Ocular Immunology and Inflammation最新文献_第5页

Tocilizumab for Silicone Oil-Induced Recalcitrant Cystoid Macular Edema in a Patient with Recurrent Acute Retinal Necrosis-Associated Retinal Detachment. 托珠单抗治疗复发性急性视网膜坏死相关视网膜脱离患者硅油诱导的顽固性囊样黄斑水肿。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-18 DOI: 10.1080/09273948.2025.2519849

Warren W Pan, Mahsaw Mansoor, David Riccardi, Jacqueline A Madison, Thomas J Wubben, Shilpa Kodati, Jason Miller

{"title":"Tocilizumab for Silicone Oil-Induced Recalcitrant Cystoid Macular Edema in a Patient with Recurrent Acute Retinal Necrosis-Associated Retinal Detachment.","authors":"Warren W Pan, Mahsaw Mansoor, David Riccardi, Jacqueline A Madison, Thomas J Wubben, Shilpa Kodati, Jason Miller","doi":"10.1080/09273948.2025.2519849","DOIUrl":"10.1080/09273948.2025.2519849","url":null,"abstract":"Purpose: We report a case of refractory silicone oil-induced cystoid macular edema in a patient with recurrent acute retinal necrosis-related retinal detachments successfully treated with tocilizumab without silicone oil removal nor reactivation of the acute retinal necrosis.Methods: Single-patient case report.Results: A monocular patient with recurrent acute retinal necrosis-related retinal detachments necessitating indefinite silicone oil tamponade developed intractable cystoid macular edema immediately after silicone oil placement that was unresponsive to multiple therapies over nearly a year. After a single dose of tocilizumab, the patient demonstrated significant clinical improvement with resolution of the macular edema and reduction in petaloid macular leakage on fluorescein angiography. With continued tocilizumab treatment, silicone oil tamponade could be maintained, and no reactivation of acute-retinal necrosis was noted.Conclusion: This case represents the first documented successful use of tocilizumab in treating silicone oil-induced recalcitrant cystoid macular edema. When silicone oil cannot be removed from an eye and when steroids risk reactivating viral retinal disease, tocilizumab may offer a safe and effective treatment alternative for such macular edema.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1869-1872"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular and Periocular Leprosy Confirmed by Polymerase Chain Reaction and Histopathology with Therapeutic Insights. 经聚合酶链反应和组织病理学证实的眼部和眼周麻风病的治疗见解。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-05-24 DOI: 10.1080/09273948.2025.2509719

Smitha Kuthyar Shambu, Kavya Nagaraj, Santosh Ramesh, Nashra Alma, Shruthi Mysore Krishna, Madhusmita Das

{"title":"Ocular and Periocular Leprosy Confirmed by Polymerase Chain Reaction and Histopathology with Therapeutic Insights.","authors":"Smitha Kuthyar Shambu, Kavya Nagaraj, Santosh Ramesh, Nashra Alma, Shruthi Mysore Krishna, Madhusmita Das","doi":"10.1080/09273948.2025.2509719","DOIUrl":"10.1080/09273948.2025.2509719","url":null,"abstract":"Purpose: Mycobacterium leprae commonly affects organs such as skin, peripheral nerves, joints and eyes. However, its intraocular presence has not been documented before. Through our retrospective case report, we aim to raise the awareness of the possibility of intraocular invasion by Mycobacterium leprae.Methods: A 56-year-old male, diagnosed with left periocular leprosy at our medical centre, developed pain, redness, and diminution of vision while still on Multi-Drug Therapy (MDT). On examination, he had corneal ulceration, corneal melt, and endophthalmitis. He underwent emergent therapeutic keratoplasty with lateral tarsorrhaphy and multiple intravitreal injections.Results: Histopathological examination of cornea using Ziehl-Neelsen and Fite-Faraco staining techniques revealed the presence of acid-fast bacilli in the corneal epithelium and anterior stroma. The Descemet's membrane was intact with an adherent endothelial plaque-like hypopyon, which also showed positivity for Lepra bacilli on special stains. The corneal button, hypopyon, and vitreous sample tested positive for Mycobacterium leprae detected via polymerase-chain reaction (PCR). He was started on topical fortified imipenem drops & intravitreal Vancomycin + Imipenem + Dexamethasone. USG-B scan after 48 h showed marked improvement with a few moderate dot echoes. Intravitreal injections were repeated every 48 h for 2 weeks, with serial USG B scans showing significant reduction in vitreous echoes.Conclusion: This case report thus provides evidence that Mycobacterium leprae can indeed penetrate the ocular coats despite a good immune response & Multi-Drug Therapy. Intravitreal injection Imipenem seems to be an effective drug choice in the management of Mycobacterium leprae endophthalmitis.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1824-1829"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular Hypertension or Glaucoma Risk Factor Prediction Models for Patients with Fuchs Uveitis Syndrome. Fuchs葡萄膜炎综合征患者高眼压或青光眼危险因素预测模型

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-11 DOI: 10.1080/09273948.2025.2507717

Xinle Zhang, Ao Lu, Yanlin Pu, Hui Liu, Keyan Li, Guannan Su, Peizeng Yang

{"title":"Ocular Hypertension or Glaucoma Risk Factor Prediction Models for Patients with Fuchs Uveitis Syndrome.","authors":"Xinle Zhang, Ao Lu, Yanlin Pu, Hui Liu, Keyan Li, Guannan Su, Peizeng Yang","doi":"10.1080/09273948.2025.2507717","DOIUrl":"10.1080/09273948.2025.2507717","url":null,"abstract":"Purpose: Fuchs uveitis syndrome (FUS) is a chronic inflammatory disorder that can lead to ocular hypertension (OHT)/glaucoma. We aimed to investigate the risk factors for OHT/glaucoma and develop prediction models for these complications in patients with FUS.Methods: Patients with FUS being referred to the uveitis centre at the First Affiliated Hospital of Chongqing Medical University between April 2008 and March 2023 were enrolled and divided into training and test sets in a 7:3 ratio. Cox regression analysis was used to construct a traditional clinical prediction model (TCPM). Multiple artificial intelligence algorithms were applied to construct 101 machine learning (ML) models. The Goldmann-Witmer coefficient (GWC) was used to investigate the relationship between antiviral antibodies in the aqueous humour and OHT/glaucoma in these patients.Results: The study included 1099 patients with FUS. Fifteen clinical features were chosen for the construction of TCPM and 101 ML models. Univariate Cox regression analysis identified seven features correlated with OHT/glaucoma. Multivariate Cox regression analysis revealed that three parameters were significantly correlated with OHT/glaucoma. The TCPM demonstrated a satisfactory predictive performance. The least absolute shrinkage and selection operator+random survival forest model was the best-performing ML model. Antiviral antibodies in the aqueous humour (GWC-positive) showed no statistically significant association with the development of OHT/glaucoma.Conclusion: The most significant risk factors for OHT/glaucoma in patients with FUS were ocularor systemic corticosteroid treatment, recurrence at least three times per year, and male sex. The TCPM demonstrated the highest utility and performance for predicting OHT/glaucoma in these patients.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1580-1588"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacovigilance Analysis of Lifitegrast-Associated Adverse Events Using the FDA Adverse Event Reporting System (FAERS) Database. 使用FDA不良事件报告系统（FAERS）数据库对lifitegrast相关不良事件进行药物警戒分析。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-12 DOI: 10.1080/09273948.2025.2518257

Dongzhi Wu, Zhijing Liu, Tao Zhang, Wenhui He, Chengjie Ke, Maohua Chen

{"title":"Pharmacovigilance Analysis of Lifitegrast-Associated Adverse Events Using the FDA Adverse Event Reporting System (FAERS) Database.","authors":"Dongzhi Wu, Zhijing Liu, Tao Zhang, Wenhui He, Chengjie Ke, Maohua Chen","doi":"10.1080/09273948.2025.2518257","DOIUrl":"10.1080/09273948.2025.2518257","url":null,"abstract":"Background: Lifitegrast is the first lymphocyte function-associated antigen-1 antagonist approved by the United States Food and Drug Administration (FDA) for the treatment of the signs and symptoms of dry eye disease. Its safety has not been fully elucidated in a real-world analysis. Thus, we conducted a pharmacovigilance analysis using data on lifitegrast-associated adverse events (AEs) from the FDA's adverse event reporting system (FAERS).Methods: A comprehensive search of the FAERS database was conducted to extract all available data on lifitegrast from the time of its initial market release (July 2016) until March 2024. Signals of lifitegrast-associated AEs were quantified by calculating reporting odds ratio, proportional reporting ratio, information component, and empirical Bayesian geometric mean.Results: In total 12 929,815 AE reports were collected from the FAERS database. Lifitegrast was deemed the primary suspect in 12 390 of these reports. Comprehensive analysis using four algorithms resulted in the identification and retention of 179 preferred terms exhibiting significant disproportionality. In addition to known AEs, unexpected and novel AEs, such as hypoacusis, instillation site infection, temporomandibular joint syndrome, and reduced blood folate levels, were identified.Conclusion: Most lifitegrast-related AEs identified in this study were consistent with those described on the drug label, but some other signals potentially associated with lifitegrast were identified. Prospective studies are needed to verify and clarify these AEs' relationship to lifitegrast.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1652-1660"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Factors for Ocular Hypertension and Glaucoma Secondary to Uveitis: Insights from a Tertiary Referral Hospital. 眼压升高和继发于葡萄膜炎的青光眼的预测因素：来自三级转诊医院的见解。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-05-20 DOI: 10.1080/09273948.2025.2506805

Mahmut Asfuroğlu, Cenk Zeki Fikret, Meltem Kılıç, Pınar Nalçacıoğlu

{"title":"Predictive Factors for Ocular Hypertension and Glaucoma Secondary to Uveitis: Insights from a Tertiary Referral Hospital.","authors":"Mahmut Asfuroğlu, Cenk Zeki Fikret, Meltem Kılıç, Pınar Nalçacıoğlu","doi":"10.1080/09273948.2025.2506805","DOIUrl":"10.1080/09273948.2025.2506805","url":null,"abstract":"Purpose: The aim of this study was to investigate the predictive factors for the development of uveitic glaucoma (UG) and ocular hypertension secondary to uveitis (OHT-SU).Method: The medical records of 1,160 patients with uveitis at a tertiary referral hospital in Ankara were analyzed. A total of 97 eyes of 81 patients with UG/OHT-SU were identified. In addition to demographic and etiological data, patients were analysed for the presence of synechiae, peak intraocular pressure (IOP) and peak anterior chamber reaction, need for glaucoma and cataract surgery during follow-up.Results: The most prominent etiologies associated with UG/OHT-SU were viral uveitis, followed by Fuchs' uveitis, Behçet's disease and pars planitis. Elevated peak IOP measurements were found to be correlated with the development of glaucoma in patients with uveitis (p < 0.001). The findings indicated that an increased peak anterior chamber reaction was a risk factor for the necessity of glaucoma surgery (OR = 4.04; 95% CI = 2.43-6.71; p < 0.001). The formation of synechiae was associated with increased peak anterior chamber reactions (p = 0.004), resulting in a higher incidence of surgical intervention for glaucoma (OR = 5.51; 95% CI = 2.00-15.20; p = 0.001).Conclusion: UG/OHT-SU is a specific condition that affects a notable proportion of uveitis patients in Turkey, requiring a multidisciplinary approach. In patients with uveitis, elevated peak IOP, pronounced anterior chamber reaction and synechia formation are crucial factors in the progression to glaucoma and the escalating necessity for surgical intervention. Early and effective control of inflammation is needed to prevent progression to refractory glaucoma and vision loss in these patients.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1565-1571"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Fundus Autofluorescence in Candida Chorioretinitis: Insights from a Clinical Case. 眼底自身荧光在念珠菌性脉络膜视网膜炎中的作用：来自一个临床病例的见解。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 DOI: 10.1080/09273948.2025.2560634

Rosario Izquierdo-Escámez, Matteo Belletti, Irene Canal-Fontcuberta, Marta Mora-Rillo, Ester Carreño

{"title":"Role of Fundus Autofluorescence in Candida Chorioretinitis: Insights from a Clinical Case.","authors":"Rosario Izquierdo-Escámez, Matteo Belletti, Irene Canal-Fontcuberta, Marta Mora-Rillo, Ester Carreño","doi":"10.1080/09273948.2025.2560634","DOIUrl":"https://doi.org/10.1080/09273948.2025.2560634","url":null,"abstract":"Purpose: To describe a case of mild Endogenous Candida Chorioretinitis (ECC) in a patient with candidemia, highlighting the value of fundus autofluorescence (FAF).Methods: A case report.Results: A 63-year-old man developed Candida albicans candidemia secondary to septic thrombophlebitis after abdominal surgery. Although he was visually asymptomatic, ophthalmologic evaluation revealed lesions consistent with ECC. FAF showed hyperautofluorescent lesions, including subtle foci missed on fundus exam. High-Definition Optical Coherence Tomography (HD-OCT) revealed inner retinal hyperreflectivity with mild ellipsoid zone disruption, while optical coherence tomography angiography (OCT-A) demonstrated choriocapillaris hypoperfusion partially matching the FAF findings. The lesions gradually resolved on FAF and HD-OCT during follow-up with systemic antifungal therapy, and no sequelae were observed at the 8-week follow-up.Conclusion: FAF could be incorporated into the routine evaluation of patients with candidemia. It can support diagnosis, facilitate the detection of overlooked foci, and assist in follow-up, therapeutic decision-making, and prognostic evaluation.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-5"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the COTS Calculator for Tubercular Uveitis: Predictive Performance and Diagnostic Utility in an Indian Cohort. 结核性葡萄膜炎的COTS计算器的验证：在印度队列中的预测性能和诊断效用。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-16 DOI: 10.1080/09273948.2025.2517309

Janakiraman Palani, Carlos Cifuentes Gonzalez, Gazal Patnaik, William Rojas-Carabali, Ludi Zhang, Zheng Xian Thng, Bernett Lee, Rupesh Agrawal, Jyotirmay Biswas

{"title":"Validation of the COTS Calculator for Tubercular Uveitis: Predictive Performance and Diagnostic Utility in an Indian Cohort.","authors":"Janakiraman Palani, Carlos Cifuentes Gonzalez, Gazal Patnaik, William Rojas-Carabali, Ludi Zhang, Zheng Xian Thng, Bernett Lee, Rupesh Agrawal, Jyotirmay Biswas","doi":"10.1080/09273948.2025.2517309","DOIUrl":"10.1080/09273948.2025.2517309","url":null,"abstract":"Purpose: Diagnosing ocular tuberculosis (OTB) is clinically challenging due to its paucibacillary nature and lack of definitive diagnostic tests. The Collaborative Ocular Tuberculosis Study (COTS) Calculator was developed as a clinical decision-support tool to guide anti-tubercular therapy (ATT) initiation. This study externally validates the COTS Calculator in a high-burden Indian cohort and assesses the additive value of radiological and immunological testing.Methods: This retrospective cohort study included 196 OTB patients treated between 2015 and 2022 at a tertiary eye care center in South India. Inclusion required complete diagnostic workup, ≥6-month follow-up post-ATT, and at least one supportive test (TST, IGRA, CT, or CXR). Two thresholds were evaluated: M4I1 (median ≥ 4) and M4I2 (median ≥ 4, IQR ≤ 2). Treatment response and recurrence were primary outcomes. Diagnostic performance was measured using AUC, sensitivity, specificity, PPV, and NPV. Composite scores (CT+CXR and TST+IGRA) were also analyzed.Results: The M4I2 threshold yielded higher sensitivity (83%) than M4I1 (60%) with comparable AUC (0.60 vs 0.58), though at lower specificity (38% vs 56%). Both thresholds achieved high PPV (94%) but poor NPV (11-17%). Composite testing showed similar high PPV (93%) and poor NPV (9-11%). Higher COTS scores and multiple positive tests correlated with favorable treatment response.Conclusions: The COTS Calculator, particularly the M4I2 model, provides a useful clinical tool to guide ATT decisions in OTB. While limited in ruling out TB, its integration with radiological and immunological testing supports early treatment decisions in TB-endemic settings. Prospective validation is warranted.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1634-1642"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine Profiling and Clinical Correlates of Conjunctival Wound Healing After Trabeculectomy: Implications for Scar Formation in Glaucoma Patients. 细胞因子谱分析和小梁切除术后结膜伤口愈合的临床相关性：青光眼患者瘢痕形成的意义。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-06-07 DOI: 10.1080/09273948.2025.2516081

Qin Zhang, Bo Zhao, Yan Bai

{"title":"Cytokine Profiling and Clinical Correlates of Conjunctival Wound Healing After Trabeculectomy: Implications for Scar Formation in Glaucoma Patients.","authors":"Qin Zhang, Bo Zhao, Yan Bai","doi":"10.1080/09273948.2025.2516081","DOIUrl":"10.1080/09273948.2025.2516081","url":null,"abstract":"Purpose: Understanding the role of scar markers and inflammatory factors in filtering bleb scarring after glaucoma surgery is essential for improving conjunctival wound healing and surgical outcomes. This study aimed to investigate conjunctival wound healing and its impact on scar formation and inflammatory responses in glaucoma patients after surgery.Methods: This study included 130 primary glaucoma patients who underwent trabeculectomy from January 2022 to January 2024. After 4 months of follow-up (with initial assessment at 14 days), patients were categorized into a scarring group (n = 38) and a nonscarring group (n = 92). Scar markers, inflammatory factors, and clinical data were analyzed. Pearson correlation and logistic regression analyses were conducted to explore the factors influencing scarring.Results: Patients in the scarring group had greater preoperative intraocular pressure, lens thickness, and postoperative bleb leakage (p < 0.05). The levels of TGF-β, PDGF, CTGF, IL-6, IL-1β, and IFN-α were significantly greater in the scarring group (p < 0.05). TGF-β, PDGF, and CTGF were positively correlated with IL-6 (p < 0.05) but not with IL-1β or TNF-α (p > 0.05). Logistic regression indicated that bleb leakage and elevated TGF-β, PDGF, CTGF, and IL-6 levels were risk factors for scarring (p < 0.05).Conclusion: Elevated levels of TGF-β, PDGF, CTGF, and IL-6, along with bleb leakage, are risk factors for filtering bleb scarring after glaucoma surgery.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1624-1633"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral Keratitis in Chronic Ocular Graft-Versus-Host Disease: Virus Species and Clinical Characteristics. 慢性眼部移植物抗宿主病的病毒性角膜炎：病毒种类和临床特征。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-07-14 DOI: 10.1080/09273948.2025.2524589

Yunke Ma, Yinghan Zhao, Rongmei Peng, Gege Xiao, Yi Qu, Jinghao Qu, Yaning Zhao, Xiaozhen Liu, Jing Hong

{"title":"Viral Keratitis in Chronic Ocular Graft-Versus-Host Disease: Virus Species and Clinical Characteristics.","authors":"Yunke Ma, Yinghan Zhao, Rongmei Peng, Gege Xiao, Yi Qu, Jinghao Qu, Yaning Zhao, Xiaozhen Liu, Jing Hong","doi":"10.1080/09273948.2025.2524589","DOIUrl":"10.1080/09273948.2025.2524589","url":null,"abstract":"Purpose: To investigate the virus species, risk factors and clinical characteristics of viral keratitis in patients with chronic ocular graft-versus-host disease (coGVHD).Methods: A chart review of patients with coGVHD who visited Peking University Third Hospital between May 2020 and September 2024 was conducted. Demographic and clinical characteristics and laboratory test results were collected. Multivariate logistic regression was performed to explore the risk factors for viral keratitis. The results of viral DNA polymerase chain reaction of aqueous humor or corneal tissue were reviewed to determine the infecting virus species.Results: A total of 373 patients with coGVHD were included. The prevalence of viral keratitis was 4.6%. The most frequent infecting virus was cytomegalovirus (64.7%). Topical steroid use (odds ratio (OR) 8.88, 95% confidence interval (CI) 1.15-68.80; p = 0.037), systemic steroid use (OR 3.15, 95% CI 1.10-0.02; p = 0.032), and eyelid margin irregularities (OR 13.36, 95% CI 1.73-102.94; p = 0.013) were risk factors for viral keratitis. CoGVHD patients with viral keratitis presented with persistent epithelial defects, corneal ulcers and even corneal perforation. Corneal edema, keratic precipitates and neovascularization were observed. Fourteen patients underwent keratoplasty, and 4 of them had to undergo repeat keratoplasty due to corneal perforation or graft dissolution.Conclusions: CMV was the most frequent infecting virus in coGVHD patients with viral keratitis. Topical and systemic steroid use and eyelid margin irregularities were identified as risk factors for viral keratitis. Viral keratitis in coGVHD patients can cause devastating vision damage, even when keratoplasty is performed.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1697-1702"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exogenous Fungal Endophthalmitis: A 20-Year Experience at a Tertiary Referral Centre in North China. 外源性真菌性眼内炎：中国北方某三级转诊中心20年的经验。

IF 2 4区医学

Ocular Immunology and Inflammation Pub Date : 2025-10-01 Epub Date: 2025-05-22 DOI: 10.1080/09273948.2025.2509715

Yan Qi, Fang Liu, Lingxiao Lun, Yan Gao, Xiaoli Xing, Kunkun Zheng, Lei Wan

{"title":"Exogenous Fungal Endophthalmitis: A 20-Year Experience at a Tertiary Referral Centre in North China.","authors":"Yan Qi, Fang Liu, Lingxiao Lun, Yan Gao, Xiaoli Xing, Kunkun Zheng, Lei Wan","doi":"10.1080/09273948.2025.2509715","DOIUrl":"10.1080/09273948.2025.2509715","url":null,"abstract":"Purpose: To report the epidemiological characteristics, causative pathogens, treatment approaches, and outcomes of culture-proven exogenous fungal endophthalmitis (EFE).Methods: This retrospective, interventional case series analysed the data of 112 patients with culture-positive EFE treated at a tertiary centre in North China between 2001 and 2020. The medical data of patients were extracted from hospital records.Results: EFE was associated with fungal keratitis, penetrating trauma, and intraocular surgery in 67 (59.8%), 39 (34.8%), and six eyes (5.4%), respectively. The primary cause of infection was mould (106/112, 94.6%), followed by yeast infection (6/112, 5.4%). Most keratitis cases were caused by Fusarium (32/67, 47.8%). Moreover, Aspergillus was the predominant species associated with penetrating trauma (15/39, 38.5%). Furthermore, Fusarium accounted for 50% (3/6) of postoperative cases. More than half of the eyes (89/112, 79.5%) were preserved through penetrating keratoplasty, vitrectomy, or intravitreal antifungal injections. However, 23 eyes (20.5%) were eviscerated, including 16 with fungal keratitis and seven with penetrating trauma.Conclusion: Fusarium and Aspergillus were the predominant pathogens in EFE, with fungal keratitis as the leading cause. Visual prognosis varied, with keratitis-associated cases showing the poorest outcomes, underscoring the need for early diagnosis and timely intervention.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1611-1617"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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