Role of Fundus Autofluorescence in Candida Chorioretinitis: Insights from a Clinical Case.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-10-01 DOI:10.1080/09273948.2025.2560634

Rosario Izquierdo-Escámez, Matteo Belletti, Irene Canal-Fontcuberta, Marta Mora-Rillo, Ester Carreño

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引用次数: 0

Abstract

Purpose: To describe a case of mild Endogenous Candida Chorioretinitis (ECC) in a patient with candidemia, highlighting the value of fundus autofluorescence (FAF).

Methods: A case report.

Results: A 63-year-old man developed Candida albicans candidemia secondary to septic thrombophlebitis after abdominal surgery. Although he was visually asymptomatic, ophthalmologic evaluation revealed lesions consistent with ECC. FAF showed hyperautofluorescent lesions, including subtle foci missed on fundus exam. High-Definition Optical Coherence Tomography (HD-OCT) revealed inner retinal hyperreflectivity with mild ellipsoid zone disruption, while optical coherence tomography angiography (OCT-A) demonstrated choriocapillaris hypoperfusion partially matching the FAF findings. The lesions gradually resolved on FAF and HD-OCT during follow-up with systemic antifungal therapy, and no sequelae were observed at the 8-week follow-up.

Conclusion: FAF could be incorporated into the routine evaluation of patients with candidemia. It can support diagnosis, facilitate the detection of overlooked foci, and assist in follow-up, therapeutic decision-making, and prognostic evaluation.

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眼底自身荧光在念珠菌性脉络膜视网膜炎中的作用：来自一个临床病例的见解。

目的：报告1例念珠菌血症患者发生轻度内源性念珠菌性脉络膜视网膜炎（ECC），强调眼底自身荧光（FAF）的价值。方法：1例病例报告。结果：1例63岁男性，腹部手术后继发感染性血栓性静脉炎白色念珠菌。虽然他在视觉上无症状，但眼科检查显示病变符合ECC。FAF显示高自荧光病变，包括眼底检查遗漏的细微病灶。高清晰度光学相干断层扫描（HD-OCT）显示视网膜内部高反射率和轻度椭球区破坏，而光学相干断层扫描血管造影（OCT-A）显示绒毛膜毛细血管灌注不足，部分与FAF结果相符。经全身抗真菌治疗后，FAF和HD-OCT检查病灶逐渐消退，随访8周未见后遗症。结论：FAF可纳入念珠菌病患者的常规评估。它可以支持诊断，促进发现被忽视的病灶，并协助随访，治疗决策和预后评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.