Risk of Ophthalmologic Comorbidities in Hidradenitis Suppurativa Patients.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-09-04 DOI:10.1080/09273948.2025.2550487

Jason J Jo, Hannah Verma, Omar Alani, Anisha Kasi, Mahaa Ayub, Nicholas Gulati, Sumayya Ahmad

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引用次数: 0

Abstract

Purpose: To assess associations between hidradenitis suppurativa (HS) and inflammatory and infectious eye diseases.

Methods: We created a matched cohort of adults with and without a diagnosis of HS and calculated relative risk (RR) ratios for inflammatory and infectious eye diseases using the Global TriNetX Database. We also calculated RR ratios for infectious and inflammatory eye diseases in HS patients based on the use of biologic medications.

Results: Based on our cohort of 57,749 adults with HS, we found an increased risk for corneal ulcers (RR: 1.66, p = 0.001), marginal corneal ulcers (RR: 2.82, p = 0.002), and scleritis (RR: 1.89, p = 0.009) and a decreased risk for conjunctivitis (RR: 0.75, p < 0.001), acute atopic conjunctivitis (RR: 0.78; p < 0.001), and mucopurulent conjunctivitis (RR: 0.71, p < 0.001) in HS patients compared to healthy controls. Subgroup analysis showed a decreased risk for conjunctivitis (RR: 0.62, p < 0.001) in adults with HS treated with adalimumab or secukinumab compared to adults with HS not treated with biologics.

Conclusion: This study found an increased risk for corneal ulcers, marginal corneal ulcers, and scleritis in adults with HS. Use of biologics was associated with a reduced risk of conjunctivitis in patients with HS compared to patients who did not have biologic exposure.

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化脓性汗腺炎患者眼部合并症的风险。

目的：评估化脓性汗腺炎（HS）与眼部炎症和感染性疾病之间的关系。方法：我们创建了一个匹配的成人队列，包括有和没有诊断为HS的成年人，并使用Global TriNetX数据库计算炎症性和感染性眼病的相对风险（RR）比。我们还根据生物药物的使用计算了HS患者感染性和炎症性眼病的RR比。结果：基于57,749名成人HS患者的队列，我们发现角膜溃疡（RR: 1.66, p = 0.001）、边缘角膜溃疡（RR: 2.82, p = 0.002）和巩膜炎（RR: 1.89, p = 0.009）的风险增加，结膜炎（RR: 0.75, p p p p）的风险降低。结论：本研究发现成人HS患者角膜溃疡、边缘角膜溃疡和巩膜炎的风险增加。与未使用生物制剂的患者相比，使用生物制剂与HS患者结膜炎风险降低相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.