Ocular Immunology and Inflammation最新文献_第5页

Retinal Vascular Parameters Changes (by Optical Coherence Tomography Angiography) in Early Rheumatoid Arthritis: A Hospital-Based Study. 早期类风湿关节炎视网膜血管参数改变（光学相干断层扫描血管造影）：一项基于医院的研究。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-02-06 DOI: 10.1080/09273948.2025.2460642

Amany M Ebaid, Enas M Mekkawy, Hala K Mattout

{"title":"Retinal Vascular Parameters Changes (by Optical Coherence Tomography Angiography) in Early Rheumatoid Arthritis: A Hospital-Based Study.","authors":"Amany M Ebaid, Enas M Mekkawy, Hala K Mattout","doi":"10.1080/09273948.2025.2460642","DOIUrl":"10.1080/09273948.2025.2460642","url":null,"abstract":"Purpose: To evaluate the retinal vascular changes related to early Rheumatoid Arthritis (RA) and to correlate these changes with disease activity.Methods: 108 eyes of 54 early RA patients and 66 eyes of 33 age and sex-matched healthy participants underwent Optical Coherence Tomography Angiography (OCTA) examination to evaluate superficial (SCP), deep retinal capillary plexus (DCP), and radial peripapillary capillaries (RPC), we collected Values of the vessel density (VD) of SCP and DCP, central foveal thickness (CFT), foveal avascular zone (FAZ) along with a full rheumatological examination and disease activity score by (DAS28).Results: RPC values were significantly lower among RA patients in all subfields apart from the temporal one. There was a significant difference between RA patients and healthy controls in foveal and all perifoveal measurements, except the nasal perifoveal region. Also, the FAZ value was significantly higher in RA patients. We performed Spearman's correlation between OCTA and RA disease parameters and detected a negative correlation between the duration of disease-related symptoms and RPC and parafoveal measurements and between DAS-28 and foveal measurements. A significant positive correlation between anti-CCP titer and FAZ measurements was detected among RA patients.Conclusion: OCTA can detect early retinal microcirculation affection in RA patients in the form of a reduction in the vascular density in most of the subfields of the peripapillary area as well as the fovea, perifoveal, and parafoveal areas. The results of the current study can provide new insight into the applications of OCTA as a diagnostic tool in RA patients' assessment and follow-up.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"812-818"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-04-17 DOI: 10.1080/09273948.2025.2491980

引用次数: 0

Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway. 去甲肾上腺素通过调节PINK1/Parkin线粒体自噬途径减轻苯扎氯铵诱导的干眼病。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2024-12-27 DOI: 10.1080/09273948.2024.2447816

Han Zhao, Wushuang Wang, Yun Yang, Changming Feng, Tong Lin, Lan Gong

{"title":"Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway.","authors":"Han Zhao, Wushuang Wang, Yun Yang, Changming Feng, Tong Lin, Lan Gong","doi":"10.1080/09273948.2024.2447816","DOIUrl":"10.1080/09273948.2024.2447816","url":null,"abstract":"Background: Increased reactive oxygen species (ROS) are involved in the pathological process of dry eye disease. Our previous results suggested that norepinephrine (NE) has a protective effect on dry eye.Purpose: This study explored the potential therapeutic role and underlying mechanisms of NE in benzalkonium chloride (BAC)-induced dry eye disease.Methods: BAC-pretreated human corneal epithelial cells (HCEpiC) were cultured with various concentrations of NE. A BAC-induced dry eye mice model was established to explore the role of NE. Alterations in mice corneal tissues, ROS levels, mitochondrial function, and mitophagy levels were analyzed.Results: In vitro, our results revealed that BAC-exposed HCEpiC led to mitochondrial malfunction, which involved excessive ROS production, decreased mitochondrial membrane potential (MMP), and promoted mitochondrial fragmentation through increased DRP1 and fission protein 1 (Fis1) expression and reduced mitofusin 2 (Mfn2) expression. Moreover, topical BAC application induced excessive mitophagy. These effects were reversed by NE. Additionally, the increased expression of LC3B, SQSTM1/p62, PINK1, and Parkin, which control mitophagy, in BAC-exposed HCEpiC was suppressed by NE. In BAC-induced C57BL/6J mice, NE resulted in lower fluorescein staining scores, decreased TUNEL-positive cells, and decreased mitochondrial fragmentation.Conclusions: In conclusion, our findings showed that NE therapy prevented HCEpiC following BAC application by regulating mitochondrial quality control, which is controlled by PINK1/Parkin-dependent mitophagy. Our research suggests a potential targeted treatment for dry eye disease.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"766-780"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal Relationship Between Autoimmune Rheumatic Diseases and Iridocyclitis: A Bidirectional Two-Sample Mendelian Randomization Study. 自身免疫性风湿病与虹膜睫状体炎的因果关系：一项双向双样本孟德尔随机研究

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-01-23 DOI: 10.1080/09273948.2025.2455965

Minghui Wang, Gongfei Li

{"title":"Causal Relationship Between Autoimmune Rheumatic Diseases and Iridocyclitis: A Bidirectional Two-Sample Mendelian Randomization Study.","authors":"Minghui Wang, Gongfei Li","doi":"10.1080/09273948.2025.2455965","DOIUrl":"10.1080/09273948.2025.2455965","url":null,"abstract":"Purpose: This study aims to explore the relationship between autoimmune rheumatic diseases (ARDs) and the risk of iridocyclitis (IC) using Mendelian randomization (MR) analysis.Methods: Data of ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), juvenile idiopathic arthritis (JIA), Behcet's disease (BD), and iridocyclitis were obtained from genome-wide association studies with large sample sizes. The instrumental variable utilized in this study for each exposure was the single nucleotide polymorphism. The inverse-variance weighted (IVW) method, which included random effects, was used to analyze causal effects. In addition, sensitivity analyses were conducted using the weighted median and MR-Egger methods. The presence of pleiotropic effects was identified and addressed through MR pleiotropic effects residual and outlier tests, as well as MR-Egger modeling.Results: We found a causal effect of AS (IVW, OR = 2.74 × 1029, 95% CI 6.39 × 107 - 1.18 × 1051, p = 0.008) on IC. Conversely, we also found a causal effect of IC on AS (IVW OR = 1.01, 95% CI 1.00 - 1.01, p < 0.001). Besides, sensitivity analysis showed no evidence of pleiotropy and heterogeneity. However, no causal relationship between SLE, JIA, BD, and IC was detected.Conclusion: Bilateral causal relationships of IC and AS were identified, which could offer evidence for clinical use and lay the groundwork for detecting potential mechanism behind them.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"800-805"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HLA-G Polymorphisms of The 3'-UTR Region Are Involved in Susceptibility to Non-Infectious Uveitis. 3'-UTR区HLA-G多态性与非感染性葡萄膜炎易感性有关

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-07-01 Epub Date: 2025-01-21 DOI: 10.1080/09273948.2025.2455969

Marta Molina-Alejandre, Ignacio Juárez, Christian Vaquero-Yuste, Marina Gorroño-Echebarría, Elisa María Molanes-López, Eduardo Fernandez-Cruz, Carmen Rodriguez-Sainz, Antonio Arnaiz-Villena, José Manuel Martin-Villa

{"title":"HLA-G Polymorphisms of The 3'-UTR Region Are Involved in Susceptibility to Non-Infectious Uveitis.","authors":"Marta Molina-Alejandre, Ignacio Juárez, Christian Vaquero-Yuste, Marina Gorroño-Echebarría, Elisa María Molanes-López, Eduardo Fernandez-Cruz, Carmen Rodriguez-Sainz, Antonio Arnaiz-Villena, José Manuel Martin-Villa","doi":"10.1080/09273948.2025.2455969","DOIUrl":"10.1080/09273948.2025.2455969","url":null,"abstract":"Purpose: HLA-G is a non-classical HLA class I gene encoding a molecule endowed with immunomodulatory properties, playing important immunosuppressive and tolerogenic roles in immuno-privileged organs. Fluctuations in its expression levels have been correlated with the predisposition to autoinflammatory disorders, notably uveitis, characterized by inflammation of the uvea. In the present work, DNA was obtained from saliva samples of 147 Spanish patients with uveitis, with subsequent analysis focusing on the distribution of polymorphisms within the 3'UTR region of the HLA-G gene (a region known to modulate the expression of the HLA-G molecule).Methods: Analysis techniques employed included PCR-RFLP or DNA sequencing. Comparative analysis was conducted against a control cohort comprising 117 healthy individuals.Results: The frequency of the UTR-2 haplotype is increased in patients affected with anterior uveitis (OR (95% CI) 2.35 (1.06-5.21); p = 0.036). Additionally, a higher number of patients with posterior uveitis bearing in homozygosis the G allele of the 3142 C/G SNP (OR (95% CI) 2.67 (1.15-6.20); p = 0.023), was observed. Both markers are associated with diminished HLA-G expression.Conclusion: These findings present the first evidence of the involvement of polymorphisms within the 3'UTR region of the HLA-G gene in susceptibility to uveitis.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"806-811"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous Endophthalmitis and Subretinal Abscess Following Rituximab Therapy in Myasthenia Gravis: A Report of Two Cases. 利妥昔单抗治疗重症肌无力后并发内源性眼内炎和视网膜下脓肿2例报告。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-28 DOI: 10.1080/09273948.2025.2524010

Sherina Thomas, Vaishnavi Prasad Rao, Suneetha Nithyanandanam, Vybhavi Rao, Dimple Shaji, Savitha Nagaraj, Merin Ann Raju

{"title":"Endogenous Endophthalmitis and Subretinal Abscess Following Rituximab Therapy in Myasthenia Gravis: A Report of Two Cases.","authors":"Sherina Thomas, Vaishnavi Prasad Rao, Suneetha Nithyanandanam, Vybhavi Rao, Dimple Shaji, Savitha Nagaraj, Merin Ann Raju","doi":"10.1080/09273948.2025.2524010","DOIUrl":"10.1080/09273948.2025.2524010","url":null,"abstract":"Purpose: Endogenous endophthalmitis is a serious vision-threatening condition commonly associated with immunosuppression and is invariably linked to a systemic focus. Rituximab infusion is one of the treatment options for refractory Myasthenia Gravis but can become a double-edged sword, increasing susceptibility to serious infections. This study reports the occurrence and management of Endogenous endophthalmitis in two patients after rituximab infusion given for refractory Myasthenia Gravis. Endogenous endophthalmitis post Rituximab has not been reported.Method: A retrospective review of patients' records was done.Results: Case 1 is a 55-year-old male, on treatment with Rituximab for refractory Myasthenia Gravis, presented with painful loss of vision in left eye for 5 days. The patient had right upper limb cellulitis, cavitary bronchopneumonia with septicaemia, 10 days prior. Left eye showed 4+ cells in the anterior chamber with fibrinous exudates and dense vitritis, confirmed on B-scan ultrasonography. Blood culture isolated Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA) sensitive to meropenem and vancomycin. The patient was administered systemic and intravitreal antibiotics along with vitrectomy. Case 2 is a 45-year-old male with a similar history and presentation to case 1, involving the right eye. Blood culture isolated Nocardia farcinia with sensitivity to amikacin and meropenem. This patient also received systemic and intravitreal antibiotics with vitrectomy. Complete resolution of the infection was noted with improvement in vision in both patients.Conclusion: With the increasing use of Rituximab, EE incidence is likely to increase. Hence, an awareness of this uncommon complication will help in early recognition and treatment, leading to good outcomes.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nationwide Trends in the Incidence and Use of Immunosuppressive Therapy for Non-Infectious Non-Anterior Uveitis in South Korea (2010-2021). 韩国非感染性非前路葡萄膜炎免疫抑制治疗的发病率和使用趋势（2010-2021）

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-27 DOI: 10.1080/09273948.2025.2524587

Sunjin Hwang, Jiyeong Kim, Min Ho Kang, Eun Hee Hong, Yong Un Shin

{"title":"Nationwide Trends in the Incidence and Use of Immunosuppressive Therapy for Non-Infectious Non-Anterior Uveitis in South Korea (2010-2021).","authors":"Sunjin Hwang, Jiyeong Kim, Min Ho Kang, Eun Hee Hong, Yong Un Shin","doi":"10.1080/09273948.2025.2524587","DOIUrl":"https://doi.org/10.1080/09273948.2025.2524587","url":null,"abstract":"Purpose: To investigate the incidence of non-infectious non-anterior uveitis (NINAU) based on steroid prescriptions recorded in the Korean National Health Insurance Service (KNHIS) database, covering nearly the entire Korean population.Methods: Data were collected from patients diagnosed with uveitis who visited clinics between 2010 and 2021. Patients categorized as having NINAU prescribed steroids within one month were defined as \"true NINAU.\" We compared the demographics and underlying comorbidities between patients treated with steroids alone and those receiving immunomodulatory therapy (IMT). Additionally, we analysed trends in IMT use.Results: Among 38 271 patients with NINAU, the average incidence (per 100, 000 persons) was 6.2 (95% confidence interval, 6.1-6.3) increasing from 2010 to 2017 before gradually declining. Incidence rates increased with age. Most patients with NINAU were managed with systemic corticosteroids alone (approximately 89%); however, steroid-sparing IMT use increased from 2010 to 2021. By 2021, nearly one-third of patients treated with IMT required combination regimens, reflecting increased therapeutic complexity in refractory cases.Conclusion: We estimated the nationwide incidence of NINAU from the KNHIS database by incorporating steroid prescriptions as an additional criterion. These findings could help inform the national impact of NINAU in South Korea and may have implications for other countries.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Efficacy of High-Dosage Infliximab in Recalcitrant Retinal Vasculitis. 大剂量英夫利昔单抗治疗顽固性视网膜血管炎的安全性和有效性。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-24 DOI: 10.1080/09273948.2025.2504577

Yanliang Li, Thitiporn Thongborisuth, Ryan Lee, Nissim Stolberg, Nadera Sweiss, Ann-Marie Lobo-Chan, Pooja Bhat

{"title":"Safety and Efficacy of High-Dosage Infliximab in Recalcitrant Retinal Vasculitis.","authors":"Yanliang Li, Thitiporn Thongborisuth, Ryan Lee, Nissim Stolberg, Nadera Sweiss, Ann-Marie Lobo-Chan, Pooja Bhat","doi":"10.1080/09273948.2025.2504577","DOIUrl":"https://doi.org/10.1080/09273948.2025.2504577","url":null,"abstract":"Purpose: We evaluated the long-term safety and efficacy of high-dosage infliximab and biosimilars (IFX+) in recalcitrant, non-infectious inflammatory retinal vasculitis (RV) after antimetabolite and adalimumab failure.Methods: This retrospective study included patients from the University of Illinois at Chicago Uveitis Service (2014-2024) who transitioned to IFX+ after prior treatment failure. Patients were categorized into low-dosage (LD, ≤5 mg/kg/Q4W, n = 14), medium-dosage (MD, 5.5-9.5 mg/kg/Q4W, n = 8), and high-dosage (HD, ≥10 mg/kg/Q4W, n = 9) groups. Efficacy was defined as ≥ 1 zone fluorescein angiographic (FA) improvement, prednisone reduction to < 10 mg/day with no flares, or both, at 6, 12, and 24 months, and last follow-up. Secondary outcomes included visual acuity (VA) and central macular thickness changes.Results: At 12 months, efficacy was achieved by 57.1%, 87.5%, and 88.9% of LD, MD, and HD IFX+ patients, increasing to 83.3%, 75.0%, and 100% by last visits. FA improvement rate was 60.0% (LD), 50.0% (MD), and 87.5% (HD) at 12 months, increasing to 71.4%, 60.0%, and 100% at last visits. VA significantly improved in HD by 12 months (p = 0.03) and MD by 24 months (p = 0.02). LD and MD groups required dosage increases to sustain inflammation control. By 24 months, no significant dosage differences between groups existed. No adverse events were reported in the HD group.Conclusion: In this retrospective study, medium- and high-dosage IFX+ achieved better inflammation control and visual outcomes versus low-dosage IFX+, with no additional safety concerns, in treating recalcitrant non-infectious inflammatory RV. Early initiation at greater dosages may optimize IFX response, reduce treatment duration, and improve health-related quality of life.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

There's Always a Bigger Fish. 总有更大的鱼。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-24 DOI: 10.1080/09273948.2025.2504581

Nicolas Kitic, Adélaïde Toutee, Isabelle Audo, Alexandre Le Joncour, Dimitri Psimaras, Valérie Touitou

{"title":"There's Always a Bigger Fish.","authors":"Nicolas Kitic, Adélaïde Toutee, Isabelle Audo, Alexandre Le Joncour, Dimitri Psimaras, Valérie Touitou","doi":"10.1080/09273948.2025.2504581","DOIUrl":"10.1080/09273948.2025.2504581","url":null,"abstract":"Purpose: To report a rare case of cancer-associated retinopathy (CAR) presenting initially as a bilateral acute vision loss in a 72-year-old female patient with a history of tongue carcinoma. Systemic work-up revealed a metastatic uterine neuroendocrine carcinoma.Methods: Case report describing clinical presentation and diagnostic work up in a patient with CAR syndrome.Results: A 72-year-old female patient was referred for bilateral acute severe vision loss immediately after axillary node dissection in the context of a tongue carcinoma. Ophthalmological examination revealed rapidly evolutive outer retinal atrophy, with acute severe vision loss to light perception in both eyes within a few days. CAR-syndrome was suspected in this patient with tongue carcinoma and a positive sentinel lymph node. However, a systemic work-up revealed a metastatic tumor of the uterine body.Despite high-dose systemic corticosteroids, plasmapheresis, and chemotherapy, she did not present any functional recovery.Conclusion: CAR-syndrome may precede the diagnosis of the associated tumor. Thorough medical history, extensive work-up is the key in order not to miss the primitive lesion causative of the CAR syndrome, even in patients with another known malignancy.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-3"},"PeriodicalIF":2.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Clinical Characteristics Among Herpetic Retinitis: Acute Retinal Necrosis and Cytomegalovirus Retinitis. 疱疹性视网膜炎的临床特点：急性视网膜坏死与巨细胞病毒性视网膜炎的比较。

IF 2.6 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-06-24 DOI: 10.1080/09273948.2025.2522955

Hiromasa Hirai, Daiki Kuraoka, Tetsuo Ueda, Satoru Kase

{"title":"Comparison of Clinical Characteristics Among Herpetic Retinitis: Acute Retinal Necrosis and Cytomegalovirus Retinitis.","authors":"Hiromasa Hirai, Daiki Kuraoka, Tetsuo Ueda, Satoru Kase","doi":"10.1080/09273948.2025.2522955","DOIUrl":"https://doi.org/10.1080/09273948.2025.2522955","url":null,"abstract":"Purpose: To compare the characteristics of patients with herpetic retinitis, specifically acute retinal necrosis (ARN) and cytomegalovirus retinitis (CMVR).Methods: This retrospective study included patients who visited Nara Medical University Hospital between 2014 and 2024. A total of 38 patients (53 eyes) diagnosed with ARN or CMVR based on the diagnostic criteria were enrolled.Results: The ARN group (11 patients, 14 eyes) showed more anterior inflammation and peripheral lesions than the CMVR group (27 patients, 39 eyes). Although initial best-corrected visual acuity (BCVA) was similar between groups, the CMVR group demonstrated significantly better BCVA at the final visit (p = 0.004). Among eyes with poor initial BCVA (≥0.3 logMAR), significant post-treatment improvement was observed in the CMVR group but not in the ARN group (p = 0.006, p = 0.30, respectively). Subgroup analysis of CMVR revealed that HIV-positive patients were all male and significantly younger than HIV-negative patients (p = 0.029). HIV-negative patients were further classified based on having either hematologic disease or receiving immunosuppressive therapy. The hematologic disease subgroup had more bilateral involvement (p = 0.0498) and higher cytomegalovirus antigen-positive cell count on the cytomegalovirus antigenemia test (C7HRP, p = 0.049).Conclusion: Although both ARN and CMVR are caused by herpesviruses, they exhibit distinct clinical features and disease progression. CMVR subtypes can also be differentiated based on patient background and laboratory findings. Appropriate evaluation of the patient's background and clinical presentation is essential for management of herpetic retinitis.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0