OCT Characterization and Monitoring of Fusarium solani Chorioretinitis Lesions.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-06-23 DOI:10.1080/09273948.2025.2522954

María Aramberri Araiz, Estibaliz Alcalde Del Río, Sofía Uncetabarrenechea Larrucea, Joseba Artaraz Beobide, Alex Fonollosa

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引用次数: 0

Abstract

Purpose: To report a case of chorioretinitis caused by Fusarium in an immunosuppressed 34-year-old patient in the context of an acute lymphoblastic leukemia and to describe its management based on optical coherence tomography (OCT) findings of the inflammatory lesions.

Methods: Case report.

Results: A 34-year-old man developed a bilateral multifocal chorioretinitis caused by Fusarium solani during the induction chemotherapy for acute lymphoblastic leukemia diagnosed three months earlier. At the time of ophthalmological diagnosis, the patient already presented a disseminated fungal infection involving skin, nasal mucosa, and lungs. The patient was treated with systemic antifungal agents (intravenous voriconazole and liposomal amphotericin B) and five intravitreal injections of voriconazole (100 µg/0.1 mL). The clinical outcome was favorable, with resolution of the lesions and a final best-corrected visual acuity of 20/20 in both eyes. Chorioretinal inflammatory lesions were monitored using OCT, enabling the evaluation and characterization of different stages of lesion evolution.

Conclusions: OCT may be useful for monitoring the evolution of inflammatory lesions in Fusarium chorioretinitis and may assist in therapeutic decision-making.

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茄枯菌性脉络膜视网膜炎病变的OCT特征与监测。

目的：报告一例免疫抑制的34岁急性淋巴细胞白血病患者镰镰菌引起的绒毛膜视网膜炎，并描述其基于光学相干断层扫描（OCT）炎性病变的处理。方法：病例报告。结果：一名34岁的男性患者在3个月前诊断为急性淋巴细胞白血病的诱导化疗期间发生了由梭兰镰刀菌引起的双侧多灶性脉络膜视网膜炎。眼科诊断时，患者已出现弥散性真菌感染，累及皮肤、鼻黏膜和肺部。患者给予全身抗真菌药物（静脉注射伏立康唑和两性霉素B脂质体）和5次玻璃体内注射伏立康唑（100µg/0.1 mL）。临床结果良好，病变消退，最终双眼最佳矫正视力为20/20。使用OCT监测绒毛膜视网膜炎性病变，从而评估和表征病变发展的不同阶段。结论：OCT可能有助于监测镰孢菌性脉络膜视网膜炎炎症病变的演变，并可能有助于治疗决策。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.