Cytokine Profiling and Clinical Correlates of Conjunctival Wound Healing After Trabeculectomy: Implications for Scar Formation in Glaucoma Patients.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-06-07 DOI:10.1080/09273948.2025.2516081

Qin Zhang, Bo Zhao, Yan Bai

{"title":"Cytokine Profiling and Clinical Correlates of Conjunctival Wound Healing After Trabeculectomy: Implications for Scar Formation in Glaucoma Patients.","authors":"Qin Zhang, Bo Zhao, Yan Bai","doi":"10.1080/09273948.2025.2516081","DOIUrl":null,"url":null,"abstract":"Purpose: Understanding the role of scar markers and inflammatory factors in filtering bleb scarring after glaucoma surgery is essential for improving conjunctival wound healing and surgical outcomes. This study aimed to investigate conjunctival wound healing and its impact on scar formation and inflammatory responses in glaucoma patients after surgery.Methods: This study included 130 primary glaucoma patients who underwent trabeculectomy from January 2022 to January 2024. After 4 months of follow-up (with initial assessment at 14 days), patients were categorized into a scarring group (n = 38) and a nonscarring group (n = 92). Scar markers, inflammatory factors, and clinical data were analyzed. Pearson correlation and logistic regression analyses were conducted to explore the factors influencing scarring.Results: Patients in the scarring group had greater preoperative intraocular pressure, lens thickness, and postoperative bleb leakage (p < 0.05). The levels of TGF-β, PDGF, CTGF, IL-6, IL-1β, and IFN-α were significantly greater in the scarring group (p < 0.05). TGF-β, PDGF, and CTGF were positively correlated with IL-6 (p < 0.05) but not with IL-1β or TNF-α (p > 0.05). Logistic regression indicated that bleb leakage and elevated TGF-β, PDGF, CTGF, and IL-6 levels were risk factors for scarring (p < 0.05).Conclusion: Elevated levels of TGF-β, PDGF, CTGF, and IL-6, along with bleb leakage, are risk factors for filtering bleb scarring after glaucoma surgery.","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1-10"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ocular Immunology and Inflammation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09273948.2025.2516081","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Understanding the role of scar markers and inflammatory factors in filtering bleb scarring after glaucoma surgery is essential for improving conjunctival wound healing and surgical outcomes. This study aimed to investigate conjunctival wound healing and its impact on scar formation and inflammatory responses in glaucoma patients after surgery.

Methods: This study included 130 primary glaucoma patients who underwent trabeculectomy from January 2022 to January 2024. After 4 months of follow-up (with initial assessment at 14 days), patients were categorized into a scarring group (n = 38) and a nonscarring group (n = 92). Scar markers, inflammatory factors, and clinical data were analyzed. Pearson correlation and logistic regression analyses were conducted to explore the factors influencing scarring.

Results: Patients in the scarring group had greater preoperative intraocular pressure, lens thickness, and postoperative bleb leakage (p < 0.05). The levels of TGF-β, PDGF, CTGF, IL-6, IL-1β, and IFN-α were significantly greater in the scarring group (p < 0.05). TGF-β, PDGF, and CTGF were positively correlated with IL-6 (p < 0.05) but not with IL-1β or TNF-α (p > 0.05). Logistic regression indicated that bleb leakage and elevated TGF-β, PDGF, CTGF, and IL-6 levels were risk factors for scarring (p < 0.05).

Conclusion: Elevated levels of TGF-β, PDGF, CTGF, and IL-6, along with bleb leakage, are risk factors for filtering bleb scarring after glaucoma surgery.

查看原文本刊更多论文

细胞因子谱分析和小梁切除术后结膜伤口愈合的临床相关性：青光眼患者瘢痕形成的意义。

目的：了解青光眼术后瘢痕标志物和炎症因子在滤过性水泡瘢痕形成中的作用，对改善结膜创面愈合和手术效果具有重要意义。本研究旨在探讨青光眼术后结膜创面愈合及其对瘢痕形成和炎症反应的影响。方法：本研究纳入了从2022年1月至2024年1月接受小梁切除术的130例原发性青光眼患者。随访4个月后（第14天进行初步评估），将患者分为瘢痕组（n = 38）和非瘢痕组（n = 92）。分析疤痕标记物、炎症因子和临床数据。采用Pearson相关分析和logistic回归分析探讨影响瘢痕形成的因素。结果：瘢痕组患者术前眼压、晶状体厚度、术后泡漏均大于对照组（p p p p > 0.05）。Logistic回归分析显示，青光眼术后滤过性水泡瘢痕形成的危险因素为水泡渗漏及TGF-β、PDGF、CTGF、IL-6水平升高(p)。结论：TGF-β、PDGF、CTGF、IL-6水平升高及水泡渗漏是青光眼术后滤过性水泡瘢痕形成的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.