strong>Result: </strong>Following rituximab administration for Birdshot Retinochoroiditis, the patient developed bilateral increase in choroidal thickness with retinal pigment epithelium undulations and subretinal fluid on enhanced depth imaging optical coherence tomography (EDI-OCT). Indocyanine green angiography (ICGA) demonstrated bilateral fuzzy and obscured choroidal vessels with diffuse late hyperfluorescence. Electroretinography (ERG) showed delayed amplitudes, indicating retinal dysfunction. The patient was rescued with intravenous methylprednisolone, followed by high-dose oral steroids. Rituximab was discontinued, and abatacept was initiated.</p><p><strong>Conclusion: </strong>This case highlights a potential paradoxical exacerbation of intraocular inflammation following rituximab in Birdshot Retinochoroiditis, an observation already reported in other areas but rarely seen in ophthalmology.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Paradoxical Exacerbation of Birdshot Retinochoroiditis Following Rituximab.\",\"authors\":\"Anamika Patel, Chi Yun Doreen Ho, William Tucker, Carlos Pavesio, Ilaria Testi\",\"doi\":\"10.1080/09273948.2025.2519869\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>We report a case of exacerbated ocular inflammation following rituximab treatment in a patient with Birdshot Retinochoroiditis.</p><p><strong>Method: </strong>Retrospective single case report.</p><p><strong>Result: </strong>Following rituximab administration for Birdshot Retinochoroiditis, the patient developed bilateral increase in choroidal thickness with retinal pigment epithelium undulations and subretinal fluid on enhanced depth imaging optical coherence tomography (EDI-OCT). Indocyanine green angiography (ICGA) demonstrated bilateral fuzzy and obscured choroidal vessels with diffuse late hyperfluorescence. Electroretinography (ERG) showed delayed amplitudes, indicating retinal dysfunction. The patient was rescued with intravenous methylprednisolone, followed by high-dose oral steroids. Rituximab was discontinued, and abatacept was initiated.</p><p><strong>Conclusion: </strong>This case highlights a potential paradoxical exacerbation of intraocular inflammation following rituximab in Birdshot Retinochoroiditis, an observation already reported in other areas but rarely seen in ophthalmology.</p>\",\"PeriodicalId\":19406,\"journal\":{\"name\":\"Ocular Immunology and Inflammation\",\"volume\":\" \",\"pages\":\"1-5\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ocular Immunology and Inflammation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/09273948.2025.2519869\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ocular Immunology and Inflammation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09273948.2025.2519869","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Paradoxical Exacerbation of Birdshot Retinochoroiditis Following Rituximab.
Purpose: We report a case of exacerbated ocular inflammation following rituximab treatment in a patient with Birdshot Retinochoroiditis.
Method: Retrospective single case report.
Result: Following rituximab administration for Birdshot Retinochoroiditis, the patient developed bilateral increase in choroidal thickness with retinal pigment epithelium undulations and subretinal fluid on enhanced depth imaging optical coherence tomography (EDI-OCT). Indocyanine green angiography (ICGA) demonstrated bilateral fuzzy and obscured choroidal vessels with diffuse late hyperfluorescence. Electroretinography (ERG) showed delayed amplitudes, indicating retinal dysfunction. The patient was rescued with intravenous methylprednisolone, followed by high-dose oral steroids. Rituximab was discontinued, and abatacept was initiated.
Conclusion: This case highlights a potential paradoxical exacerbation of intraocular inflammation following rituximab in Birdshot Retinochoroiditis, an observation already reported in other areas but rarely seen in ophthalmology.
期刊介绍：
Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.
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